Abstract: Provided are methods and compositions for enhancing the transmucosal absorption of bioactive peptides and proteins. More particularly, the invention provides compositions for enhancing the transmucosal absorption of bioactive peptides and proteins, such as exendin-4, PYY, PYY3-36, and GLP-1 and their analogs and derivatives, wherein the compositions comprise an absorption enhancing mixture of a cationic polyamino acid, at least one additional absorption enhancing agent, and a buffer that is compatible with the polyamino acid. Also provided are methods for enhancing the transmucosal absorption and bioavailability of bioactive peptides and proteins using such compositions.

Abstract: A molding apparatus for making a continuous molded article generally includes a pair of spaced-apart molding assemblies, which cooperatively generate a movable mold having a dynamic mold-cavity therein, each of the molding assemblies including a series of movable mold segments, which are adapted to fit together to form a portion of the dynamic mold-cavity, a drive mechanism for conveying the mold segments along a path, and a dispenser for dispensing a moldable, expandable material into the dynamic mold-cavity.

Abstract: A molding apparatus for making a continuous molded article or continuous series of molded articles generally includes a pair of spaced-apart molding assemblies, which cooperatively generate a movable mold having a dynamic mold-cavity therein, each of the molding assemblies including a series of movable mold segments, which are adapted to fit together to form a portion of the dynamic mold-cavity, a drive mechanism for conveying the mold segments along a path, and a dispenser for dispensing a moldable, expandable material into the dynamic mold-cavity.

Abstract: Compounds of formula (I): wherein R2, W, A, Y, and R1 are as defined in the specification, and pharmaceutically acceptable salts thereof, are p38 MAPK inhibitors, and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.

Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof: wherein R2, W, A, Y and R1 are as defined in the specification, are p38 MAPK inhibitors, and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.

Abstract: Compounds of formula (I) described herein are p38 MAPK inhibitors and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract

Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof: wherein R2, W, A, Y and R1 are as defined in the specification, are p38 MAPK inhibitors, and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.

Abstract: Compounds of formula (I): wherein R2, W, A, Y, and R1 are as defined in the specification, and pharmaceutically acceptable salts thereof, are p38 MAPK inhibitors, and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.

Abstract: Carbon monoxide conversion processes are described for the conversion of carbon monoxide via hydrogenation to methanol. The process utilizes initial carbon monoxide priming before introduction of 3:1 hydrogen/carbon dioxide mixture to the reactor. After the optimum reaction conditions are established the feed of carbon monoxide may be withdrawn and any required carbon monoxide provided via reactor effluent recycle. The process provides for enhanced catalyst performance and life.

Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof: wherein R2, W, A, Y and R1 are as defined in the specification, are p38 MAPK inhibitors, and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.

Abstract: Carbon dioxide conversion processes are described for the conversion of carbon dioxide via hydrogenation to hydrocarbons. The process utilizes an initial feed of carbon monoxide and hydrogen converted under Fischer Tropsch conditions to hydrocarbons followed by subsequent displacement of the carbon monoxide in the reactor feed with carbon dioxide, which is then converted to carbon monoxide under reverse water gas shift conditions and the initial carbon monoxide feed being terminated once the reverse water gas shift conversion of carbon dioxide. After the optimum reaction conditions are established the feed of carbon monoxide may be withdrawn and any required carbon monoxide provided via reactor effluent recycle. The process provides for enhanced catalyst performance and life.

Abstract: Compounds of formula (I): wherein R2, W, A, Y, and R1 are as defined in the specification, and pharmaceutically acceptable salts thereof, are p38 MAPK inhibitors, and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.

Abstract: Described herein is an optical fuze for a guided missile that comprises an array of a large number of optical apertures distributed about the outer surface of the missile. An optical waveguide network selectively couples the array of apertures to a laser source and to a photodetector such that light from the laser source is emitted by selected ones of said apertures, and light returned from a target is received by selected ones of said apertures and directed by said optical waveguide network to said photodetector. These apertures might be arranged to form a composite target images in a particular direction, and/or may be arranged to perform a sensing operation along selected directions. The optical proximity fuze described herein provides inherent flexibility in the way the fuze can be configured in the missile for optimisation for different applications.

Abstract: Microparticles are prepared by a method that includes: (a) forming a layer comprising a first polymer on a solid surface by depositing a first composition one or more times on the solid surface, wherein the first composition comprises the first polymer and a first solvent, and evaporating the first solvent in the first composition; (b) forming one or more layers comprising a second polymer and a therapeutic agent by depositing a second composition on all or part of the layer formed in step (a), wherein the second composition comprises the second polymer, the therapeutic agent, and a second solvent; and evaporating the second solvent in the second composition; and (c) forming an additional layer comprising a third polymer by depositing a third composition one or more times on a previously formed layer, wherein the third composition comprises the third polymer and a third solvent; and evaporating the third solvent in the third composition.

Abstract: A molding apparatus for making a continuous molded article generally includes a pair of spaced-apart molding assemblies, which cooperatively generate a movable mold having a dynamic mold-cavity therein, each of the molding assemblies including a series of movable mold segments, which are adapted to fit together to form a portion of the dynamic mold-cavity, a drive mechanism for conveying the mold segments along a path, and a dispenser for dispensing a moldable, expandable material into the dynamic mold-cavity.

Abstract: A molding apparatus for making a continuous molded article or continuous series of molded articles generally includes a pair of spaced-apart molding assemblies, which cooperatively generate a movable mold having a dynamic mold-cavity therein, each of the molding assemblies including a series of movable mold segments, which are adapted to fit together to form a portion of the dynamic mold-cavity, a drive mechanism for conveying the mold segments along a path, and a dispenser for dispensing a moldable, expandable material into the dynamic mold-cavity.

Abstract: A target scene generator for testing an imaging ladar in a Hard Ware in the Loop arrangement, such as might be employed for testing an optical seeker on a guided missile, the generator comprising an array of pixel elements, a photodetector for detecting incident light from a ladar a laser source for generating pulses of light representing returned ladar pulses, and a reconfigurable fiber network including an optical switch selectively coupling the laser to the pixel elements, and a controller which selectively reconfigures the fiber network, to present to selected pixel elements the pulses of light with selected time delay characteristics such that light emitted from the pixels represent light returned from a target illuminated by the ladar.

Abstract: A method of detecting the direction of incidence of an incoming modulated continuous wave light signal in a field of view of a detector comprising introducing a phase shift into the modulated light signal received by at least one portion of the field of view relative to the modulated light signal received by at least one other portion of the field of view and utilising the phase shift in determining the direction of incidence.

Abstract: A stapler capable of dispensing staples therefrom and comprising a head and a handle. The head comprises a staple dispenser configured to dispense a staple from the stapler when a compressive force is applied to the staple dispenser, and a blade carriage that carries a blade and is configured such that the blade is extendable from the head of the stapler and is retractable into the head of the stapler. The handle is attached to the head, and permits the stapler to be swung like a hammer to drive staples dispensed from the staple dispenser.

Abstract: A method of creating a sensor network from a plurality of sensing devices that includes identifying a plurality of subsets of the sensing devices, each of the subsets providing a preferred (e.g., desired or specified) sensing quality coverage. Communication signal strengths of the sensing devices in the subsets are adjusted to seek to enable direct or indirect communication between active sensing devices in all of the plurality of subsets, thereby creating a sensor network.