Abstract: An apparatus for providing an infused or brewed beverage comprises a brewing arrangement which is configured to brew a beverage according to a selected one of a plurality of brewing processes, at least one being a hot brewing processes and at least one being a cold brewing process. The apparatus includes a controller configured to receive a user selection indicative of a required beverage, and to control the brewing arrangement in dependence upon the user selection. The apparatus may for example be used to provide either hot brew or cold brew coffee as required, without the need for multiple machines.

Abstract: The present disclosure relates generally to the use of an ERK1/2 inhibitor in combination with a EGFR inhibitor for treating cancer, specifically solid tumors. The present disclosure also relates to the use of an ERK 1/2 inhibitor in combination with a EGFR inhibitor and a BRAF inhibitor for treating cancer, specifically solid tumors.

Abstract: The present disclosure relates generally to the use an ERK1/2 inhibitor in combination with a SHP2 inhibitor for treating cancer, specifically solid tumors.

Abstract: The present disclosure provides methods of treating cancer with a combination therapy of a SHP2 inhibitor and an inhibitor of CDK4/6.

Abstract: The present disclosure relates generally to the use of an ERK 1/2 inhibitor in combination with a KRAS G12C inhibitor for treating cancer, specifically solid tumors.

Abstract: The present disclosure relates generally to the use of an ERK1/2 inhibitor or a SHP2 inhibitor in combination with a FLT3 inhibitor, such as gilteritinib, for treating cancer, specifically acute myeloid leukemia (AML).

Abstract: An apparatus for providing an infused or brewed beverage comprises a brewing arrangement which is configured to brew a beverage according to a selected one of a plurality of brewing processes, at least one being a hot brewing processes and at least one being a cold brewing process. The apparatus includes a controller configured to receive a user selection indicative of a required beverage, and to control the brewing arrangement in dependence upon the user selection. The apparatus may for example be used to provide either hot brew or cold brew coffee as required, without the need for multiple machines.

Abstract: The present disclosure provides methods of treating cancer with a combination therapies of a SHP2 inhibitor, such as the compound of Formula I, and an FGFR inhibitor, a B-Raf inhibitor, a MEK inhibitor, or a MET inhibitor

Abstract: The present disclosure provides methods of treating cancer with combination therapies of a SHP2 inhibitor and EGFR inhibitor.

Abstract: A coordinate locating device comprising a support structure removably connectable to a wearable sensor device being worn by an individual. The support structure comprising a planar surface. The device includes a plurality of different fiducial marker components connected to the planar surface. The plurality of different fiducial marker components includes a set of fiducial markers connected to the planar surface in a non-collinear configuration relative to each other to define a three-dimensional (3D) space of pixels in an image. The plurality of different fiducial marker components includes a distance calibration fiducial marker connected to the planar surface and being configured to define a distance calibration length of pixels in the image, the distance calibration fiducial marker being perpendicular to the planar surface and defining a calibration length to locate a point of origin of motion sensing by the wearable sensor device. A system and method are also provided.

Abstract: A surgical sterilization system includes a surgical table and a sterilization member disposable with the surgical table and including a dispenser configured for alignment with a selected surface of a body disposed with the surgical table. The surface and the dispenser are relatively movable. In some embodiments, surgical instruments and methods are disclosed.

Abstract: A surgical drape includes a seal connectable with a selected surface of a body disposed with a surgical table. A draping is connected with the seal and a track of the surgical table. The draping is movable relative to the seal to define a sterile region about the body. Surgical instruments, systems and methods are disclosed.

Abstract: A system for assessing a status of a spinal implant includes a reader device, a wearable body sensor, and a spinal implant. The wearable body sensor includes a first short-range receiver, a first short-range transmitter, and an inertial measurement unit. The wearable body sensor is configured to be positioned over a portion of a spine of a wearer, and measure movement information corresponding to spinal motion of the wearer while the wearer performs one or more movements while wearing the wearable body sensor. The spinal implant includes one or more sensors configured to measure implant information comprising one or more characteristics of a fusion status of the spinal implant, a second short-range receiver, and a second short-range transmitter. The wearable body sensor is configured to communicate movement information to the reader device. The spinal implant is configured to communicate implant information to the reader device via the second transmitter.

Abstract: A load sensing assembly for a spinal implant includes a set screw having a central opening that extends from a first end of the set screw toward a second end of the set screw. The second end of the set screw is configured to engage with an anchoring member. The load sensing assembly includes an antenna, an integrated circuit in communication with the antenna, where the integrated circuit is positioned within the central opening of the set screw, and a strain gauge in connection with the integrated circuit. The strain gauge is located within the central opening of the set screw in proximity to the second end of the set screw.

Abstract: A system for assessing a spinal disorder includes a wearable electronic device having one or more sensors and an assessment system. The wearable electronic device is configured to be positioned on a portion of a lower back of a wearer, and the one or more sensors are configured to obtain patient data associated with the wearer. The system receives patient data from the one or more sensors, where the patient data includes movement data associated with movement of the lower back of the wearer, classifies the movement data into an initial grouping, further classifies the at least a portion of the movement data into one of the plurality of activity categories, generate a score corresponding to the at least a portion of the movement data based on the activity category to which the movement data is classified, and cause the score to be displayed via a client electronic device.

Abstract: A system for assessing a status of a spinal implant includes a reader device, a wearable body sensor, and a spinal implant. The wearable body sensor includes a first short-range receiver, a first short-range transmitter, and an inertial measurement unit. The wearable body sensor is configured to be positioned over a portion of a spine of a wearer, and measure movement information corresponding to spinal motion of the wearer while the wearer performs one or more movements while wearing the wearable body sensor. The spinal implant includes one or more sensors configured to measure implant information comprising one or more characteristics of a fusion status of the spinal implant, a second short-range receiver, and a second short-range transmitter. The wearable body sensor is configured to communicate movement information to the reader device. The spinal implant is configured to communicate implant information to the reader device via the second transmitter.

Abstract: A coordinate locating device comprising a support structure removably connectable to a wearable sensor device being worn by an individual. The support structure comprising a planar surface. The device includes a plurality of different fiducial marker components connected to the planar surface. The plurality of different fiducial marker components includes a set of fiducial markers connected to the planar surface in a non-collinear configuration relative to each other to define a three-dimensional (3D) space of pixels in an image. The plurality of different fiducial marker components includes a distance calibration fiducial marker connected to the planar surface and being configured to define a distance calibration length of pixels in the image, the distance calibration fiducial marker being perpendicular to the planar surface and defining a calibration length to locate a point of origin of motion sensing by the wearable sensor device. A system and method are also provided.

Abstract: A food processing hub (10) comprising an attachment connector (15) for connecting to a food processing attachment (20); wherein the hub (10) is adapted to supply a fluid to the attachment (20) via the attachment connector (15).

Abstract: An apparatus for providing an infused or brewed beverage comprises a brewing arrangement which is configured to brew a beverage according to a selected one of a plurality of brewing processes, at least one being a hot brewing processes and at least one being a cold brewing process. The apparatus includes a controller configured to receive a user selection indicative of a required beverage, and to control the brewing arrangement in dependence upon the user selection. The apparatus may for example be used to provide either hot brew or cold brew coffee as required, without the need for multiple machines.

Abstract: A foodstuff grinding attachment for connection to a rotary drive outlet of a host device. The attachment includes a main body part having a generally tubular hollowed portion for attachment to the host device. A rotatable scroll-type extruding tool is capable of rotating within a cavity formed in the tubular portion of the main body part and couples with the rotary drive outlet when the main body part is attached to the host device. The main body part includes first and second separable components configured to be secured together for operation of the attachment. The components are separable from one another to provide access to the cavity for cleaning.