Patents by Inventor Robert E. Davis

Robert E. Davis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Production of adenine nucleotide translocator (ANT), novel ANT ligands and screening assays therefor.
    Patent number: 6906175
    Abstract: Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.
    Type: Grant
    Filed: March 16, 2001
    Date of Patent: June 14, 2005
    Assignee: MIGENIX Corp.
    Inventors: Christen M. Anderson, Robert E. Davis, William Clevenger, Sandra Eileen Wiley, Scott W. Miller, Tomas R. Szabo, Soumitra S. Ghosh, Walter H. Moos, Yazhong Pei
  • Production of adenine nucleotide translocator (ANT), novel ANT ligands and screening assays therefor
    Patent number: 6906173
    Abstract: Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.
    Type: Grant
    Filed: November 3, 1998
    Date of Patent: June 14, 2005
    Assignee: Migenix Corp.
    Inventors: Christen M. Anderson, Robert E. Davis, William Clevenger, Sandra Eileen Wiley
  • Production of adenine nucleotide translocator (ANT), novel ANT ligands and screening assays therefor
    Patent number: 6906174
    Abstract: Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.
    Type: Grant
    Filed: March 16, 2001
    Date of Patent: June 14, 2005
    Assignee: Migenix Corp.
    Inventors: Christen M. Anderson, Robert E. Davis, William Clevenger, Sandra Eileen Wiley
  • Production of adenine nucleotide translocator (ANT), novel ANT ligands and screening assays therefor
    Patent number: 6902908
    Abstract: Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.
    Type: Grant
    Filed: March 14, 2001
    Date of Patent: June 7, 2005
    Assignee: Migenix Corp.
    Inventors: Christen M. Anderson, Robert E. Davis, William Clevenger, Sandra Eileen Wiley, Scott W. Miller, Tomas R. Szabo, Soumitra S. Ghosh, Walter H. Moos, Yazhong Pei
  • Cobalt-porphyrin complexes and use thereof as an anti-obesity agent
    Patent number: 6900197
    Abstract: Cobalt-porphyrin (Co-P) complexes for use as anti-obesity agents, and compositions and methods related thereto. The Co-P complexes exhibit reduced redox activity compared to cobalt mesoporphyrin (Co-MP) and cobalt protoporphyrin (Co-PP), which alleviates the deleterious effects associated with administration of Co-P associated with oxidative stress, particularly in the context of injection site toxicity.
    Type: Grant
    Filed: December 14, 2001
    Date of Patent: May 31, 2005
    Assignee: MitoKor
    Inventors: Tomas R. Szabo, Soumitra S. Ghosh, Robert E. Davis
  • Production of adenine nucleotide translocator (ANT), novel ANT ligands and screening assays therefor
    Patent number: 6887670
    Abstract: Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.
    Type: Grant
    Filed: March 14, 2001
    Date of Patent: May 3, 2005
    Assignee: MIGENIX Corp.
    Inventors: Christen M. Anderson, Robert E. Davis, Tomas R. Szabo, Soumitra S. Ghosh, Walter H. Moos, Yazhong Pei
  • Method of targeting conjugate molecules to mitochondria
    Patent number: 6867197
    Abstract: The present invention relates to genetic mutations in mitochondrial cytochrome c oxidase genes that segregate with Alzheimer's disease (AD). The invention provides methods for detecting such mutations, as a diagnostic for Alzheimer's Disease, either before or after the onset of clinical symptoms. The invention further provides treatment of cytochrome c oxidase dysfunction.
    Type: Grant
    Filed: November 23, 1999
    Date of Patent: March 15, 2005
    Assignee: Mitokor
    Inventors: Robert E. Davis, Soumitra S. Ghosh, John S. Kiely
  • Selective serotonin 2A/2C receptor inverse agonists as therapeutics for neurodegenerative diseases
    Publication number: 20040213816
    Abstract: Behavioral pharmacological data with the compound of formula (I), a novel and selective 5HT2A/2C receptor inverse agonist, demonstrate in vivo efficacy in models of psychosis and dyskinesias. This includes activity in reversing MK-801 induced locomotor behaviors, suggesting that this compound may be an efficacious anti-psychotic, and activity in an MPTP primate model of dyskinesias, suggesting efficacy as an anti-dyskinesia agent. These data support the hypothesis that 5HT2A/2C receptor inverse agonism may confer antipsychotic and anti-dyskinetic efficacy in humans, and indicate a use of the compound of formula (I) and related agents as novel therapeutics for Parkinson's Disease, related human neurodegenerative diseases, and psychosis.
    Type: Application
    Filed: January 15, 2004
    Publication date: October 28, 2004
    Inventors: David M. Weiner, Robert E. Davis, Mark R. Brann
  • Compositions and methods for determining interactions of mitochondrial components, and for identifying agents that alter such interactions
    Patent number: 6797467
    Abstract: Compositions and methods are provided for identifying agents that alter mitochondrial membrane permeability transition. The screening methods generally detect agents that alter the interaction between the mitochondrial adenine nucleotide translocator and cyclophilin D. Such agents may be used, for example, in the treatment of a variety of conditions associated with altered mitochondrial function.
    Type: Grant
    Filed: November 3, 2000
    Date of Patent: September 28, 2004
    Assignee: MitoKor, Inc.
    Inventors: Anne N. Murphy, William Clevenger, Sandra Eileen Wiley, Alexander Y. Andreyev, Luciano G. Frigeri, Gonul Velicelebi, Robert E. Davis
  • Migratory fish channel associated with one or more dams in a river
    Publication number: 20040165955
    Abstract: A bypass channel (C) for fish extends along line one side of a river, for the full length of a section of the river in which reservoirs (22, 24, 26, 28) have been created by dams (14, 16, 18, 20). The channel (C) follows the grade of the natural river. It includes an inner wall (34) that varies in height so that it is always higher than the water level in any of the reservoirs. It also includes an outer wall (36) and a bottom wall (38) which are formed on the natural terrain that borders the river and reservoirs. In at least its taller regions, the inner wall (38) may be braced by a diagonal member or a system of member (40). Water flow into the channel (C) maybe regulated by horizontal and/or vertical gates (50, 52) or some other structure for changing the cross sectional area of the channel (C).
    Type: Application
    Filed: February 23, 2004
    Publication date: August 26, 2004
    Inventor: Robert E. Davis
  • Compositions and methods for determining interactions of mitochondrial components, and for identifying agents that alter such interactions
    Publication number: 20040146892
    Abstract: Compositions and methods are provided for identifying agents that alter mitochondrial membrane permeability transition. The screening methods generally detect agents that alter the interaction between the mitochondrial adenine nucleotide translocator and cyclophilin D. Such agents may be used, for example, in the treatment of a variety of conditions associated with altered mitochondrial function.
    Type: Application
    Filed: October 10, 2003
    Publication date: July 29, 2004
    Applicant: MitoKor, Inc.
    Inventors: Anne N. Murphy, William Clevenger, Sandra Eileen Wiley, Alexander Y. Andreyev, Luciano G. Frigeri, Gonul Velicelebi, Robert E. Davis
  • Indicators of altered mitochondrial function in predictive methods for determining risk of type 2 diabetes mellitus
    Publication number: 20030235812
    Abstract: The present invention relates to improved diagnostic methods for early detection of a risk for developing type 2 diabetes mellitus in humans, and screening assays for therapeutic agents useful in the treatment of type 2 diabetes mellitus, by comparing the levels of one or more indicators of altered mitochondrial function. Indicators of altered mitochondrial function include enzymes such as mitochondrial enzymes and ATP biosynthesis factors. Other indicators of altered mitochondrial function include mitochondrial mass, mitochondrial number and mitochondrial DNA content, cellular responses to elevated intracellular calcium and to apoptogens, and free radical production. Methods of treating, and of stratifying, human patients as such methods relate to disclosed indicators of altered mitchondrial function are also provided.
    Type: Application
    Filed: January 24, 2003
    Publication date: December 25, 2003
    Applicant: MitoKor
    Inventors: Christen M. Anderson, Robert E. Davis
  • Fluid presence and qualitative measurements by transient immitivity response
    Patent number: 6664793
    Abstract: An apparatus and method for obtaining a measurement of various qualities of an electrochemical cell. The apparatus includes first and second electrodes and an excitation source for providing a time varying excitation voltage to the first electrode. The excitation voltage is switched between two voltage levels with the first and second voltages alternately applied to the first electrode for predetermined times. An external capacitance is connected between the second electrode and ground. The apparatus is capable of determining the time related rates at which electrical charge is transferred from the first electrode to charge the external capacitance. These rates, here termed Transient Immitivity Response (TIR), may be provided as a digital or analog output.
    Type: Grant
    Filed: March 1, 2002
    Date of Patent: December 16, 2003
    Inventors: Allen R. Sampson, Robert E. Davis
  • Indicators of altered mitochondrial function in predictive methods for determining risk of type 2 diabetes mellitus
    Patent number: 6653094
    Abstract: The present invention relates to improved diagnostic methods for early detection of a risk for developing type 2 diabetes mellitus in humans, and screening assays for therapeutic agents useful in the treatment of type 2 diabetes mellitus, by comparing the levels of one or more indicators of altered mitochondrial function. Indicators of altered mitochondrial function include enzymes such as mitochondrial enzymes and ATP biosynthesis factors. Other indicators of altered mitochondrial function include mitochondrial mass, mitochondrial number and mitochondrial DNA content, cellular responses to elevated intracellular calcium and to apoptogens, and free radical production. Methods of treating, and of stratifying, human patients as such methods relate to disclosed indicators of altered mitchondrial function are also provided.
    Type: Grant
    Filed: August 7, 2001
    Date of Patent: November 25, 2003
    Assignee: Mitokor, Inc.
    Inventors: Christen M. Anderson, Robert E. Davis
  • Apparatus and method for removal of impurities from hydrocarbon fuels
    Publication number: 20030192830
    Abstract: A filter and a method of using the filter for removing contaminants from liquid propane gas. The liquid propane gas enters the filter through an inlet and passes through a first filtration element where chemical contaminants are removed by a molecular sieving agent. The molecular sieving agent may be a zeolite. Subsequently, the liquid propane gas passes through a second filtration element where particulate contaminants are removed. The invention is also a method of removing contaminants from liquid propane gas including the step of routing the flow of the liquid propane gas through chemical and particulate filter elements so that chemical and particulate contaminants are sequentially removed.
    Type: Application
    Filed: April 10, 2002
    Publication date: October 16, 2003
    Inventors: Bryan S. Memmott, Robert E. Davis
  • Thrust vector adjustment device
    Publication number: 20030178525
    Abstract: The present invention provides a robust means of adjusting the angular mounting of thrust producing devices such as airplane engines. The device provides independent adjustment of the thrust vector for each axis and offset adjustment to maintain the center line of the engine. A means of indicating the angle of adjustment is inherent in the design. The invention also provides for an opening along the centerline to accommodate power take-off shafts or to mount jet or ducted fan engines.
    Type: Application
    Filed: March 22, 2003
    Publication date: September 25, 2003
    Applicant: KRR Enterprises, Inc.
    Inventors: Ronald L. Ramer, Robert E. Davis
  • Mitochondria protecting agents for treating mitochondria associated diseases
    Publication number: 20030176448
    Abstract: The present invention relates generally to mitochondria protecting agents for treating diseases in which mitochondrial dysfunction leads to tissue degeneration and, more specifically, to compounds, compositions and methods related to the same. The methods of this invention involve administration of a pharmaceutically effective amount of a mitochondria protecting agent to a warm-blooded animal in need thereof, and composition of this invention contain a mitochondria protecting agent in combination with a pharmaceutically acceptable carrier or diluent. Mitochondrial associated diseases that may be treated by the present invention include (but are not limited to) Alzheimer's Disease, diabetes mellitus, Parkinson's Disease, neuronal and cardiac ischemia, Huntington's disease and stroke.
    Type: Application
    Filed: August 30, 2002
    Publication date: September 18, 2003
    Applicant: MitoKor
    Inventors: Soumitra S. Ghosh, Scott W. Miller, Robert E. Davis, Walter H. Moos
  • Proteomic determination of protein nitrotyrosine modifications using mass spectrometry
    Publication number: 20030165983
    Abstract: Compositions and methods are provided for identifying oxidative modifications of proteins by mass spectrometric analysis, including MALDI-TOF MS, of protein and peptide fractions of biological samples to determine specific occurrences of nitrotyrosine at amino acid sequence and proteomic levels. Diagnostic methods for diseases characterized by elevated free radicals and oxidative stress, and screening assays for therapeutic agents useful in treating such diseases, are also disclosed.
    Type: Application
    Filed: May 1, 2001
    Publication date: September 4, 2003
    Inventors: Bradford W. Gibson, Soumitra S. Ghosh, Robert E. Davis
  • Parallel fish channel
    Publication number: 20030118406
    Abstract: Currently migratory fisheries are impeded in their upstream and downstream movements by one or more dams across rivers. A method and structure is described that overcomes the shortcomings of currently employed methods such as fish ladders, water spilling and barging. A channel of sufficient dimensions to simulate a natural stream bed is employed to parallel the entire length of river and reservoirs and provide passage for the fish. This is accomplished without the breaching and destruction of the dams bypassed.
    Type: Application
    Filed: December 19, 2002
    Publication date: June 26, 2003
    Inventor: Robert E. Davis
  • Apparatus and method for displaying objects
    Patent number: 6578306
    Abstract: Display apparatus for displaying objects includes a display panel including a panel layer formed of a penetrable, stiff material sandwiched between a layer formed of a penetrable, flexible sheet material and a layer formed of mesh material. The objects are held in position by wires looping about the objects and extending through the display panel.
    Type: Grant
    Filed: November 15, 2001
    Date of Patent: June 17, 2003
    Inventor: Robert E. Davis, Jr.