Abstract: (FIG. 1) 1 2 The present disclosure provides a method of manufacturing a metal structure (1). The 3 method comprises: depositing molten metal material to form a first deposit region on a 4 support (102); and depositing further molten metal material to form a plurality of further 5 deposit regions forming, together with the first deposit region, the metal structure. Each 6 further deposit region is arranged to at least partially contact and overlap a respective 7 at least one previously solidified deposit region of the first deposit region and the 8 plurality of further deposit regions when all of the deposited metal material forming the 9 at least one previously solidified deposit region has cooled to have a temperature within 10 a threshold temperature range. The threshold temperature range has an upper bound 11 lower than a solidification temperature of the metal material and a lower bound greater 12 than 100 degrees Celsius.

Abstract: The present invention provides compositions and methods for treating a neuromuscular disorder. In certain embodiments, the invention provides compositions and methods for assessing weaning readiness and continuation of weaning off of a mechanical ventilator in a subject with X-linked myotubular myopathy (XLMTM).

Abstract: Optical fiber connections and their applications in downhole assemblies are described herein. The downhole assembly includes a well completion element with an end that couples with a corresponding well completion element. An optical fiber extends along at least a portion of the well completion element and transmits an optical signal using a first mode. The well completion element includes an optical fiber connector that is coupled to the optical fiber. The connector also includes a mode converter that receives the optical signal from the optical fiber and converts the optical signal from the first mode to a second larger mode. This second larger mode may be more robustly communicated to a corresponding optical fiber connector affixed to the corresponding well completion element.

Abstract: Optical fiber connections and their applications in downhole assemblies are described herein. The downhole assembly includes a well completion element with an end that couples with a corresponding well completion element. An optical fiber extends along at least a portion of the well completion element and transmits an optical signal using a first mode. The well completion element includes an optical fiber connector that is coupled to the optical fiber. The connector also includes a mode converter that receives the optical signal from the optical fiber and converts the optical signal from the first mode to a second larger mode. This second larger mode may be more robustly communicated to a corresponding optical fiber connector affixed to the corresponding well completion element.

Abstract: Methods of treating Alzheimer's Disease (AD) in patients suffering from mild to moderate AD, including ApoE4 positive patients and patients suffering from mild AD are provided. Also provided are methods of selecting or identifying patients for treatment with an anti-Abeta antibody. Methods include the use of prognostic and/or predictive biomarkers.

Abstract: Optical fiber connections and their applications in downhole assemblies are described herein. The downhole assembly includes a well completion element with an end that couples with a corresponding well completion element. An optical fiber extends along at least a portion of the well completion element and transmits an optical signal using a first mode. The well completion element includes an optical fiber connector that is coupled to the optical fiber. The connector also includes a mode converter that receives the optical signal from the optical fiber and converts the optical signal from the first mode to a second larger mode. This second larger mode may be more robustly communicated to a corresponding optical fiber connector affixed to the corresponding well completion element.

Abstract: The present disclosure relates to multi-core semi-pneumatic tires and methods for manufacturing the same. In one exemplary embodiment, a semi-pneumatic tire includes an outer surface configured to contact ground; an inner surface configured to contact a wheel; and a plurality of hollow cores formed between the inner and outer surfaces in the semi-pneumatic tire, wherein each hollow core extends around a circumference of the tire.

Abstract: A collapsible fish filleting station system that relates generally to the field of work-tables and more specifically relates to fish-holding and auxiliary devices in connection with work-tables. The collapsible fish filleting station includes a cutting board comprising a rigid, substantially rectangular, panel and a support assembly configured to support the cutting board in a stable working position over the gunwale of a boat.

Abstract: A technique provides protection against unwanted conditions in wellhead structures and other structures. According to the technique, a system provides a feed through in a wellhead structure or other type of structure. The feed through may accommodate a communication line routed therethrough. A closing device is positioned in the structure at a location to enable closing of the feed through via the closing device. Additionally, a condition-sensitive device is operatively engaged with the closing device to initiate actuation of the closing device once the condition-sensitive device is exposed to a predetermined condition. Upon exposure to the predetermined condition, the condition-sensitive device initiates closing of the feed through via the closing device.

Abstract: The present invention is an apparatus and method for allowing for the use of commercial dual inline memory module (DIMM) in high shock and vibration environments while preserving serviceability. This system extends the performance of the standard Joint Electron Device Engineering (JEDEC) memory connectors in said environments without sacrificing high speed electrical performance. The system provides a simple clip which locks the module in place using the standard connector latches preventing relative motion of the connector and the DIMM thereby insuring uninterrupted computational performance. The clip may be formed with resilient ends that snap onto pivotal latching devices to prevent inadvertent opening of these latching devices. The clips may also include bumper spacers (205) on their opposite faces to engage bumper spacers of adjacent clips to maintain the modules in proper orientation.

Abstract: The present invention is an apparatus and method for allowing for the use of commercial dual inline memory module (DIMM) in high shock and vibration environments while preserving serviceability. This system extends the performance of the standard Joint Electron Device Engineering (JEDEC) memory connectors in said environments without sacrificing high speed electrical performance. The system provides a simple clip which locks the module in place using the standard connector latches preventing relative motion of the connector and the DIMM thereby insuring uninterrupted computational performance.

Abstract: Methods of treating Alzheimer's Disease (AD) in patients suffering from mild to moderate AD, including ApoE4 positive patients and patients suffering from mild AD are provided. Also provided are methods of selecting or identifying patients for treatment with an anti-Abeta antibody. Methods include the use of prognostic and/or predictive biomarkers.

Abstract: Optical fiber connections and their applications in downhole assemblies are described herein. The downhole assembly includes a well completion element with an end that couples with a corresponding well completion element. An optical fiber extends along at least a portion of the well completion element and transmits an optical signal using a first mode. The well completion element includes an optical fiber connector that is coupled to the optical fiber. The connector also includes a mode converter that receives the optical signal from the optical fiber and converts the optical signal from the first mode to a second larger mode. This second larger mode may be more robustly communicated to a corresponding optical fiber connector affixed to the corresponding well completion element.

Abstract: A portable device for inflating an inflatable bag (60) comprises at least one inlet (46), for forming a fluid connection to a gas source. The gas source is attached or attachable to the inlet. The device further comprises an air intake chamber (32) which has an opening allowing atmospheric air to be admitted and an outlet intended to be connected to the bag to be inflated. The gas source comprises a first and at least a different second gas component. The first component is stored at least partially in liquid form; preferably, the first component is carbon dioxide. The gas source contains at least 10%, preferably more than 30% and most preferably more than 60% of the first component. The second component is gaseous or supercritical at a temperature of 243K and up to a pressure of 200 bar, preferably, the second component has a critical temperature below 243K.

Abstract: Methods of treating Alzheimer's Disease (AD) in patients suffering from mild to moderate AD, including ApoE4 positive patients and patients suffering from mild AD are provided. Also provided are methods of selecting or identifying patients for treatment with an anti-Abeta antibody. Methods include the use of prognostic and/or predictive biomarkers.

Abstract: Methods for determining whether a patient is at increased risk of developing wet AMD or whether a patient has an increased likelihood of benefiting from treatment with a high-affinity anti-VEGF antibody.

Abstract: A system, devices and methods are provided for facilitating stabilization of periarticular fractures. The system includes a compression plate and one or more of a cerclage cable for encircling the bone and securing the compression plate to the bone, a crimp lug for securing the cable in tension relative to the bone and/or a plate, and a supplemental plate coupled to the compression plate and adapted to receive bicortical or unicortical bone screws to further secure the compression plate relative to the bone. In addition, the system includes a cable tensioner for temporarily retaining the cable in tension and then applying a tension to the cable until a desired compression is effected between a plate and bone and while a cable retaining structure is secured to the cable to retain the applied tension on the cable. Also provided is a jig for use with plates for minimally invasive fracture stabilization.

Abstract: The present invention is directed to the upgrading of heavy petroleum oils of high viscosity and low API gravity that are typically not suitable for pipelining without the use of diluents.

Abstract: A portable device for inflating an inflatable bag (60) comprises at least one inlet (46), for forming a fluid connection to a gas source. The gas source is attached or attachable to the inlet. The device further comprises an air intake chamber (32) which has an opening allowing atmospheric air to be admitted and an outlet intended to be connected to the bag to be inflated. The gas source comprises a first and at least a different second gas component. The first component is stored at least partially in liquid form; preferably, the first component is carbon dioxide. The gas source contains at least 10%, preferably more than 30% and most preferably more than 60% of the first component. The second component is gaseous or supercritical at a temperature of 243K and up to a pressure of 200 bar, preferably, the second component has a critical temperature below 243K.

Abstract: Removable drill guide tips are provided for simultaneous assembly relative to the holes of a bone plate. The drill guide tips are used as a guide for a drill bit without any additional extension and then removed with a tool to allow insertion of a screw within the same hole in the bone plate. Alternatively, the drill guide tips may be used with an extension to extend the effective length of the drill guide.