Patents by Inventor Robert Epple

Robert Epple has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INHIBITORS OF CATHEPSIN S
    Publication number: 20080242671
    Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
    Type: Application
    Filed: March 25, 2008
    Publication date: October 2, 2008
    Applicant: IRM LLC
    Inventors: Hong Liu, Phillip Alper, Arnab Chatterjee, David Tully, Badry Bursulaya, David Woodmansee, Robert Epple, Jennifer Leslie Harris, Jun Li
  • Inhibitors of cathepsin S
    Patent number: 7384970
    Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
    Type: Grant
    Filed: March 23, 2004
    Date of Patent: June 10, 2008
    Assignee: IRM LLC
    Inventors: Hong Liu, Phil Alper, Arnab Chatterjee, David Tully, Badry Bursulaya, David Woodmansee, Robert Epple, Jennifer Leslie Harris, Jun Li
  • Compounds And Compositions As Ppar Modulators
    Publication number: 20080114044
    Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families, particularly the activity of PPAR.
    Type: Application
    Filed: May 12, 2005
    Publication date: May 15, 2008
    Inventors: Robert Epple, Ross Russo, Mihai Azimioara, Yongping Xie
  • Inhibitors of cathepsin S
    Patent number: 7307095
    Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
    Type: Grant
    Filed: January 5, 2007
    Date of Patent: December 11, 2007
    Assignee: IRM LLC
    Inventors: Hong Liu, David Tully, Phillip Alper, Robert Epple, Arnab Chatterjee, Michael Roberts
  • Compounds and Compositions as Ppar Modulators
    Publication number: 20070259890
    Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families, particularly the activity of PPAR?.
    Type: Application
    Filed: May 13, 2005
    Publication date: November 8, 2007
    Inventors: Robert Epple, Mihai Azimioara
  • Compounds and Compositions as Ppar Modulators
    Publication number: 20070244130
    Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families, particularly the activity of PPAR.
    Type: Application
    Filed: May 24, 2005
    Publication date: October 18, 2007
    Applicant: IRM LLC
    Inventors: Robert Epple, Yongping Xie, Xing Wang, Christopher Cow, Ross Russo
  • Compounds And Compositions As Ppar Modulators
    Publication number: 20070203155
    Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families, particularly the activity of PPAR.
    Type: Application
    Filed: May 24, 2005
    Publication date: August 30, 2007
    Applicant: IRM LLC
    Inventors: Robert Epple, Christopher Cow, Yongping Xie, Xing Wang, Ross Russo, Mihai Azimioara, Enrique Saez
  • INHIBITORS OF CATHEPSIN S
    Publication number: 20070123523
    Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
    Type: Application
    Filed: January 5, 2007
    Publication date: May 31, 2007
    Applicant: IRM LLC
    Inventors: Hong Liu, David Tully, Phillip Alper, Robert Epple, Arnab Chatterjee, Michael Roberts
  • Inhibitors of cathepsin S
    Patent number: 7173051
    Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
    Type: Grant
    Filed: June 10, 2004
    Date of Patent: February 6, 2007
    Assignee: IRM, LLC
    Inventors: Hong Liu, David Tully, Phillip Alper, Robert Epple, Arnab Chatterjee, Michael Roberts
  • Inhibitors of cathepsin S
    Patent number: 7109243
    Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme (e.g., cathespin K). The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
    Type: Grant
    Filed: March 23, 2004
    Date of Patent: September 19, 2006
    Assignee: IRM LLC
    Inventors: Hong Liu, David Tully, Robert Epple, Badry Bursulaya, Jennifer Williams, Arnab Chatterjee, Jennifer Leslie Harris, Jun Li
  • Nucleoside analog libraries
    Patent number: 7034147
    Abstract: The present invention provides combinatorial libraries of nucleoside analog compounds and methods of making the libraries. In addition, the present invention provides methods of assaying the libraries for agonists or antagonists of a broad array of targets of therapeutic importance.
    Type: Grant
    Filed: May 8, 2003
    Date of Patent: April 25, 2006
    Assignee: IRM LLC
    Inventors: Robert Epple, William Greenberg, Romas Kudirka
  • Inhibitors of cathepsin S
    Publication number: 20050049244
    Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
    Type: Application
    Filed: June 10, 2004
    Publication date: March 3, 2005
    Applicant: IRM LLC
    Inventors: Hong Liu, David Tully, Phillip Alper, Robert Epple, Arnab Chatterjee, Michael Roberts
  • Second cycle asymmetric dihydroxylation reaction
    Patent number: 6852874
    Abstract: A process for catalyzing asymmetric dihydroxylations of olefins employs an Os(VI) complex as a catalytic intermediate in the formation of chiral vicinal diol products. The process requires a chiral bidentate ligand that favors diol formation in the “second cycle” of asymmetric dihydroxylation.
    Type: Grant
    Filed: August 28, 2001
    Date of Patent: February 8, 2005
    Assignee: The Scripps Research Institute
    Inventors: K. Barry Sharpless, Malin Andersson, Robert Epple, Valery Fokin
  • Inhibitors of cathepsin S
    Publication number: 20040248887
    Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
    Type: Application
    Filed: March 23, 2004
    Publication date: December 9, 2004
    Applicant: IRM LLC
    Inventors: Hong Liu, Phil Alper, Arnab Chatterjee, David Tully, Badry Bursulaya, David Woodmansee, Robert Epple, Jennifer Leslie Harris, Jun Li
  • Inhibitors of cathepsin S
    Publication number: 20040198780
    Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme (e.g., cathespin K). The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
    Type: Application
    Filed: March 23, 2004
    Publication date: October 7, 2004
    Applicant: IRM LLC
    Inventors: Hong Liu, David Tully, Robert Epple, Badry Bursulaya, Jennifer Williams, Arnab Chatterjee, Jennifer Leslie Harris, Jun Li
  • Nucleoside analog libraries
    Publication number: 20040006176
    Abstract: The present invention provides combinatorial libraries of nucleoside analog compounds and methods of making the libraries. In addition, the present invention provides methods of assaying the libraries for agonists or antagonists of a broad array of targets of therapeutic importance.
    Type: Application
    Filed: November 27, 2002
    Publication date: January 8, 2004
    Applicant: IRM LLC, a Delaware Limited Liability Company
    Inventors: Robert Epple, William Greenberg, Romas Kudirka
  • Nucleoside analog libraries
    Publication number: 20030225205
    Abstract: The present invention provides combinatorial libraries of nucleoside analog compounds and methods of making the libraries. In addition, the present invention provides methods of assaying the libraries for agonists or antagonists of a broad array of targets of therapeutic importance.
    Type: Application
    Filed: May 8, 2003
    Publication date: December 4, 2003
    Applicant: IRM LLC, a Delaware Limited Liability Company
    Inventors: Robert Epple, William Greenberg, Romas Kudirka
  • Second cycle asymmetric dihydroxylation reaction
    Publication number: 20020042545
    Abstract: A process for catalyzing asymmetric dihydroxylations of olefins employs an Os(VI) complex as a catalytic intermediate in the formation of chiral vicinal diol products. The process requires a chiral bidentate ligand that favors diol formation in the “second cycle” of asymmetric dihydroxylation.
    Type: Application
    Filed: August 28, 2001
    Publication date: April 11, 2002
    Applicant: The Scripps Research Institute
    Inventors: K. Barry Sharpless, Malin Andersson, Robert Epple, Valery Fokin