Abstract: A launched zipline amusement ride has a carrier 200 carrying a rider 202. The carrier 200 is adapted to move along a tensioned, suspended cable 102. A launch mechanism 300 engages with the carrier 200 between an engagement and a release position 304 to accelerate the carrier 200 along the cable 102, and to disengage from the carrier 200 at the release position 304.

Abstract: A method of controlling an HVAC system comprising an air handling unit having at least one supply air fan or motorised supply air damper, the system comprising a plurality of VAV diffuser units, each VAV diffuser unit comprising a diffuser, a motorised variable damper to alter a diffuser airflow rate of a diffuser airflow delivered by the corresponding diffuser unit into the corresponding zone, and a diffuser pressure sensor for determining a pressure of the diffuser airflow; the system further comprising a plurality of zone temperature sensors; the method comprising determining a target thermal capacity for a selected diffuser unit with reference to a target diffuser airflow rate and a target diffuser temperature differential and controlling the motorised variable damper of the selected diffuser unit with reference to the determined target thermal capacity for the selected diffuser unit.

Abstract: Various implementations include headrest speakers and approaches for forming such headrest speakers. In certain implementations, a headrest speaker includes: an acoustic channel; a three-dimensional (3D) acoustically transparent mesh in the acoustic channel; and a foam retaining the acoustically transparent mesh in the acoustic channel.

Abstract: Catheter apparatuses and methods are provided for repairing heart valves, particularly mitral valves. The method includes providing a catheter having an elongate, flexible body, with a proximal end and a distal end. The distal end can be transluminally advanced from the left atrium through the mitral valve. A distal anchor zone or portion coupled with the proximal end can extend and along the left ventricular outflow tract into the ascending aorta. A valve repair device is deployed to permanently connect leaflets at a mid-section of a mitral valve while permitting medial and lateral portions of the natural leaflets to open and close. The catheter apparatuses may be positionable using a steering device. The valve repair device detachably connects the distal and proximal ends of the catheter. The valve repair device can be detached using low profile devices actuatable from the proximal or distal ends, e.g., at a venous or arterial access site.

Abstract: A portable, handheld system designed for anchoring and securing ladders, pump jack scaffolding, and walkways on pitched roofs or inclined surfaces. The invention includes three platform configurations, each with a variable pitch adjustment for leveling across multiple roof angles: (1) a ladder stop platform equipped with a 360-degree stop mechanism for multi-directional ladder stabilization; (2) a pump jack platform that provides a stable base for supporting pump jack systems and scaffolding; and (3) a walkway platform configured with parallel plank attachment bars and integrated guardrails for safe foot traffic. Each platform features anchor beds for secure attachment to structural elements like roof trusses and reinforced lateral rib members for uniform load distribution, enhancing structural integrity and load-bearing capacity across the system.

Abstract: An optical atomic clock can include a group of optical frequency references. A system for improving frequency stability in the clock output signal can use an optical combination of the group of optical frequency references. The system can include a first optical frequency reference comprising an output configured to generate a first optical signal; a second optical frequency reference comprising an output configured to generate a second optical signal; an optical frequency comparator configured to generate a first electrical feedback signal based on an optical combination of the first optical signal and the second optical signal; and an optical frequency comb, wherein the first optical frequency reference is configured to receive the first electrical feedback signal; and modify the first optical signal based on the first electrical feedback signal, wherein the optical frequency comb is configured to output a radio-frequency electrical signal based on the modified first optical signal.

Abstract: Electric vehicle supply equipment (EVSE) and related methods are provided. The EVSE can include a housing and charging cable. The EVSE can also include a charge coupler coupled to the charge cable and configured to supply power to an electric vehicle.

Abstract: Computer controlled systems and methods of an automated homecage monitoring system predict a state of an animal and of its homecage. The prediction of the state of the animal may be based on a pose estimate of the animal, and at least one sensor input from an at least one sensor. The pose estimate may include a graph of connected nodes, the nodes representing coordinates of the sensor input corresponding to predicted indicia on the animal's body. The animal state may include a behavioral state of an animal, a social state of an animal, a position state of an animal, a sleep state of an animal, and a biological state of an animal. The automated homecage monitoring system may allow for animal state data to be reported for an animal or animals in situ.

Abstract: A method is for providing a uniform resource locator. In an embodiment, the method includes receiving a medical data record via an interface, the medical data record being related to a patient; determining the uniform resource locater related to the medical data record via a computation unit, the uniform resource locator including an authorization token based on the medical data record, the medical data record being accessible by following the uniform resource locator; and providing the uniform resource locator with the interface to the patient. By providing a uniform resource locator of an embodiment including an authorization token, access to the medical data record can be granted fast and efficient, e.g. by a patient forwarding the uniform resource locator to another entity (e.g. a physician), while at the same time non-authorized entities cannot access the medical data record due to their lack of the suitable authorization token.

Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating cystic fibrosis, e.g., in subjects having a mutation resulting in F508del, are described.

Abstract: A dynamic, computerized, and Internet-assisted method for organizing recreational golfers in engaging in golf tournaments using a multitude of in-app options. The Golf-A-Day app utilizes a variety of unique, patentable options. This includes novel sports betting options (including “skins”), dynamic handicap changes, user score verification, and accountability checking. These features, and others, are designed to produce an outstanding recreational golf experience. The back-end structure and unique functional flow process can be used in all sport and recreational game options.

Abstract: The operations of a computer program include receiving login credentials from a person using a computing device during an active login attempt to gain access to a system resource. A user profile associated with the login credentials is identified, and data is obtained from a plurality of user data sources identified within the user profile, such as a user calendar, positioning system sensor, and/or biometric sensor. For each user data source, it is determined whether the obtained data supports a conclusion that the person attempting the login is the authorized user associated with the user profile. A set of authentication factors is selected as a function of the user data sources for which the obtained data does not support the person being the authorized user. The person may be granted access to the system resource upon receiving additional input from the person satisfying the selected set of authentication factors.

Abstract: Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.

Abstract: A method of repitching workpieces in an automated mass production system includes: (a) unloading a set of workpieces from a plurality of first retainers arranged at a first pitch, the unloading step including gripping of the workpieces by corresponding grippers of a repitch robot; (b) adjusting the workpieces from the first pitch to a second pitch different from the first pitch, the adjusting step including translating the grippers relative to each other from a first spacing corresponding to the first pitch to a second spacing corresponding to the second pitch; and (c) loading the workpieces into a plurality of corresponding second retainers arranged at the second pitch, the loading step including positioning and releasing the workpieces in the second retainers via the grippers.

Abstract: Processing O-rings in an automated mass production system includes advancing an O-ring retainer toward a loading position in alignment with an output end of a feed device, discharging a leading O-ring from the output end in electronic synchronization with advancement of the O-ring retainer to the loading position to initiate loading of the O-ring into the retainer prior to the retainer arriving at the loading position, after loading the O-ring into the retainer, advancing the retainer away from the loading position toward an unloading position, and moving an end effector in electronic synchronization with advancement of the retainer to the unloading position to synchronize arrival of the retainer at the unloading position with arrival of the end effector at a pick-up position in alignment with the O-ring at the unloading position for pick up of the O-ring by the end effector.