Patents by Inventor Robert J. Ife

Robert J. Ife has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrimidylalkylthio benzimidale compounds, pharmaceutical compositions and use
    Patent number: 4777172
    Abstract: This invention relates to 2- and 4-pyrimidinylmethylsulphinyl(and thio)benzimidazoles in which the pyrimidyl group is substituted by an optionally substituted amino group. These compounds inhibit exogenously and endogenously stimulated gastric acid secretion.
    Type: Grant
    Filed: February 14, 1986
    Date of Patent: October 11, 1988
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Robert J. Ife, Thomas H. Brown
  • Histamine antagonist triadiazole derivatives, compositions, and method of use therefor
    Patent number: 4728648
    Abstract: New 3,4-diamino-1,2,5-thiadiazole oxide derivatives which are histamine H.sub.1 -antagonists. A specific compound of this invention is 3-[3-[N-(4-fluorobenzyl)-N-pyrid-2-yl-amino]propylamino]-4-[pyrimidin-4-yl -methylamino]-1,2,5-thiadiazole-1-oxide.
    Type: Grant
    Filed: February 4, 1986
    Date of Patent: March 1, 1988
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Andrew D. Gribble, Robert J. Ife
  • 3-Pyridylaminoalkyleneamino-4-amino-1,2,5-thiadiazole-1-oxides, composition containing them, and use of them to block histamine h.sub.2 -receptors
    Patent number: 4692456
    Abstract: New 3,4-diamino-1,2,5-thiadiazole oxide derivatives which are histamine H.sub.1 -antagonists. A specific compound of this invention is 3-[3-(N-propyl-N-2-pyridylamino)-propylamino]-4-(4-pyridylmethyl)amino-1,2 ,5-thiadiazole-1-oxide.
    Type: Grant
    Filed: March 12, 1986
    Date of Patent: September 8, 1987
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: Robert J. Ife
  • Tricyclic derivatives and pharmaceutical use
    Patent number: 4668671
    Abstract: This invention describes tricyclic derivatives which are useful as histamine H.sub.1 -antagonists. A particular compound of this invention is 3-[3-(pyrido[3,2-b][1,4]-benzothiazin-10-yl)propylamino]-4-(pyrid-4-ylmeth ylamino)-1,2,5-thiadiazole-1-oxide.
    Type: Grant
    Filed: April 23, 1986
    Date of Patent: May 26, 1987
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Andrew D. Gribble, Robert J. Ife
  • 3-(2-pyridylaminoalkylamino)cyclobutenediones and pyridones useful as histamine H.sub.1 -antagonists
    Patent number: 4659725
    Abstract: Pyridine derivatives are disclosed which are useful as histamine H.sub.1 -antagonists.
    Type: Grant
    Filed: June 19, 1986
    Date of Patent: April 21, 1987
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: Robert J. Ife
  • Pyridylaminoalkylamine intermediates
    Patent number: 4652650
    Abstract: Pyridine derivatives are disclosed which are useful as histamine H.sub.1 -antagonists.
    Type: Grant
    Filed: August 5, 1985
    Date of Patent: March 24, 1987
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: Robert J. Ife
  • Pyrimidine compounds
    Patent number: 4649141
    Abstract: The compounds are substituted pyrimidine compounds which are histamine H.sub.2 -antagonists. A specific compound of the present invention is 2-[2-(5-dimethylaminomethyl)-2-furylmethylthio)ethylamino]-5-(3-pyridylmet hyl)-4-pyrimidone.
    Type: Grant
    Filed: June 21, 1985
    Date of Patent: March 10, 1987
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Thomas H. Brown, Robert J. Ife
  • 2-substituted alkylaminopyrimidones useful as H.sub.2 -antagonists and antiinflamatory agents
    Patent number: 4639519
    Abstract: The compounds are isoureas and isothioureas which have an O- or S-alkylpyrimidone substituent and which are histamine H.sub.2 -antagonists and antiinflammatory agents.A specific compound of this invention is 2-[5-(O-isoureido)pentylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone.
    Type: Grant
    Filed: May 1, 1985
    Date of Patent: January 27, 1987
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Charon R. Ganellin, Robert J. Ife, David A. A. Owen
  • 3-(2-pyridylaminoalkylamino)thiazoles useful as histamine H.sub.1 -antagonists
    Patent number: 4607106
    Abstract: Pyridine derivatives are disclosed which are useful as histamine H.sub.1 -antagonists.
    Type: Grant
    Filed: May 17, 1985
    Date of Patent: August 19, 1986
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: Robert J. Ife
  • 2-Substituted alkylaminopyrimidones
    Patent number: 4558128
    Abstract: The compounds are isoureas and isothioureas which have an O- or S- alkylpyrimidone substituent and which are histamine H.sub.2 -antagonists and antiinflammatory agents. A specific compound of this invention is 2-[5-(O-isoureido)pentylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone.
    Type: Grant
    Filed: November 9, 1983
    Date of Patent: December 10, 1985
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Charon R. Ganellin, Robert J. Ife, David A. A. Owen
  • Pyridylaminoalkylaminopyrimidones useful as histamine H.sub.1 -antagonists
    Patent number: 4548940
    Abstract: Pyridine derivatives are disclosed which are useful as histamine H.sub.1 -antagonists.
    Type: Grant
    Filed: December 20, 1983
    Date of Patent: October 22, 1985
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: Robert J. Ife
  • 2-Pyridylaminoakylamino-4-pyrimidones useful as histamine H.sub.1 -antagonists
    Patent number: 4547506
    Abstract: Pyridine derivatives are disclosed which are useful as histamine H.sub.1 -antagonists.
    Type: Grant
    Filed: December 20, 1983
    Date of Patent: October 15, 1985
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: Robert J. Ife
  • Pyrimidine compounds
    Patent number: 4539207
    Abstract: The compounds are substituted pyrimidine compounds which are histamine H.sub.2 -antagonists. A specific compound of the present invention is 2-[2-(5-dimethylaminomethyl)-2-furylmethylthio)ethylamino]-5-(3-pyridylmet hyl)-4-pyrimidone.
    Type: Grant
    Filed: June 4, 1980
    Date of Patent: September 3, 1985
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Thomas H. Brown, Robert J. Ife
  • 2-(2-Pyridylaminoalkylamino)-4-pyrimidones
    Patent number: 4532246
    Abstract: Pyridine derivatives are disclosed which are useful as histamine H.sub.1 -antagonists.
    Type: Grant
    Filed: December 20, 1983
    Date of Patent: July 30, 1985
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: Robert J. Ife
  • Phenyl alkylaminopyrimidones
    Patent number: 4496567
    Abstract: The compounds are phenyl alkylaminopyrimidones which are histamine H.sub.2 -antagonists. A specific compound of the present invention is 2-[2-[3-(dimethylaminomethyl)benzylthio]ethylamino]-5-(6-methyl-3-pyridylm ethyl)-4-pyrimidone.
    Type: Grant
    Filed: November 6, 1979
    Date of Patent: January 29, 1985
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Thomas H. Brown, Robert J. Ife
  • Isoureas and isothioureas
    Patent number: 4439435
    Abstract: The compounds are isoureas and isothioureas which have an O- or S- alkylpyrimidone substituent and which are histamine H.sub.2 -antagonists and antiinflammatory agents. A specific compound of this invention is 2-[5-(O-isoureido)pentylamino]-5-(6-methyl-3-pyridyl-methyl)-4-pyrimidone.
    Type: Grant
    Filed: August 6, 1981
    Date of Patent: March 27, 1984
    Assignee: Smith Kline & French Laboratories Ltd.
    Inventors: Charon R. Ganellin, Robert J. Ife, David A. A. Owen
  • Isoureas and isothioureas
    Patent number: 4305945
    Abstract: The compounds are isoureas and isothioureas which have an O- or S- alkylpyrimidone substituent and which are histamine H.sub.2 -antagonists and antiinflammatory agents. A specific compound of this invention is 2-[5-(O-isoureido)pentylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone.
    Type: Grant
    Filed: July 10, 1979
    Date of Patent: December 15, 1981
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Charon R. Ganellin, Robert J. Ife, David A. A. Owen
  • Pyrimidine compounds
    Patent number: 4234588
    Abstract: The compounds are substituted pyrimidine compounds which are histamine H.sub.2 -antagonists. A specific compound of the present invention is 2-[2-(5-dimethylaminomethyl)-2-furylmethylthio)ethylamino]-5-(3-pyridylmet hyl)-4-pyrimidone.
    Type: Grant
    Filed: February 7, 1979
    Date of Patent: November 18, 1980
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Thomas H. Brown, Robert J. Ife
  • Triazinones
    Patent number: 4220767
    Abstract: The compounds are substituted 1,2,4-triazin-5-ones which are histamine H.sub.2 -antagonists. Two specific compounds of the present invention are 3-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-6-(3-methoxybenzyl)-1,2, 4-triazin-5-one and 3-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-6-(3-pyridylmethyl)-1,2, 4-triazin-5-one.
    Type: Grant
    Filed: June 20, 1979
    Date of Patent: September 2, 1980
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Thomas H. Brown, Robert J. Ife
  • Pharmacologically active compounds
    Patent number: RE30457
    Abstract: The compounds are substituted S-(aminoalkyl)-isothioureas which are histamine H.sub.2 -antagonists. Two specific compounds of the present invention are S-[6-(N'-methylthioureido)hexyl]isothiourea and S-[5-(N'-cyano-N"-methylguanidino)pentyl]isothiourea.
    Type: Grant
    Filed: August 10, 1978
    Date of Patent: December 23, 1980
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham J. Durant, Charon R. Ganellin, Robert J. Ife