Abstract: The disclosure provides new transmucosal and subcutaneous pharmaceutical compositions comprising 1-(4-fluoro-phenyl)-4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3?,4?:4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-butan-1-one or 1-(4-fluoro-phenyl)-4-((6bR,10aS)-2,2-d2-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3?,4?:4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-butan-1-one or comprising -(4-fluoro-phenyl)-4-((6bR,10aS)-1,1,2,2-d4-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3?,4?:4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-butan-1-one, in free base, co-crystal or salt form, together with methods of making and using them.

Abstract: The invention relates to particular substituted heterocycle fused gamma-carbolines, their prodrugs, in free, solid, pharmaceutically acceptable salt and/or substantially pure form as described herein, pharmaceutical compositions thereof, and methods of use in the treatment of diseases involving 5-HT2A receptor, serotonin transporter (SERT) and/or pathways involving dopamine D1/D2 receptor signaling systems, and/or the treatment of residual symptoms.

Abstract: The invention relates to substituted pyrido[3?,4?:4,5]pyrrolo[1,2,3-de]-quinoxaline compounds, represented by Formula 1, defined herein, free base or pharmaceutically acceptable salt forms of the compounds, pharmaceutical compositions thereof, and methods of treating conditions of the central nervous system therewith:

Abstract: A method for connecting endpoints. The method may include determining, using a first group of software threads, cross-connection information regarding various cross-connections among various network elements. The network elements may include a first network element and a second network element. The method may further include determining, using the first group of software threads, link information regarding various links between the network elements. The method may further include processing, within a network cache, the cross-connection information and the link information into various network resources groups. Each network resource group of the network resources groups may describe adjacent cross-connections for a link among the links.

Abstract: The disclosure provides the use of particular substituted heterocycle fused gamma-carboline compounds as pharmaceuticals for the treatment of residual symptoms of psychosis or schizophrenia. The disclosure also provides novel long acting injectable formulations of particular substituted heterocycle fused gamma-carboline compounds and use of such long acting injectable formulations for the treatment of residual symptoms of psychosis or schizophrenia.

Abstract: A radiotherapy apparatus and method, comprising a source of radiation for delivering pulses of radiation at a base frequency; and a control unit configured to generate a time-averaged power level of x by generating an nth pulse when n is equal to the rounded value of an integer multiple of 1/x, where x is a value between 0 and 1 representing a proportion of a maximum power output of the radiotherapy apparatus. The pulses may form a repeating pulse train pattern, and the control unit may comprise a processing unit configured to provide a pulse train pattern having a number of available slots, the slots being marked as a permitted pulse or a suppressed pulse.

Abstract: A wireless client device having a touchscreen may run a class assessment tool. The tool may have an interface that displays a row of student pictures and names and enables a teacher to assess the students on various key aspects. The tool may display a rubric for each key aspect when the key aspect is hovered over or selected. The interface may include a matrix of assessment blocks having a plurality of individually selectable areas that enable a teacher to enter a key aspect score for each key aspect for each student. The interface may include a row of comment areas configured to receive a private message for a student and a row of final scores based on the key aspect scores of the student. A row of results may be displayed, where each result reflects whether a student passed or failed the class based on the student's final score.

Abstract: A wireless client device having a touchscreen may run a class assessment tool. The tool may have an interface that displays a row of student pictures and names and enables a teacher to assess the students on various key aspects. The tool may display a rubric for each key aspect when the key aspect is hovered over or selected. The interface may include a matrix of assessment blocks having a plurality of individually selectable areas that enable a teacher to enter a key aspect score for each key aspect for each student. The interface may include a row of comment areas configured to receive a private message for a student and a row of final scores based on the key aspect scores of the student. A row of results may be displayed, where each result reflects whether a student passed or failed the class based on the student's final score.

Abstract: The invention relates to the administration of inhibitors of phosphodiesterase 1 (PDE1) for the treatment of diseases or disorders characterized by disruption of or damage to various cGMP/PKG mediated pathways. In one embodiment the invention relates to inhibitors of phosphodiesterase 1 (PDE1) for treatment of cardiovascular disease and related disorders, e.g., congestive heart disease, atherosclerosis, myocardial infarction, and stroke.

Abstract: The present approach relates to the fabrication and use of a probe array having multiple individual probes. In one embodiment, the probes of the probe array may be functionalized such that certain of the probes are suitable for electrical sensing (e.g., recording) or stimulation, non-electrical sensing or stimulation (e.g., chemical sensing and/or release of biomolecules when activated), or a combination of electrical and non-electrical sensing or stimulation.

Abstract: An optical coupler can be provided for coupling a light beam into a waveguide. The optical coupler can include a stepped structure, such as to reduce difficulties during manufacture, reduce expenses associated with manufacture, and additionally, to provide an increased acceptance angle of the optical coupler. The waveguide can include a guiding region where a cladding thickness can be increased relative to a coupling region, such as to reduce losses due to evanescent outcoupling in the guiding region.

Abstract: A system and method for dynamically obtaining data associated with a performance metric associated with access devices associated with a resource provider in a specific geographic location and comparing it to data associated with the performance of other access devices associated with another resource provider is disclosed. A processing server computer can perform the comparison and may provide the comparison to a user device, so that corrective action, if any, may be taken.

Abstract: The disclosure provides the use of particular substituted heterocycle fused gamma-carboline compounds as pharmaceuticals for the treatment of residual symptoms of psychosis or schizophrenia. The disclosure also provides novel long acting injectable formulations of particular substituted heterocycle fused gamma-carboline compounds and use of such long acting injectable formulations for the treatment of residual symptoms of psychosis or schizophrenia.

Abstract: A pitch bearing assembly for a wind turbine may include an outer race and an inner race rotatable relative to the outer race. The inner race may define an inner circumference and may include a plurality of gear teeth around the inner circumference. The inner race may also include a circumferential flange extending at least partially around the inner circumference. In addition, the pitch bearing assembly may include a stiffener coupled to the circumferential flange.

Abstract: Embodiments described herein provide approaches for associating a user identity to a wireless signal based on information received at an access point. Specifically, when a first user presents a set of user credentials to a physical access point, his/her profile is accessed to authenticate the first user. A set of wireless signals emanating from one or more wireless devices operated by the first user is also received at the physical access point and associated with the first user. Information about the first user may then be broadcast and accessed by a second user (e.g., via his/her mobile device) in proximity to the first user and in receipt of the set of wireless signals associated with the first user.

Abstract: Embodiments described herein provide approaches for associating a user identity to a wireless signal based on information received at an access point. Specifically, when a first user presents a set of user credentials to a physical access point, his/her profile is accessed to authenticate the first user. A set of wireless signals emanating from one or more wireless devices operated by the first user is also received at the physical access point and associated with the first user. Information about the first user may then be broadcast and accessed by a second user (e.g., via his/her mobile device) in proximity to the first user and in receipt of the set of wireless signals associated with the first user.

Abstract: A processor receives service availability data for at least one service, where the service availability data indicates an amount time the at least one service was available and an amount of time one or more resources utilized in the service was available. A processor receives service configuration data for the service, where the service configuration data indicates one or more resource requirements of the at least one service. A processor determines one or more resource unavailability scores for the one or more resources utilized in providing the service. A processor determines one or more resource replacement scores for the one or more resources utilized in the service. A processor determines availability risk scores for the at least one service based on the one or more resource unavailability scores and the one or more resource replacement scores. A processor generates an indication of at-risk services of the at least one service.

Abstract: The invention relates to the administration of inhibitors of phosphodiesterase 1 (PDE1) for the treatment of diseases or disorders characterized by disruption of or damage to various cGMP/PKG mediated pathways. In one embodiment the invention relates to inhibitors of phosphodiesterase 1 (PDE1) for treatment of cardiovascular disease and related disorders, e.g., congestive heart disease, atherosclerosis, myocardial infarction, and stroke.

Abstract: A method for dynamically assembling a mobile application includes the steps of: (i) receiving a first probability of a potential failure occurring within a first computing environment; (ii) comparing the first probability to a first threshold; (iii) automatically provisioning a first portion of a second computing environment in response to the first probability exceeding the first threshold; (iv) receiving a second probability of the potential failure occurring within the first computing environment; (v) comparing the second probability to a second threshold; and (vi) automatically provisioning a second portion of the second computing environment in response to the second probability exceeding the second threshold.

Abstract: The invention relates to particular substituted heterocycle fused gamma-carbolines, their prodrugs, in free, solid, pharmaceutically acceptable salt and/or substantially pure form as described herein, pharmaceutical compositions thereof, and methods of use in the treatment of diseases involving the 5-HT2A receptor, the serotonin transporter (SERT), pathways involving the dopamine D1 and D2 receptor signaling system, and/or the ?-opioid receptor.