Patents by Inventor Robert Epple

Robert Epple has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY
    Publication number: 20110190263
    Abstract: The invention provides compounds of Formula (I): pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119.
    Type: Application
    Filed: February 20, 2009
    Publication date: August 4, 2011
    Applicant: IRM LLC
    Inventors: Mihai Azimioara, Christopher Cow, Robert Epple, Songchun Jiang, Gerald Lelais, Baogen Wu, Daniel Mutnick
  • 4-PHENOXYMETHYLPIPERIDINES AS MODULATORS OF GPR119 ACTIVITY
    Publication number: 20110190298
    Abstract: The present invention provides compounds of Formula I, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent; diseases or disorders associated with the activity of GPR119.
    Type: Application
    Filed: July 9, 2009
    Publication date: August 4, 2011
    Applicant: IRM LLC
    Inventors: Robert Epple, Gerald Lelais, Victor Nikulin
  • COMPOUNDS AND METHODS FOR MODULATING G PROTEIN-COUPLED RECEPTORS
    Publication number: 20110172278
    Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with or mediated by G protein-coupled receptors, in particular G protein-coupled receptor 120.
    Type: Application
    Filed: June 23, 2009
    Publication date: July 14, 2011
    Applicant: IRM LLC
    Inventors: Xiaohui He, Xuefeng Zhu, Kunyong Yang, Robert Epple, Hong Liu
  • COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY
    Publication number: 20110172244
    Abstract: The invention provides compounds, of Formula I: pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119.
    Type: Application
    Filed: February 20, 2009
    Publication date: July 14, 2011
    Applicant: IRM LLC
    Inventors: Phillip B. Alper, Robert Epple, Pierre-Yves Michellys, Daniel Mutnick, Victor Nikulin
  • COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY
    Publication number: 20110166176
    Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119.
    Type: Application
    Filed: February 20, 2009
    Publication date: July 7, 2011
    Applicant: IRM LLC
    Inventors: Phillip B. Alper, Christopher Cow, Robert Epple, Pierre-Yves Michellya, Daniel Mutnick
  • Compounds and compositions as PPAR modulators
    Patent number: 7820705
    Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families, particularly the activity of PPAR.
    Type: Grant
    Filed: May 12, 2005
    Date of Patent: October 26, 2010
    Assignee: IRM LLC
    Inventors: Robert Epple, Ross Russo, Mihai Azimioara, Yongping Xie
  • Compounds and compositions as PPAR modulators
    Patent number: 7750032
    Abstract: The invention provides trisubstituted pyrazoles and imidazoles of Formula I: wherein L2, q, R13, R14, R15, R16, Z1 and Z2 are as described in the Summary of the Invention; and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the peroxisome proliferator-activated receptor (PPAR) families, particularly the activity of PPAR?.
    Type: Grant
    Filed: February 3, 2006
    Date of Patent: July 6, 2010
    Assignee: IRM LLC
    Inventors: Christopher Cow, Robert Epple, Xing Wang, Yongping Xie, Hans Martin Seidel
  • Compounds and compositions as PPAR modulators
    Patent number: 7745445
    Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families, particularly the activity of PPAR?.
    Type: Grant
    Filed: May 13, 2005
    Date of Patent: June 29, 2010
    Assignee: IRM LLC
    Inventors: Robert Epple, Mihai Azimioara
  • COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY
    Publication number: 20100120807
    Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119.
    Type: Application
    Filed: March 5, 2008
    Publication date: May 13, 2010
    Applicant: IRM LLC
    Inventors: Phillip B. Alper, Gerald Lelais, Robert Epple, Daniel Mutnick
  • OXAZOLE AND THIAZOLE PPAR MODULATOR
    Publication number: 20100048453
    Abstract: The invention provides compounds (I) pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families, particularly the activity of PPAR?.
    Type: Application
    Filed: November 7, 2006
    Publication date: February 25, 2010
    Applicant: IRM LLC
    Inventors: Robert Epple, Christopher N. Cow, Mihai Azimioara, Ross Russo
  • COMPOUNDS AND METHODS FOR MODULATING G PROTEIN-COUPLED RECEPTORS
    Publication number: 20100035944
    Abstract: The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating G protein-coupled receptor 20 (GPR20), and methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated GPR20.
    Type: Application
    Filed: January 8, 2008
    Publication date: February 11, 2010
    Applicant: IRM LLC
    Inventors: Robert Epple, Mihal Azimioara, Christopher Cow, Ross Russo, Victor Nikulin, Gerald Lelais
  • COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY
    Publication number: 20100022515
    Abstract: The invention provides compounds, pharmaceutical compositions comprising compound of following formula (I), and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119 (G protein-coupled receptor 119) such as obesity, diabetes and hyperlipidemia.
    Type: Application
    Filed: January 22, 2008
    Publication date: January 28, 2010
    Applicant: IRM LLC
    Inventors: Phillip B. Alper, Mihai D. Azimioara, Christopher Cow, Robert Epple, Songchun Jiang, Gerald Lelais, Pierre-Yves Michellys, Truc Ngoc Nguyen, Lucas Westcott-Baker, Baogen Wu
  • THIAZOLE DERIVATIVES AS MODULATORS OF G PROTEIN-COUPLED RECEPTORS
    Publication number: 20100022592
    Abstract: The invention provides compounds of formula (IA) or (IB) and pharmaceutical compositions thereof, which are useful for modulating G protein-coupled receptor 120 (GPR120), and methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated GPR120.
    Type: Application
    Filed: January 7, 2008
    Publication date: January 28, 2010
    Applicant: IRM LLC
    Inventors: Robert Epple, Mihai Azimioara, Christopher Cow, Ross Russo, Victor Nikulin, Gerald Lelais
  • COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY
    Publication number: 20090270409
    Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of GPR119.
    Type: Application
    Filed: September 4, 2008
    Publication date: October 29, 2009
    Applicant: IRM LLC
    Inventors: Phillip B. Alper, Mihai Azimioara, Christopher Cow, Robert Epple, Songchun Jiang, Gerald Lelais, Pierre-Yves Michellys, Daniel Mutnick, Victor Nikulin, Lucas Westcott-Baker
  • COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS
    Publication number: 20090192203
    Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families.
    Type: Application
    Filed: November 7, 2006
    Publication date: July 30, 2009
    Applicant: IRM LLC
    Inventors: Robert Epple, Christopher Cow, Mihai Azimioara, Ross Russo, Yongping Xie, Xing Wang
  • SPIRO IMIDOZOLE DERIVATIVES AS PPAR MODULATORS
    Publication number: 20090137610
    Abstract: The invention provides compounds (Ia), (Ib) and (Ic), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families.
    Type: Application
    Filed: January 25, 2007
    Publication date: May 28, 2009
    Applicant: IRM LLC
    Inventors: Robert Epple, Ross Russo, Mihai Azimioara, Christopher Cow, Valentina Molteni, Xiaolin Li, Donatella Chianelli
  • COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS
    Publication number: 20090137591
    Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families, particularly the activity of PPAR?.
    Type: Application
    Filed: February 3, 2006
    Publication date: May 28, 2009
    Applicant: IRM LLC
    Inventors: Christopher Cow, Robert Epple, Xing Wang, Yongping Xie, Hans Martin Seidel
  • COMPOSITIONS COMPRISING THEM AS PPAR MODULATORS
    Publication number: 20090088368
    Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families.
    Type: Application
    Filed: January 25, 2007
    Publication date: April 2, 2009
    Applicant: IRM LLC
    Inventors: Robert Epple, Ross Russo, Mihai Azimioara
  • Polycyclic 1,2,3,4-Tetrahydro-Isoquinoline Derivatives and Compositions Comprising Them As Ppar Modulators
    Publication number: 20090012097
    Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families.
    Type: Application
    Filed: January 25, 2007
    Publication date: January 8, 2009
    Applicant: IRM LLC
    Inventors: Robert Epple, Christopher Cow
  • Compounds and Compositions as Ppar Modulators
    Publication number: 20080292608
    Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families.
    Type: Application
    Filed: November 7, 2006
    Publication date: November 27, 2008
    Applicant: IRM LLC
    Inventors: Robert Epple, Yongping Xie, Xing Wang, Ross Russo, Christopher Cow, Mihai Azimioara