Abstract: A flowing water sterilization filter comprising a clear plastic sectional canister with an inlet conduit and outlet conduit mounted to said different sections of the canister. A polyurethane iodine treated sponge is positioned in said canister between the inlet conduit and outlet conduit to sterilize water passing therethrough.

Abstract: Malignant, neoplastic cells are treated by inhibiting glucose transport into the cell by administering phlorizin, phloretin or its analogs while concurrently administering adjunct therapy such as heat, radiation or chemotherapy. In this manner, the cells are prevented from growing or repairing the damage caused by the adjunct therapy, which can be administered in dosages that would otherwise be non-lethal if used alone.

Abstract: The present invention relates to a non-enzymatic and non-toxic urease antigen and a method for its production. Administration of the urease antigen in living organisms serves to immunize the same from certain types of ammonia production without causing ammonia toxicity when injected, thereby promoting several advantageous biological activities including the promotion of wound healing, and general immunity from ammonia toxicity and the related effects thereof, and the cessation of toxic ammonia production in infections caused by urea splitting organisms.

Abstract: A medical stent for use in an aneurysm constructed with a flexible tubular body formed from a medical thermoplastic in the form of a helix. The flexible tubular body defines a lumen and the body is adapted to assume a substantial linear configuration when mounted on a stylet with the material of the body having a recovery memory which causes it to assume a helical configuration when it is removed from the stylet. The body is provided with strands which are connected to adjacent loops of the helix and extend in the space defined by each coil of the helix to allow clot and ingrowth of tissue to seal off the dilated portion of the vessel.

Abstract: An apparatus and method of use thereof which quantifies the processes of hemostasis occuring in human blood. The apparatus utilizes an oscillator transducer which is sensitive to changes of viscosity and tensile strength of surrounding blood as coagulation occurs in the latter. An oscillator, which may be excited to oscillate at a natural resonant frequency, is housed within an enclosure designed to accommodate a finite quantity of blood in contact with the oscillator. As hemostasis occurs, the frequency at which the oscillator resonates is impaired. A control and computation system for measurement of the change of frequency is coupled to the oscillator, which counts the number of oscillations of the oscillator transducer during a predetermined time period, and computes the frequency as a function of the known time period and the counted oscillations.

Abstract: Phlorizin, its gluconuride and 4-deoxyphloretin-2-D-glucoside are used in treatment of cancer, particularly in combination with radio frequency thermotherapy and other modalities to accentuate the effect of such thermotherapy or other modality.

Abstract: A low-power personal epilepsy seizure warning system is disclosed based on the clinical observation that while the brain potentials marking the onset of epilepsy vary from patient to patient, indicative brain potentials in any one patient are highly likely to remain constant. The system includes an implantable monitor to detect brain potentials and recognize the onset of a seizure, and an external warning unit to warn the patient when a seizure is imminent. The monitor is configured to recognize a patient's indicative potentials after preoperative EEG observation, and may include relatively simple analog circuitry to recognize simple forms, or a microprocessor and programmed memory to recognize complex forms utilizing algorithms such as the fast Fourier transform. An external program adjustment unit may also be utilized to increase or decrease the sensitivity of the monitor corresponding to the patient's experience of insufficient or excessive warnings after implantation.

Abstract: The present inventive apparatus measures the output of urine optically, totalizes it and prints it on a self-adherent paper which can easily be afixed to the hospital chart. The apparatus includes a measurement column, an optical sensor to determine when the measurement column is empty, a peristaltic pump to empty the measurement column at a known rate, into a collection bag or specimen bottle and control logic to determine the volume removed from the column based on the pump rate. A display is also provided for easy observation of current output statistics. Specimens can be collected under automatic or manual control for biochemical analysis without contamination by contact or alteration by electrical current. An alarm may be sounded when the collection bag is in need of replacement, or when the urine output falls or rises to predetermined rates.

Abstract: A process for the production of tumor angiogenetic factor and the production of antigens from a purified angiogenetic factor is shown in the present invention. The production of tumor angiogenetic factor is accomplished by injecting a material of a suitable composition to initiate production of fluid in the cavity of a living animal by inciting an inflammatory response in the cavity tissues, which response is characterized by the production of granulation tissue comprised mostly of new capillaries. After the body cavity is partly filled with the exudate, the fluid is tapped out of the cavity and purified to yield angiogenetic factor. The production of antigens is accomplished by dissolving the purified angiogenetic factor in an equal volume of distilled water, reacting the dissolved angiogenetic factor in the distilled water with a gluteraldehyde solution for at least twelve (12) hours and lyophilizing resulting mixture for storage.

Abstract: A catheter having first and second inflatable balloon structures with a valved coupling permitting the balloon structures to be separated while remaining inflated.

Abstract: A balloon catheter is formed by blow molding an elongated polyurethane tube so that one section of the tube has a thinned cross sectional balloon area between the distal end of tube which is sealed and its open proximal end. The balloon portion which is positioned adjacent the distal end has a thinner cross sectional area which allows a balloon to be formed if a fluid is introduced into the catheter by a syringe apparatus which is adapted to be attached to the lumen by a connection adaptor. A wire guide member is adapted to be inserted through the lumen for stretching the catheter when it is inserted into a blood vessel to stiffen the catheter and position it in a proper position. The wire guide member may also be mitred at predetermined intervals to determine the position of the catheter within the blood vessel.

Abstract: A novel balloon catheter apparatus for treatment of atherosclerotic occlusions within the cardiovascular system, comprising a catheter defining a through-going lumen, a fluid supply syringe attached to one end of the catheter for supplying fluid through the lumen, and a balloon attached to the other end of the catheter which is inflatable by forcing fluid through the lumen. A pulse generator is also attached to the catheter for generating pressure pulses in the fluid through the lumen, which pulses cause the balloon to sharply expand and contract at intervals. The pulse generator includes a pulse syringe communicating with the lumen, a spring-driven ram to contact the piston of the pulse syringe, and a cam rotor to move the ram away from the piston, thereby compressing the spring unitl the cam rotates further and the ram is released to strike the piston.

Abstract: An apparatus for vessel transfer comprising a tubular outer member and an inner slidable member one of which is rigid and the other of which is flexible. After the apparatus has been inserted in the body tissue, the rigid member is withdrawn from the body leaving the flexible member in place. A vein, prosthesis or elastomeric tubing attaching structure is secured to the end of the flexible member so that the flexible member can be used to pull said vein, prosthesis or elastomeric tubing through the body tissues to an elected distant site where the tip of the flexible member has been surgically exposed.

Abstract: A technique and a device for cutting off the flow of blood through an unwanted opening in a major blood vessel to facilitate surgical closure of the opening utilizing a dual balloon catheter inserted into the blood vessel with the balloons inflated on opposite sides of the opening.

Abstract: A tubular device for advancing a medical treatment or examination instrument in a tubular passageway and having a head portion with outwardly biassed, rearwardly extending, flexible legs and a tail portion with outwardly biassed, rearwardly extending, flexible legs. The head and tail portions are interconnected by a fluid extensible bellows, and alternate expansion and contraction of the bellows causes advance of the head and following motion by the tail, the legs engaging the passageway wall and permitting forward motion but preventing backward motion through the passageway. In one embodiment of the device the head and tail parts are generally cylindrical and relatively rigid. In another embodiment, the head and tail portions each has extensible bellows arranged within a deformable cage constituted by jointed, flexible legs arranged to project outwardly to engage the passageway wall when the bellows they surround is contracted.

Abstract: There is provided a polymeric bacteriocidal composition comprising a thermoplastic, partially cross-linked polyurethane having --NH--(C.dbd.O)--O-- urethane linkages and/or urea linkages --NH--(C.dbd.O)--NH-- and iodine complexed with a sufficient number of these linkages to provide bacteriocidal properties to said composition. The polyurethane has an average molecular weight between 35,000 and 50,000, an ultimate elongation of 200 to 800% and a Shore A scale hardness of 60 to 95. The composition is shaped into a conventional medical appliance form, e.g. a catheter.

Abstract: An inflatable oral-nasal gastric tube constructed with double walls allowing the tube to be stiffened by inflation for purposes of initial placement in the patient, and deflated thereafter in order to minimize internal tissue irritation and necrosis. The tube comprises thin flexible outer and inner substantially cylindrical walls which are sealed together at their proximal and distal ends to form an inflatable structure, with a lumen defined inside the inner wall. The lumen is throughgoing and communicates with a funnel attached to the proximal end for administration of food and/or medicine and a weight is attached at the lower distal end to aid in initial placement efforts. A valve and air tube are provided on the proximal end of the tube to inject and withdraw fluid between the inner and outer walls of the tube.

Abstract: A syringe comprising a cylindrical barrel with a wall at one end with a nozzle and with a threaded actuating rod extending from its other end, the rod carrying a piston in fluid tight engagement with the inner wall of the barrel. The rod also carries a collar with threads which mate with the rod threads, and the collar has slots which engage projections on the barrel and prevent movement of the collar relative to the barrel but which permit the collar to be disengaged readily from the barrel. A manually engageable knob is rotatably mounted on the rod at its end remote from the piston and is interconnected with the rod by a compressible, spiral spring. A ratchet wheel is mounted on the rod so as to rotate therewith and is adjacent the knob. The knob carries a spring biased pawl in the form of a tooth which is engageable with the ratchet wheel teeth.

Abstract: A syringe comprising a cylindrical barrel with a wall at one end with a nozzle and with a threaded actuating rod extending from its other end, the rod having an axial bore and a piston in fluid tight engagement with the inner wall of the barrel is connected to the rod by compressible spring means which is an extension of the rod threads. The rod also carries a collar with threads which mate with the rod threads, and the collar has slots which engage projections on the barrel and prevent movement of the collar relative to the barrel but which permit the collar to be disengaged readily from the barrel. An indicator rod is connected at one end to the piston and is slidable in the bore of the actuating rod. The opposite end of the indicator rod, bearing graduation marks, extends axially outwardly of the actuating rod.

Abstract: A syringe comprising a cylindrical barrel with a wall at one end with a nozzle and with a threaded actuating rod extending from its other end. The rod has a piston at the end thereof within the barrel, the piston being in fluid tight engagement with the inner wall of the barrel, and has a knob at its opposite end for rotating the rod. The rod also carries a collar with threads which mate with the rod threads, and the collar has slots which engage projections on the barrel and prevent movement of the collar relative to the barrel but which permit the collar to be disengaged readily from the barrel. Rotation of the rod causes movement of the piston axially of the barrel when the collar is engaged, but the rod can be moved axially without rotation when the collar is disengaged.