Abstract: The present disclosure is directed to systems, methods and devices for replacing a static map image with an interactive map that approximates the geographic area depicted by the static map image. A static image may be inspected and a determination may be made as to whether the static image meets a map identification threshold value. At least one signal associated with the static image may be evaluated and based on that evaluation at least one geo-entity of intent may be identified. The static image may be replaced with a static image corresponding to at least one of the identified geo-entities of intent.

Abstract: The invention relates to the use of flibanserin, or a pharmaceutically acceptable acid addition salt thereof, for the treatment of disorders of sexual desire.

Abstract: A seal for a connector is provided for connecting a bathtub tailpipe to a drain pipe. The connector has an inlet end to receive the tailpipe and an outlet end that is mountable to the drain pipe, and has a passage extending therebetween. A seal extends about the passage for slidably engaging the tailpipe in a fluid sealing manner.

Abstract: A cable may include a central strength member, a plurality of optical fiber buffer tubes positioned around the central strength member, and a jacket surround the plurality of buffer tubes and the central strength member. The central strength member may include a plurality of longitudinally extending and twisted conductive components. Each conductive component may include an inner conductor, a dielectric strength member formed around the inner conductor and having a tensile strength of at least 10,000 MPa, and an outer conductor formed around the dielectric strength member. The inner and outer conductor may form a balanced pair of conductors.

Abstract: An inter-axial inline fluid heater is presented. The inter-axial inline fluid heater includes an outer retaining sheath defining a first area, and an interior flow tube disposed within the outer sheath and capable of having fluid flow therethrough. Further, the interaxial inline fluid heater includes a resistance wire disposed between the interior flow tube and the outer retaining sheath, the resistance wire capable of producing heat for heating a fluid passing through the interior flow tube when power is applied to the resistance wire. Also includes is a dielectric heat transfer material disposed between the interior flow tube and the outer retaining sheath and surrounding at least a portion of the resistance wire.

Abstract: Systems and methods for controlling an autonomous vehicle are provided. In one example embodiment, a computer-implemented method includes determining vehicle diagnostics information associated with a first autonomous vehicle that is part of a fleet of vehicles controlled by a first entity to provide a vehicle service to a second entity. The method includes determining remote inspection information that includes an assessment of one or more categories pertaining to a third entity, based at least in part on the vehicle diagnostics information. The method includes providing the remote inspection information to the third entity to provide the vehicle service.

Abstract: A system and method of removing target material debris deposits simultaneously with generating EUV light includes generating hydrogen radicals in situ in the EUV vessel, proximate to the target material debris deposits and volatilizing the target material debris deposits and purging the volatilized target material debris deposits from the EUV vessel without the need of an oxygen containing species in the EUV vessel.

Abstract: Systems and methods for controlling an autonomous vehicle in response to vehicle instructions from a remote computing system are provided. In one example embodiment, a computer-implemented method includes controlling a first autonomous vehicle to provide a vehicle service, the first autonomous vehicle being associated with a first convoy that includes one or more second autonomous vehicles. The method includes receiving one or more communications from a remote computing system associated with a third-party entity, the one or more communications including one or more vehicle instructions. The method includes coordinating with the one or more second autonomous vehicles to determine one or more vehicle actions to perform in response to receiving the one or more vehicle instructions from the third-party entity. The method includes controlling the first autonomous vehicle to implement the one or more vehicle actions.

Abstract: The present invention provides methods for enhancing the efficacy and/or safety of a vaccine. In certain embodiments, the invention provides methods to increase or potentiate the immune response to a vaccine in a subject in need thereof. The methods of the present invention comprise administering to a subject in need thereof an interleukin-4 receptor (IL-4R) antagonist such as an anti-IL-4R antibody in combination with said vaccine. In certain embodiments, the methods of the present invention are used to afford enhanced protection to an infectious disease such as whooping cough.

Abstract: The invention relates to the use of flibanserin, or a pharmaceutically acceptable acid addition salt thereof, for the treatment of disorders of sexual desire.

Abstract: Systems and methods for providing a vehicle service are provided. In one example embodiment, a computer-implemented method includes receiving data indicative of a service request to provide a vehicle service for an entity with respect to one or more cargo items designated for autonomous transport. The method includes obtaining a first cargo item among the one or more cargo items, from a representative of the entity at a dedicated first transfer hub proximate to a first location associated with the first cargo item. The method includes controlling a first autonomous vehicle to transport the first cargo item from the first transfer hub to a dedicated second transfer hub proximate to a second location associated with the first cargo item. The method includes providing the first cargo item to a representative of the entity at the second transfer hub, to provide the vehicle service.

Abstract: A modular drive train assembly is disclosed for the rail wheels of a railcar mover that provides a plurality of electric drive motors. Each electric drive motor may be connected to a gearbox and subsequently connected to a rail wheel. An automated control system may further control the power supplied to each of the electric drive motors such that the power supplied to each electric drive motor may be individually controlled to enhance the traction of each rail wheel. In addition, a plurality of sensors may monitor and communicate information from the electric drive motors to allow the control system to automatically control the power to each of the electric drive motors to enhance traction of the railcar mover.

Abstract: An handheld illuminating device with orb-shaped lens for enhancing forward and lateral visibility including a flashlight having at least one light source that emits light rays through an orb-shaped lens. The orb-shaped lens is semi-spherical and adapted to disperse the light rays through a substantially 270° arc of uniform light for illuminating more than one area around the user, diffusing the light rays to soften the illumination from the light source, and eliminates shadows that are inherent in flat or curvilinear lenses. A reflector reflects light rays from the light source to the orb-shaped lens. A power supply powers the light source. A switch regulates power and intensity of the light source. A transparent cover protects the orb-shaped lens from physical damage.

Abstract: A rupture disc device and method of assembly thereof are provided. The rupture disc device has a device body formed so that there are no leakage pathways to the radially outer surface thereof. The rupture disc is welded to the device body so that the weld joint therebetween is not relied upon to provide structural support, and instead strictly acts as a seal. In one form, the weld joint is formed with the weld beam directed axially transverse to thickness of the rupture disc to minimize unwanted variances in the rupture disc burst pressure that otherwise may be created due to the heat generated during weld joint formation.

Abstract: The present invention provides methods for decreasing a nasal polyp score in a subject. The methods include administering to a subject in need thereof a therapeutic composition comprising an interleukin-4 receptor (IL-4R) antagonist such as an anti-IL-4R antibody or antigen binding fragment thereof.

Abstract: The present invention provides methods for treating nasal polyposis. The methods include administering to a subject in need thereof a therapeutic composition comprising an interleukin-4 receptor (IL-4R) antagonist such as an anti-IL-4R antibody or antigen binding fragment thereof.

Abstract: Methods for preparing lyophilized pellets of biological materials are described. The pellets have a substantially spherical shape and are prepared by freezing droplets of a liquid composition of a desired biological material on a flat, solid surface, in particular, a surface that does not have any cavities, followed by lyophilizing the frozen droplets. These methods are useful for preparing lyophilized pellets having a high concentration of a desired biological material, in particular a therapeutic protein or vaccine, and which have a faster reconstitution time than lyophilized powder cakes prepared in vials.

Abstract: The invention relates to the use of flibanserin, or a pharmaceutically acceptable acid addition salt thereof, for the treatment of disorders of sexual desire.

Abstract: In an aspect, the disclosure provides methods for making neurotransmitters in a host organism. The neurotransmitters can be cannabinoids and derivatives of cannabinoids. The host cells can be microalgae, fungi or other host cells. In a related aspect, the disclosure provides host cells engineered to have biochemical pathways for making neurotransmitters such as cannabinoids.

Abstract: An all-dielectric self-supporting (ADSS) cable may include a central strength member and a plurality of buffer tubes helically wrapped around the central member. Each of the plurality of buffer tubes may house at least one optical fiber, and an outer jacket may surround the plurality of buffer tubes and the central strength member. Additionally the central strength member may include a plurality of different strength layers including a first layer formed from relatively flexible material and a second layer formed from relatively rigid material.