Abstract: A liquid crystal waveguide (LCW) can include actively controlled incoupling of light into a LCW, such as by using a voltage-controlled electrode to actively vary a property of an LC material arranged to affect the incoupling of light into the LCW. Actively varying light incoupling into the LCW can be used, for example, such as for calibration or compensation or to provide closed-loop feedback such as to stabilize the amount of light into the LCW while accommodating or reducing sensitivity of the LCW to variations in one or more of: input laser light incidence angle, input laser wavelength, LCW or input laser temperature, input laser optical power level, or the like. This can advantageously help improve or maximize light incoupling efficiency, which can improve performance and robustness of the LCW under actual operating conditions. The LCW can be used for, among other things, beamsteering in in-plane and out-of-plane directions.

Abstract: A method and system for determining work ticket priority is provided. The method includes enabling a work ticket for a work assignment associated with an entity. The work ticket is assigned an initial priority value. Relevant data from multiple sources is associated with the work ticket and an updated priority value is requested. In response, multiple priority scores for the work ticket with respect to additional work tickets are published to an enterprise service bus (ESB) and an aggregate score for work ticket is calculated from the multiple priority scores.

Abstract: A leak test apparatus including a sleeve member having a first end and a second end and being configured to surround a portion of a transmission medium, a first retaining device configured to couple the first end of the sleeve member to a boundary fitting to which the transmission medium is coupled, and where the sleeve member is configured to contain a leak detection medium and effect a pressurization of the boundary fitting with the leak detection medium.

Abstract: An electro-optical beamsteerer can be coupled with other optical structures. For example, such optical structures can be used to shape a beam being steered by the beamsteerer or shape a field-of-regard (FOR) addressable from the perspective of the beamsteerer. Optical elements placed at an output of the LCW can be used as a “spot mapper” to increase or decrease the field of view that can be scanned by a beam steered by the LCW, as an illustrative example, Lenses or other optical elements can also be used to correct distortion in the steered beam distribution across the field of view, such as to provide a “smile corrector.” In a similar manner, optical elements can be placed at an input to the beamsteerer, such as to provide a beam expander to change the size of the beam profile inside the beamsteerer device.

Abstract: The present invention relates to use of particular substituted heterocycle fused gamma-carbolines as described herein, in free, pharmaceutically acceptable salt or prodrug form, and pharmaceutical composition comprising the same optionally in combination with one or more agents, for the prophylaxis or treatment of one or more disorders associated with dementia, particularly behavioral or mood disturbances (e.g., agitation/aggression), psychosis, depression and sleep disturbances among others in patients suffering from dementia.

Abstract: A hydraulically activated setting tool for setting an auxiliary tool in a well, the setting tool including a housing that prevents a well fluid from entering inside the housing; a floating piston placed inside the housing and closing an end of a pressure chamber; an attached piston placed inside the housing and configured to actuate the auxiliary tool; a fluid chamber located between the floating piston and the attached piston, wherein the fluid chamber holds a fluid; and a communication element configured to establish a fluid communication between an outside and an inside of the housing. The fluid communication makes a well fluid in the well to directly act on the floating piston.

Abstract: A system and method for providing a dynamic composite field of view in a scanning lidar system, such as to improve a signal-to-noise ration of detected light. The dynamic composite field of view can include a subset of the available detector pixels, and can thereby reduce noise introduce by noise sources that can scale with a detector area, such as dark current and gain peaking that can be caused by a capacitance of the photodetector.

Abstract: A cybersecurity alert management system and method includes: a database storing a set of cybersecurity event filter records and a set of pre-defined action instructions; a processor in communication with cybersecurity tools that generate cybersecurity data; wherein the processor; generates a cybersecurity event record assigned at least one identifying attribute; compares the at least one attribute against the set of cybersecurity event filter records; when the at least one identifying attribute assigned to the cybersecurity event record does not match at least one of the pre-defined cybersecurity event filter records, generates an alert message that prompts an end user to investigate the cybersecurity event record; and when the at least one identifying attribute assigned to the cybersecurity event record matches at least one of the pre-defined cybersecurity event filter records, acts upon the cybersecurity event record in accordance with a selected pre-defined action instruction.

Abstract: The invention relates to particular substituted heterocycle fused gamma-carbolines, their prodrugs, in free, solid, pharmaceutically acceptable salt and/or substantially pure form as described herein, pharmaceutical compositions thereof, and methods of use in the treatment of diseases involving the 5-HT2A receptor, the serotonin transporter (SERT), pathways involving the dopamine D1 and D2 receptor signaling system, and/or the ?-opioid receptor.

Abstract: The invention relates to pharmaceutical compositions comprising 4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3?,4?:4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-1-(4-fluorophenyl)butan-1-one in toluenesulfonic acid addition salt form: and methods of use in the treatment of diseases involving the 5-HT2A receptor pathway, the serotonin transporter (SERT) pathway and/or the dopamine D2 receptor pathway signaling systems.

Abstract: The invention relates to particular substituted heterocycle fused gamma-carbolines, their prodrugs, in free, solid, pharmaceutically acceptable salt and/or substantially pure form as described herein, pharmaceutical compositions thereof, and methods of use in the treatment of diseases involving the 5-HT2A receptor, the serotonin transporter (SERT), pathways involving the dopamine D1 and D2 receptor signaling system, and/or the ?-opioid receptor.

Abstract: The disclosure provides the use of particular substituted heterocycle fused gamma-carboline compounds as pharmaceuticals for the treatment of residual symptoms of psychosis or schizophrenia. The disclosure also provides novel long acting injectable formulations of particular substituted heterocycle fused gamma-carboline compounds and use of such long acting injectable formulations for the treatment of residual symptoms of psychosis or schizophrenia.

Abstract: A hemp powder is provided having at least 95% CBD along with some other percentage of extract plant material and other minor cannabinoids. In some examples, the hemp powder does not include additives, such as drying agents, anti-caking agents, or flow agents.

Abstract: This invention provides, among other things, an asphalt-based sealcoat composition comprising high levels of titanium oxide particles. In some embodiments, the invention also provides a highly solar reflective asphalt-based sealcoat composition comprising high levels of titanium oxide particles. In some embodiments, the invention provides an asphalt-based sealcoat composition capable of reducing pollutants comprising high levels of titanium oxide particles. In some embodiments, the invention provides methods for preparing asphalt-based sealcoat compositions as well as their application to asphalt surfaces.

Abstract: The disclosure provides the use of particular substituted heterocycle fused gamma-carboline compounds as pharmaceuticals for the treatment of residual symptoms of psychosis or schizophrenia. The disclosure also provides novel long acting injectable formulations of particular substituted heterocycle fused gamma-carboline compounds and use of such long acting injectable formulations for the treatment of residual symptoms of psychosis or schizophrenia.

Abstract: An integrated circuit comprises an ADC including a first track-and-hold amplifier and a timing generator configured to generate a clock signal for controlling the ADC. The timing generator comprises a quadrature filter responsive to a differential input signal for generating a differential quadrature (I/Q) output signal. The timing generator further comprises at least one first vector sum circuit operatively coupled or connected to an output of the quadrature filter and configured to weight and sum components of the differential I/Q output signal for generating a clock signal having a desired delay.

Abstract: The disclosure provides the use of particular substituted heterocycle fused gamma-carboline compounds as pharmaceuticals for the treatment of residual symptoms of psychosis or schizophrenia. The disclosure also provides novel long acting injectable formulations of particular substituted heterocycle fused gamma-carboline compounds and use of such long acting injectable formulations for the treatment of residual symptoms of psychosis or schizophrenia.

Abstract: The invention relates to the administration of inhibitors of phosphodiesterase 1 (PDE1) for the treatment of diseases or disorders characterized by disruption of or damage to various cGMP/PKG mediated pathways. In one embodiment the invention relates to inhibitors of phosphodiesterase 1 (PDE1) for treatment of cardiovascular disease and related disorders, e.g., congestive heart disease, atherosclerosis, myocardial infarction, and stroke.

Abstract: Contact lens blister packages and related methods are described. The present devices include a thermoplastic base member with a grip portion, a distal end region, a first side region extending from the proximal end region to the distal end region, a second side region opposing the first side region, and a cavity configured to contain a packaging solution and a contact lens. The cavity comprises has a bottom wall with a bottom wall perimeter and a sidewall extending upwardly from the bottom wall perimeter to an upper cavity edge defining a cavity perimeter. A plane formed at the intersection of the bottom wall perimeter with the sidewall slopes away from the substantially linear portion of the cavity perimeter.

Abstract: A computer-implemented embodiment heals an information technology (IT) system. A cognitive computing hardware system receives an error history log that describes a history of past errors that have occurred in the IT system. The cognitive computing hardware system receives a listing of alternative IT systems that have been predetermined to have a same functionality as the IT system and that have a history of experiencing one or more errors currently being detected in the IT system. The cognitive computing hardware system receives a record of real-time events, which are external to the IT system and which impact a performance of the alternative IT systems. The cognitive computing hardware system generates a prioritized set of solutions to overcome the one or more errors currently being detected in the IT system, based on the error history log, the listing of alternative IT systems, and the record of real-time events.