Patents by Inventor Robert John Ife

Robert John Ife has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds
    Patent number: 9266841
    Abstract: Pyrimidone compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in treating atherosclerosis.
    Type: Grant
    Filed: October 24, 2014
    Date of Patent: February 23, 2016
    Assignee: Glaxo Group Limited
    Inventors: Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, Ivan Leo Pinto, Stephen Allan Smith, Steven James Stanway
  • NOVEL COMPOUNDS
    Publication number: 20150045375
    Abstract: Pyrimidone compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in treating atherosclerosis.
    Type: Application
    Filed: October 24, 2014
    Publication date: February 12, 2015
    Inventors: Deirdre Mary Bernadette HICKEY, Robert John IFE, Colin Andrew LEACH, Ivan Leo PINTO, Stephen Allan SMITH, Steven James STANWAY
  • Compounds
    Patent number: 8871775
    Abstract: Pyrimidone compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in treating atherosclerosis.
    Type: Grant
    Filed: December 2, 2011
    Date of Patent: October 28, 2014
    Assignee: Glaxo Group Limited
    Inventors: Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, Ivan Leo Pinto, Stephen Allan Smith, Steven James Stanway
  • NOVEL COMPOUNDS
    Publication number: 20120172378
    Abstract: Pyrimidone compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in treating atherosclerosis.
    Type: Application
    Filed: December 2, 2011
    Publication date: July 5, 2012
    Inventors: Deirdre Mary Bernadette HICKEY, Robert John Ife, Colin Andrew Leach, Ivan Leo Pinto, Stephen Allan Smith, Steven James Stanway
  • 5,6-TRIMETHYLENEPYRIMIDIN-4-ONE COMPOUNDS
    Publication number: 20100144765
    Abstract: Pyrimidone compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in treating atherosclerosis.
    Type: Application
    Filed: February 18, 2010
    Publication date: June 10, 2010
    Inventors: Deidre Mary Bernadette HICKEY, Robert John IFE, Colin Andrew LEACH, Ivan Leo PINTO, Stephen Allan SMITH, Steven James STANWAY
  • 5,6-trimethylenepyrimidin-4-one compounds
    Patent number: 7652019
    Abstract: Pyrimidone compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in treating atherosclerosis.
    Type: Grant
    Filed: January 6, 2009
    Date of Patent: January 26, 2010
    Assignee: SmithKline Beecham PLC
    Inventors: Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, Ivan Leo Pinto, Stephen Allan Smith, Steven James Stanway
  • Pyrimidine compounds
    Patent number: 7638520
    Abstract: Pyrimidone compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in treating atheroscelerosis.
    Type: Grant
    Filed: November 21, 2006
    Date of Patent: December 29, 2009
    Assignee: SmithKline Beecham, plc
    Inventors: Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, Ivan Leo Pinto, Stephen Allan Smith, Steven James Stanway
  • 5,6-Trimethylenepyrimidin-4-one compounds
    Publication number: 20090170877
    Abstract: Pyrimidone compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in treating atherosclerosis.
    Type: Application
    Filed: February 18, 2009
    Publication date: July 2, 2009
    Inventors: Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, Ivan Leo Pinto, Stephen Allan Smith, Steven James Stanway
  • Novel Compounds
    Publication number: 20090118313
    Abstract: Pyrimidone compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in treating atherosclerosis.
    Type: Application
    Filed: January 6, 2009
    Publication date: May 7, 2009
    Inventors: Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, Ivan Leo Pinto, Stephen Allan Smith, Steven James Stanway
  • Pyridinone derivatives for treatment of atherosclerosis
    Patent number: 7235566
    Abstract: Compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in therapy, in particular for treating atherosclerosis.
    Type: Grant
    Filed: July 28, 2004
    Date of Patent: June 26, 2007
    Assignee: Smithkline Beecham p.l.c.
    Inventors: Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, John Liddle, Ivan Leo Pinto, Stephen Allan Smith, Steven James Stanway
  • Pyrimidinone derivatives and their use in the treatment of atherosclerosis
    Patent number: 7169924
    Abstract: Compound of formula (I): are disclosed in which: R1 is an aryl group, optionally substituted by 1, 2, 3 or 4 substituents which may be the same or different selected from C(1-6)alkyl, C(1-6)alkoxy, C(1-6)alkylthio, hydroxy, halogen, CN, and mono to perfluoro-C(1-4)alkyl; R2 is halogen, C(1-3)alkyl, C(1-3)alkoxy, hydroxyC(1-3)alkyl, C(1-3)alkylthio, C(1-3)alkylsulphinyl, aminoC(1-3)alkyl, mono- or di-C(1-3)alkylaminoC(1-3)alkyl, C(1-3)alkylcarbonylaminoC(1-3)alkyl, C(1-3)alkoxyC(1-3)alkylcarbonylaminoC(1-3)alkyl, C(1-3)alkylsulphonylaminoC(1-3)alkyl, C(1-3)alkylcarboxy, C(1-3)alkylcarboxyC(1-3)alkyl, and R3 is hydrogen, halogen, C(1-3)alkyl, or hydroxyC(1-3)alkcyl; or R2 and R3 together with the pyrimidone ring carbon atoms to which they are attached form a fused 5-or 6-membered carbocyclic ring; or R2 and R3 together with the pyrimidone ring carbon atoms to which they are attached form a fused benzo or heteroaryl ring ring optionally substituted by 1, 2, 3 or 4 substituents which may be the same or dif
    Type: Grant
    Filed: October 5, 2001
    Date of Patent: January 30, 2007
    Assignee: SmithKline Beecham plc
    Inventors: Richard Leonard Elliott, Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, Ivan Leo Pinto, Stephen Allan Smith
  • Pyrimidinone compounds
    Patent number: 7115616
    Abstract: Pyrimidinone compounds of formula (10 are inhibitors of the enzyme Lp-PLA2 and of use in therapy, in particular for treating atherosclerosis.
    Type: Grant
    Filed: February 11, 2004
    Date of Patent: October 3, 2006
    Assignee: SmithKline Beecham Plc
    Inventors: Ashley Edward Fenwick, Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, Ivan Leo Pinto, Stephen Allan Smith
  • ?-substituted ?-aminoethyl phosphonate derivatives
    Patent number: 6872711
    Abstract: The present invention relates to novel ?-substituted-?-aminoethylphosphonate derivatives and their uses for lowering plasma levels of apo (a), Lp(a), apo B, apo B associated lipoproteins (low density lipoproteins and very low density lipoproteins) and for lowering plasma levels of total cholesterol.
    Type: Grant
    Filed: October 22, 2001
    Date of Patent: March 29, 2005
    Assignee: Ilex Oncology Research S.A.
    Inventors: Hieu Trung Phan, Lan Mong Nguyen, Vinh Van Diep, Raymond Azoulay, Eric Joseph Niesor, Craig Leigh Bentzen, Robert John Ife
  • Pyrimidinone compounds
    Publication number: 20040167142
    Abstract: Pyrimidinone compounds of formula (I) are inhibitors of the enzyme Lp-PLA2 and of use in therapy, in particular for treating atherosclerosis.
    Type: Application
    Filed: February 11, 2004
    Publication date: August 26, 2004
    Applicant: SmithKline Beecham p.l.c.
    Inventors: Ashley Edward Fenwick, Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, Ivan Leo Pinto, Stephen Allan Smith
  • Novel Compounds
    Publication number: 20040097525
    Abstract: Pyrimidone compounds of formula (I): 1
    Type: Application
    Filed: October 27, 2003
    Publication date: May 20, 2004
    Applicant: SmithKline Beecham plc
    Inventors: Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, Ivan Leo Pinto, Stephen Allan Smith, Steven James Stanway
  • Method and compounds
    Patent number: 6719520
    Abstract: A method for the treatment of conditions associated with a need for inhibition of GSK-3, such as diabetes, dementias such as Alzheimer's disease and manic depression which method comprises the administration of a pharmaceutically effective, non-toxic amount of a compound of formula (I): or a pharmaceutically acceptable derivative thereof, wherein: R is hydrogen, alkyl, aryl, or aralkyl; R1 is hydrogen, alkyl, aralkyl, hydroxyalkyl or alkoxyalkyl; R2 is substituted or unsubstituted aryl or substituted or unsubstituted heterocyclyl; R3 is hydrogen, substituted or unsubstituted alkyl, cycloalkyl, alkoxyalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl or aralkyl wherein the aryl moiety is substituted or unsubstituted; or, R1 and R3 together with the nitrogen to which they are attached form a single or fused, optionally substituted, saturated or unsaturated heterocylic ring; to a human or non-human mammal in need thereof, and compounds of formula I.
    Type: Grant
    Filed: May 28, 2003
    Date of Patent: April 13, 2004
    Assignee: SmithKline Beecham Corporation
    Inventors: Matthew Paul Coghlan, Ashley Edward Fenwick, David Haigh, Julie Caroline Holder, Robert John Ife, Alastair David Reith, David Glynn Smith, Robert William Ward
  • Pyridinone derivatives for treatment of atherosclerosis
    Publication number: 20040063753
    Abstract: Compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in therapy, in particular for treating atherosclerosis.
    Type: Application
    Filed: September 9, 2003
    Publication date: April 1, 2004
    Inventors: Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, John Liddle, Ivan Leo Pinto, Stephen Allan Smith, Steven James Stanway
  • Pyrimidinone derivatives and their use in the treatment of atherosclerosis
    Publication number: 20040058941
    Abstract: Compounds of formula (I) are inhibitors of the enzyme Lp-PLA2 and are of use in therapy, in particular for treating athereosclerosis.
    Type: Application
    Filed: September 2, 2003
    Publication date: March 25, 2004
    Inventors: Richard Leonard Elliott, Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, Ivan Leo Pinto, Stephen Allan Smith
  • &agr;-Substituted &bgr;-aminoethyl phosphonate derivatives
    Patent number: 6706698
    Abstract: The present invention relates to novel &agr;-substituted-&bgr;-aminoethylphosphonate and &agr;-substituted-&bgr;-aminovinylphosphonate derivatives and their uses for lowering plasma levels of apo (a), Lp(a), apo B, apo B associated lipoproteins (low density lipoproteins and very low density lipoproteins) and for lowering plasma levels of total cholesterol.
    Type: Grant
    Filed: September 26, 2001
    Date of Patent: March 16, 2004
    Assignee: Ilex Products, Inc.
    Inventors: Hieu Trung Phan, Lan Mong Nguyen, Vinh Van Diep, Raymond Azoulay, Harald Eschenhof, Eric Joseph Niesor, Craig Leigh Bentzen, Robert John Ife
  • Novel method and compounds
    Publication number: 20040010031
    Abstract: A method for the treatment of conditions associated with a need for inhibition of GSK-3, such as diabetes, dementias such as Alzheimer's disease and manic depression which method comprises the administration of a pharmaceutically effective, non-toxic amount of a compound of formula (I): 1
    Type: Application
    Filed: May 28, 2003
    Publication date: January 15, 2004
    Applicant: SmithKline Beecham p.l.c.
    Inventors: Matthew Paul Coghlan, Ashley Edward Fenwick, David Haigh, Julie Caroline Holder, Robert John Ife, Alastair David Reith, David Glynn Smith, Robert William Ward