Abstract: The present invention relates to novel glycomimetic compounds that are rationally designed to inhibit the binding of various pathogens to cell surface sialylated galactose and methods of use thereof. Specifically sialic acid glycosides and C-glycosides are disclosed that form a lactam ring structure or a cyclic ether/amine ring structure with the adjacent monosaccharide residue.

Abstract: An apparatus, system and method for providing health-care equipment in a plurality of customizable configurations. A configuration includes a selection and arrangement of health-care equipment modules that each provide specialized support for the provision of health care, including the measurement of physiological parameters. Various types of configurations include those adapted to be mounted upon a desk top or a wall surface, or adapted for wheel mounting or hand-carriable mobile configurations.

Abstract: A printed stretchable strain sensor comprises a seamless elastomeric body and a strain-sensitive conductive structure embedded in the seamless elastomeric body. The strain-sensitive conductive structure comprises one or more conductive filaments arranged in a continuous pattern. A method of printing a stretchable strain sensor comprises depositing one or more conductive filaments in a predetermined continuous pattern into or onto a support matrix. After the depositing, the support matrix is cured to embed a strain-sensitive conductive structure in a seamless elastomeric body.

Abstract: An Engine Start and Battery Support Module (or a vehicle is provided that utilizes a bank of Ultra Capacitors (UCs) charged with or without running the vehicle's alternator to levels that support both engine starting assistance and hotel load support. The UCs' per-cell charge can be adjured and raided during periods of low temperatures and even higher during ultralow temperatures. The adjustment, which can be dynamic and/or automatic, increases the UC energy storage capability. Further, the release of energy from the UCs is controlled by a pulse width modulation (PWM) controller based on the DC bus voltage. The UCs can be charged either from an onboard DC/DC converter, an AC hook up, or from smartly switching the banks of UCs between parallel and serial configurations.

Abstract: A multi-layer, super-planar laminate structure can be formed from distinctly patterned layers. The layers in the structure can include at least one rigid layer and at least one flexible layer; the rigid layer includes a plurality of rigid segments, and the flexible layer can extend between the rigid segments to serve as a joint. The layers are then stacked and bonded at selected locations to form a laminate structure with inter-layer bonds, and the laminate structure is flexed at the flexible layer between rigid segments to produce an expanded three-dimensional structure, wherein the layers are joined at the selected bonding locations and separated at other locations. A layer with electrical wiring can be included in the structure for delivering electric current to devices on or in the laminate structure.

Abstract: A device has a capacitive surface and a light source. A user of the device uses the capacitive surface to change the intensity of light emitted by the light source. To increase and decrease the intensity of the light emitted by the light source, the user touches the capacitive surface with one or more fingers.

Abstract: A light assembly for a hand-held medical diagnostic instrument. The light assembly includes a substrate having a top surface and a bottom surface, a light source mounted to the top surface, and the bottom surface having first and second electrical terminals. The light assembly further includes a circuit board disposed inclined to the substrate, the circuit board having first and second electrical terminals, a first connector mounting and electrically connecting the first electrical terminal of the substrate to the first electrical terminal of the circuit board, a second connector mounting and electrically connecting the second electrical terminal of the substrate to the second electrical terminal of the circuit board, a heat sink, and a thermal conductor thermally connecting at least one of the first and second electrical terminals of the substrate to the heat sink.

Abstract: A handheld device includes an electronic instrument and a capacitive power supply for storing and delivering power to the electronic instrument. The capacitive power supply includes at least one capacitor, and an electronic circuit operable to boost a voltage from the capacitor to a higher voltage for use by the electronic instrument. The capacitive power supply can be rapidly recharged. Some configurations include an accelerometer which permits the handheld device to detect movement and perform various operations responsive to detected movement. A dual charging station is also disclosed.

Abstract: A self-folding machine comprises a laminate including a flexible layer with a first side and a second side; a first rigid layer including at least one gap laminated to the first side of the flexible layer; a second rigid layer including at least one gap laminated to the second side of the flexible layer, wherein the rigid layers are more rigid than the flexible layer; a first contractible layer laminated to the first rigid layer and extending across at least one gap in the first rigid layer; and a second contractible layer laminated to the second rigid layer and extending across at least one gap in the second rigid layer, wherein the first and second contractible layers retract to respectively create folds in the machine across gaps in the first and second rigid layers when activated.

Abstract: A circuit for driving a plurality of capacitive actuators, the circuit having a low-voltage side, a high voltage side and a flyback transformer between the two. The low-voltage side comprises first and second pairs of low-side switches connected in series across an input voltage. The flyback transformer has a primary winding connected to the two pairs of switches. The high-voltage side has a pair of switches connected between the secondary winding of the flyback transformer and a ground and a plurality of capacitive loads and bidirectional switches to connect the loads to the secondary winding of the flyback transformer and a ground.

Abstract: A hyperelastic, soft microfluidic film measures bending curvature using a novel non-differential mechanism. Disclosed embodiments of the elastomer-based solution allows for curvature sensing directly on a bending plane and thus eliminates limitations imposed by strain gauge factor (GF) and sensor thickness (Z). Due to soft lithography microfabrication and design methods the disclosed curvature sensors are elastically soft (modulus 0.1-1 MPa) and stretchable (100-1000% strain). In contrast to existing curvature sensors that measure differential strain, embodiments of the present invention measures curvature directly and allows for arbitrary gauge factor and film thickness. Moreover, the sensor is composed entirely of soft elastomer (PDMS or Ecoflex® and conductive liquid (eutectic gallium indium, (eGaIn)) and thus remains functional even when stretched to several times its natural length.

Abstract: A pneumatically powered, fully untethered mobile soft robot is described. Composites consisting of silicone elastomer, polyaramid fabric, and hollow glass microspheres were used to fabricate a sufficiently large soft robot to carry the miniature air compressors, battery, valves, and controller needed for autonomous operation. Fabrication techniques were developed to mold a 0.65 meter long soft body with modified Pneumatic network actuators capable of operating at the elevated pressures (up to 138 kPa) required to actuate the legs of the robot and hold payloads of up to 8 kg. The soft robot is safe to handle, and its silicone body is innately resilient to a variety of adverse environmental conditions including snow, puddles of water, direct (albeit limited) exposure to flames, and the crushing force of being run over by an automobile.

Abstract: An apparatus, system and method for providing health-care equipment in a plurality of customizable configurations. A configuration includes a selection and arrangement of health-care equipment modules that each provide specialized support for the provision of health care, including the measurement of physiological parameters. Various types of configurations include those adapted to be mounted upon a desk top or a wall surface, or adapted for wheel mounting or hand-carriable mobile configurations.

Abstract: A light assembly for a hand-held medical diagnostic instrument. The light assembly includes a substrate having a top surface and a bottom surface, a light source mounted to the top surface, and the bottom surface having first and second electrical terminals. The light assembly further includes a circuit board disposed inclined to the substrate, the circuit board having first and second electrical terminals, a first connector mounting and electrically connecting the first electrical terminal of the substrate to the first electrical terminal of the circuit board, a second connector mounting and electrically connecting the second electrical terminal of the substrate to the second electrical terminal of the circuit board, a heat sink, and a thermal conductor thermally connecting at least one of the first and second electrical terminals of the substrate to the heat sink.

Abstract: A pneumatic artificial muscle (PAM) actuator body can be formed from an elastic material that includes an inflatable chamber and a restraining component, such as flexible, but inextensible fibers, that causes the actuator to contract when the chamber is inflated with fluid (e.g., air or water). The actuator body can be cylindrical or flat. The actuator body can include a sensor layer formed of an elastic material including a microchannel filled with a conductive fluid to sense the expansion of the actuator body. The sensor layer can be configured to expand when the actuator body is inflated causing the electrical resistance of the conductive fluid to change. A sensor layer between the actuator body and restraining component can be used to measure changes in the contraction force of the actuator and a sensor layer outside of the restraining component can be used to measure changes in the length of the actuator.

Abstract: A sensor including a layer having viscoelastic properties, the layer comprising a void, the void filled with a fluid; and optionally, a more rigid sensing element embedded within the layer. When a force is applied to a surface of the sensor, the shape of the void changes, causing the electrical resistance of the fluid in the void to change. When included, the more rigid sensing element can bear upon the void to cause the electrical resistance of the fluid in the void to change. A direction and intensity of the force can be determined by measuring the change of the electrical resistance of different voids positioned about the sensing element. The layer can be an elastomer, preferably silicone rubber. The fluid can be a conductive liquid, preferably Eutectic Gallium Indium. The sensing element can be plastic and can have a “Joystick” shape. The voids can take the form of channels or microchannels having a predefined pattern and/or shape.

Abstract: A handheld device includes an electronic instrument and a capacitive power supply for storing and delivering power to the electronic instrument. The capacitive power supply includes at least one capacitor, and an electronic circuit operable to boost a voltage from the capacitor to a higher voltage for use by the electronic instrument. The capacitive power supply can be rapidly recharged. Some configurations include an accelerometer which permits the handheld device to detect movement and perform various operations responsive to detected movement. A dual charging station is also disclosed.

Abstract: An apparatus, system and method for providing health-care equipment in a plurality of customizable configurations. A configuration includes a selection and arrangement of health-care equipment modules that each provide specialized support for the provision of health care, including the measurement of physiological parameters. Various types of configurations include those adapted to be mounted upon a desk top or a wall surface, or adapted for wheel mounting or hand-carriable mobile configurations.

Abstract: A handheld device includes a capacitance sensing variable control that detects the presence of and movement of a user's finger on an external surface of the device. The handheld device also includes a variable output power supply and an electronic device that is powered by the variable output power supply. Upon detection of the movement on the external surface of the device, the output of the variable output power supply is adjusted. The adjusted output changes the operation of the electronic device.

Abstract: A handheld device includes a capacitive storage device and energy storage cells. The capacitive storage device can be rapidly charged. The energy from the capacitive storage device is used to recharge the energy storage cells over a longer period of time.