Abstract: The present invention relates to methods of inhibiting neurodegeneration in a subject suffering from or genetically at risk and/or destined to develop Huntington's Disease comprising increasing, in neurons of the subject, the activity of the TIM23 mitochondrial protein import complex.

Abstract: The present invention relates to methods of inhibiting neurodegeneration in a subject suffering from or genetically at risk and/or destined to develop Huntington's Disease comprising increasing, in neurons of the subject, the activity of the TIM23 mitochondrial protein import complex.

Abstract: The present invention relates to methods of inhibiting neurodegeneration in a subject suffering from or genetically at risk and/or destined to develop Huntington's Disease comprising increasing, in neurons of the subject, the activity of the TIM23 mitochondrial protein import complex.

Abstract: The present invention relates to methods of inhibiting neurodegeneration in a subject suffering from or genetically at risk and/or destined to develop Huntington's Disease comprising increasing, in neurons of the subject, the activity of the TIM23 mitochondrial protein import complex.

Abstract: A computer implemented method, apparatus, and computer usable program code for determining aggregate values of health data items from heterogeneously coded databases containing heterogeneously coded medical data. The data, in heterogeneous databases, is queried using a series of semantic layers including i) cascaded asymmetric association tables and ii) semantic search. The heterogeneously coded medical data items are translated into conformal dimensions and denominator files of combinations of disease data are derived. The denominator files of combinations of disease are aggregated based on a mapping of the coded medical and demographic conditions. The data is stored in a target data repository.

Abstract: A computer implemented method, apparatus, and computer usable program code for determining aggregate values of health data items from heterogeneously coded databases containing heterogeneously coded medical data. The data, in heterogeneous databases, is queried using a series of semantic layers including i) cascaded asymmetric association tables and ii) semantic search. The heterogeneously coded medical data items are translated into conformal dimensions and denominator files of combinations of disease data are derived. The denominator files of combinations of disease are aggregated based on a mapping of the coded medical and demographic conditions. The data is stored in a target data repository.

Abstract: Method, system, and program product for configuring and using a federated database and data structure management system with error prone data. The design of the metadata and queries includes the steps of first determining schema and metadata configurations of the data source servers. The next step is enumerating available resources, and enumerating security and confidentiality requirements. These are used for calculating an optimal federated database management system design based on the schema and metadata, the enumerated available resources, and the enumerated security and confidentiality requirements; and designing an optimal federated database management system with provision for exception detection and error handling.

Abstract: Compositions and methods used for preventing mitochondrial component-based diseases are disclosed herein. In particular, heterocyclic compositions and methods that are directed toward protecting against changes in mitochondrial permeability transition that could result in cell death.

Abstract: A method for displaying information related to a chaotic event. A mathematical optimization algorithm is used to select an optimal decision set for a user. The mathematical optimization algorithm takes as input a decision template, chaotic event information regarding a chaotic event, and a user profile. The optimal decision set is displayed for the user.

Abstract: Systems and computer program products for relating facts stored in healthcare databases are provided. At least two fact tables stored in a healthcare database including data meeting a criteria of interest are located. An identification key is assigned to the at least two fact tables including the located data meeting the criteria of interest. The identification key provides access to a dimension table including a list of subjects associated with the at least two fact tables including the located data meeting the criteria of interest so as to allow future identification of the subjects meeting the criteria of interest.

Abstract: Methods for associating healthcare records in healthcare databases with an individual are provided. One or more attribute types are located in first and second records. The one or more attribute types being associated with the individual. A weighted score is determined for the located at least one attribute type based on a comparison of the located at least one attribute type in the first record and the located at least one attribute type in the second record. The weighted score indicates a likelihood that the located at least one attribute type in the first and second records are both associated with the individual. A confidence is provided and is associated with the first and second records based on the weighted score. The confidence score indicates a likelihood that both the first and second records are associated with the individual.

Abstract: Method, system, and program product for configuring and using a federated database management system. The design of the metadata and queries includes the steps of first determining schema and metadata configurations of the data source servers. The next step is enumerating available resources, and enumerating security and confidentiality requirements. These are used for calculating an optimal federated database management system design based on the schema and metadata, the enumerated available resources, and the enumerated security and confidentiality requirements; and designing an optimal federated database management system.

Abstract: Methods, systems and computer program products are provided for storing, organizing and/or manipulating cohort based information associated with a research study. Project information associated with a first project is received at an interface of a computer database environment. The project information associated with the first project includes cohort information associated with one or more cohorts of the first project and patient information associated with members of the one or more cohorts of the first project. A first virtual project drawer is generated associated with the first project to be stored in the computer database environment. The first virtual project drawer includes the project information associated with the first project, at least one cohort file and/or at least two cohort member files.

Abstract: Methods, systems and computer program products are provided for providing a level of anonymity to patient records/information. A unique user identification (ID) associated with a current user is received at an interface of a computer database environment. A first role code associated with a first role of the current user is received at the interface of the computer database environment. The current user is allowed access to a defined set of patient records/information in the computer database environment. The defined set of patient records/information being defined based on the user ID and the first role code of the current user.

Abstract: Methods, systems and computer program products for synthesizing medical procedure information stored in healthcare databases are provided. A medical procedure query associated with a single patient or a group of patients is received. Query results are provided responsive to the medical procedure query. The query results may include medical procedures from multiple sources that are expressed in multiple standards formats.

Abstract: Methods, data structures, systems and computer program products are provided for identifying patterns in available healthcare related data. A triggering observation in the available healthcare related data is hierarchically related to at least one additional observation in the available healthcare related data based on a possible relationship between the triggering observation and the at least one additional observation in a computer database environment.

Abstract: Method, system, and program product for managing research grants. This is done by capturing at least one grant description into a database. Next one or more of researcher capability, researcher availabilities, and research subject availabilities are entered into the database. The grant description is then text mined to identify matches between the grant descriptions and the data items. Then a gain is defined and determined for each such match. This gain is then tabulated.

Abstract: Methods, systems and computer program products for synthesizing diagnoses stored in healthcare databases are provided. A diagnosis query associated with a single patient or a group of patients is received. Query results are provided responsive to the diagnosis query. The query results may include diagnoses from multiple sources that are expressed in multiple standards formats.

Abstract: Methods, systems and computer program products for relating facts stored in healthcare databases are provided. At least two fact tables stored in a healthcare database including data meeting a criteria of interest are located. An identification key is assigned to the at least two fact tables including the located data meeting the criteria of interest. The identification key provides access to a dimension table including a list of subjects associated with the at least two fact tables including the located data meeting the criteria of interest so as to allow future identification of the subjects meeting the criteria of interest.

Abstract: Methods, systems and computer program products for associating healthcare records in healthcare databases with an individual are provided. One or more attribute types are located in first and second records. The one or more attribute types being associated with the individual. A weighted score is determined for the located at least one attribute type based on a comparison of the located at least one attribute type in the first record and the located at least one attribute type in the second record. The weighted score indicates a likelihood that the located at least one attribute type in the first and second records are both associated with the individual. A confidence is provided and is associated with the first and second records based on the weighted score. The confidence score indicates a likelihood that both the first and second records are associated with the individual.