Abstract: Small molecule inhibitors of XBP1 splicing by IRE1? are provided, as well as methods for their use in treating or preventing cancer (e.g., endocrine resistant breast cancer), diabetes, and obesity.

Abstract: In an embodiment, an electronic component includes a power semiconductor device embedded in a dielectric core layer and at least one contact layer protruding from a first side face of the dielectric core layer. The contact layer includes an electrically insulating layer and at least one contact pad arranged on the electrically insulating layer. The at least one contact pad is electrically coupled with the power semiconductor device.

Abstract: A secondary window includes a first glazing, a film, and a first frame. The first glazing includes a glass substrate having a thickness, between a first glazing surface opposite a second glazing surface, less than 2.0 millimeters. The film is attached to the first glazing surface. The first glazing is secured in the first frame, which at least partially surrounds the glazing. A second secondary window includes a second glazing secured in a second frame, which at least partially surrounds the second glazing. The second glazing includes (a) a first pane having a first-pane thickness less than 2.0 millimeters and (b) a second pane having a second-pane thickness that exceeds the first-pane thickness.

Abstract: A method, system, and computer program product provides efficient matching of shipments with carriers and real time online tracking of shipments. The method includes receiving a carrier input that includes a desired end destination of an equipment of the carrier, and a processor locating at least one available shipment having one of (i) a shipment pick-up point within a pre-established, shipment pick-up zone and (ii) a shipment delivery point within an acceptable shipment drop-off zone of the desired end destination. The processor dynamically determines and maps an optimal route and generates and displays an available shipment (AV) user interface (UI), with a complete route for the equipment from a desired starting point to the desired end destination. The processor then calculates and provides, via the AV UI, an opportunity cost of the shipment, based in part on a total number of empty miles associated with the route.

Abstract: In an embodiment, a method includes inserting an electronic component including a power semiconductor device embedded in a dielectric core layer into a slot in a side face of a circuit board. The inserting the electronic component causes one or more electrically conductive contacts on one or more surfaces of the electronic component to electrically couple with one or more corresponding electrical contacts arranged on one or more surfaces of the slot.

Abstract: The present invention is an HVAC fan array wiring system that provides a quick connect box that is provided within the air stream of an HVAC air handler. Because the wiring for each fan within the fan array is to be connected to the quick connect box, the wiring materials and placement of the wiring can be predetermined at the time the fan array is designed. Accordingly, the novel wiring system and quick connect box reduces redundancies in manufacturing and installation of the fan array. Furthermore, the quick connect box and wiring system allows for easy installation of the HVAC fan array at a job site and improves a customer's experience with the control panel. This is primarily because, with the use of the claimed invention, an electrician need only link a main control and power line to the quick connect box and therefore, can install the control panel in a location that provides ease of access to the customer.

Abstract: The invention is directed to a process that combines the solvent deasphalting with resin hydrotreatment so as to reduce the costs associated with performing each of the steps separately. The integrated process of the invention permits higher product yields coupled with lower energy and transportation costs.

Abstract: Described is a medicament delivery device comprising a body adapted to be placed on the eye and a reservoir formed in the body containing a medicament. The body has a first surface adapted to contact at least a portion of the eye and be centered around a cornea. At least one projection is formed on the first surface. The projection includes a channel adapted to create a fluid flow path for the medicament from the reservoir to a terminal end of the projection.

Abstract: The invention relates to methods of inhibiting the growth or proliferation of a cell, the method comprising reducing the expression or activity of at least one gene in the cell selected from the group consisting of BLOC1S1, CDC2L1, CNOT1, DDX54, EIF3I, FANCG, FBP1, IER2, KIF1A, LCK, NR2F1, PNRC1, POLR2A, POLR2B, POLR2C, PRPF6, PSMB4, PSMC5, PSMD1, RPS2, SCNN1A, SF3A3, TAF2, TOB1 and TSC22D4.

Abstract: Compositions, devices, and methods of stabilizing Magneli phase materials are presented where the modified materials have a host phase and a locking phase in which locking compounds prevent rearrangement of a Magneli shear plane to a rutile structure and so prevent or reduce the oxidation of the Magneli phase material.

Abstract: A remotely deployable network of multi-rotor aircraft and landing stations enable widespread use of multi-rotor aircraft in varied environments and application scenarios. A multi-rotor aircraft having modular components to facilitate a range of applications performs remote operations. Landing stations provide a power source to remote aircraft and facilitate semi-autonomous landing. A computing device facilitates use interaction with a network of multi-rotor aircraft and landing stations that together form a network for transmitting data concerning individual and regional aircraft operations.

Abstract: There are many manufactures, makes, and models of solar radiometers to choose from. There are also many radiometer housings to choose from. I have not observed or deployed any of the combinations available for solar radiometers to satisfy the requirements of unattended perfect solar radiation measurements in cold climates. There is a large expense involved with deploying radiometers in remote Arctic and Alpine regions. Huge expense is continually lost due to the lack of consistent quality data. My concept has continually proven and guarantees that time and money will not be lost. This was proven with an intensive parametric comparison study that by focusing a volume of air with the proper amount of force, specifically with the Albee Arctic Kick-ice System Radiometer Housing (Patent pending #61/934,754, Patent pending #62/107,441), is completely effective in combating all icing issues using a variety of radiometers from quality radiometer manufacturers.

Abstract: Small molecule inhibitors of XBP1 splicing by IRE1? are provided, as well as methods for their use in treating or preventing cancer (e.g., endocrine resistant breast cancer), diabetes, and obesity.

Abstract: The invention relates to cancer, and more specifically to breast cancer, and particularly to estrogen receptor positive breast cancer that is resistant to endocrine therapy. The invention provides methods for selecting subgroups of subjects for treatment, and methods of treatment of a subgroup of subjects.

Abstract: A method, system, and computer program product provides efficient matching of shipments with carriers and real time online tracking of shipments. The method includes receiving a carrier input that includes a desired end destination of an equipment of the carrier, and a processor locating at least one available shipment having one of (i) a shipment pick-up point within a pre-established, shipment pick-up zone and (ii) a shipment delivery point within an acceptable shipment drop-off zone of the desired end destination. The processor dynamically determines and maps an optimal route and generates and displays an available shipment (AV) user interface (UI), with a complete route for the equipment from a desired starting point to the desired end destination. The processor then calculates and provides, via the AV UI, an opportunity cost of the shipment, based in part on a total number of empty miles associated with the route.

Abstract: The present invention is based, in part, on the unexpected discovery that particles for pulmonary delivery of a therapeutic, prophylactic or diagnostic agent that comprise a phospholipid and a sufficient amount of leucine can produce sustained effect of the agent. Specifically, particles for pulmonary delivery of a therapeutic, prophylactic or diagnostic agent that contain a phospholipid or combination of phospholipids, wherein the phospholipid or combination of phospholipids is present in the particles in an amount of about 1 to 46 weight percent; and leucine, wherein leucine is present in the particles in an amount of at least 46 weight percent, can contribute to sustained effect of the agent. Particles that comprise at least 46 weight percent leucine but that do not contain phospholipids do not exhibit these same sustained effect properties.

Abstract: Described is an apparatus for intraocular injection comprising a body adapted to accommodate a syringe having a needle, an outer sleeve telescopically coupled to the body, and at least two arms hingedly coupled to the outer sleeve. Each of the arms comprises a medial portion adapted to encase at least a portion of the needle. When the body moves distally relative 10 to said outer sleeve, the body engages the arms separating the medial portions.

Abstract: Compositions, devices, and methods of stabilizing Magneli phase materials are presented where the modified materials have a host phase and a locking phase in which locking compounds prevent rearrangement of a Magneli shear plane to a rutile structure and so prevent or reduce the oxidation of the Magneli phase material.

Abstract: Small molecule inhibitors of XBP1 splicing by IRE1 are provided, as well as methods for their use in treating or preventing cancer (e.g., endocrine resistant breast cancer), diabetes, and obesity.

Abstract: The invention provides a radio frequency identification (RFID) tag particularly suitable for use as a linen or laundry tag, and methods for producing RFID tags. The RFID tag in one embodiment comprises a backing layer, a first adhesive layer overlaying the backing layer, an RFID transponder and antenna overlaying the first adhesive layer, and a second adhesive layer overlaying the RFID transponder and antenna. The layers are laminated together, hermetically sealing the RFID transponder and antenna within the RFID tag.