Patents by Inventor Robert J. Ife

Robert J. Ife has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds substituted quinoline derivatives
    Patent number: 5432182
    Abstract: Substituted 4-aminoquinazoline derivatives which are inhibitors of gastric acid secretion. A compound of the invention are the salts of strong acids of 3-butyryl-4-(2-methylphenylamino)-8-(hydroxymethyl)quinoline.
    Type: Grant
    Filed: January 29, 1992
    Date of Patent: July 11, 1995
    Assignee: SmithKline Beecham Intercredit B.V.
    Inventors: Robert J. Ife, Colin A. Leach
  • Substituted quinoline derivatives
    Patent number: 5420135
    Abstract: Substituted quinoline derivatives are described as inhibitors bone resorption with in particular, the compound 1-(2-methylphenyl)imidazo[4,5-c]quinoline hydrochloride.
    Type: Grant
    Filed: December 10, 1990
    Date of Patent: May 30, 1995
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Thomas H. Brown, Robert J. Ife, Colin A. Leach, David J. Keeling
  • [(alkoxy)pyridinyl]amine compounds which are useful in the treatment of gastrointestinal disorders
    Patent number: 5409943
    Abstract: The present invention relates to N-pyridylamidine and N-pyridylguanidine derivatives of general formula (I) in which: Ar.sup.1 is an optionally substituted phenyl ring; Ar.sup.2 is an optionally substituted phenyl ring; R.sup.1 is hydrogen or C.sub.1-4 alkyl; R.sup.2 is hydrogen or C.sub.1-4 alkyl; R.sup.3 is hydrogen or C.sub.1-4 alkyl; R.sup.4 is hydrogen, halogen, C.sub.1-6 alkyl or C.sub.1-6 alkoxy; X is CH.sub.2 or NR.sup.5, and R.sup.5 is hydrogen or C.sub.1-4 alkyl, and the salts thereof, and their use in therapy as gastric acid secretion inhibitors.
    Type: Grant
    Filed: July 20, 1994
    Date of Patent: April 25, 1995
    Assignee: SmithKline Beecham Intercredit B.V.
    Inventors: Robert J. Ife, Colin A. Leach, Dashyant Dhanak
  • Thienopyrimidines
    Patent number: 5280026
    Abstract: Thienopyrimidine compounds are disclosed as inhibitors of the H.sup.+ K.sup.+ ATPase enzyme useful in the treatment of gastric acid secretion. A compound of the invention is 2-(2-methylphenylamino)-4-(N-methylphenylamino)thieno[3,2-d]pyrimidine.
    Type: Grant
    Filed: November 24, 1992
    Date of Patent: January 18, 1994
    Assignee: SmithKline Beecham Intercredit B.V.
    Inventors: Thomas H. Brown, Robert J. Ife, Colin A. Leach
  • Pyridyl containing benzimidazoles, compositions and use
    Patent number: 5250527
    Abstract: The invention relates to 4-amino-2-pyridylmethylsulfinyl-(and thio)-benzimidazoles which are inhibitors of potassium stimulated H.sup.+ -K.sup.+ ATPase activity. A compound of the invention is 2-(4-amino-5-bromo-2-pyridylmethylsulphinyl)-5-methoxy-(1H)-benzimidazole.
    Type: Grant
    Filed: September 23, 1988
    Date of Patent: October 5, 1993
    Assignee: SmithKline & French Laboratories Limited
    Inventor: Robert J. Ife
  • Substituted 4-amino-isoquinoline compounds, pharmaceutical composition and method of use
    Patent number: 5200417
    Abstract: Isoquinoline compounds, compositions containing them and their use in the inhibition of gastric acid secretion in mammals. A compound of the invention is 1-[(2-Methoxyphenylmethyl)amino]isoquinoline hydrochloride.
    Type: Grant
    Filed: April 4, 1990
    Date of Patent: April 6, 1993
    Assignee: Smithkline Beecham Intercredit B.V.
    Inventors: Thomas H. Brown, Robert J. Ife, Colin A. Leach
  • Substituted 4-aminoquinoline derivatives as gastric secretion inhibitors
    Patent number: 5143920
    Abstract: Substituted 4-aminoquinazoline derivatives of the formula: ##STR1## wherein R.sup.1 is hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.1-6 alkoxy C.sub.1-6 alkyl,C.sub.3-6 cycloalkyl, C.sub.3-6 cycloalkyl C.sub.1-6 alkyl, phenyl C.sub.1-6 alkyl, the phenyl group being optionally substituted;R.sup.2 is hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, amino, C.sub.1-6 alkylthio, halogen, cyano, hydroxy, C.sub.1-6 alkanoyl or trifuromethyl;m is 1 to 3;R.sup.3 is hydrogen, C.sub.1-6 alkyl, phenyl, C.sub.1-6 alkoxy, C.sub.1-6 alkylthio, C.sub.1-6 alkanoyl, amino, C.sub.1-6 alkylamino, ci-C.sub.1-6 alkylamino, halogen, trifluoromethyl or cyano;n is 1 or 2; andR.sup.4 is hydrogen; or a salt thereof are useful as inhibitors of gastric acid secretion.
    Type: Grant
    Filed: February 23, 1989
    Date of Patent: September 1, 1992
    Assignee: SmithKline Beckman Intercredit B.V.
    Inventors: Robert J. Ife, Thomas H. Brown, Colin A. Leach
  • Substituted 4-aminoquinoline derivatives as gastric acid secretion inhibitors
    Patent number: 5089498
    Abstract: Substituted 4-aminiquinazoline derivatives of the formula: ##STR1## in which R.sup.1 hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.1-6 alkoxyC.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, C.sub.3-6 cycloalkylC.sub.1-6 alkyl, phenylC.sub.1-6 alkyl, the phenyl group being optionally substituted;R.sup.2 is hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, amino, C.sub.1-6 alkylthio, halogen, cyano, hydroxy, carbamoyl, carboxy, C.sub.1-6 alkanoyl or trifluromethyl;m is 1 to 3;p is 0 to 4;R.sup.3 is COR.sup.4 ;R.sup.4 is hydroxy, C.sub.1-6 alkoxy, or NR.sup.5 R.sup.6 ;R.sup.5 and R.sup.6 are each hydrogen or C.sub.1-6 alkyl or together with the nitrogen atom to which they are attached form a heterocyclic ring; andR.sup.7 is hydrogen, C.sub.1-6 alkoxy or C.sub.1-6 alkyl;or a salt thereof.
    Type: Grant
    Filed: February 23, 1989
    Date of Patent: February 18, 1992
    Assignee: SmithKline Beckman Intercredit B.V.
    Inventors: Robert J. Ife, Thomas H. Brown, Colin A. Leach
  • Substituted 4-aminoquinoline derivatives as gastric acid secretion inhibitors
    Patent number: 5089504
    Abstract: Substituted 4-aminoquinazoline derivatives of the formula: ##STR1## in which R.sup.1 is hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, C.sub.1-6 alkoxyC.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, C.sub.3-6 cycloalkylC.sub.1-6 alkyl, phenylC.sub.1-6 alkyl, the phenyl group being optionally substituted;R.sup.2 is hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, amino, C.sub.1-6 alkylthio, halogen, cyano, hydroxy, carbamoyl, carboxy, C.sub.1-6 alkanoyl or trifluoromethyl;m is 1 to 3;p is 0 to 4;R.sup.3 is COR.sup.4 ;R.sup.4 is hydroxy, C.sub.1-6 alkoxy, or NR.sup.5 R.sup.6 ;R.sup.5 and R.sup.6 are each hydrogen or C.sub.1-6 alkyl or together with the nitrogen atom to which they are attached form a heterocyclic ring; andR.sup.7 is hydrogen, C.sub.1-6 alkoxy or C.sub.1-6 alkyl;or a salt thereof.
    Type: Grant
    Filed: February 23, 1989
    Date of Patent: February 18, 1992
    Assignee: SmithKline Beckman Intercredit B.V.
    Inventors: Robert J. Ife, Thomas H. Brown, Colin A. Leach
  • Substituted 4-aminoquinoline derivatives as gastric acid secretion inhibitors
    Patent number: 5082848
    Abstract: Substituted 4-aminoquinoline derivatives of the formula: ##STR1## wherein R.sup.1 is hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxyC.sub.1-6 alkyl; C.sub.3-6 cycloalkyl, C.sub.3-6 cycloalkyl-C.sub.1-6 alkyl, phenyl C.sub.1-6 alkyl, the phenyl groups being optionally substituted;R.sup.2 is hydroxy C.sub.1-6 alkyl, C.sub.1-6 alkoxyC.sub.1-6 alkyl or two adjacent groups R.sup.2 together form a C.sub.1-4 alkylenedioxy group;R.sup.3 is hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, amino, C.sub.1-6 alkylthio, halogen, cyano, hydroxy, C1-6alkanoyl, or trifluromethyl;R.sup.4 is hydrogen, C.sub.1-6 alkyl, phenyl, C.sub.1-6 alkoxy, C.sub.1-6 alkylthio, C.sub.1-6 alkanoyl, amino, C.sub.1-6 alkylamino, di- C.sub.1-6 alkyl amino, halogen, or trifluromethyl;n is 1 or 2;q is 0 to 4;m is 1, 2, or 3; andp is 1, 2, 3, or 4 provided that m+p is not greater than 5;or a salt thereof are useful as inhibitors of gastric acid secretion.
    Type: Grant
    Filed: February 23, 1989
    Date of Patent: January 21, 1992
    Assignee: Smith Kline & French Laboratories, Ltd.
    Inventors: Robert J. Ife, Thomas H. Brown, Colin A. Leach
  • 3-carbonyl-4-amino-8-substituted quinoline compounds useful in inhibiting gastric acid secretions.
    Patent number: 5082841
    Abstract: Aminoquinoline derivatives are described as inhibitors of the H.sup.+ K.sup.+ ATPase enzyme useful in the treatment of gastric acidity. A compound of the invention is 3-butyryl-4-(2-methylphenylamino)-8-(3-dimethylaminopropoxy)quinoline.
    Type: Grant
    Filed: August 7, 1990
    Date of Patent: January 21, 1992
    Assignee: SmithKline Beecham Intercredit B.V.
    Inventors: Thomas H. Brown, Robert J. Ife, Colin A. Leach
  • Substituted quinazoline derivatives for use in gastrointestinal diseases
    Patent number: 5064833
    Abstract: 2,4-diaminoquinazoline compounds are inhibitors of the H.sup.+ K.sup.+ ATPase enzyme and useful for the treatment of diseases of the stomach based on excessive gastric acid secretion. A compound of the invention is 2-[2-methyl-4-fluorophenyl)amino]-4-(N-methylphenylamino)quinazoline.
    Type: Grant
    Filed: May 8, 1990
    Date of Patent: November 12, 1991
    Assignee: Smithkline Beecham Intercredit B.V.
    Inventors: Robert J. Ife, Thomas H. Brown, Colin A. Leach, David J. Keeling
  • Dihydropyrrolo quinoline derivatives
    Patent number: 5051508
    Abstract: 1,4-Substituted 2,3-dihydropyrrolo[3,2-c]quinolines which are inhibitors of H.sup.+ K.sup.+ ATPase activity and useful as inhibitors of gastric acid secretion. A compound of the invention is 1-(2-methylphenyl)-4-amino-6-methyl-2,3-dihydropyrrolo[3,2-c]quinoline.
    Type: Grant
    Filed: June 19, 1990
    Date of Patent: September 24, 1991
    Assignee: SmithKline Beckman Intercredit B.V.
    Inventors: Thomas H. Brown, Robert J. Ife, Colin A. Leach
  • Substituted 4-aminoquinazoline derivatives and method of use
    Patent number: 5049567
    Abstract: Substituted 4-aminoquinazoline derivatives which are inhibitors of gastric acid secretion. A compound of the invention is ethyl 8-methoxy-4-(4-methyl-3-thinenylamino)quinoline-3-carboxylate.
    Type: Grant
    Filed: January 9, 1991
    Date of Patent: September 17, 1991
    Assignee: SmithKline Beckman Intercredit B.V.
    Inventors: Robert J. Ife, Thomas H. Brown, Colin A. Leach
  • Substituted heterocylic 4-aminoquinoline derivatives as gastric acid secretion inhibitors
    Patent number: 5006535
    Abstract: Substituted 4-aminoquinazoline derivatives which are inhibitors of gastric acid secretion. A compound of the invention is ethyl 8-methoxy-4-(4-methyl-3-thienyl-amino)quinoline-3-carboxylate.
    Type: Grant
    Filed: February 23, 1989
    Date of Patent: April 9, 1991
    Assignee: Smith Kline & French Laboratories Ltd.
    Inventors: Robert J. Ife, Thomas H. Brown, Colin A. Leach
  • Biologically active compounds
    Patent number: 4997847
    Abstract: The invention relates to phenylsulphonamidolkanoic acids which have thromboxane A.sub.2 receptor antagonist activity.
    Type: Grant
    Filed: August 22, 1988
    Date of Patent: March 5, 1991
    Assignees: Smith Kline & French Laboratories Limited, Boehringer Mannheim GmbH
    Inventors: Robert J. Ife, David G. Cooper, Robert A. Slater, Karlheinz Stegmeier, Ernst-Christian Witte
  • Substituted 7-amino-thienopyridine derivatives as gastric acid secretion inhibitors
    Patent number: 4935431
    Abstract: Substituted 4-aminothienopyridine derivatives which are inhibitors of gastric acid secretion. A compound of the invention is 6-butyryl-7-(2-isopropylphenylamino)-thieno[3,2-b]pyridine.
    Type: Grant
    Filed: February 23, 1989
    Date of Patent: June 19, 1990
    Assignee: SmithKline Beckman Intercredit B.V.
    Inventors: Robert J. Ife, Thomas H. Brown, Colin A. Leach
  • Pyrimidylalkylthio benzimidazole compounds, pharmaceutical compositions and use
    Patent number: 4820708
    Abstract: This invention relates to 2- and 4-pyrimidinylmethylsulphinyl(and thio)benzimidazoles in which the pyrimidyl group is substituted by an optionally substituted amino group. These compounds inhibit exogenously and endogenously stimulated gastric acid secretion.
    Type: Grant
    Filed: July 22, 1988
    Date of Patent: April 11, 1989
    Assignee: Smith Kline & French Laboratories
    Inventors: Robert J. Ife, Thomas H. Brown
  • 4-Amino-3-carbonyl substituted quinolines as inhibitors of gastric acid secretion
    Patent number: 4806550
    Abstract: This invention relates to novel substituted 4-aminoquinoline derivatives which are inhibitors of gastric acid secretion in mammals. A compound of the invention is 3-butyryl-4-(2-methylphenylamino)-8-methoxyquinoline.
    Type: Grant
    Filed: May 12, 1988
    Date of Patent: February 21, 1989
    Assignee: SmithKline & French Laboratories Limited
    Inventors: Robert J. Ife, Thomas H. Brown, Colin A. Leach
  • 4-amino-3-carbonyl substituted quinolines
    Patent number: 4806549
    Abstract: This invention relates to novel substituted 4-aminoquinoline derivatives which are inhibitors of gastric acid secretion in mammals. A compound of the invention is 3-butyryl-4-(2-methylphenylamino)-8-methoxyquinoline.
    Type: Grant
    Filed: September 3, 1987
    Date of Patent: February 21, 1989
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Robert J. Ife, Thomas H. Brown, Colin A. Leach