Patents by Inventor Robert Leanna
Robert Leanna has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240115724Abstract: The invention relates generally to conjugated activatable antibodies that bind CD71 in their active form and methods of making and using these anti-CD71 conjugated activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.Type: ApplicationFiled: May 19, 2023Publication date: April 11, 2024Inventors: Shweta SINGH, Jennifer Hope RICHARDSON, Laura Patterson SERWER, Jonathan Alexander TERRETT, Susan E. MORGAN-LAPPE, Tracy HENRIQUES, Sherry L. RALSTON, Marvin Robert LEANNA, Ilaria BADAGNANI
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Publication number: 20210145978Abstract: The invention relates generally to conjugated activatable antibodies that bind CD71 in their active form and methods of making and using these anti-CD71 conjugated activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.Type: ApplicationFiled: November 25, 2020Publication date: May 20, 2021Inventors: Shweta Singh, Jennifer Hope Richardson, Laura Patterson Serwer, Jonathan Alexander Terret, Susan E. Morgan-Lappe, Tracy Henriques, Sherry L. Ralston, Marvin Robert Leanna, Ilari Badagnani, Sahana Bose
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Publication number: 20190262417Abstract: The invention provides methods for obtaining compositions having antibody drug conjugates (ADCs) with specified drug to antibody ratios (DARs). Included in the invention is a method for purifying an ADC mixture having ADCs with a drug loaded species of 6 or more by contacting the mixture with a hydrophobic resin such that a composition comprising less than 15% of the 6 or more drug loaded species is obtained. The invention also provides a composition wherein 70% or more of the ADCs present have a drug loaded species of 4 or less, wherein the ADC comprises an anti-EGFR antibody and an auristatin.Type: ApplicationFiled: February 11, 2019Publication date: August 29, 2019Inventors: Marvin Robert Leanna, Calvin Lawrence Becker
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Publication number: 20190111150Abstract: The invention relates generally to conjugated activatable antibodies that bind CD71 in their active form and methods of making and using these anti-CD71 conjugated activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.Type: ApplicationFiled: October 12, 2018Publication date: April 18, 2019Inventors: Shweta SINGH, Jennifer Hope RICHARDSON, Laura Patterson SERWER, Jonathan Alexander TERRETT, Susan E. MORGAN-LAPPE, Tracy HENRIQUES, Sherry L. RALSTON, Marvin Robert LEANNA, Ilaria BADAGNANI, Sahana BOSE
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Publication number: 20140286968Abstract: The invention provides methods for obtaining compositions having antibody drug conjugates (ADCs) with specified drug to antibody ratios (DARs). Included in the invention is a method for purifying an ADC mixture having ADCs with a drug loaded species of 6 or more by contacting the mixture with a hydrophobic resin such that a composition comprising less than 15% of the 6 or more drug loaded species is obtained. The invention also provides a composition wherein 70% or more of the ADCs present have a drug loaded species of 4 or less, wherein the ADC comprises an anti-EGFR antibody and an auristatin.Type: ApplicationFiled: March 14, 2014Publication date: September 25, 2014Inventors: Marvin Robert Leanna, Calvin Lawrence Becker
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Patent number: 8124129Abstract: There is provided a hemihydrate of (3?,5?,7?,12?)-7,12-dihydroxy-3-{2-[{4-[17?-hydroxy-3-oxo-17?-prop-1-ynylestra-4,9-dien-11?-yl]phenyl}(methyl)amino]ethoxy}cholan-24-oic acid in a crystalline form which is characterised by an X-ray diffraction pattern having major peaks at 2?=6.58±0.2, 8.54+0.2, 12.28±0.2, and 19.68±0.2. This crystalline material is useful in the treatment of conditions associated with an excess of hepatic glucocorticoid response.Type: GrantFiled: July 12, 2006Date of Patent: February 28, 2012Assignee: Karo Bio ABInventors: Russell Drew Cink, Daozhong Zou, Marvin Robert Leanna, Pascal H. Toma, Michelle Andrée Long
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Publication number: 20120028908Abstract: A process for preparing a crystalline rapamycin analog includes: combining the rapamycin analog with an organic medium to form a mixture; incubating the mixture until the rapamycin analog crystallizes; and recovering the crystalline rapamycin analog. The organic medium can be a solvent, and the process can include causing the rapamycin analog to dissolve into the solvent, and incubating the solvent until the rapamycin analog crystallizes. The following can also be performed: forming a slurry of crystalline rapamycin analog; stirring the rapamycin analog mixture until the rapamycin analog crystallizes; saturating the rapamycin analog solution; forming a supersaturated rapamycin analog solution; combining an antisolvent with the rapamycin analog and the solvent to form a biphasic mixture, and incubating the biphasic mixture to cause a liquid-liquid phase split.Type: ApplicationFiled: October 1, 2011Publication date: February 2, 2012Applicant: Abbott LaboratoriesInventors: Shekhar VISWANATH, Larry Bartelt, Robert Leanna, Michael Rasmussen, Madhup Dhaon, Rodger Henry, Thomas Borchardt, Shuang Chen, Geoff Zhang
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Patent number: 8034926Abstract: A process for preparing a crystalline rapamycin analog includes: combining the rapamycin analog with an organic medium to form a mixture; incubating the mixture until the rapamycin analog crystallizes; and recovering the crystalline rapamycin analog. The organic medium can be a solvent, and the process can include causing the rapamycin analog to dissolve into the solvent, and incubating the solvent until the rapamycin analog crystallizes. The following can also be performed: forming a slurry of crystalline rapamycin analog; stirring the rapamycin analog mixture until the rapamycin analog crystallizes; saturating the rapamycin analog solution; forming a supersaturated rapamycin analog solution; combining an antisolvent with the rapamycin analog and the solvent to form a biphasic mixture, and incubating the biphasic mixture to cause a liquid-liquid phase split.Type: GrantFiled: September 20, 2010Date of Patent: October 11, 2011Assignee: Abbott LaboratoriesInventors: Shekhar Viswanath, Larry Bartelt, Robert Leanna, Michael Rasmussen, Madhup Dhaon, Rodger Henry, Thomas Borchardt, Shuang Chen, Geoff Zhang
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Patent number: 8030326Abstract: Provided is a rapamycin analog composition including a crystalline form of a rapamycin analog. The crystal can be a hydrate. dehydrate, solvate, or desolvate.Type: GrantFiled: September 20, 2010Date of Patent: October 4, 2011Assignee: Abbott LaboratoriesInventors: Shekhar Viswanath, Larry Bartelt, Robert Leanna, Michael Rasmussen, Madhup Dhaon, Rodger Henry, Thomas Borchardt, Shuang Chen, Geoff Zhang
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Publication number: 20110009325Abstract: Provided is a rapamycin analog composition including a crystalline form of a rapamycin analog. The crystal can be a hydrate. dehydrate, solvate, or desolvate.Type: ApplicationFiled: September 20, 2010Publication date: January 13, 2011Applicant: Abbott LaboratoriesInventors: SHEKHAR VISWANATH, Larry Bartelt, Robert Leanna, Michael Rasmussen, Madhup Dhaon, Rodger Henry, Thomas Borchardt, Shuang Chen, Geoff Zhang
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Publication number: 20110009618Abstract: A process for preparing a crystalline rapamycin analog includes: combining the rapamycin analog with an organic medium to form a mixture; incubating the mixture until the rapamycin analog crystallizes; and recovering the crystalline rapamycin analog. The organic medium can be a solvent, and the process can include causing the rapamycin analog to dissolve into the solvent, and incubating the solvent until the rapamycin analog crystallizes. The following can also be performed: forming a slurry of crystalline rapamycin analog; stirring the rapamycin analog mixture until the rapamycin analog crystallizes; saturating the rapamycin analog solution; forming a supersaturated rapamycin analog solution; combining an antisolvent with the rapamycin analog and the solvent to form a biphasic mixture, and incubating the biphasic mixture to cause a liquid-liquid phase split.Type: ApplicationFiled: September 20, 2010Publication date: January 13, 2011Applicant: Abbott LaboratoriesInventors: Shekhar Viswanath, Larry Bartelt, Robert Leanna, Michael Rasmussen, Madhup Dhaon, Rodger Henry, Thomas Borchardt, Shuang Chen, Geoff Zhang
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Patent number: 7820812Abstract: A process for preparing a crystalline rapamycin analog includes: combining the rapamycin analog with an organic medium to form a mixture; incubating the mixture until the rapamycin analog crystallizes; and recovering the crystalline rapamycin analog. The organic medium can be a solvent, and the process can include causing the rapamycin analog to dissolve into the solvent, and incubating the solvent until the rapamycin analog crystallizes. The following can also be performed: forming a slurry of crystalline rapamycin analog; stirring the rapamycin analog mixture until the rapamycin analog crystallizes; saturating the rapamycin analog solution; forming a supersaturated rapamycin analog solution; combining an antisolvent with the rapamycin analog and the solvent to form a biphasic mixture, and incubating the biphasic mixture to cause a liquid-liquid phase split.Type: GrantFiled: July 23, 2007Date of Patent: October 26, 2010Assignee: Abbott LaboratoriesInventors: Shekhar Viswanath, Larry Bartelt, Robert Leanna, Michael Rasmussen, Madhup Dhaon, Rodger Henry, Thomas Borchardt, Shuang Chen, Geoff Zhang
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Patent number: 7812032Abstract: A rapamycin analog composition includes a crystalline form of a rapamycin analog. The crystal can be a hydrate, dehydrate, solvate, or desolvate.Type: GrantFiled: July 23, 2007Date of Patent: October 12, 2010Assignee: Abbott LaboratoriesInventors: Shekhar Viswanath, Larry Bartelt, Robert Leanna, Michael Rasmussen, Madhup Dhaon, Rodger Henry, Thomas Borchardt, Shuang Chen, Geoff Zhang
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Publication number: 20090176754Abstract: There is provided a hemihydrate of (3?, 5?, 7?, 12?)-7,12-dihydroxy-3-{2-[{4-[17?-hydroxy-3-oxo-17?-prop-1-ynylestra-4,9-dien-11?-yl]phenyl}(methyl)amino]ethoxy}cholan-24-oic acid in a crystalline form which is characterised by an X-ray diffraction pattern having major peaks at 2?=6.58±0.2, 8.54+0.2, 12.28±0.2, and 19.68±0.2. This crystalline material is useful in the treatment of conditions associated with an excess of hepatic glucocorticoid response.Type: ApplicationFiled: July 12, 2006Publication date: July 9, 2009Inventors: Russell Drew Cink, Daozhong Zou, Marvin Robert Leanna, Pascal H. Toma, Michelle Andree Long
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Patent number: 7538105Abstract: Compounds having the formula are hepatitis C(HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C(HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.Type: GrantFiled: April 4, 2008Date of Patent: May 26, 2009Assignee: Abbott LaboratoriesInventors: Douglas K. Hutchinson, John R. Bellettini, David A. Betebenner, Richard D. Bishop, Thomas B. Borchardt, Todd D. Bosse, Russell D. Cink, Charles A. Flentge, Bradley D. Gates, Brian E. Green, Mira M. Hinman, Peggy P. Huang, Larry L. Klein, Allan C. Krueger, Daniel P. Larson, M. Robert Leanna, Dachun Liu, Darold L. Madigan, Keith F. McDaniel, John T. Randolph, Todd W. Rockway, Teresa A. Rosenberg, Kent D. Stewart, Vincent S. Stoll, Rolf Wagner, Ming C. Yeung
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Patent number: 7521439Abstract: This invention relates to novel compounds that are liver selective glucocorticoid receptor antagonists, to methods of preparing such compounds, and to methods for using such compounds in the regulation of metabolism, especially lowering serum glucose levels, insulin levels, or lipid levels, and/or decreasing body weight.Type: GrantFiled: July 21, 2006Date of Patent: April 21, 2009Assignee: Karo Bio ABInventors: Richard D. Bishop, Russell Drew Cink, Bradley D. Gates, Lars T. Hagberg, Peer B. Jacobsen, Philip R. Kym, Chunqiu Lai, Marvin Robert Leanna, James T. Link, Steven J. Richards, Noah Tu, Tom W. von Geldern
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Publication number: 20080193413Abstract: Compounds having the formula are hepatitis C(HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C(HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.Type: ApplicationFiled: April 4, 2008Publication date: August 14, 2008Applicant: ABBOTT LABORATORIESInventors: Douglas K. Hutchinson, John R. Bellettini, David A. Betebenner, Richard D. Bishop, Thomas B. Borchardt, Todd D. Bosse, Russell D. Cink, Charles A. Flentge, Bradley D. Gates, Brian E. Green, Mira M. Hinman, Peggy P. Huang, Larry L. Klein, Allan C. Krueger, Daniel P. Larson, M. Robert Leanna, Dachun Liu, Darold L. Madigan, Keith F. McDaniel, John T. Randolph, Todd W. Rockway, Teresa A. Rosenberg, Kent D. Stewart, Vincent S. Stoll, Rolf Wagner, Ming C. Yeung
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Patent number: 7378414Abstract: Compounds having the formula are hepatitis C (HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C (HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.Type: GrantFiled: August 24, 2004Date of Patent: May 27, 2008Assignee: Abbott LaboratoriesInventors: Douglas K. Hutchinson, John R. Bellettini, David A. Betebenner, Richard D. Bishop, Thomas B. Borchardt, Todd D. Bosse, Russell D. Cink, Charles A. Flentge, Bradley D. Gates, Brian E. Green, Mira M. Hinman, Peggy P. Huang, Larry L. Klein, Allan C. Krueger, Daniel P. Larson, M. Robert Leanna, Dachun Liu, Darold L. Madigan, Keith F. McDaniel, John T. Randolph, Todd W. Rockway, Teresa A. Rosenberg, Kent D. Stewart, Vincent S. Stoll, Rolf Wagner, Ming C. Yeung
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Publication number: 20080091008Abstract: A process for preparing a crystalline rapamycin analog includes: combining the rapamycin analog with an organic medium to form a mixture; incubating the mixture until the rapamycin analog crystallizes; and recovering the crystalline rapamycin analog. The organic medium can be a solvent, and the process can include causing the rapamycin analog to dissolve into the solvent, and incubating the solvent until the rapamycin analog crystallizes. The following can also be performed: forming a slurry of crystalline rapamycin analog; stirring the rapamycin analog mixture until the rapamycin analog crystallizes; saturating the rapamycin analog solution; forming a supersaturated rapamycin analog solution; combining an antisolvent with the rapamycin analog and the solvent to form a biphasic mixture, and incubating the biphasic mixture to cause a liquid-liquid phase split.Type: ApplicationFiled: July 23, 2007Publication date: April 17, 2008Applicant: ABBOTT LABORATORIESInventors: Shekhar Viswanath, Larry Bartelt, Robert Leanna, Michael Rasmussen, Madhup Dhaon, Rodger Henry, Thomas Borchardt, Shuang Chen, Geoff Zhang
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Publication number: 20080085880Abstract: A rapamycin analog composition includes a crystalline form of a rapamycin analog. The crystal can be a hydrate, dehydrate, solvate, or desolvate.Type: ApplicationFiled: July 23, 2007Publication date: April 10, 2008Applicant: ABBOTT LABORATORIESInventors: Shekhar Viswanath, Larry Bartelt, Robert Leanna, Michael Rasmussen, Madhup Dhaon, Rodger Henry, Thomas Borchardt, Shuang Chen, Geoff Zhang