Patents by Inventor Robert John Ife

Robert John Ife has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds and pharmaceutical compositions containing them
    Patent number: 6660724
    Abstract: Aminophosphonates alpha substituted by phenol groups of formula (I) have lipoprotein(a) lowering activity.
    Type: Grant
    Filed: April 3, 2000
    Date of Patent: December 9, 2003
    Assignee: Ilex Products, Inc.
    Inventors: Lan Mong Nguyen, Eric Niesor, Craig Leigh Bentzen, Hieu Trung Phan, Vinh Van Diep, Simon Floret, Raymond Azoulay, Alexandre Bulla, Yves Guyon-Gellin, Robert John Ife
  • Compounds
    Patent number: 6649619
    Abstract: Pyrimidone compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in treating atheroscelerosis.
    Type: Grant
    Filed: February 3, 2003
    Date of Patent: November 18, 2003
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, Ivan Leo Pinto, Stephen Allan Smith, Steven James Stanway
  • Alpha-substituted beta-aminoethyl phosphonate derivatives
    Publication number: 20030114421
    Abstract: The present invention relates to novel &agr;-substituted-&bgr;-aminoethylphosphonate and &agr;-substituted-&bgr;-aminovinylphosphonate derivatives and their uses for lowering plasma levels of apo (a), Lp(a), apo B, apo B associated lipoproteins (low density lipoproteins and very low density lipoproteins) and for lowering plasma levels of total cholesterol.
    Type: Application
    Filed: September 4, 2002
    Publication date: June 19, 2003
    Inventors: Hieu Trung Phan, Lan Mong Nguyen, Vinh Van Diep, Raymond Azoulay, Harald Eschenhof, Eric Joseph Niesor, Craig Leigh Bentzen, Robert John Ife
  • Pyrimidinone compounds and pharmaceutical compositions containing them
    Publication number: 20020120139
    Abstract: A group of novel pyrimidone compounds are inhibitors of the enzyme LDL PLA2 and therefore of use in treating atherosclerosis.
    Type: Application
    Filed: April 2, 2002
    Publication date: August 29, 2002
    Inventors: Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, Ivan Leo Pinto, Roderick Alan Porter, Stephen Allan Smith
  • Alpha-substituted beta-aminoethyl phosphonate derivatives
    Publication number: 20020111332
    Abstract: The present invention relates to novel &agr;-substituted-&bgr;-aminoethylphosphonate and &agr;-substituted-&bgr;-aminovinylphosphonate derivatives and their uses for lowering plasma levels of apo (a), Lp(a), apo B, apo B associated lipoproteins (low density lipoproteins and very low density lipoproteins) and for lowering plasma levels of total cholesterol.
    Type: Application
    Filed: September 26, 2001
    Publication date: August 15, 2002
    Inventors: Hieu Trung Phan, Lan Mong Nguyen, Vinh Van Diep, Raymond Azoulay, Harald Eschenhof, Eric Joseph Niesor, Craig Leigh Bentzen, Robert John Ife
  • Beta-substitued beta-aminoethyl phosphonate derivatives
    Publication number: 20020111488
    Abstract: The present invention relates to novel &bgr;-substituted-&bgr;-aminoethylphosphonate derivatives and their uses for lowering plasma levels of apo (a), Lp(a), apo B, apo B associated lipoproteins (low density lipoproteins and very low density lipoproteins) and for lowering plasma levels of total cholesterol.
    Type: Application
    Filed: October 22, 2001
    Publication date: August 15, 2002
    Inventors: Hieu Trung Phan, Lan Mong Nguyen, Vinh Van Diep, Raymond Azoulay, Eric Joseph Niesor, Craig Leigh Bentzen, Robert John Ife
  • Novel compounds
    Publication number: 20020103213
    Abstract: Pyrimidone compounds of formula (I): 1
    Type: Application
    Filed: February 14, 2001
    Publication date: August 1, 2002
    Inventors: Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, Ivan Leo Pinto, Stephen Allan Smith, Steven James Stanway
  • Pyrimidinone compounds and pharmaceutical compositions containing them
    Patent number: 6417192
    Abstract: A group of novel pyrimidone compounds are inhibitors of the enzyme LDL PLA2 and therefore of use in treating atherosclerosis.
    Type: Grant
    Filed: June 28, 2000
    Date of Patent: July 9, 2002
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Deirdre Mary Bernadette Hickey, Robert John Ife, Colin Andrew Leach, Ivan Leo Pinto, Roderick Alan Porter, Stephen Allan Smith
  • Pharmaceutical aminophosphonic acid derivatives
    Publication number: 20020082423
    Abstract: Aminophosphonates alpha substituted by phenol groups, of formula (I) have lipoprotein(a) lowering activity.
    Type: Application
    Filed: September 4, 2001
    Publication date: June 27, 2002
    Applicant: SmithKline Beecham p.l.c. and Symphar
    Inventors: Lan Mong Nguyen, Hieu Trung Phan, Vinh Van Diep, Simon Floret, Raymond Azoulay, Eric Niesor, Craig Leigh Bentzen, Robert John Ife
  • Pharmaceutical aminophosphonic acid derivatives
    Patent number: 6303784
    Abstract: Aminophosphonates alpha substituted by phenol groups, of formula (I) have lipoprotein(a) lowering activity.
    Type: Grant
    Filed: June 18, 1999
    Date of Patent: October 16, 2001
    Assignees: SmithKline Beecham p.l.c., Symphar SA
    Inventors: Lan Mong Nguyen, Hieu Trung Phan, Vinh Van Diep, Simon Floret, Raymond Azoulay, Eric Niesor, Craig Leigh Bentzen, Robert John Ife
  • Azetidinone derivatives for the treatment of atherosclerosis
    Patent number: 6071899
    Abstract: Azetidinone derivatives of formula (I) in which R.sup.1 and R.sup.2, which may be the same or different, is each selected from hydrogen or C.sub.(1-8) alkyl; R.sup.3 is C.sub.(1-8) alkyl or C.sub.(3-8) cycloalkyl each of which may be optionally substituted; X is a linker group; Y is an aryl group; and n is 0, 1 or 2; and excluding benzyl (4-methylthio-2-oxo-azetidin-1-yl)acetate are inhibitors of the enzyme Lp PLA2 and are of use in therapy, in particular treating atherosclerosis.
    Type: Grant
    Filed: September 30, 1997
    Date of Patent: June 6, 2000
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Deirdre Mary Bernadette Hickey, Dashyant Dhanak, Colin Andrew Leach, Robert John Ife, David Graham Tew
  • Compounds and pharmaceutical compositions containing them
    Patent number: 6060464
    Abstract: Aminophosphonates alpha substituted by phenol groups of formula (I) have lipoprotein(a) lowering activity.
    Type: Grant
    Filed: April 3, 1998
    Date of Patent: May 9, 2000
    Assignees: SmithKline Beecham p.l.c., Symphar SA
    Inventors: Lan Mong Nguyen, Eric Niesor, Craig Leigh Bentzen, Hieu Trung Phan, Vinh Van Diep, Simon Floret, Raymond Azoulay, Alexandre Bulla, Yves Guyon-Gellin, Robert John Ife
  • Substituted azetidin-2-ones for treatment of atherosclerosis
    Patent number: 5990102
    Abstract: Compounds of formula (I) in which R.sup.1 and R.sup.2, which may be the same or different, is each selected from hydrogen, halogen or C.sub.(1-8) alkyl; R.sup.3 is aryl or aryl C.sub.(1-4) alkyl which may be optionally substituted; X is a linker group; Y is an optionally substituted aryl group; and n is 0, 1 or 2; are inhibitors of the enzyme Lp-PLA.sub.2 and thereof of use in treating atherosclerosis.
    Type: Grant
    Filed: November 21, 1997
    Date of Patent: November 23, 1999
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Deirdre Mary Bernadette Hickey, Dashyant Dhanak, Colin Andrew Leach, Robert John Ife, David Graham Tew
  • Imidazolylmethylthio-ethyl isothiourea compounds
    Patent number: 4120972
    Abstract: The compounds are dithiocarbamates and isothioureas which are histamine H.sub.2 -antagonists. Two compounds of the invention are 2-(5-methyl-4-imidazolylmethylthio)ethyl N-methyldithiocarbamate and S-[2-(5-methyl-4-imidazolylmethylthio)ethyl]-N-cyano-N'-methylisothiourea.
    Type: Grant
    Filed: August 11, 1977
    Date of Patent: October 17, 1978
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Thomas Henry Brown, Graham John Durant, Charon Robin Ganellin, Robert John Ife
  • Heterocyclic-methylthioethyl-dithiocarbamates and isothioureas
    Patent number: 4120966
    Abstract: The compounds are dithiocarbamates and isothioureas which are histamine H.sub.2 -anatagonists. Two compounds of the invention are 2-(5-methyl-4-imidazolylmethylthio)ethyl N-methyldithiocarbamate and S-[2-(5-methyl-4-imidazolyl-methylthio)ethyl]-N-cyano-N'-methylisothiourea .
    Type: Grant
    Filed: August 11, 1977
    Date of Patent: October 17, 1978
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Thomas Henry Brown, Graham John Durant, Charon Robin Ganellin, Robert John Ife
  • Pharmacologically active compounds
    Patent number: 4084001
    Abstract: The compounds are substituted S-(aminoalkyl)isothioureas which are histamine H.sub.2 -antagonists. Two specific compounds of the present invention are S-[6-(N'-methylthioureido)hexyl]isothiourea and S-[5-(N'-cyano-N"-methylguanidino)pentyl]isothiourea.
    Type: Grant
    Filed: November 23, 1976
    Date of Patent: April 11, 1978
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, Charon Robin Ganellin, Robert John Ife
  • Imidazolylmethylthioethyl dithiocarbamate compounds
    Patent number: 4056621
    Abstract: The compounds are dithiocarbamates and isothioureas which are histamine H.sub.2 -antagonists. Two compounds of the invention are 2-(5-methyl-4-imidazolylmethylthio)ethyl N-methyldithiocarbamate and S-[2-(5-methyl-4-imidazolyl-methylthio)ethyl]-N-cyano-N'-methylisothiourea .
    Type: Grant
    Filed: January 27, 1976
    Date of Patent: November 1, 1977
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Thomas Henry Brown, Graham John Durant, Charon Robin Ganellin, Robert John Ife