Patents by Inventor Robert J. Hariri

Robert J. Hariri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20130028871
    Abstract: The present invention provides placental stem cells and placental stem cell populations, and methods of culturing, proliferating and expanding the same. The invention also provides methods of differentiating the placental stem cells. The invention further provides methods of using the placental stem cells in assays and for transplanting.
    Type: Application
    Filed: May 16, 2012
    Publication date: January 31, 2013
    Inventors: James EDINGER, Qian YE, Jai-Lun WANG, Robert J. HARIRI
  • Publication number: 20130022581
    Abstract: The present invention provides placental stem cells and placental stem cell populations, and methods of culturing, proliferating and expanding the same. The invention also provides methods of differentiating the placental stem cells. The invention further provides methods of using the placental stem cells in assays and for transplanting.
    Type: Application
    Filed: May 24, 2012
    Publication date: January 24, 2013
    Inventors: James EDINGER, Qian Ye, Jai-Lun Wang, Robert J. Hariri
  • Patent number: 8293223
    Abstract: The present invention provides a method of extracting and recovering embryonic-like stem cells, including, but not limited to pluripotent or multipotent stem cells, from an exsanguinated human placenta. A placenta is treated to remove residual umbilical cord blood by perfusing an exsanguinated placenta, preferably with an anticoagulant solution, to flush out residual cells. The residual cells and perfusion liquid from the exsanguinated placenta are collected, and the embryonic-like stem cells are separated from the residual cells and perfusion liquid. The invention also provides a method of utilizing the isolated and perfused placenta as a bioreactor in which to propagate endogenous cells, including, but not limited to, embryonic-like stem cells. The invention also provides methods for propagation of exogenous cells in a placental bioreactor and collecting the propagated exogenous cells and bioactive molecules therefrom.
    Type: Grant
    Filed: September 30, 2011
    Date of Patent: October 23, 2012
    Assignee: Anthrogenesis Corporation
    Inventor: Robert J. Hariri
  • Patent number: 8263065
    Abstract: Provided herein are placental perfusate, placental perfusate cells, and placenta-derived intermediate natural killer cells, and combinations thereof. Also provided herein are compositions comprising the same, and methods of using placental perfusate, placental perfusate cells, and placenta-derived intermediate natural killer cells, and combinations thereof, to suppress the growth or proliferation of tumor cells, cancer cells, and the like, and to treat individuals having tumor cells.
    Type: Grant
    Filed: September 29, 2008
    Date of Patent: September 11, 2012
    Assignee: Anthrogenesis Corporation
    Inventors: Robert J. Hariri, Mohammad A. Heidaran, Lin Kang, Neerav Dilip Padliya, Ajai Pal, Vanessa Voskinarian-Berse, Andrew Zeitlin, Xiaokui Zhang
  • Publication number: 20120225096
    Abstract: The present invention provides methods of immunomodulation using placental stem cells and placental stem cell populations. The invention also provides methods of producing and selecting placental cells and cell populations on the basis of immunomodulation, and compositions comprising such cells and cell populations.
    Type: Application
    Filed: May 17, 2012
    Publication date: September 6, 2012
    Inventors: Casper Paludan, James Edinger, Ryhor Harbacheuski, RoseAnn Murray, Robert J. Hariri
  • Patent number: 8216566
    Abstract: The present invention provides methods of immunomodulation using placental stem cells and placental stem cell populations. The invention also provides methods of producing and selecting placental cells and cell populations on the basis of immunomodulation, and compositions comprising such cells and cell populations.
    Type: Grant
    Filed: January 14, 2010
    Date of Patent: July 10, 2012
    Assignee: Anthrogenesis Corporation
    Inventors: Casper Paludan, James W. Edinger, Ryhor Harbacheuski, RoseAnn Murray, Robert J. Hariri
  • Patent number: 8202703
    Abstract: The present invention provides placental stem cells and placental stem cell populations, and methods of culturing, proliferating and expanding the same. The invention also provides methods of differentiating the placental stem cells. The invention further provides methods of using the placental stem cells in assays and for transplanting.
    Type: Grant
    Filed: July 30, 2010
    Date of Patent: June 19, 2012
    Assignee: Anthrogenesis Corporation
    Inventors: James Edinger, Qian Ye, Jai-Lun Wang, Robert J. Hariri
  • Publication number: 20120148553
    Abstract: Provided herein are methods of producing natural killer cells using a two-step expansion and differentiation method. Also provided herein are methods of suppressing tumor cell proliferation, of treating individuals having cancer or a viral infection, comprising administering the NK cells produced by the method to an individual having the cancer or viral infection.
    Type: Application
    Filed: July 13, 2011
    Publication date: June 14, 2012
    Inventors: Robert J. HARIRI, Mohammad A. Heidaran, Stephen Jasko, Lin Kang, Eric Law, Ajai Pal, Bhavani Stout, Vanessa Voskinarian-Berse, Andrew Zeitlin, Xiaokui Zhang
  • Publication number: 20120122215
    Abstract: The present invention provides placental stem cells and placental stem cell populations, and methods of culturing, proliferating and expanding the same. The invention also provides methods of differentiating the placental stem cells. The invention further provides methods of using the placental stem cells in assays and for transplanting.
    Type: Application
    Filed: October 18, 2011
    Publication date: May 17, 2012
    Inventors: James Edinger, Qian Ye, Jia-Lun Wang, Robert J. Hariri
  • Publication number: 20120058089
    Abstract: The present invention provides a method of extracting and recovering embryonic-like stem cells, including, but not limited to pluripotent or multipotent stem cells, from an exsanguinated human placenta. A placenta is treated to remove residual umbilical cord blood by perfusing an exsanguinated placenta, preferably with an anticoagulant solution, to flush out residual cells. The residual cells and perfusion liquid from the exsanguinated placenta are collected, and the embryonic-like stem cells are separated from the residual cells and perfusion liquid. The invention also provides a method of utilizing the isolated and perfused placenta as a bioreactor in which to propagate endogenous cells, including, but not limited to, embryonic-like stem cells. The invention also provides methods for propagation of exogenous cells in a placental bioreactor and collecting the propagated exogenous cells and bioactive molecules therefrom.
    Type: Application
    Filed: September 30, 2011
    Publication date: March 8, 2012
    Inventor: Robert J. HARIRI
  • Publication number: 20120034195
    Abstract: The present invention provides compositions and methods of using placental stem cells that originate from a post-partum placenta with conventional cord blood compositions or other stem or progenitor cells. The placental stem cells can be used alone or in a mixture with other stem cell populations. In accordance with the present invention, the placental stem cells may be mixed with other stem cell populations, including but not limited to, umbilical cord blood, fetal and neonatal hematopoietic stem cells and progenitor cells, human stem cells and progenitor cells derived from bone marrow. The placental stem cells and the mixed populations of placental stem cells and stem cells have a multitude of uses and applications, including but not limited to, therapeutic uses for transplantation and treatment and prevention of disease, and diagnostic and research uses.
    Type: Application
    Filed: October 17, 2011
    Publication date: February 9, 2012
    Inventor: Robert J. HARIRI
  • Publication number: 20120020936
    Abstract: The present invention provides a method of extracting and recovering embryonic-like stem cells, including, but not limited to pluripotent or multipotent stem cells, from an exsanguinated human placenta. A placenta is treated to remove residual umbilical cord blood by perfusing an exsanguinated placenta, preferably with an anticoagulant solution, to flush out residual cells. The residual cells and perfusion liquid from the exsanguinated placenta are collected, and the embryonic-like stem cells are separated from the residual cells and perfusion liquid. The invention also provides a method of utilizing the isolated and perfused placenta as a bioreactor in which to propagate endogenous cells, including, but not limited to, embryonic-like stem cells. The invention also provides methods for propagation of exogenous cells in a placental bioreactor and collecting the propagated exogenous cells and bioactive molecules therefrom.
    Type: Application
    Filed: October 3, 2011
    Publication date: January 26, 2012
    Inventor: Robert J. Hariri
  • Publication number: 20110318401
    Abstract: The present invention provides a method of treating a leg ulcer comprising contacting the leg ulcer with a collagen biofabric. The leg ulcer may be a venous, arterial, diabetic or decubitus (pressure) ulcer. The invention further provides kits comprising one or more pieces of collagen biofabric for the treatment of a leg ulcer.
    Type: Application
    Filed: April 18, 2011
    Publication date: December 29, 2011
    Inventors: Robert J. Hariri, Janice M. Smiell
  • Publication number: 20110280849
    Abstract: Provided herein are methods of suppressing tumor cell proliferation, of treating individuals having cancer or a viral infection, comprising contacting the tumor cells, or administering to the individual, placental perfusate, placental perfusate cells, or natural killer cells, e.g., placenta-derived intermediate natural killer cells, with an immunomodulatory compound or thalidomide.
    Type: Application
    Filed: March 24, 2011
    Publication date: November 17, 2011
    Applicant: Anthrogenesis Corporation
    Inventors: Xiaokui ZHANG, Lin Kang, Mohammad A. Heidaran, Stephen Jasko, Andrew Zeitlin, Ajai Pal, Robert J. Hariri
  • Publication number: 20110280845
    Abstract: Provided herein are methods of treatment of individuals having an immune-related disease, disorder or condition, for example, inflammatory bowel disease, graft-versus-host disease, multiple sclerosis, rheumatoid arthritis, psoriasis, lupus erythematosus, diabetes, mycosis fungoides (Alibert-Bazin syndrome), or scleroderma using placental stem cells or umbilical cord stem cells.
    Type: Application
    Filed: May 13, 2011
    Publication date: November 17, 2011
    Inventors: James W. EDINGER, Robert J. Hariri, Jia-Lun Wang, Qian Ye, Herbert Faleck
  • Publication number: 20110280843
    Abstract: Provided herein are methods of treatment of individuals having an immune-related disease, disorder or condition, for example, inflammatory bowel disease, graft-versus-host disease, multiple sclerosis, rheumatoid arthritis, psoriasis, lupus erythematosus, diabetes, mycosis fungoides (Alibert-Bazin syndrome), or scleroderma using placental stem cells or umbilical cord stem cells.
    Type: Application
    Filed: May 13, 2011
    Publication date: November 17, 2011
    Inventors: James W. EDINGER, Robert J. Hariri, Jia-Lun Wang, Qian Ye, Herbert Faleck
  • Patent number: 8057789
    Abstract: The present invention provides compositions and methods of using placental stem cells that originate from a postpartum placenta with conventional cord blood compositions or other stem or progenitor cells. The placental stem cells can be used alone or in a mixture with other stem cell populations. In accordance with the present invention, the placental stem cells may be mixed with other stem cell populations, including but not limited to, umbilical cord blood, fetal and neonatal hematopoietic stem cells and progenitor cells, human stem cells and progenitor cells derived from bone marrow. The placental stem cells and the mixed populations of placental stem cells and stem cells have a multitude of uses and applications, including but not limited to, therapeutic uses for transplantation and treatment and prevention of disease, and diagnostic and research uses.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: November 15, 2011
    Assignee: Anthrogenesis Corporation
    Inventor: Robert J. Hariri
  • Patent number: 8057788
    Abstract: The present invention provides placental stem cells and placental stem cell populations, and methods of culturing, proliferating and expanding the same. The invention also provides methods of differentiating the placental stem cells. The invention further provides methods of using the placental stem cells in assays and for transplanting.
    Type: Grant
    Filed: December 28, 2006
    Date of Patent: November 15, 2011
    Assignee: Anthrogenesis Corporation
    Inventor: Robert J. Hariri
  • Publication number: 20110250182
    Abstract: Provided herein are methods of treating individuals having diseases or disorders of the circulatory system, using placental cells, e.g., the placental stem cells and placental multipotent cells (PDACs) described herein, and populations of such placental cells. The invention also provides methods of angiogenesis using such cells or populations of cells comprising such cells.
    Type: Application
    Filed: April 6, 2011
    Publication date: October 13, 2011
    Applicant: ANTHROGENESIS CORPORATION
    Inventors: Stewart ABBOT, James W. EDINGER, Aleksandar FRANCKI, Robert J. HARIRI, Vladimir JANKOVIC, Aleksandr KAPLUNOVSKY, Kristen LABAZZO, Eric LAW, Neerav D. PADLIYA, Jennifer PAREDES, Jia-Lun WANG
  • Publication number: 20110250185
    Abstract: The present invention provides methods of suppression of tumor cell proliferation and tumor growth using placental stem cells and placental stem cell populations. The invention also provides methods of producing and selecting placental cells and cell populations on the basis of tumor suppression, and compositions comprising such cells and cell populations.
    Type: Application
    Filed: June 20, 2011
    Publication date: October 13, 2011
    Inventors: Casper Paludan, James W. Edinger, Ryhor Harbacheuski, RoseAnn Murray, Robert J. Hariri, Qian Ye