Abstract: The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells and administering to the patient a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.

Abstract: A host server computer with an uncorrectable memory error can be repaired without a reboot operation. While initially booting a hypervisor, a special software Application Programming Interface (API) can be loaded between a BIOS System Management Mode (SMM) code and the hypervisor. Once the host server computer is booted and a number of virtual machines are executing, a memory error (e.g., uncorrectable error correction code (UECC)) can occur. In response, the hypervisor calls into the special software API identifying the defective memory rows that the BIOS needs to repair. The BIOS starts a soft Post Package Repair (PPR) process on those rows and gives back control to the hypervisor. When the repair is completed, the hypervisor loads a scrubbing virtual machine and validates that the memory is corrected. After the repair is validated, the hypervisor allows the available partition to take a new customer instance.

Abstract: An air conditioner system includes an outdoor unit, an indoor unit, and a sealed cooling system coupled between the outdoor unit and the indoor unit to circulate refrigerant through an indoor heat exchanger of the indoor unit and an outdoor heat exchanger of the outdoor unit. A method of operating the air conditioner system includes detecting a refrigerant leak at the indoor unit and shutting off refrigerant flow to the indoor unit in response to the detected refrigerant leak.

Abstract: Introduced here are pressure-mitigation apparatuses for mitigating the pressure applied to a human body by the support surface of an object. The pressure-mitigation apparatus can include a series of chambers that can be individually controlled to vary the pressure therein. By varying the chamber pressure, the main point of pressure applied by the support surface to the human body may be moved across the surface of the human body. An attachment apparatus may be used to securely adhere the pressure-mitigation apparatus to the support surface.

Abstract: A downhole electric submersible pump (ESP) assembly. The downhole ESP assembly disposed comprises a permanent magnet motor (PMM) comprising a first drive shaft, a stator, and a rotor within the stator and comprising a core coupled to the first drive shaft, wherein the core retains a first permanent magnet element within a first magnet pocket defined by the core that extends axially parallel to the first drive shaft and retains a second permanent magnet element within a second magnet pocket defined by the core that extends axially parallel to the first drive shaft; a seal section having a second drive shaft coupled to the first drive shaft; and a pump assembly having a third drive shaft coupled to the second drive shaft.

Abstract: A cable structure for use in a wellbore formed in a subsurface formation. The cable structure comprises superconducting material configured to provide power to a downhole tool in the wellbore. The cable structure comprises a cryogenic liquid supply channel configured to supply fluid to reduce temperature of the superconducting material. The cable structure comprises one or more cryogenic liquid return channels.

Abstract: Aspects of the disclosure relate to a clutch assembly for handling a container, and an associated method for using the clutch assembly. The clutch assembly includes a shaft configured to rotate in a first direction and a second direction, opposite from the first direction. The clutch assembly further includes a clutch coupled to a first end of the shaft. The clutch includes at least two rollers configured to move into a first position, extending radially beyond a periphery of the clutch, and out of the first position, extending radially flush with or inward from the periphery of the clutch.

Abstract: Introduced here are pressure-mitigation apparatuses for mitigating the pressure applied to a human body by the support surface of an object. The pressure-mitigation apparatus can include a series of chambers that can be individually controlled to vary the pressure therein. By varying the chamber pressure, the main point of pressure applied by the support surface to the human body may be moved across the surface of the human body. An attachment apparatus may be used to securely adhere the pressure-mitigation apparatus to the support surface.

Abstract: A method for automated assessment of aseptic technique of compounding in a compounding hood includes collecting, using sensors positioned in or around a compounding hood, data from which positions, orientations, and movements of objects used in an aseptic compounding task can be determined. The method further includes feeding the data into an automated aseptic technique evaluator. The method further includes identifying, using the automated aseptic technique evaluator and from the data, phases of the aseptic compounding task. The method further includes automatically detecting, by the automated aseptic technique evaluator, errors occurring during at least some of the phases. The method further includes generating and displaying, by the automated aseptic technique evaluator, output indicative of the errors.

Abstract: Systems, methods and apparatus for controlling operation of dual fuel engines are disclosed that regulate the fuelling amounts provided by a first fuel and a second fuel during operation of the engine. The first fuel can be a liquid fuel and the second fuel can be a gaseous fuel. The fuelling amounts are controlled to improve operational outcomes of the duel fuel engine.

Abstract: A routing platform coupled to a data network maintains, on local storage of the routing platform, a reflected file system structure corresponding to that of a file system on a network file share. The file system includes a file system object including file system object data, and the reflected file system structure includes a copy of the file system object lacking the file system object data. The routing platform presents, as a proxy, the network file share to a client node communicatively coupled to the routing platform via the data network. The routing platform routes file system protocol traffic between the client node and the network file share, and, if needed, does so by reference to the reflected file system structure.

Abstract: A system and method for triggering on platform usage can include at a platform, receiving and storing a trigger configuration of an account; operating a platform comprising internally executing a process on behalf of an account and publishing at least one event when executing the process; at the platform, incrementing a counter in response to the at least one event and if the stored trigger configuration species a usage key associated with a category of counted events of the at least one event; monitoring counters in a context of an associated trigger; and processing the trigger upon the counter satisfying condition of an associated trigger.

Abstract: A downhole electric submersible pump (ESP) assembly. The downhole ESP assembly comprises a permanent magnet motor (PMM) comprising a first drive shaft, a stator, and a rotor disposed within the stator and comprising a core coupled to the first drive shaft, wherein the core retains a first permanent magnet element within a first magnet pocket defined by the core that extends axially parallel to the first drive shaft and retains a second permanent magnet element within a second magnet pocket defined by the core that extends axially parallel to the first drive shaft; a seal section having a second drive shaft coupled to the first drive shaft; and a pump assembly having a third drive shaft coupled to the second drive shaft.

Abstract: Systems, methods, and non-transitory computer-readable media can access a plurality of schema-based encodings providing a structured representation of an environment captured by one or more sensors associated with a plurality of vehicles traveling through the environment. The plurality of schema-based encodings can be clustered into one or more clusters of schema-based encodings. At least one scenario associated with the environment can be determined based at least in part on the one or more clusters of schema-based encodings.

Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating cystic fibrosis, e.g., in subjects having a mutation resulting in F508del, are described.

Abstract: Described herein is a system for heating and/or cooling a fluid that includes a temperature forcing device having a bottom plate and a top plate hingedly coupled to the bottom plate. At least one of the bottom plate and the top plate has a recess or other area for receiving at least one flexible fluid holder (e.g., a polymer bag). The bottom plate and/or top plate also has at least one protrusion and/or recession in its interior wall(s) such that a fluid passageway in the flexible fluid holder is defined when the fluid holder is placed between the top and bottom plates, and the plates are closed together. The fluid holder then has a fluid inlet for receiving the fluid to be heated and/or cooled and a fluid outlet for delivering the fluid. The fluid, upon being heated and/or cooled by the temperature forcing device, may then be delivered to a patient or may be delivered to another system component, e.g., for additional heating/cooling.

Abstract: Some implementations include an apparatus configured to, in a wellbore, eliminate voltage on one or more first conductors that are electrically connected to a surface-based power source. The apparatus may include a shorting ring electrically connectable to the first conductors and configured to electrically short the first conductors upon establishing an electrical connection with the first conductors. The apparatus may include a solenoid assembly to actuate in response to power on the first conductors from the surface-based power source. The apparatus may include a pin slider assembly connected to the first conductors and configured to move, in response to actuation by the solenoid assembly, between an electrical connection with the shorting ring and an electrical connection with one or more second conductors that have an electrical connection with a permanent magnet motor winding in the wellbore.

Abstract: An illustrative valve block includes a plate, a fluid transfer block, and a diaphragm. The plate includes a channel configured to receive a first fluid and a recess connected to the channel. The fluid transfer block includes an inlet connection configured to receive a second fluid and an outlet connection. The fluid transfer block also includes a plurality of valve inlet bores connected to the inlet connection. The plurality of valve inlet bores are distributed along at least part of a first curved shape. The fluid transfer block further includes a plurality of valve outlet bores each fluidly connected to the outlet connection. The plurality of valve outlet bores are distributed along at least part of a second curved shape. The diaphragm is between the pressure plate and the fluid transfer block. The plurality of valve inlet bores and the plurality of valve outlet bores adjoin the recess.

Abstract: Aspects of the disclosure relate to a clutch assembly (100) for handling a container, and an associated method for using the clutch assembly. The clutch assembly includes a shaft (102) configured to rotate in a first direction and a second direction, opposite from the first direction. The clutch assembly further includes a clutch coupled to a first end of the shaft. The clutch includes at least two rollers (108) configured to move into a first position, extending radially beyond a periphery of the clutch, and out of the first position, extending radially flush with or inward from the periphery of the clutch.

Abstract: Sun shelves are described. An example sun shelf has a main body and a tubular member. The main body has a first wall, a second wall, a third wall, a fourth wall, a base, and defines a first intake, an outlet, and a recess. The first wall has a first height from the base. The second wall has a second height from the base. The third wall has a third height from the base. The fourth wall has a fourth height from the base. The fourth height is less than the first height, the second height, and the third height. The tubular member is attached to the main body and extends from the first intake to the outlet.