Patents by Inventor Robert E. Sievers
Robert E. Sievers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10857106Abstract: Methods for treating and/or delaying onset of dysplastic lesions in the bronchial airway of an individual comprise delivering to the respiratory track of the individual an inhalable dry powder composition including an effective amount of myo-inositol.Type: GrantFiled: February 12, 2018Date of Patent: December 8, 2020Assignees: The Regents of the University of Colorado, a Body Corporate, Aktiv-Dry LLCInventors: Robert E. Sievers, Stephen Cape, David McAdams, J'aime Manion, Pankaj Pathak
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Patent number: 10780062Abstract: A tobacco product includes a dry powder composition comprising an amount of myo-inositol effective for treating and/or delaying onset of dysplastic lesions in the bronchial airway of an individual. A method for administering myo-inositol to an individual comprises the individual consuming the tobacco product.Type: GrantFiled: March 22, 2019Date of Patent: September 22, 2020Assignee: COLORADO CAN LLCInventor: Robert E. Sievers
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Publication number: 20190275095Abstract: A salve for topical application comprises beeswax, coconut oil and at least one cannabinoid extract. A lotion for topical application comprises grapeseed oil, sweet almond oil, and at least one cannabinoid extract. Methods of alleviating pain, for example, associated with at least one of osteoarthritis, restless leg syndrome, carpal tunnel syndrome, localized spasticity, pinched nerve, fibromyalgia, neuropathy, muscle pain, lymphedema, tissue injury involving swelling, and damaged, dry, or cracking skin, in an individual, comprise topically applying the salve or the lotion to the skin of the individual.Type: ApplicationFiled: March 11, 2019Publication date: September 12, 2019Inventors: Christie Sievers Spencer, Robert E. Sievers
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Publication number: 20190216748Abstract: A tobacco product includes a dry powder composition comprising an amount of myo-inositol effective for treating and/or delaying onset of dysplastic lesions in the bronchial airway of an individual. A method for administering myo-inositol to an individual comprises the individual consuming the tobacco product.Type: ApplicationFiled: March 22, 2019Publication date: July 18, 2019Inventor: Robert E. SIEVERS
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Patent number: 10206873Abstract: Methods of making a dry powder, comprise (a) delivering a liquid solution or suspension and a second, immiscible fluid to a flow path, (b) transporting the liquid solution or suspension and the immiscible fluid along the flow path, wherein the flow path includes two or more flow passages of different diameters, at least one flow divider which divides and diverts the flowing mixture into at least two separate passages, wherein the separate passages subsequently intersect to combine their respective flows into a single flowing stream, (c) rapidly reducing the pressure of the single flowing stream, whereby droplets are formed, and (d) passing the droplets through a flow of inert drying gas to form a dry powder. A nebulizing nozzle includes an inlet, a flow path as described, and a restrictor nozzle outlet.Type: GrantFiled: August 4, 2017Date of Patent: February 19, 2019Assignee: COLORADO CAN LLCInventors: Xuno Gildelamadrid, Robert E. Sievers
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Publication number: 20190038552Abstract: Methods of making a dry powder, comprise (a) delivering a liquid solution or suspension and a second, immiscible fluid to a flow path, (b) transporting the liquid solution or suspension and the immiscible fluid along the flow path, wherein the flow path includes two or more flow passages of different diameters, at least one flow divider which divides and diverts the flowing mixture into at least two separate passages, wherein the separate passages subsequently intersect to combine their respective flows into a single flowing stream, (c) rapidly reducing the pressure of the single flowing stream, whereby droplets are formed, and (d) passing the droplets through a flow of inert drying gas to form a dry powder. A nebulizing nozzle includes an inlet, a flow path as described, and a restrictor nozzle outlet.Type: ApplicationFiled: August 4, 2017Publication date: February 7, 2019Applicant: COLORADO CAN LLCInventors: Xuno GILDELAMADRID, Robert E. SIEVERS
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Publication number: 20180271826Abstract: Dry powders comprise a cannabinoid, a polymer binding agent, a dispersing agent, and a bulking agent, and optionally an antioxidant, and are formed by carbon dioxide-assisted nebulization and drying in a flowing dry stream of gas. The dry powders have an aerodynamic particle distribution effective for delivery by respiration into the lungs of a patient. Methods of preparing a dry powder comprise subjecting a solution of a volatile component, a cannabinoid, a polymer binding agent, a dispersing agent, and a bulking agent, and optionally an antioxidant, to carbon dioxide-assisted nebulization, and drying droplets formed by the nebulization in a flowing dry gas stream to form a dry powder. The dry powder has an aerodynamic particle distribution effective for delivery of the dry powder by respiration into a lung of a patient and/or exhibit increased bioavailability and/or storage stability of a cannabinoid. The dry powder can be compressed into a wafer.Type: ApplicationFiled: March 22, 2017Publication date: September 27, 2018Applicant: COLORADO CAN LLCInventors: Robert E. Sievers, Lia Rebits
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Publication number: 20180161283Abstract: Methods for treating and/or delaying onset of dysplastic lesions in the bronchial airway of an individual comprise delivering to the respiratory track of the individual an inhalable dry powder composition including an effective amount of myo-inositol.Type: ApplicationFiled: February 12, 2018Publication date: June 14, 2018Inventors: Robert E. SIEVERS, Stephen CAPE, David MCADAMS, J'aime MANION, Pankaj PATHAK
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Patent number: 9895321Abstract: Methods and products for treating and/or delaying onset of dysplastic lesions, and wafers for oral administration employ dry powder compositions including myo-inositol. Methods for administering a vaccine for a virus or bacteria to an individual comprising administering a first portion of the vaccine to the individual via one route and administering a second portion via a second, different route. In a specific embodiment, the first route is sublingually. Vaccines are provided in the form of dry powder compositions comprising a combination of nanoparticles and microparticles, or in the form of a wafer which dissolves in water at room temperature in less than about one minute. Storage stable unit dosages of a vaccine are provided by individually packaging individual unit dosages of a dry powder composition comprising the vaccine and a carrier in blister compartments formed of gas and moisture resistant material.Type: GrantFiled: April 22, 2011Date of Patent: February 20, 2018Assignee: AKTIV-DRY LLCInventors: Robert E. Sievers, Stephen P. Cape, David McAdams, J'aime Manion, Pankaj Pathak
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Publication number: 20160228385Abstract: A purified cannabidiol (CBD) extract and/or cannabidiolic acid (CBDA) extract is isolated from industrial hemp and comprises less than 0.5 wt % organic impurities as measured by HPLC and 1H NMR spectroscopy exhibits no detectable peak at 4.07 ppm as measured by 1H NMR spectroscopy. The CBD and/or CBDA extract is in crystalline form. The CBD extract exhibits a melting point as measured by differential scanning calorimetry (DSC) of 69-70° C. Dry powder compositions comprise such extracts. Additional dry powder compositions comprise polyvinylpyrrolidone and an amorphous CBD extract. An adduct comprises CBD and/or CBDA bonded to a paramagnetic trivalent lanthanide (III) metal chelate.Type: ApplicationFiled: February 5, 2016Publication date: August 11, 2016Applicant: COLORADO CAN LLCInventors: Robert E. Sievers, Lia Rebits
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Publication number: 20130202655Abstract: Methods and products for treating and/or delaying onset of dysplastic lesions, and wafers for oral administration employ dry powder compositions including myo-inositol. Methods for administering a vaccine for a virus or bacteria to an individual comprising administering a first portion of the vaccine to the individual via one route and administering a second portion via a second, different route. In a specific embodiment, the first route is sublingually. Vaccines are provided in the form of dry powder compositions comprising a combination of nanoparticles and microparticles, or in the form of a wafer which dissolves in water at room temperature in less than about one minute. Storage stable unit dosages of a vaccine are provided by individually packaging individual unit dosages of a dry powder composition comprising the vaccine and a carrier in blister compartments formed of gas and moisture resistant material.Type: ApplicationFiled: April 22, 2011Publication date: August 8, 2013Applicant: AKTIV-DRY LLCInventors: Robert E. Sievers, Stephen P. Cape, David McAdams, J'aime Manion, Pankaj Pathak
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Publication number: 20120045479Abstract: Respirable dry powder formulations comprise myo-inositol and leucine. Dry powder human papillomavirus (HPV) vaccine formulations comprise a least one HPV capsid protein and a carrier comprising myo-inositol and leucine. Methods of administering an HPV vaccine to an individual comprise inhalation administration to the individual of a dry powder HPV vaccine formulation comprising a least one HPV capsid protein and a carrier comprising myo-inositol and leucine.Type: ApplicationFiled: October 15, 2009Publication date: February 23, 2012Inventors: Robert E. Sievers, Robert L. Garcea, Stephen P. Cape
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Publication number: 20100269819Abstract: In one embodiment, a human-powered dry powder inhaler comprises a human-powered compressible component operable to discharge an air pulse at an outlet at a pressure of about 1-40 psi; an inflatable reservoir operable to receive an air pulse discharged from the human-powered compressible component to provide an aerosol of a dry powder pharmaceutical formulation in the reservoir, the reservoir including an outlet valve; and a receiving mask in communication with the outlet valve and operable to receive an aerosol of dry powder from the reservoir and to deliver the aerosol to at least a mouth or nose of a patient. In another embodiment, the inhaler comprises a human-powered compressible component operable to discharge an air pulse at an outlet of a polymeric pressure release valve at a pressure of about 1-40 psi; and a receiving mask in communication with the outlet of the compressible component and operable to deliver an aerosol of dry powder to at least a mouth or nose of a patient.Type: ApplicationFiled: August 14, 2007Publication date: October 28, 2010Inventors: Robert E. Sievers, Jessica A. Best, Stephen P. Cape
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Publication number: 20040067259Abstract: A method of making fine dry particles of substances is provided by forming a composition comprising a substance of interest and a supercritical or near critical fluid; rapidly reducing the pressure on said composition, whereby droplets are formed; and passing said droplets through a flow of heated gas. The process does not require any organic solvent.Type: ApplicationFiled: October 7, 2003Publication date: April 8, 2004Inventors: Robert E. Sievers, Scott P. Sellers, John F. Carpenter
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Patent number: 6630121Abstract: A method of making fine dry particles of substances is provided by forming a composition comprising a substance of interest and a supercritical or near critical fluid; rapidly reducing the pressure on said composition, whereby droplets are formed; and passing said droplets through a flow of heated gas. The process does not require any organic solvent.Type: GrantFiled: June 9, 2000Date of Patent: October 7, 2003Assignee: The Regents of the University of ColoradoInventors: Robert E. Sievers, Scott P. Sellers, John F. Carpenter
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Publication number: 20020018815Abstract: Methods and apparatuses are provided for forming fine particles of a desired substance comprising dissolving said substance in a fluid such as water to form a solution and mixing the solution with a second fluid such as supercritical carbon dioxide which becomes a gas upon rapid pressure release, and with which the first fluid is at least partially immiscible, and releasing the pressure to form an air-borne dispersion or aerosol comprising particles having an average diameter between about 0.1 and about 6.5 &mgr;m.Type: ApplicationFiled: May 16, 2001Publication date: February 14, 2002Inventors: Robert E. Sievers, Uwe Karst
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Patent number: 6095134Abstract: Methods and apparatuses are provided for forming fine particles of a desired substance comprising dissolving said substance in a fluid such as water to form a solution and mixing the solution with a second fluid such as supercritical carbon dioxide which becomes a gas upon rapid pressure release, and with which the first fluid is at least partially immiscible, and releasing the pressure to form an air-borne dispersion or aerosol comprising particles having an average diameter between about 0.1 and about 6.5 .mu.m.Type: GrantFiled: April 24, 1997Date of Patent: August 1, 2000Assignee: The Board of Regents of the University of CoInventors: Robert E. Sievers, Uwe Karst
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Patent number: 5639441Abstract: Methods and apparatuses are provided for forming fine particles of a desired substance comprising dissolving said substance in a fluid such as water to form a solution and mixing the solution with a second fluid such as supercritical carbon dioxide which becomes a gas upon rapid pressure release, and with which the first fluid is at least partially immiscible, and releasing the pressure to form an air-borne dispersion or aerosol comprising particles having an average diameter between about 0.1 and about 6.5 .mu.m.Type: GrantFiled: April 8, 1994Date of Patent: June 17, 1997Assignee: Board of Regents of University of ColoradoInventors: Robert E. Sievers, Uwe Karst
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Patent number: 5301664Abstract: Methods and apparatus for delivering physiologically active compounds to a target human or animal employ a supercritical fluid solution comprising a supercritical fluid solvent and a physiologically active solute. The supercritical fluid solution is passed into a subcritical region to evaporate the solvent and form a gas-borne dispersion of solute particles. The gas-borne dispersion of solute particles is administered directly to the target human or animal. The apparatus for delivering the physiologically active compound are of the hand-held type.Type: GrantFiled: March 6, 1992Date of Patent: April 12, 1994Inventors: Robert E. Sievers, Brooks M. Hybertson, Brian N. Hansen
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Patent number: 5089466Abstract: Stable mixed metal oxide compositions containing nitrogen are formed by treating an oxygen-deficient perovskite composition with nitrogen dioxide. Preferably, the oxygen-deficient perovskite is of the formula X.sub.a Z.sub.b Cu.sub.c O.sub.h wherein X is a member selected from the group consisting of yttrium, scandium, lanthanum, neodymium, samarium, europium, gadolinium, terbium, dysprosium, holmium, erbium, thulium, ytterbium, lutetium, bismuth and thallium, Z is a member selected from the group consisting of barium, strontium, calcium, magnesium and mixtures thereof, a is not less than 1, b is from 0 to 3, c is from 0 to 3, and h is not greater than about 6, and the mixed metal oxides are of the formula X.sub.a Z.sub.b Cu.sub.c N.sub.j O.sub.k where X, Z, a, b and c are as previously defined, j is from about 0.001 to about 3, and k is from about 6 to about 13.Type: GrantFiled: July 8, 1988Date of Patent: February 18, 1992Assignee: The University of Colorado Foundation, Inc.Inventors: Robert E. Sievers, Stephen A. Montzka