Patents by Inventor Robert G. Matheny

Robert G. Matheny has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Extracellular Matrix Structures
    Publication number: 20170312389
    Abstract: A tissue prosthesis comprising an extracellular matrix (ECM) composition, the ECM composition comprising decellularized ECM derived from mesothelial tissue and an exogenously added basic fibroblast growth factor (bFGF).
    Type: Application
    Filed: July 18, 2017
    Publication date: November 2, 2017
    Inventor: Robert G. Matheny
  • Compositions for Regenerating Defective or Absent Myocardium
    Publication number: 20170312394
    Abstract: Compositions of the invention for regenerating defective or absent myocardium comprise an emulsified or injectable extracellular matrix composition. The composition may also include an extracellular matrix scaffold component of any formulation, and further include added cells, proteins, or other components to optimize the regenerative process and restore cardiac function.
    Type: Application
    Filed: July 18, 2017
    Publication date: November 2, 2017
    Inventor: Robert G. Matheny
  • Extracellular Matrix Sheet Structures
    Publication number: 20170304507
    Abstract: A sheet structure formed from an extracellular matrix (ECM) composition that includes acellular ECM derived from small intestine submucosa (SIS) tissue, gentamicin and vancomycin. The sheet structure is configured to modulate inflammation of damaged biological tissue and induce cell and tissue proliferation, bioremodeling of the damaged biological tissue, and regeneration of new tissue and tissue structures with site-specific structural and functional properties, when the tissue structure is delivered to the damaged biological tissue.
    Type: Application
    Filed: April 25, 2017
    Publication date: October 26, 2017
    Inventor: Robert G. Matheny
  • Extracellular matrix encasement structures and methods
    Patent number: 9744264
    Abstract: A bioremodelable encasement structure comprising a pouch formed from at least one sheet of bioremodelable material, the pouch including an internal region that is configured to receive a device therein, the bioremodelable material comprising mesothelial tissue.
    Type: Grant
    Filed: December 16, 2014
    Date of Patent: August 29, 2017
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventor: Robert G Matheny
  • Vascular casted prostheses and methods of forming same for treating biological tissue
    Patent number: 9744261
    Abstract: Bioremodelable tissue prostheses having a vasculature that is infused with a biomaterial composition.
    Type: Grant
    Filed: March 23, 2015
    Date of Patent: August 29, 2017
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventors: Robert G Matheny, Craig N Ferrante
  • Systems, apparatus and methods for sealing perivalvular leaks
    Patent number: 9737399
    Abstract: An expandable member that is configured to engage an interior region of a prosthetic valve and capable of transitioning from a pre-deployment configuration at a pre-deployment temperature, where the expandable member is capable of being positioned in the valve at an interior valve region when the valve is disposed in a cardiovascular structure, to a post-deployment configuration when the expandable member is subjected to cardiovascular tissue temperature, where an outer surface region of the valve proximate the interior valve region is placed in intimate contact with host cardiovascular tissue of the cardiovascular structure at a first position and seals perivalvular leaks present at the first cardiovascular structure position.
    Type: Grant
    Filed: September 11, 2014
    Date of Patent: August 22, 2017
    Assignee: CORMATRIX CARDIOVASCULAR, INC.
    Inventor: Robert G Matheny
  • Compositions and methods for treatment of cardiovascular disorders
    Patent number: 9737569
    Abstract: ECM based compositions including amniotic membrane and methods for employing same to treat cardiovascular disorders.
    Type: Grant
    Filed: March 11, 2015
    Date of Patent: August 22, 2017
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventor: Robert G Matheny
  • Extracellular matrix (ECM) structures for tissue regeneration
    Patent number: 9700654
    Abstract: A multi-sheet extracellular matrix (ECM) structure for tissue regeneration, the ECM structure having joined first and second ECM sheet members and an agent dispersal network disposed between the sheets, the dispersal network being configured to receive and transfer a bioactive agent through the network and, when the ECM structure is attached to tissue, administer the bioactive agent to the tissue.
    Type: Grant
    Filed: August 6, 2014
    Date of Patent: July 11, 2017
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventors: Robert G Matheny, Craig N Ferrante
  • Vascular casted prostheses and methods of forming same for treating biological tissue
    Patent number: 9694104
    Abstract: Methods of treating biological tissue with bioremodelable tissue prostheses having a vasculature that is infused with a biomaterial composition.
    Type: Grant
    Filed: March 23, 2015
    Date of Patent: July 4, 2017
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventors: Robert G Matheny, Craig N Ferrante
  • Vascular casted prostheses and methods of forming same for treating biological tissue
    Patent number: 9694105
    Abstract: Bioremodelable tissue prostheses having a vasculature that is infused with a biomaterial composition.
    Type: Grant
    Filed: March 23, 2015
    Date of Patent: July 4, 2017
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventors: Robert G Matheny, Craig N Ferrante
  • Extracellular matrix constructs for treating damaged biological tissue
    Patent number: 9681937
    Abstract: Extracellular matrix (ECM) constructs having a biodegradable support scaffold and an anchoring mechanism, which includes a plurality of biodegradable microneedles that are capable of piercing tissue and anchoring therein. In a preferred embodiment, the support scaffold and anchoring mechanism comprise an ECM material. In some embodiments, the microneedles are also capable of administering a biologically active agent and/or a pharmacological composition to the engaged tissue.
    Type: Grant
    Filed: August 21, 2015
    Date of Patent: June 20, 2017
    Assignee: CORMATRIX CARDIOVASCULAR, INC.
    Inventor: Robert G Matheny
  • Extracellular matrix encasement structures and methods
    Patent number: 9682171
    Abstract: A bioremodelable encasement structure comprising a pouch formed from at least one sheet of bioremodelable material, the pouch including an internal region that is configured to receive a device therein, the bioremodelable material comprising mesothelial tissue.
    Type: Grant
    Filed: August 24, 2015
    Date of Patent: June 20, 2017
    Assignee: CORMATRIX CARDIOVASCULAR, INC.
    Inventor: Robert G Matheny
  • Prosthetic Tissue Valves and Methods for Anchoring Same to Cardiovascular Structures
    Publication number: 20170156855
    Abstract: A prosthetic atrioventricular tissue valve comprising a continuous tubular member formed from a first biocompatible material, the tubular member having proximal and distal ends, and at least one valve leaflet formed therein, the distal end of the tubular member including cardiovascular structure engagement means for connecting the tubular member to a cardiovascular structure, the cardiovascular structure engagement means comprising a plurality of elongated members that extend distally from the distal end of the tubular member.
    Type: Application
    Filed: December 5, 2015
    Publication date: June 8, 2017
    Inventor: Robert G. Matheny
  • Extracellular matrix encasement structures and methods
    Patent number: 9669133
    Abstract: A pouch structure formed from extracellular matrix (ECM) derived from small intestine submucosa (SIS) that includes an internal region configured to receive a medical device therein. The pouch structure is configured to modulate inflammation of damaged biological tissue and induce cell and tissue proliferation, bioremodeling of the damaged biological tissue, and regeneration of tissue structures with site-specific structural and functional properties, when implanted in a subject.
    Type: Grant
    Filed: August 24, 2015
    Date of Patent: June 6, 2017
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventor: Robert G Matheny
  • Extracellular matrix encasement structures and methods
    Patent number: 9662418
    Abstract: A bioremodelable encasement structure comprising a pouch formed from at least one sheet of bioremodelable material, the pouch including an internal region that is configured to receive a device therein, the bioremodelable material comprising mesothelial tissue.
    Type: Grant
    Filed: April 14, 2015
    Date of Patent: May 30, 2017
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventor: Robert G Matheny
  • Extracellular matrix encasement structures and methods
    Patent number: 9662419
    Abstract: A bioremodelable encasement structure comprising a pouch formed from at least one sheet of bioremodelable material, the pouch including an internal region that is configured to receive a device therein, the bioremodelable material comprising mesothelial tissue.
    Type: Grant
    Filed: August 24, 2015
    Date of Patent: May 30, 2017
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventor: Robert G Matheny
  • Extracellular matrix constructs for treating damaged biological tissue
    Patent number: 9642692
    Abstract: Extracellular matrix (ECM) constructs having a biodegradable support scaffold and an anchoring mechanism, which includes a plurality of biodegradable microneedles that are capable of piercing tissue and anchoring therein. In a preferred embodiment, the support scaffold and anchoring mechanism comprise an ECM material. In some embodiments, the microneedles are also capable of administering a biologically active agent and/or a pharmacological composition to the engaged tissue.
    Type: Grant
    Filed: August 21, 2015
    Date of Patent: May 9, 2017
    Assignee: CORMATRIX CARDIOVASCULAR, INC.
    Inventor: Robert G Matheny
  • Extracellular matrix encasement structures and methods
    Patent number: 9636437
    Abstract: A bioremodelable encasement structure comprising a pouch formed from at least one sheet of bioremodelable material, the pouch including an internal region that is configured to receive a device therein, the bioremodelable material comprising mesothelial tissue.
    Type: Grant
    Filed: August 24, 2015
    Date of Patent: May 2, 2017
    Assignee: CORMATRIX CARDIOVASCULAR, INC.
    Inventor: Robert G Matheny
  • Prosthetic tissue valve
    Patent number: D790705
    Type: Grant
    Filed: July 11, 2016
    Date of Patent: June 27, 2017
    Assignee: CORMATRIX CARDIOVASCULAR, INC
    Inventors: Robert G Matheny, Minh X Vo, Carlos C Chang, Selvamuthu k Natarajan
  • Prosthetic tissue valve
    Patent number: D790706
    Type: Grant
    Filed: July 11, 2016
    Date of Patent: June 27, 2017
    Assignee: CorMatrix Cardiovascular, Inc.
    Inventors: Robert G Matheny, Minh X Vo, Carlos C Chang, Selvamuthu k Natarajan