Abstract: A compound having the following structure of Formula (IV): or a stereoisomer, salt, or tautomer thereof, wherein R1, R2, R3, A, B, X, and Y are as defined herein. Pharmaceutical composition comprising the compounds, and their use in methods of treating diseases are also described.

Abstract: An intermediate transition for connecting a crash cushion to a rigid structure includes a housing and an energy absorbing module. The housing defines an inner space and includes a top wall, a front wall, a rear wall, and a side wall. The front wall is operatively associated with the top wall and is operable to connect to the crash cushion. The rear wall is operatively associated with the top wall and is operable to connect to the rigid structure. The side wall is operatively associated with the top wall and includes a weakened portion. The energy absorbing module is located in the inner space of the housing.

Abstract: A system and method utilizes a machine readable garment identification tag at a first station to enter information on the specific garment into a computer system. The garment data from the garment identification tag is assigned to a garment identifier which is printed or formed on a hanger neck sleeve member. The hanger neck sleeve member provides a consistent scan point through all the subsequent sorting stations in the system. This eliminates the need to search for the position of the garment tag to scan in sort stations subsequent to the initial station. Each hanger neck sleeve member has a machine readable code that is assigned to the associated garment and is placed on the neck of the hanger for that garment. The position of the hanger neck sleeve member on the neck of the hanger makes it readily accessible and readable, significantly more so than the garment tag in these regards.

Abstract: A crash cushion apparatus broadly comprising a rail assembly, a number of dividers and a number of side panels forming a number of collapsible bays, and a number of crushable tubes. The rail assembly includes a number of anchor plates and a rail. The dividers are longitudinally spaced apart from each other and slidably entrained on the rail. The side panels link the dividers together. The crushable tubes are oriented longitudinally in spaces formed by the collapsible bays and extend between sequentially adjacent ones of the dividers. The dividers entrain the crushable tubes in the longitudinal orientation without the crushable tubes being fixed to the dividers. The dividers are configured to be driven rearward along the rail and crush the crushable tubes to collapse the collapsible bays.

Abstract: A closure [10] for a cylindrical vessel includes at least one holding means [30] configured to move the closure into a fully closed state, the holding means having a predetermined actuation force or torque to properly close the closure, the closure including one or both of the following failsafe failure detection features: a mechanical fuse [20] having a predetermined load failure force below that of a load failure force of at least one component of the holding means and above that of a predetermined actuation force or torque to properly close the closure; or a block[40] sized to at least partially overlap a pressure warning lock hole [19] of the closure door when the closure is not in the fully closed state and to fully expose the pressure warning lock hole when the closure is in the fully closed state, thereby permitting insertion of a pressure warning lock [17].

Abstract: A pigging device of this disclosure includes a wear indicator configured to visually indicate an amount of material loss of a pipe wall contacting surface. The material loss may be symmetrical or asymmetrical. The pipe wall contacting surface may be any shape suitable, including but not limited to spherical-shaped, cylindrical-shaped, cup-shaped, disc-shaped, conical-shaped, frusto-conical shaped, bowl-shaped, and bullet-shaped. In some embodiments, the pigging device is a pipeline pig such as but not limited to a spherical foam pig, cylindrical-shaped foam pig, or a bullet-shaped foam pig. In other embodiments, the pigging device is a component of a pipeline pig such as but not limited to a cup or disc arranged about a body of the pipeline pig. The pigging device may also be a pigging disc element. The pigging device may be made of any suitable material, including but not limited to an elastomer such as urethane.

Abstract: Method and apparatus associated with clocking synchronization are disclosed herein. In various embodiment, a method for communication comprises: entering a clock training period, on successful performance of clock training handshake; entering a start static phase measurement (SSPM) sequence of clock training period, receiving a recovered clock; and processing the recovered clock to determine parts-per-million (PPM) differences, to be subsequently applied to compensate for the PPM differences determined during subsequent clocking synchronization. Linking training is performed after the subsequent clocking synchronization. In various embodiments, clocking synchronization comprises SSC synchronization. Other embodiments are also described and claimed.

Abstract: A sequencing capture array for identifying mutations in Multiple Myeloma is disclosed. Also disclosed are targeted next generation sequencing methods for identifying SNV, CNV, and translocation mutations in Multiple Myeloma tumor cells. A capture array representing fewer than 500 genes implicated in Multiple Myeloma can be used to analyze tumor mutations and create a personalized treatment plan for a Multiple Myeloma patient. Analytical methods are presented that allow tumor mutations to be elucidated with coverage at a sequencing depth of no more than 500×, or as low as 100×, with optimal efficiency achieved at a sequencing depth of about 300×.

Abstract: A pigging device of this disclosure includes a wear indicator configured to visually indicate an amount of material loss of a pipe wall contacting surface. The material loss may be symmetrical or asymmetrical. The pipe wall contacting surface may be any shape suitable, including but not limited to spherical-shaped, cylindrical-shaped, cup-shaped, disc-shaped, conical-shaped, frusto-conical shaped, bowl-shaped, and bullet-shaped. In some embodiments, the pigging device is a pipeline pig such as but not limited to a spherical foam pig, cylindrical-shaped foam pig, or a bullet-shaped foam pig. In other embodiments, the pigging device is a component of a pipeline pig such as but not limited to a cup or disc arranged about a body of the pipeline pig. The pigging device may also be a pigging disc element. The pigging device may be made of any suitable material, including but not limited to an elastomer such as urethane.

Abstract: A closure [10] for a cylindrical vessel includes at least one holding means [30] configured to move the closure into a fully closed state, the holding means having a predetermined actuation force or torque to properly close the closure, the closure including one or both of the following failsafe failure detection features: a mechanical fuse [20] having a predetermined load failure force below that of a load failure force of at least one component of the holding means and above that of a predetermined actuation force or torque to properly close the closure; or a block[40] sized to at least partially overlap a pressure warning lock hole [19] of the closure door when the closure is not in the fully closed state and to fully expose the pressure warning lock hole when the closure is in the fully closed state, thereby permitting insertion of a pressure warning lock [17].

Abstract: Method and apparatus associated with clocking synchronization are disclosed herein. In various embodiment, a method for communication comprises: entering a clock training period, on successful performance of clock training handshake; entering a start static phase measurement (SSPM) sequence of clock training period, receiving a recovered clock; and processing the recovered clock to determine parts-per-million (PPM) differences, to be subsequently applied to compensate for the PPM differences determined during subsequent clocking synchronization. Linking training is performed after the subsequent clocking synchronization. In various embodiments, clocking synchronization comprises SSC synchronization. Other embodiments are also described and claimed.

Abstract: An algae-based powdered fuel is configured to be fluidized in a gas stream. The algae-based powdered fuel is manufactured by drying an algae slurry to produce a powdered composition and then comminuting the powdered composition to produce the fuel. The algae-based powdered fuel can be combusted in a gas turbine to generate electricity and/or to propel an aircraft.

Abstract: Described is an apparatus for over-clocking or under-clocking, the apparatus comprises: a locked loop (e.g., phase locked loop or frequency locked loop) having a feedback divider, the locked loop to receive a reference clock and to compare it with a feedback clock which is output from the feedback divider, and to generate an output clock; a post locked loop divider, coupled to the locked loop, to receive the output clock and to generate a base clock for other logic units; and a control logic to adjust first and second divider ratios for the feedback divider and the post locked loop divider respectively for over-clocking or under-clocking the base clock such that the locked loop remains locked while being over-clocked or under-clocked.

Abstract: A sequencing capture array for identifying mutations in Multiple Myeloma is disclosed. Also disclosed are targeted next generation sequencing methods for identifying SNV, CNV, and translocation mutations in Multiple Myeloma tumor cells. A capture array representing fewer than 500 genes implicated in Multiple Myeloma can be used to analyze tumor mutations and create a personalized treatment plan for a Multiple Myeloma patient. Analytical methods are presented that allow tumor mutations to be elucidated with coverage at a sequencing depth of no more than 500×, or as low as 100×, with optimal efficiency achieved at a sequencing depth of about 300×.

Abstract: An algae-based powdered fuel is configured to be fluidized in a gas stream. The algae-based powdered fuel is manufactured by drying an algae slurry to produce a powdered composition and then comminuting the powdered composition to produce the fuel. The algae-based powdered fuel can be combusted in a gas turbine to generate electricity and/or to propel an aircraft.

Abstract: Described is an apparatus for over-clocking or under-clocking, the apparatus comprises: a locked loop (e.g., phase locked loop or frequency locked loop) having a feedback divider, the locked loop to receive a reference clock and to compare it with a feedback clock which is output from the feedback divider, and to generate an output clock; a post locked loop divider, coupled to the locked loop, to receive the output clock and to generate a base clock for other logic units; and a control logic to adjust first and second divider ratios for the feedback divider and the post locked loop divider respectively for over-clocking or under-clocking the base clock such that the locked loop remains locked while being over-clocked or under-clocked.

Abstract: An algae-based powdered fuel is configured to be fluidized in a gas stream. The algae-based powdered fuel is manufactured by drying an algae slurry to produce a powdered composition and then comminuting the powdered composition to produce the fuel. The algae-based powdered fuel can be combusted in a gas turbine to generate electricity and/or to propel an aircraft.

Abstract: An apparatus for clock generation is presented. In one embodiment, the apparatus comprises a phase interpolator that generates an output with a phase value within reference phases associated with two input clocks. Logic units are coupled to determine a number of phase settings for the phase interpolator. A divider is coupled to the phase interpolator to generate an output clock based on a modifiable divider setting.

Abstract: An apparatus for clock generation is presented. In one embodiment, the apparatus comprises a phase interpolator that generates an output with a phase value within reference phases associated with two input clocks. Logic units are coupled to determine a number of phase settings for the phase interpolator. A divider is coupled to the phase interpolator to generate an output clock based on a modifiable divider setting.

Abstract: A system is provided for locating and identifying an acoustic event. An acoustic sensor having a pair of concentric opposing microphones at a fixed distance on a microphone axis is used to measure an acoustic intensity, from which a vector incorporating the acoustic event is identified. A second acoustic sensor or movement of the first acoustic sensor is used to provide a second vector incorporating the acoustic event. Combination of the first and the second vector locates the acoustic event in space. A command unit in communication with the acoustic sensors can be used for combining the vectors as well as comparing a signal spectra of the acoustic event to stored identified spectra to provide an identification of acoustic event.