Abstract: A prosthetic device includes a main body, a first anchor, and a second anchor. The main body has an atrial end and a ventricular end. The main body tapers from the atrial end to the ventricular end. The first and second anchors are coupled to the main body and are movable toward and away from the main body.

Abstract: A method for treating a heart valve involves delivering a catheter into a ventricle of a heart, advancing a coil from the catheter, rotating the coil at least partially around a papillary muscle of the ventricle, embedding a distal end of the coil in tissue of the ventricle, and manipulating a suture coupled to the coil to adjust a position of the papillary muscle.

Abstract: Prosthetic valve support structures of this specification include a body portion, an atrial flange portion, and a leaflet engaging portion. As the support structure (and the valve as a whole) is pushed out of or otherwise unrestrained from a delivery device, the free end(s) of the leaflet engaging portion will begin to bend radially outward or away from the body portion and will continue bending as more is exposed until its free end(s) are angled in an inflow direction, thereby positioning themselves between the radial outside of the native valve leaflets and the outflow track beyond the native valve annulus. As the support structure fully expands, the native valve leaflets remain trapped or engaged between the leaflet engaging portion and the body portion.

Abstract: A shunt is described that expands to an hourglass shape. As the shunt expands, both of its ends radially flare outwards relative to its middle section and the length of the shunt foreshortens, which causes the flared ends to engage the tissue surrounding a puncture or aperture within a patient's tissue.

Abstract: A prosthetic heart valve for implantation within a native atrioventricular heart valve. The prosthetic heart valve includes a self-expanding frame having an annular main body and a valve member disposed within the main body. The prosthetic heart valve includes an atrial sealing member formed by a fabric cover and a plurality of arms that are arranged side-by-side in a circumferential direction around the main body. The atrial sealing member extends radially outwardly from the main body and a peripheral portion of the atrial sealing member curves upwardly for conforming to surrounding native anatomy. The prosthetic heart valve further includes one or more ventricular anchors extending from the main body for capturing native leaflet tissue and thereby securing the prosthetic heart valve within the native atrioventricular heart valve.

Abstract: A shunt is described that expands to an hourglass shape. As the shunt expands, both of its ends radially flare outwards relative to its middle section and the length of the shunt foreshortens, which causes the flared ends to engage the tissue surrounding a puncture or aperture within a patient's tissue.

Abstract: A method of implanting a prosthetic apparatus preferably includes delivering the prosthetic apparatus to a native mitral valve and exposing ventricular anchors and a spacer body of the prosthetic apparatus from a distal end portion of a delivery apparatus. The ventricular anchors are controllably and forcibly expanded outwardly from the spacer body to an expanded configuration. The prosthetic apparatus is positioned relative to the native mitral valve such that native mitral valve leaflets are located between the ventricular anchors and the spacer body. The ventricular anchors are then contracted radially inwardly toward the spacer body to a compressed configuration. In the compressed configuration, the native mitral valve leaflets are secured between the ventricular anchors and the spacer body. After implantation, the spacer body is held between the native mitral valve leaflets, thereby blocking regurgitation and improving the function of the native mitral valve.

Abstract: Disclosed herein are devices and methods for creating a shunt between two vessels or lumens within a patient. While these devices and methods are generally described with regard to treatment of hypertension (e.g., pulmonary arterial hypertension) and/or right heart failure/disfunction, they can be used with a variety of different vessels and lumens for other purposes. The devices include puncturing guidewire embodiments that can more accurately pierce two vessels, as well as snare catheter designs that can prevent unwanted damage from a puncturing guidewire.

Abstract: Methods and devices that prevent stasis in the LAA by either increasing the flow through the LAA or by closing off or sealing the LAA. Increasing the flow is accomplished through shunts, flow diverters, agitators, or by increasing the size of the ostium. Closing off the LAA is accomplished using seals or by cinching the LAA.

Abstract: Methods and devices that prevent stasis in the LAA by either increasing the flow through the LAA or by closing off or sealing the LAA. Increasing the flow is accomplished through shunts, flow diverters, agitators, or by increasing the size of the ostium. Closing off the LAA is accomplished using seals or by cinching the LAA.

Abstract: Described herein are improved blood pumping devices, including improved intra-aortic balloon pumps and ventricular assist devices. The pumping efficiency of either device may be improved with the use of one or more valves, counter pulsation balloons, non-compliant tubular structures, secondary pumping balloons, and similar components.

Abstract: A shunt is described that expands to an hourglass shape. As the shunt expands, both of its ends radially flare outwards relative to its middle section and the length of the shunt foreshortens, which causes the flared ends to engage the tissue surrounding a puncture or aperture within a patient's tissue.

Abstract: Devices and methods of treating conditions cause or exacerbated by excessive fluid pressures or retentions, such as pulmonary hypertension, that involves shunting excessive fluid pressure from one bodily chamber or vessel to another bodily chamber or vessel.

Abstract: A shunt is described that expands to an hourglass shape. As the shunt expands, both of its ends radially flare outwards relative to its middle section and the length of the shunt foreshortens, which causes the flared ends to engage the tissue surrounding a puncture or aperture within a patient's tissue.

Abstract: A variety of methods and devices for manipulating tissue using stents and shunts that foreshorten when expanded. Many of the devices have ends that expand radially more than a center portion of the device, creating an hourglass or rivet shape that is useful for anchoring the device or putting a squeezing force on the tissue.

Abstract: A crimping device for a prosthetic heart valve can comprise an annular outer frame and an inner frame extending through the outer frame, the inner frame comprising first and second axial end portions and a plurality of jaw guides extending therebetween, where the inner frame defines a central opening extending therethrough. The crimping device can comprise a plurality of jaws operatively coupled to the inner and outer frames, each jaw having an inner portion positioned within the central opening of the inner frame and an engagement portion configured to slide along a respective jaw guide, each jaw guide comprising an inclined guiderail extending between the first and second axial end portions. Relative axial motion between the outer and inner frames causes radial motion of the jaws for crimping a prosthetic device positioned within the central opening.

Abstract: Devices and methods of treating conditions cause or exacerbated by excessive fluid pressures or retentions, such as pulmonary hypertension, that involves shunting excessive fluid pressure from one bodily chamber or vessel to another bodily chamber or vessel.

Abstract: A crimping system for a prosthetic heart valve comprises a split funnel comprising an elongated annular body having an enlarged insertion end, a narrower outlet end, and a central opening extending along a central longitudinal axis of the split funnel, between the insertion end and the outlet end. The body comprises first and second slots extending axially along opposite sides of the body from the outlet end toward the insertion end, the first and second slots defining first and second split portions of the body extending circumferentially between the first and second slots on opposite sides of the central opening. The crimping device is configured to crimp a prosthetic heart valve moving axially through the central opening from the insertion end to the outlet end while allowing portions of the prosthetic heart valve to protrude through the first and second slots and remain in an expanded configuration.

Abstract: Methods and devices that prevent stasis in the LAA by either increasing the flow through the LAA or by closing off or sealing the LAA. Increasing the flow is accomplished through shunts, flow diverters, agitators, or by increasing the size of the ostium. Closing off the LAA is accomplished using seals or by cinching the LAA.

Abstract: Several embodiments and methods are described for draining a lymphatic system for therapeutic purposes. The lymphatic draining can be performed by removal of fluid from the lymphatic system via a needle, a catheter, an access port, a reservoir, a shunt, or a combination of these devices. The drainage devices can be configured for use during only a single procedure or for reoccurring procedures.