Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating phenylketonuria (PKU) are described.

Abstract: Disclosed are various approaches for providing personalized recommendations in a privacy preserving manner. A request from a provider application is received, the request comprising an anonymized user identifier and a navigation identifier that identifies a location of a user associated with the anonymized user identifier within a user interface of the provider application. A user associated with the anonymized user identifier is identified. Then, an activity history of the user is analyzed in order to select a layout order, wherein the layout order is selected based at least in part on the navigation identifier and the activity history of the user. The layout order is then provided to the provider application.

Abstract: A mask forming system for protecting a structure and a method of forming a mask for protecting the structure includes a masking material having a first layer, a second layer, and a third layer sandwiched together. The masking material is unrolled across a platform and a plurality of features are generated in the masking material, wherein the features include printing, kiss cutting, and double-kiss cutting the masking material. Data is printed on the first layer of the masking material. The first layer of the masking material is kiss cut. The second layer of the masking material is double-kiss cut. The third layer remains uncut and unprinted on during the formation of the mask. The masking material remains in the same orientation during printing and kiss cutting of the first layer, and the masking material remains in the same orientation during double-kiss cutting of the second layer.

Abstract: A shampoo composition comprising i) 0.9 to 2 wt % of an alkali metal salt of an aldonic acid, which is sodium gluconate; ii) 0.1 to 2 wt %, citric acid by weight of the total composition; and iii) an anionic surfactant; iv) a preservative, which is sodium benzoate; and wherein the composition has a pH of from 3 to 5, provides repair to damaged internal protein of hair.

Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating alpha-1 antitrypsin deficiency (AATD) are described.

Abstract: Techniques for standardizing a catalog of data and for using the standardized data to implement various APIs are disclosed. Non-standardized data is received. This data includes information describing items, customer information, and unstructured review data. The non-standardized data is converted to a standardized format, resulting in the generation of standardized data. The standardized data includes a hierarchy of defined categories. Each category is associated with a set of attribute types. The standardized data also includes anonymized profiles. The unstructured review data is also provided structure. A data model is generated based on the standardized data. Various APIs can then use the data model to perform operations.

Abstract: A system may include a router that may receive a plurality of data packets from one or more devices that communicatively couples to the router. The system may also include at least one processor that identifies an identity of a device based on a data packet received by the router from the device, generate an insurance policy that includes the device in response to identifying the identity of the device, and sends a notification indicative of the insurance policy to a computing device in response to generating the insurance policy.

Abstract: The invention relates to compounds of formula I wherein R1, R2 and - - - - - are as defined herein, pharmaceutical compositions comprising the compounds and methods of treating COVID-19 in a patient by administering therapeutically effective amounts of the compounds and methods of inhibiting or preventing replication of SARS-CoV-2 with the compounds.

Abstract: A milling device for machining a slot into an inner surface of a casing for a gas turbine engine. The milling device includes a frame assembly including multiple structural guides configured to engage structural features on the inner surface of the casing to maintain an axial position of the milling device relative to a longitudinal axis of the casing. The milling device also includes a milling cutter coupled to the frame assembly. The milling device is configured to be displaced in a circumferential direction relative to the longitudinal axis to machine the slot, via the milling cutter, along the inner surface of the casing in the circumferential direction.

Abstract: The present disclosure is directed toward systems and methods for an augmented reality transportation system. For example, the systems and methods described herein present an augmented reality environment for a driver or a passenger including augmented reality elements to mark specific locations within a display of real-world surroundings. Additionally, the systems and methods described herein analyze historical information to determine placements for augmented reality elements. The systems and methods also enable a user to share an augmented reality or virtual reality environment with another user.

Abstract: Some embodiments relate to non-woven composite materials, methods of making and uses thereof, including articles including the composite structures. More particularly, some embodiments relates to non-woven composite materials possessing desirable impact performance and penetration resistance.

Abstract: An optical cable assembly comprising: (a) a plurality of fibers; (b) a connector; (c) at least a first flat ribbonized portion comprising at least a first portion of the plurality of fibers, the first flat ribbonized portion being terminated to the connector; and (d) at least a first non-flat portion comprising at least a second portion of the plurality of fibers.

Abstract: A speaker can have a main body with a generally spheroidal shape, which can be supported standing on its end. The speaker can include a subwoofer that faces forward. A plurality of mid-range drivers can be distributed around the sub-woofer, facing generally forward and radially outward. A plurality of tweeters can be distributed around the sub-woofer, facing generally forward and generally outward. The outer housing portion of the speaker can be covered with a fabric material. A user interface ring 162 can be touch sensitive to receive input, and can have a plurality of lights that can be illuminated separately to convey information to the user.

Abstract: Methods and systems disclosed provide for creating private networks for secured communication between devices. The devices can communicate with each other over a secure tunnel created for a closed circle of devices. Furthermore, the methods and systems can enable offline communication between devices on a private network.

Abstract: Methods and systems disclosed provide for creating private networks for secured communication between devices. The devices can communicate with each other over a secure tunnel created for a closed circle of devices. Furthermore, the methods and systems can enable offline communication between devices on a private network.

Abstract: Various aspects described herein relate to presenting drug dispensing information. Data related to a plurality of dispensing events initiated by one or more employees, of an electronic drug dispensing system can be received. A set of dispensing events of the plurality of dispensing events can be determined as constituting possible misappropriation of drugs by the one or more employees. An alert related to the set of dispensing events can be provided based on determining that the set of dispensing events constitute possible misappropriation of drugs.

Abstract: According to an aspect, an electrochemical cell may include a vessel, at least two instances of an anode assembly, at least two instances of an oxygen evolution electrode (OEE), and a gas diffusion electrode (GDE). In the vessel, the GDE may be disposed between mirrored arrangements of the at least two instances of the OEE and the at least two instances of the anode assembly.

Abstract: Provided herein are methods of preparing a poloxamer for use in a cell culture medium. Also provided herein are cell culture media containing the poloxamer prepared by the methods herein, as well as methods of using the media for cell culturing and polypeptide production from cells.

Abstract: Systems and methods for automated extrusion of main elements for building construction are disclosed wherein sub-components of sub-elements are extruded by automated means, and sub-elements are assembled by automated means, and the sub-elements are incorporated into main elements by automated means.