Patents by Inventor Robert J. Hariri

Robert J. Hariri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IMMUNOMODULATION USING PLACENTAL STEM CELLS
    Publication number: 20150140044
    Abstract: The present invention provides methods of immunomodulation using placental stem cells and placental stem cell populations. The invention also provides methods of producing and selecting placental cells and cell populations on the basis of immunomodulation, and compositions comprising such cells and cell populations.
    Type: Application
    Filed: October 22, 2014
    Publication date: May 21, 2015
    Applicant: ANTHROGENESIS CORPORATION
    Inventors: Casper Paludan, James W. Edinger, Ryhor Harbacheuski, RoseAnn Murray, Robert J. Hariri
  • Method of propagating cells
    Patent number: 8986984
    Abstract: A method of collecting embryonic-like stem cells from a placenta which has been treated to remove residual cord blood by perfusing the drained placenta with an anticoagulant solution to flush out residual cells, collecting the residual cells and perfusion liquid from the drained placenta, and separating the embryonic-like cells from the residual cells and perfusion liquid. Exogenous cells can be propagated in the placental bioreactor and bioactive molecules collected therefrom.
    Type: Grant
    Filed: November 13, 2009
    Date of Patent: March 24, 2015
    Assignee: Anthrogenesis Corporation
    Inventor: Robert J. Hariri
  • METHODS OF GENERATING NATURAL KILLER CELLS
    Publication number: 20150072425
    Abstract: Provided herein are methods of producing natural killer cells using a two-step expansion and differentiation method. Also provided herein are methods of suppressing tumor cell proliferation, of treating individuals having cancer or a viral infection, comprising administering the NK cells produced by the method to an individual having the cancer or viral infection.
    Type: Application
    Filed: November 18, 2014
    Publication date: March 12, 2015
    Applicant: ANTHROGENESIS CORPORATION
    Inventors: Robert J. HARIRI, Mohammad A. HEIDARAN, Stephen JASKO, Lin KANG, Eric LAW, Ajai PAL, Bhavani STOUT, Vanessa VOSKINARIAN-BERSE, Andrew ZEITLIN, Xiaokui ZHANG
  • TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS USING PLACENTAL STEM CELLS
    Publication number: 20150044177
    Abstract: Provided herein are methods of treatment of an individual having amyotrophic lateral sclerosis, comprising administering to the individual a therapeutically effective amount of placental stem cells, e.g., tissue culture surface-adherent placental stem cells (PDACs). In one aspect, provided herein is a method of treating amyotrophic lateral sclerosis (ALS) comprising administering to an individual having ALS a therapeutically effective amount of placental stem cells. In certain embodiments, “therapeutically effective” means an amount effective to reduce or ameliorate one or more symptoms of ALS.
    Type: Application
    Filed: September 10, 2012
    Publication date: February 12, 2015
    Applicant: ANTHROGENESIS CORPORATION
    Inventors: Robert J. Hariri, Jodi P. Gurney
  • Placental Stem Cell Populations
    Publication number: 20150037316
    Abstract: The present invention provides placental stem cells and placental stem cell populations, and methods of culturing, proliferating and expanding the same. The invention also provides methods of differentiating the placental stem cells. The invention further provides methods of using the placental stem cells in assays and for transplanting.
    Type: Application
    Filed: June 6, 2014
    Publication date: February 5, 2015
    Inventors: James Edinger, Qian Ye, Jai-Lun Wang, Robert J. Hariri
  • TREATMENT OF RADIATION INJURY USING AMNION DERIVED ADHERENT CELLS
    Publication number: 20150023926
    Abstract: Provided herein are methods of treating individuals having suffered exposure to radiation, e.g., individuals having radiation injury, by administering to the individuals angiogenic cells from amnion, referred to as amnion derived adherent cells, or populations of and compositions comprising, such cells.
    Type: Application
    Filed: July 13, 2012
    Publication date: January 22, 2015
    Applicant: ANTHROGENESIS CORPORATION
    Inventors: Aleksandar Francki, Ajai Pal, Robert J. Hariri, Vladimir Jankovic
  • IDENTIFICATION OF ANTITUMOR COMPOUNDS USING PLACENTA
    Publication number: 20150017663
    Abstract: Provided herein are methods of evaluating potential antitumor compounds, and thereby identifying antitumor compounds, using placenta or a portion thereof and tumor cells, and compositions for accomplishing the same. In one embodiment, provided herein is a method of determining whether a potential antitumor compound is effective against a plurality of tumor cells, comprising introducing a plurality of tumor cells to, e.g., into or onto, a mammalian placenta or portion thereof; contacting said plurality of tumor cells for a period of time with said antitumor compound; and determining whether said antitumor compound is effective against said tumor cells, wherein said antitumor compound is effective against said tumor cells if said antitumor compound over said period of time reduces the number of said tumor cells or reduces the growth rate of said tumor cells.
    Type: Application
    Filed: February 22, 2013
    Publication date: January 15, 2015
    Applicant: Anthrogenesis Corporation
    Inventors: Robert J. Hariri, Mohit B. Bhatia, Qian Ye
  • ORGANOIDS COMPRISING DECELLULARIZED AND REPOPULATED PLACENTAL VASCULAR SCAFFOLD
    Publication number: 20150017140
    Abstract: Provided herein are organoids comprising decellularized placental vascular scaffold comprising, or consisting of, a decellularized placental vascular scaffold, and methods of making and using the same.
    Type: Application
    Filed: December 21, 2012
    Publication date: January 15, 2015
    Applicant: Anthrogenesis Corporation
    Inventors: Mohit B. Bhatia, Robert J. Hariri, Wolfgang Hofgartner, Jia-Lun Wang, Qian Ye
  • Methods of generating natural killer cells
    Patent number: 8926964
    Abstract: Provided herein are methods of producing natural killer cells using a two-step expansion and differentiation method. Also provided herein are methods of suppressing tumor cell proliferation, of treating individuals having cancer or a viral infection, comprising administering the NK cells produced by the method to an individual having the cancer or viral infection.
    Type: Grant
    Filed: July 13, 2011
    Date of Patent: January 6, 2015
    Assignee: Anthrogenesis Corporation
    Inventors: Robert J. Hariri, Mohammad A. Heidaran, Stephen Jasko, Lin Kang, Eric Law, Ajai Pal, Bhavani Stout, Vanessa Voskinarian-Berse, Andrew Zeitlin, Xiaokui Zhang
  • Placental Stem Cell Populations
    Publication number: 20140377230
    Abstract: The present invention provides placental stem cells and placental stem cell populations, and methods of culturing, proliferating and expanding the same. The invention also provides methods of differentiating the placental stem cells. The invention further provides methods of using the placental stem cells in assays and for transplanting.
    Type: Application
    Filed: February 14, 2014
    Publication date: December 25, 2014
    Applicant: Anthrogenesis Corporation
    Inventors: James Edinger, Qian Ye, Jai-Lun Wang, Robert J. Hariri
  • Treatment of inflammatory diseases using placental stem cells
    Patent number: 8916146
    Abstract: Provided herein are methods of treatment of individuals having an immune-related disease, disorder or condition, for example, inflammatory bowel disease, graft-versus-host disease, multiple sclerosis, rheumatoid arthritis, psoriasis, lupus erythematosus, diabetes, mycosis fungoides (Alibert-Bazin syndrome), or scleroderma using placental stem cells or umbilical cord stem cells.
    Type: Grant
    Filed: May 10, 2013
    Date of Patent: December 23, 2014
    Assignee: Anthrogenesis Corporation
    Inventors: James W. Edinger, Robert J. Hariri, Jia-Lun Wang, Qian Ye, Herbert Faleck
  • METHOD OF COLLECTING PLACENTAL STEM CELLS
    Publication number: 20140349391
    Abstract: A method of collecting embryonic-like stem cells from a placenta which has been treated to remove residual cord blood by perfusing the drained placenta with an anticoagulant solution to flush out residual cells, collecting the residual cells and perfusion liquid from the drained placenta, and separating the embryonic-like cells from the residual cells and perfusion liquid. Exogenous cells can be propagated in the placental bioreactor and bioactive molecules collected therefrom.
    Type: Application
    Filed: June 6, 2014
    Publication date: November 27, 2014
    Applicant: Anthrogenesis Corporation
    Inventor: Robert J. Hariri
  • Immunomodulation using placental stem cells
    Patent number: 8895256
    Abstract: The present invention provides methods of immunomodulation using placental stem cells and placental stem cell populations. The invention also provides methods of producing and selecting placental cells and cell populations on the basis of immunomodulation, and compositions comprising such cells and cell populations.
    Type: Grant
    Filed: May 17, 2012
    Date of Patent: November 25, 2014
    Assignee: Anthrogenesis Corporation
    Inventors: Casper Paludan, James Edinger, Ryhor Harbacheuski, RoseAnn Murray, Robert J. Hariri
  • Modulation of stem and progenitor cell differentiation, assays, and uses thereof
    Patent number: 8889411
    Abstract: The present invention relates to methods of modulating mammalian stem cell and progenitor cell differentiation. The methods of the invention can be employed to regulate and control the differentiation and maturation of mammalian, particularly human stem cells along specific cell and tissue lineages. The methods of the invention relate to the use of certain small organic molecules to modulate the differentiation of stem or progenitor cell populations along specific cell and tissue lineages, and in particular, to the differentiation of embryonic-like stem cells originating from a postpartum placenta or for the differentiation of early progenitor cells to a granulocytic lineage. Finally, the invention relates to the use of such differentiated stem or progenitor cells in transplantation and other medical treatments.
    Type: Grant
    Filed: March 2, 2009
    Date of Patent: November 18, 2014
    Assignee: Anthrogenesis Corporation
    Inventors: Robert J. Hariri, David I. Stirling, Laure A. Moutouh-De Parseval, Kyle W. H. Chan
  • Use Of Umbilical Cord Blood To Treat Individuals Having A Disease, Disorder Or Condition
    Publication number: 20140322175
    Abstract: The present invention provides methods of using cord blood and cord blood-derived stem cells in high doses to treat various conditions, diseases and disorders. The high-dose cord blood and cord blood-derived stem cells have a multitude of uses and applications, including but not limited to, therapeutic uses for transplantation and treatment and prevention of disease, and diagnostic and research uses. In particular, the cord blood or cord blood-derived stem cells are delivered in high doses, e.g., at least 3 billion nucleated cells per treatment, where treatment may comprise a single or multiple infusions. The invention also provides for the use of cord blood or cord blood-derived stem cells from multiple donors without the need for HLA typing.
    Type: Application
    Filed: November 20, 2013
    Publication date: October 30, 2014
    Applicant: Anthrogenesis Corporation
    Inventor: Robert J. Hariri
  • Treatment of psoriasis using placental stem cells
    Patent number: 8753883
    Abstract: Provided herein are methods of treatment of individuals having an immune-related disease, disorder or condition, for example, inflammatory bowel disease, graft-versus-host disease, multiple sclerosis, rheumatoid arthritis, psoriasis, lupus erythematosus, diabetes, mycosis fungoides (Alibert-Bazin syndrome), or scleroderma using placental stem cells or umbilical cord stem cells.
    Type: Grant
    Filed: May 13, 2011
    Date of Patent: June 17, 2014
    Assignee: Anthrogenesis Corporation
    Inventors: James W. Edinger, Robert J. Hariri, Jia-Lun Wang, Qian Ye, Herbert Faleck
  • Placental stem cell populations
    Patent number: 8691217
    Abstract: The present invention provides placental stem cells and placental stem cell populations, and methods of culturing, proliferating and expanding the same. The invention also provides methods of differentiating the placental stem cells. The invention further provides methods of using the placental stem cells in assays and for transplanting.
    Type: Grant
    Filed: May 24, 2012
    Date of Patent: April 8, 2014
    Assignee: Anthrogenesis Corporation
    Inventors: James Edinger, Qian Ye, Jai-Lun Wang, Robert J. Hariri
  • TUMOR SUPPRESSION USING HUMAN PLACENTAL PERFUSATE AND HUMAN PLACENTA-DERIVED INTERMEDIATE NATURAL KILLER CELLS
    Publication number: 20140093488
    Abstract: Provided herein are placental perfusate, placental perfusate cells, and placenta-derived intermediate natural killer cells, and combinations thereof. Also provided herein are compositions comprising the same, and methods of using placental perfusate, placental perfusate cells, and placenta-derived intermediate natural killer cells, and combinations thereof, to suppress the growth or proliferation of tumor cells, cancer cells, and the like, and to treat individuals having tumor cells.
    Type: Application
    Filed: August 13, 2012
    Publication date: April 3, 2014
    Applicant: ANTHROGENESIS CORPORATION
    Inventors: Robert J. Hariri, Mohammad A. Heidaran, Lin Kang, Neerav Dilip Padliya, Ajai Pal, Vanessa Voskinarian-Berse, Andrew Zeitlin, Xiaokui Zhang
  • TREATMENT OF RADIATION INJURY USING AMNION DERIVED ADHERENT CELLS
    Publication number: 20140072538
    Abstract: Provided herein are methods of treating individuals having suffered exposure to radiation, e.g., individuals having radiation injury, by administering to the individuals angiogenic cells from amnion, referred to as amnion derived adherent cells, or populations of, and compositions comprising, such cells.
    Type: Application
    Filed: July 12, 2013
    Publication date: March 13, 2014
    Inventors: Aleksandar Francki, Ajai Pal, Robert J. Hariri, Vladimir Jankovic
  • METHODS AND COMPOSITIONS FOR TREATMENT OF BONE DEFECTS WITH PLACENTAL CELL POPULATIONS
    Publication number: 20140017211
    Abstract: Provided herein are methods of using adherent placental stem cells and placental stem cell populations, and methods of culturing, proliferating and expanding the same. Also provided herein are methods of differentiating the placental stem cells. Further provided herein are methods of using the placental stem cells to formulate implantable or injectable compositions suitable for administration to a subject. Still further provided herein are provides methods for treating bone defects with stem cells and compositions comprising stem cells.
    Type: Application
    Filed: September 16, 2013
    Publication date: January 16, 2014
    Applicant: Anthrogenesis Corporation
    Inventors: James W. Edinger, Robert J. Hariri, Jia-Lun Wang, Qian Ye, Kristen S. Labazzo, Marian Pereira, Sascha Dawn Abramson