Abstract: The present invention covers the use of chymase inhibitors in general and more in particular substituted bicyclically substituted uracils of general formula (I) as described and defined herein, and 3-methylbenzo-[b]thiophene)-2-sulfonamido derivatives of general formula (II) for manufacturing pharmaceutical compositions for the treatment or prophylaxis of stroke, pulmonary embolism, deep or superficial vein thrombosis, thrombotic microangiopathy, thrombotic microangiopathy in hypercoagulable states after infection, inflammation, transplantation, disseminated intravascular coagulation, vaccine-induced immune thrombotic thrombocytopenia, vascular access site thrombosis or occlusion.

Abstract: The present invention covers the use of chymase inhibitors in general and more in particular substituted bicyclically substituted uracils of general formula (I) as described and defined herein, and 3-methylbenzo-[b]thiophene)-2-sulfonamido derivatives of general formula (II) for manufacturing pharmaceutical compositions for the treatment or prophylaxis of stroke, pulmonary embolism, deep or superficial vein thrombosis, thrombotic microangiopathy, thrombotic microangiopathy in hypercoagulable states after infection, inflammation, transplantation, disseminated intravascular coagulation, vaccine-induced immune thrombotic thrombocytopenia, vascular access site thrombosis or occlusion.

Abstract: This disclosure provides systems, devices, apparatus, and methods, including computer programs encoded on storage media, for processing pool care information. A processing device receives an input indicating a condition associated with water of a swimming pool. The condition has an impact on balancing a water chemistry of the water. The processing device computes, based on the input, a current water chemistry of the water of the swimming pool and determines a target water chemistry for the water of the swimming pool. The target water chemistry is different from the current water chemistry. The processing device outputs a pool care recommendation for the balancing the water chemistry of the water from the current water chemistry to the target water chemistry. The pool care recommendation is based on how the condition impacts the balancing the water chemistry.

Abstract: A HOCl manufacturing system is disclosed for production of high potency, safe, consistently pure, stable, authentic HOCl in a deployable, portable, high volume, localized manufacturing unit. The electrolysis method uses a deployable, remote-controlled manufacturing system. The method includes: controlling water flow rate into an electrolysis chamber by providing feedback controlled water pressure; applying feedback controlled current to the electrolysis chamber via an adjustable and high-current power supply; adding sodium chloride brine, via a feedback controlled actuator, to an anode chamber inlet and creating an aqueous mixture; adding sodium hydroxide, via a feedback controlled actuator, to the aqueous mixture; and producing aqueous hypochlorous acid free from hypochlorites, phosphates, oxides, and stabilizers.

Abstract: The disclosure relates to a method for specific detection of a target analyte using probe DNA specific to the target analyte and non-functionalized, carbohydrate-capped metal nanoparticles such as non-functionalized, dextrin-capped gold nanoparticles. A sample mixture including a target DNA analyte and a probe DNA specific thereto is incubated to from a probe DNA-target DNA complex. The non-functionalized, carbohydrate-capped metal nanoparticles and an ionic species such as sodium chloride or other salt are added to the probe DNA-target DNA complex, and the mixture is incubated. Addition of the ionic species creates a detectable distinction, such as color of the resultant mixture, between stabilized metal nanoparticles when the probe DNA-target DNA complex is present and destabilized metal nanoparticles when the probe DNA-target DNA complex is absent. The method can be used for colorimetric detection of plant pathogens and associated diseases in agricultural production systems.

Abstract: A variable height workstation system comprises a base, a variable height platform, a lift mechanism, a lower adjustable pivot assembly, and an upper adjustable pivot assembly. The base is configured to be mounted to a support surface. The lift mechanism is configured to move the variable height platform between a fully lowered and raised position. The lower adjustable pivot assembly is configured to be connected be to the base and the lift mechanism. The lower adjustable pivot assembly comprises a lower adjustable force regulator configured to adjust a force required to rotate a lower pivot member about its first vertical rotational axis. The upper adjustable pivot assembly is configured to be connected to the lift mechanism and the variable height platform. The upper adjustable pivot assembly comprises an upper adjustable force regulator configured to adjust a force required to rotate an upper pivot member about its second vertical rotational axis.

Abstract: Methods of treating, managing or preventing diseases ameliorated by inhibiting PDE4 such as psoriasis, ankylosing spondylitis, Behcet's disease, rheumatoid arthritis, atopic dermatitis, Crohn's disease, and ulcerative colitis are disclosed. Specific methods encompass the administration of apremilast in specific dosage titration schedule, alone or in combination with a second active agent.

Abstract: A variable height workstation system comprises a base, a variable height platform, a lift mechanism, a lower adjustable pivot assembly, and an upper adjustable pivot assembly. The base is configured to be mounted to a support surface. The lift mechanism is configured to move the variable height platform between a fully lowered and raised position. The lower adjustable pivot assembly is configured to be connected be to the base and the lift mechanism. The lower adjustable pivot assembly comprises a lower adjustable force regulator configured to adjust a force required to rotate a lower pivot member about its first vertical rotational axis. The upper adjustable pivot assembly is configured to be connected to the lift mechanism and the variable height platform. The upper adjustable pivot assembly comprises an upper adjustable force regulator configured to adjust a force required to rotate an upper pivot member about its second vertical rotational axis.

Abstract: The disclosure relates to a method for specific detection of a target analyte using probe DNA specific to the target analyte and non-functionalized, carbohydrate-capped metal nanoparticles such as non-functionalized, dextrin-capped gold nanoparticles. A sample mixture including a target DNA analyte and a probe DNA specific thereto is incubated to from a probe DNA-target DNA complex. The non-functionalized, carbohydrate-capped metal nanoparticles and an ionic species such as sodium chloride or other salt are added to the probe DNA-target DNA complex, and the mixture is incubated. Addition of the ionic species creates a detectable distinction, such as color of the resultant mixture, between stabilized metal nanoparticles when the probe DNA-target DNA complex is present and destabilized metal nanoparticles when the probe DNA-target DNA complex is absent. The method can be used for colorimetric detection of plant pathogens and associated diseases in agricultural production systems.

Abstract: A variable height workstation system comprises a base, a variable height platform, a lift mechanism, a lower adjustable pivot assembly, and an upper adjustable pivot assembly. The base is configured to be mounted to a support surface. The lift mechanism is configured to move the variable height platform between a fully lowered and raised position. The lower adjustable pivot assembly is configured to be connected be to the base and the lift mechanism. The lower adjustable pivot assembly comprises a lower adjustable force regulator configured to adjust a force required to rotate a lower pivot member about its first vertical rotational axis. The upper adjustable pivot assembly is configured to be connected to the lift mechanism and the variable height platform. The upper adjustable pivot assembly comprises an upper adjustable force regulator configured to adjust a force required to rotate an upper pivot member about its second vertical rotational axis.

Abstract: It is provided a tumor promoting alternative splicing isoform of PACE4, named PACE4-alt CT, analytes specifically binding to PACE4-alt CT, such as antibodies, and use of same for detecting a cancer, such as prostate cancer. It is also provided a method treating a cancer in a patient comprising administering an inhibitor of PACE4-altCT to a patient in need thereof and a kit comprising an analyte specific reagent specifically binding to PACE4-altCT for detecting a cancer.

Abstract: The present invention generally relates to nanoscale wires, and to methods of producing nanoscale wires. In some aspects, the nanoscale wires are nanowires comprising a core which is continuous and a shell which may be continuous or discontinuous, and/or may have regions having different cross-sectional areas. In some embodiments, the shell regions are produced by passing the shell material (or a precursor thereof) over a core nanoscale wire under conditions in which Plateau-Raleigh crystal growth occurs, which can lead to non-homogenous deposition of the shell material on different regions of the core. The core and the shell each independently may comprise semiconductors, and/or non-semiconductor materials such as semiconductor oxides, metals, polymers, or the like. Other embodiments are generally directed to systems and methods of making or using such nanoscale wires, devices containing such nanoscale wires, or the like.

Abstract: Embodiments of the present invention provide methods for providing a non-registering endpoint with non-registration services (such as the ability to make a call) in an IMS network without requiring the non-registering endpoint to register. A request for a non-registration service is received and processed by an entity in the IMS network that is configured to handle such requests. The entity requires information about the non-registering endpoint itself before it can process the request. Since the non-registering endpoint is part of the network, a Home Subscriber Server (HSS) knows some information about the non-registering endpoint, but can only provide this information to the entity if the non-registering endpoint is registered or being registered by the entity. Consequently, in embodiments, the entity makes it look like the non-registering endpoint is registering, in order for the entity to obtain the information from the HSS.

Abstract: A variable height workstation system comprises a base, a variable height platform, a lift mechanism, a lower adjustable pivot assembly, and an upper adjustable pivot assembly. The base is configured to be mounted to a support surface. The lift mechanism is configured to move the variable height platform between a fully lowered and raised position. The lower adjustable pivot assembly is configured to be connected be to the base and the lift mechanism. The lower adjustable pivot assembly comprises a lower adjustable force regulator configured to adjust a force required to rotate a lower pivot member about its first vertical rotational axis. The upper adjustable pivot assembly is configured to be connected to the lift mechanism and the variable height platform. The upper adjustable pivot assembly comprises an upper adjustable force regulator configured to adjust a force required to rotate an upper pivot member about its second vertical rotational axis.

Abstract: Methods of treating, managing or preventing diseases ameliorated by inhibiting PDE4 such as psoriasis, ankylosing spondylitis, Behcet's disease, rheumatoid arthritis, atopic dermatitis, Crohn's disease, and ulcerative colitis are disclosed. Specific methods encompass the administration of apremilast in specific dosage titration schedule, alone or in combination with a second active agent.

Abstract: Embodiments of radiant barriers for vehicles are disclosed. According to one embodiment, a vehicle includes an interior cabin at least partially enclosed by a roof panel, a floor panel, and an engine compartment firewall, and a radiant barrier positioned within the interior cabin. The radiant barrier includes a first thermally reflective surface and a second thermally reflective surface opposite the first thermally reflective surface and separated from the first thermally reflective surface by a thickness t. The thickness t is constant along a length and a width of the radiant barrier. The radiant barrier at least partially thermally isolates the interior cabin from an external environment.

Abstract: Methods of treating, managing or preventing diseases ameliorated by inhibiting PDE4 such as psoriasis, ankylosing spondylitis, Behcet's disease, rheumatoid arthritis, atopic dermatitis, Crohn's disease, and ulcerative colitis are disclosed. Specific methods encompass the administration of apremilast in specific dosage titration schedule, alone or in combination with a second active agent.

Abstract: The present invention generally relates to nanoscale wires, including anisotropic deposition in nanoscale wires. In one set of embodiments, material may be deposited on certain portions of a nanoscale wire, e.g., anisotropically. For example, material may be deposited on a first facet of a crystalline nanoscale wire but not on a second facet. In some cases, additional materials may be deposited thereon, and/or the portions of the nanoscale wire may be removed, e.g., to produce vacant regions within the nanoscale wire, which may contain gas or other species. Other embodiments of the invention may be directed to articles made thereby, devices containing such nanoscale wires, kits involving such nanoscale wires, or the like.

Abstract: Methods of treating, managing or preventing psoriatic arthritis are disclosed. Specific methods encompass the administration of apremilast, alone or in combination with a second active agent.

Abstract: The present invention generally relates to nanoscale wires and, in particular, to nanoscale wires with heterojunctions, such as tip-localized homo- or heterojunctions. In one aspect, the nanoscale wire may include a core, an inner shell surrounding the core, and an outer shell surrounding the inner shell. The outer shell may also contact the core, e.g., at an end portion of the nanoscale wire. In some cases, such nanoscale wires may be used as electrical devices. For example a p-n junction may be created where the inner shell is electrically insulating, and the core and the outer shell are p-doped and n-doped. Other aspects of the present invention generally relate to methods of making or using such nanoscale wires, devices, or kits including such nanoscale wires, or the like.