Abstract: Prosthetic valves that include conical shaped base valve members having an annular engagement end, a closed distal end region that restricts fluid flow therethrough, and a plurality of elongated ribbon members, which transition from an open fluid flow configuration to a closed fluid flow configuration in response to expansion and contraction of the base valve member, and a support structure that is configured and adapted to exert retaining forces on the annular engagement ends of the base valve members, whereby the support structure (i) conforms to the shape of the annular engagement ends of the base valve members, (ii) securely positions the annular engagement ends of the base valve members adjacent to and, thereby, in contact with a valve annulus, whereby the annular engagement ends of the base valve members conform to the shape of the valve annulus, and (iii) the annular engagement ends of the base valve members adapt to at least one fluctuation in the configuration and/or dimension of the valve annulus, w

Abstract: Prosthetic heart valves having a conical shaped base valve structure formed from collagenous mammalian tissue and an expandable stent structure. The base valve structure includes a plurality of elongated ribbon members that are positioned proximate each other in a joined relationship, wherein the elongated ribbon members are positioned adjacent each other and form a plurality of fluid flow modulating regions that open when fluid into and through the base valve structure exhibits a positive pressure relative to the exterior pressure, i.e., a positive pressure differential, wherein the fluid is allowed to be transmitted out of the base valve structure, and transition to a closed configuration when the pressure differential between the interior valve pressure and exterior pressure reduces, wherein the fluid is restricted from flowing out of the base valve structure.

Abstract: A prosthetic valve comprising a conical shaped sheet structure and a support structure, the sheet structure having a closed distal end and a plurality of elongated ribbon members that are positioned proximate each other in a joined relationship, whereby the ribbon members form a plurality of fluid flow modulating regions that close when fluid flow through the valve exhibits a negative flow pressure and open when fluid flow through the valve exhibits a positive flow pressure, the support structure having at least one elongated cardiovascular structure engagement member that is associated with one of the ribbon members and adapted to engage a cardiovascular structure.

Abstract: A prosthetic valve comprising a conical shaped sheet structure and a support structure, the sheet structure having a closed distal end and a plurality of elongated ribbon members that are positioned proximate each other in a joined relationship, whereby the ribbon members form a plurality of fluid flow modulating regions that close when fluid flow through the valve exhibits a negative flow pressure and open when fluid flow through the valve exhibits a positive flow pressure, the support structure having at least one elongated cardiovascular structure engagement member that is associated with one of the ribbon members and adapted to engage a cardiovascular structure.

Abstract: The invention is to articles of extracellular matrix. The articles comprise one or more sheets of mammalian extracellular matrix laminated together. A single sheet can be folded over and laminated on 3 sides. Two or more sheets can be laminated to each other at their edges. The sheets can further encase a composition comprising a cell or cells, such as for example, a stem cell. A single sheet can be folded over to encase a composition, or rolled to encase a composition with lamination at either end of the roll, for example. The invention also includes methods of using these articles to regenerate tissue at tissue defects, or heal wounds in damaged tissue.

Abstract: Prosthetic heart valves having a conical shaped base valve structure formed from collagenous mammalian tissue. The base valve structure includes a plurality of elongated ribbon members that are positioned proximate each other in a joined relationship, wherein the elongated ribbon members are positioned adjacent each other and form a plurality of fluid flow modulating regions that open when fluid into and through the base valve structure exhibits a positive pressure relative to the exterior pressure, i.e., a positive pressure differential, wherein the fluid is allowed to be transmitted out of the base valve structure, and transition to a closed configuration when the pressure differential between the interior valve pressure and exterior pressure reduces, wherein the fluid is restricted from flowing out of the base valve structure.

Abstract: A conical shaped venous valve structure with a plurality of fluid flow modulating means that open and allow antegrade blood to be transmitted out of the valve structure and into and through an associated cardiovascular vessel when the valve structure is disposed in the cardiovascular vessel and the antegrade blood exhibits a positive pressure relative to the exterior pressure.

Abstract: A prosthetic valve comprising a tubular shaped sheet member comprising an extracellular matrix (ECM) composition, the sheet member having a plurality of ribbons having proximal and distal ends, the distal ends of the ribbons projecting from the sheet member proximal end.

Abstract: A percutaneous transcatheter valve delivery method for replacing a dysfunctional heart valve; particularly, an atrioventricular (AV) valve, with a prosthetic valve comprising a base valve structure and a stent structure. The transcatheter implantation method accurately positions and securely engages the prosthetic valve in a valve annulus region.

Abstract: A biocompatible and biodegradable construct comprising a base expandable member and an outer coating comprising poly(glycerol sebacate) (PGS), the base expandable member comprising acellular extracellular matrix (ECM) derived from a mammalian tissue source, the acellular ECM exhibiting a flexible, porous, expandable structure, which is adapted to expand upon exposure to and absorption of a bodily fluid, wherein the construct seals a perivalvular leak when disposed proximate thereto.

Abstract: Disclosed herein are cardiovascular prostheses tissue that are formed from acellular extracellular matrix (ECM), an ECM-mimicking composition, or a combination thereof. The cardiovascular prostheses also comprise poly(glycerol sebacate) (PGS) and various antibiotics, cytokines, exosomes, growth factors, and/or everolimus. In some embodiments, the cardiovascular prostheses involves a plurality of particulate structures having an acellular ECM core and an outer layer or coating PGS and everolimus. Also disclosed are cardiovascular prostheses having particulate structures that include a decellularized placental tissue and a polymer component that includes poly(glycerol sebacate) (PGS).

Abstract: Disclosed herein are cardiovascular prostheses for treating, reconstructing and replacing damaged or diseased cardiovascular tissue that include particulate structures that are formed from poly(glycerol sebacate) (PGS) and a pharmacological agent. The cardiovascular prostheses can comprise various structures and compositions, including, but not limited to, mesh constructs, encasement structures, coated structures and multi-sheet laminate structures. In some embodiments, the prostheses comprise a plurality of particulate structures. In some embodiments, the ECM-mimicking composition consists of PGS.

Abstract: Disclosed herein is a continuous tubular shaped valve member formed from crosslinked, acellular pericardium tissue. The tubular shaped valve member can have a lumen, an outer wall, a longitudinal axis, an inlet portion, and an outlet portion, the outlet portion comprising a top edge, wherein said top edge is disposed proximate said inlet portion, the outlet portion defining an outlet in fluid communication with said lumen of said tubular shaped valve member, said inlet portion defining an inlet in fluid communication with said lumen of said tubular shaped valve member.

Abstract: A prosthetic valve comprising a tubular shaped sheet member comprising an extracellular matrix (ECM) composition, the sheet member having a plurality of ribbons having proximal and distal ends, the distal ends of the ribbons projecting from the sheet member proximal end.

Abstract: A conical shaped venous valve structure formed from collagenous mammalian tissue.

Abstract: Cardiovascular prostheses for treating, reconstructing and replacing damaged or diseased cardiovascular tissue that include particulate structures that are formed from PGS, cerivastatin and everolimus. The particulate structures are configured to modulate inflammation of damaged cardiovascular tissue in vivo by increasing expression of Kruppel like factor 2 (KLF-2), whereby localized expression of monocyte chemoattractant protein 1 (MCP-1) and C-C chemokine receptor type 2 (CCR2) is inhibited at transcriptional and translational levels as a function of the KLF-2 modulation.

Abstract: A sheet structure comprising two joined extracellular matrix (ECM) tissue or sheet layers and a physiological sensor disposed therebetween; the ECM tissue being derived from a mammalian tissue source that includes small intestine submucosa (SIS), urinary bladder submucosa (UBS), stomach submucosa (SS), urinary basement membrane (UBM), liver basement membrane (LBM), amniotic membrane, mesothelial tissue, placental tissue and cardiac tissue.

Abstract: Low profile, self-expanding endovascular prostheses having a Ni-Ti alloy stent structure that is particularly well-suited for accessing and traversing narrow anatomical passageways and providing physiologically acceptable radial or hoop strength and longitudinal flexibility.

Abstract: The invention is to articles of extracellular matrix. The articles comprise one or more sheets of mammalian extracellular matrix laminated together. A single sheet can be folded over and laminated on 3 sides. Two or more sheets can be laminated to each other at their edges. The sheets can further encase a composition comprising a cell or cells, such as for example, a stem cell. A single sheet can be folded over to encase a composition, or rolled to encase a composition with lamination at either end of the roll, for example. The invention also includes methods of using these articles to regenerate tissue at tissue defects, or heal wounds in damaged tissue.

Abstract: Cardiovascular prostheses that include an ECM-mimicking composition, which is adapted to induce modulated healing of damaged or diseased cardiovascular tissue and, thereby, associated structures, when administered thereto. The ECM-mimicking composition includes a polymer component and a pharmacological component. The polymer component includes poly(glycerol sebacate) (PGS). The pharmacological component includes a corticosteroid. The ECM-mimicking composition can also include a biological component having a biologically active agent, such as an exosome, a cytokine and a growth factor.