Patents by Inventor Robert Fletcher

Robert Fletcher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9255095
    Abstract: A compound according to Formula Ia: wherein L1, G, and R1 are as described herein. The present invention relates to novel compounds according to Formula I that antagonize GPR84, a G-protein-coupled receptor that is involved in inflammatory conditions, and methods for the production of these novel compounds, pharmaceutical compositions comprising these compounds, and methods for the prevention and/or treatment of inflammatory conditions (for example inflammatory bowel diseases (IBD), rheumatoid arthritis, vasculitis, lung diseases (e.g. chronic obstructive pulmonary disease (COPD) and lung interstitial diseases (e.g. idiopathic pulmonary fibrosis (IPF))), neuroinflammatory conditions, infectious diseases, autoimmune diseases, endocrine and/or metabolic diseases, and/or diseases involving impairment of immune cell functions by administering a compound of the invention.
    Type: Grant
    Filed: January 6, 2014
    Date of Patent: February 9, 2016
    Assignee: GALAPAGOS NV
    Inventors: Frédéric Gilbert Labéguère, Gregory John Robert Newsome, Luke Jonathan Alvey, Laurent Raymond Maurice Sanière, Stephen Robert Fletcher
  • Patent number: 9233316
    Abstract: We provide an alkylation process, comprising: separating and recycling a hydrogen gas and a hydrogen chloride from an offgas of a hydrogenation reactor; wherein the hydrogen gas is recycled to the hydrogenation reactor; and wherein the hydrogen chloride is recycled to an alkylation reactor. We also provide an alkylation process unit for performing this process.
    Type: Grant
    Filed: July 31, 2012
    Date of Patent: January 12, 2016
    Assignee: Chevron U.S.A. Inc.
    Inventors: Hye Kyung Cho Timken, Robert Fletcher Cleverdon, Bong-Kyu Chang, Donald Henry Mohr, Christine Marie Phillips
  • Publication number: 20150150856
    Abstract: [1,2,4]triazolo[1,5-a]pyridine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, diseases involving cartilage degradation, bone and/or joint degradation, for example osteoarthritis; and/or conditions involving inflammation or immune responses, such as Crohn's disease, rheumatoid arthritis, psoriasis, allergic airways disease (e.g. asthma, rhinitis), juvenile idiopathic arthritis, colitis, inflammatory bowel diseases, endotoxin-driven disease states (e.g. complications after bypass surgery or chronic endotoxin states contributing to e.g. chronic cardiac failure), diseases involving impairment of cartilage turnover (e.g.
    Type: Application
    Filed: October 6, 2014
    Publication date: June 4, 2015
    Inventors: Christel Jeanne Marie MENET, Luc Juliaan Corina VAN ROMPAEY, Stephen Robert FLETCHER, Javier BLANC, Nolwenn JOUANNIGOT, Alastair James HODGES, Koen Kurt SMITS
  • Publication number: 20150025285
    Abstract: Processes for eliminating oxygenates and water from a light hydrocarbon processing system, wherein oxygenates are removed from a light hydrocarbon stream by adsorption of the oxygenates on an oxygenate adsorption unit to provide a deoxygenated hydrocarbon stream, the oxygenate adsorption unit is regenerated via a regenerant stream to provide an oxygenated regenerant stream comprising the oxygenates, and the oxygenated regenerant stream is subjected to hydro-deoxygenation to convert the oxygenates into paraffins and water, wherein the water may also be permanently removed from the system.
    Type: Application
    Filed: July 17, 2013
    Publication date: January 22, 2015
    Applicant: Chevron U.S.A. Inc.
    Inventors: Robert Fletcher Cleverdon, Clifford Michael Lowe, Hye Kyung Cho Timken
  • Publication number: 20150025284
    Abstract: Processes for eliminating water and oxygenates from a light hydrocarbon processing system, wherein oxygenates are removed from a light hydrocarbon stream by adsorption of the oxygenates on a primary oxygenate adsorption unit to provide a deoxygenated hydrocarbon stream, the primary oxygenate adsorption unit is regenerated via a first regenerant stream to provide an oxygenated first regenerant stream, the oxygenated first regenerant stream is deoxygenated via a secondary oxygenate adsorption unit, and the secondary oxygenate adsorption unit is regenerated via a second regenerant stream to provide an oxygenated second regenerant stream for permanent removal from the system.
    Type: Application
    Filed: July 17, 2013
    Publication date: January 22, 2015
    Applicant: Chevron U.S.A. Inc.
    Inventors: Clifford Michael Lowe, Robert Fletcher Cleverdon
  • Patent number: 8927543
    Abstract: A compound according to Formula Ia: wherein L1, G, and R1 are as described herein. The present invention relates to novel compounds according to Formula I that antagonize GPR84, a G-protein-coupled receptor that is involved in inflammatory conditions, and methods for the production of these novel compounds, pharmaceutical compositions comprising these compounds, and methods for the prevention and/or treatment of inflammatory conditions (for example inflammatory bowel diseases (IBD), rheumatoid arthritis, vasculitis, lung diseases (e.g. chronic obstructive pulmonary disease (COPD) and lung interstitial diseases (e.g. idiopathic pulmonary fibrosis (IPF))), neuroinflammatory conditions, infectious diseases, autoimmune diseases, endocrine and/or metabolic diseases, and/or diseases involving impairment of immune cell functions by administering a compound of the invention.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: January 6, 2015
    Assignee: Galapagos NV
    Inventors: Frédéric Gilbert Labéguére, Gregory John Robert Newsome, Luke Jonathan Alvey, Laurent Raymond Maurice Saniére, Stephen Robert Fletcher
  • Patent number: 8920755
    Abstract: Methods for converting an H2SO4 alkylation unit to an ionic liquid alkylation system configured for performing ionic liquid catalyzed alkylation processes may comprise connecting at least one component configured for ionic liquid catalyzed alkylation to at least one component of the H2SO4 alkylation unit, wherein the at least one component of the H2SO4 alkylation unit is retained, modified or adapted for use in the ionic liquid alkylation system. Ionic liquid catalyzed alkylation systems derived from existing conventional alkylation units, and ionic liquid catalyzed alkylation processes are also disclosed.
    Type: Grant
    Filed: September 12, 2011
    Date of Patent: December 30, 2014
    Assignee: Chevron U.S.A. Inc.
    Inventors: Robert Fletcher Cleverdon, Christine Marie Phillips, Hye Kyung Cho Timken
  • Patent number: 8921636
    Abstract: Methods for converting an HF alkylation unit to an ionic liquid alkylation system configured for performing ionic liquid catalyzed alkylation processes may comprise connecting at least one component configured for ionic liquid catalyzed alkylation to at least one component of the HF alkylation unit, wherein the at least one component of the HF alkylation unit is retained, modified or adapted for use in the ionic liquid alkylation system. An ionic liquid alkylation system derived from an existing or prior HF alkylation unit is also disclosed.
    Type: Grant
    Filed: September 12, 2011
    Date of Patent: December 30, 2014
    Assignee: Chevron U.S.A. Inc.
    Inventors: Robert Fletcher Cleverdon, Christine Marie Phillips, Hye Kyung Cho Timken
  • Publication number: 20140308215
    Abstract: An anhydrous antiperspirant composition comprising a dehydrated alum salt, a water soluble calcium salt, and a liquid carrier material comprising 50% or more by weight of hydrophobic oils.
    Type: Application
    Filed: September 12, 2012
    Publication date: October 16, 2014
    Inventors: Michael Richard Baker, Neil Robert Fletcher, Kevin Ronald Franklin, Kirill Shafran
  • Patent number: 8853240
    Abstract: [1,2,4]triazolo[1,5-a]pyridine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, diseases involving cartilage degradation, bone and/or joint degradation, for example osteoarthritis; and/or conditions involving inflammation or immune responses, such as Crohn's disease, rheumatoid arthritis, psoriasis, allergic airways disease (e.g. asthma, rhinitis), juvenile idiopathic arthritis, colitis, inflammatory bowel diseases, endotoxin-driven disease states (e.g. complications after bypass surgery or chronic endotoxin states contributing to e.g. chronic cardiac failure), diseases involving impairment of cartilage turnover (e.g.
    Type: Grant
    Filed: July 24, 2009
    Date of Patent: October 7, 2014
    Assignee: Galapagos NV
    Inventors: Christel Jeanne Marie Menet, Nolwenn Jouannigot, Javier Blanc, Luc Juliaan Corina Van Rompaey, Stephen Robert Fletcher, Alastair James Hodges, Koen Kurt Smits
  • Publication number: 20140278889
    Abstract: A system and method directed at a consumer interaction system and program that provides an option to participate in said program, and provides incentives for participating in certain defined behavior, such as dimming the screen of or rendering silent a phone during the showing of a movie in a movie theater, participating in an activity in a particular geographic area, or making purchases.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Applicant: CINEMARK USA, INC.
    Inventors: Douglas Scott FAY, Joseph Daniel GALYEAN, Robert Fletcher CARMONY, James MEREDITH
  • Publication number: 20140227215
    Abstract: A method for reducing perspiration comprising the application to the surface of the human body of an alum salt and calcium chloride and compositions suitable for use in said method, in particular anhydrous compositions comprising both an alum salt and calcium chloride.
    Type: Application
    Filed: September 12, 2012
    Publication date: August 14, 2014
    Inventors: Michael Richard Baker, Neil Robert Fletcher, Kevin Ronald Franklin, Kirill Shafran
  • Publication number: 20140134065
    Abstract: We provide an alkylation process, comprising: separating and recycling a hydrogen gas and a hydrogen chloride from an offgas of a hydrogenation reactor; wherein the hydrogen gas is recycled to the hydrogenation reactor; and wherein the hydrogen chloride is recycled to an alkylation reactor. We also provide an alkylation process unit for performing this process.
    Type: Application
    Filed: January 17, 2014
    Publication date: May 15, 2014
    Applicant: Chevron U.S.A. Inc.
    Inventors: Hye Kyung Cho Timken, Robert Fletcher Cleverdon, Bong-Ku Chang, Donald Henry Mohr, Christine Marie Phillips
  • Publication number: 20140121204
    Abstract: A compound according to Formula Ia: wherein L1, G, and R1 are as described herein. The present invention relates to novel compounds according to Formula I that antagonize GPR84, a G-protein-coupled receptor that is involved in inflammatory conditions, and methods for the production of these novel compounds, pharmaceutical compositions comprising these compounds, and methods for the prevention and/or treatment of inflammatory conditions (for example inflammatory bowel diseases (IBD), rheumatoid arthritis, vasculitis, lung diseases (e.g. chronic obstructive pulmonary disease (COPD) and lung interstitial diseases (e.g. idiopathic pulmonary fibrosis (IPF))), neuroinflammatory conditions, infectious diseases, autoimmune diseases, endocrine and/or metabolic diseases, and/or diseases involving impairment of immune cell functions by administering a compound of the invention.
    Type: Application
    Filed: January 6, 2014
    Publication date: May 1, 2014
    Applicant: GALAPAGOS NV
    Inventors: Frédéric Gilbert Labéguère, Gregory John Robert NEWSOME, Luke Jonathan ALVEY, Laurent Raymond Maurice Sanière, Stephen Robert FLETCHER
  • Publication number: 20140039231
    Abstract: We provide an alkylation process, comprising: separating and recycling a hydrogen gas and a hydrogen chloride from an offgas of a hydrogenation reactor; wherein the hydrogen gas is recycled to the hydrogenation reactor; and wherein the hydrogen chloride is recycled to an alkylation reactor. We also provide an alkylation process unit for performing this process.
    Type: Application
    Filed: July 31, 2012
    Publication date: February 6, 2014
    Applicant: Chevron U.S.A. Inc.
    Inventors: Hye Kyung Cho Timken, Robert Fletcher Cleverdon, Bong-Kyu Chang, Donald Henry Mohr, Christine Marie Phillips
  • Patent number: 8518384
    Abstract: Spray compositions and particularly anhydrous aerosol compositions containing particulate antiperspirant actives exhibit a tendency for nozzle blockage, impeding discharge of the contents when a polyol humectant, such as glycerol, is blended into its base composition. The problem is overcome or at least ameliorated by preparation of a base composition, suitable for employment in conjunction with a propellant, that contains a low molecular weight (liquid) polyethylene glycol (PEG) as humectant, and particularly a PEG of molecular weight 150 to 500.
    Type: Grant
    Filed: July 27, 2006
    Date of Patent: August 27, 2013
    Assignee: Conopco Inc.
    Inventors: Neil Robert Fletcher, Michael Massaro, Joseph Muscat, Graham Andrew Turner
  • Publication number: 20130066133
    Abstract: Methods for converting an HF alkylation unit to an ionic liquid alkylation system configured for performing ionic liquid catalyzed alkylation processes may comprise connecting at least one component configured for ionic liquid catalyzed alkylation to at least one component of the HF alkylation unit, wherein the at least one component of the HF alkylation unit is retained, modified or adapted for use in the ionic liquid alkylation system. An ionic liquid alkylation system derived from an existing or prior HF alkylation unit is also disclosed.
    Type: Application
    Filed: September 12, 2011
    Publication date: March 14, 2013
    Applicant: Chevron U.S.A. Inc.
    Inventors: Robert Fletcher Cleverdon, Christine Marie Phillips, Hye Kyung Cho Timken
  • Publication number: 20130066132
    Abstract: Methods for converting an H2SO4 alkylation unit to an ionic liquid alkylation system configured for performing ionic liquid catalyzed alkylation processes may comprise connecting at least one component configured for ionic liquid catalyzed alkylation to at least one component of the H2SO4 alkylation unit, wherein the at least one component of the H2SO4 alkylation unit is retained, modified or adapted for use in the ionic liquid alkylation system. Ionic liquid catalyzed alkylation systems derived from existing conventional alkylation units, and ionic liquid catalyzed alkylation processes are also disclosed.
    Type: Application
    Filed: September 12, 2011
    Publication date: March 14, 2013
    Applicant: Chevron U.S.A. Inc.
    Inventors: Robert Fletcher Cleverdon, Christine Marie Phillips, Hye Kyung Cho Timken
  • Patent number: 8203004
    Abstract: Tetrahydroindole derivatives of formula (I): are disclosed. These compounds modulate the activity of gamma-secretase and hence find use in treatment or prevention of Alzheimer's disease.
    Type: Grant
    Filed: November 3, 2006
    Date of Patent: June 19, 2012
    Assignee: Merck, Sharp & Dohme Limited
    Inventors: Frank Burkamp, Graham David Checksfield, Stephen Robert Fletcher, Stephen John Lewis, Edward Giles Mciver, Paul Joseph Oakley, Martin Richard Teall
  • Publication number: 20110190260
    Abstract: [1,2,4]Triazolo[1,5-a]pyridine compounds are disclosed that have a formula represented by the formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, diseases involving cartilage degradation, bone and/or joint degradation, for example osteoarthritis; and/or conditions involving inflammation or immune responses, such as Crohn's disease, rheumatoid arthritis, psoriasis, allergic airways disease (e.g. asthma, rhinitis), juvenile idiopathic arthritis, colitis, inflammatory bowel diseases, endotoxin-driven disease states (e.g. complications after bypass surgery or chronic endotoxin states contributing to e.g. chronic cardiac failure), diseases involving impairment of cartilage turnover (e.
    Type: Application
    Filed: July 24, 2009
    Publication date: August 4, 2011
    Inventors: Christel Jeanne Marie Menet, Nolwenn Jouannigot, Javier Blanc, Luc Juliaan Corina Van Rompaey, Stephen Robert Fletcher, Alastair James Hodges, Koen Kurt Smits