Abstract: The disclosure describes improved vectors, such as adeno-associated virus (AAV) vectors, for expressing beta-gluco-cerebrosidase (GCase) in transduced cells, and use of such vectors to increase the amount of GCase in subjects experiencing a GCase deficiency, such as subjects with Gaucher disease Type 1.

Abstract: The present invention is directed to a squeezable insulated water bottle. In a preferred embodiment, the bottle has an outer shell of cylindrical shape with an opening at one end and a closed second end with an indented center shell portion dividing top and bottom shell portions, a layer of insulation material positioned about the inner surface of the top and bottom outer shell portions, and an inner liner of cylindrical shape having a neck opening. The outer shell, the inner liner, and the insulation layer are all made from flexible materials which allow the bottle to be insulated yet squeezable.