Abstract: A pallet wrapper and imaging system a pallet loaded with containers to calculate a sustainability based upon a type of the pallet and the containers on the pallet. The system also determines the stability of the pallet and containers, a speed at which the pallet and containers can be wrapped, and an amount of stretch film needed to secure the load for transport. After validation by the imaging system (with or without a wrapper), a QC bot assists a QC worker in remedying or checking any detected errors or potential errors.

Abstract: Apelin receptor modulators can improve physical performance, slow progression of age-related frailty, and can reduce age-related muscle weakness in human patients. This disclosure provides methods for treating muscle conditions using a particular class of apelin receptor modulators (e.g., agonists). The muscle condition can be an age-related muscle condition. Also provided is a method for maintaining and/or increasing muscle mass, muscle function, and/or muscle strength in an elderly subject by administration of the apelin receptor modulator. In some embodiments, the apelin receptor modulator (e.g., agonist) is BGE-105, or a pharmaceutically acceptable salt thereof.

Abstract: A crop prediction system performs various machine learning operations to predict crop production and to identify a set of farming operations that, if performed, optimize crop production. The crop prediction system uses crop prediction models trained using various machine learning operations based on geographic and agronomic information. Responsive to receiving a request from a grower, the crop prediction system can access information representation of a portion of land corresponding to the request, such as the location of the land and corresponding weather conditions and soil composition. The crop prediction system applies one or more crop prediction models to the access information to predict a crop production and identify an optimized set of farming operations for the grower to perform.

Abstract: A plurality of storage controllers configured to initiate an action based on redundant copies of metadata, such that a source authority of one of the plurality of storage controllers receives a message, records the message redundantly throughout the plurality of storage controllers, and delivers the message to a destination authority of a further one of the storage controllers responsive to achieving a level of redundancy for the redundant copies of the metadata regarding the message is provided, wherein at least one of the plurality of storage controllers comprises a zoned storage drive.

Abstract: Hybrid orthodontic archwire designs are disclosed. Hybrid archwires may have bracket-archwire sections and interproximal archwire sections in which each section can vary in cross-section shape, size, and/or material properties. Bracket-archwire sections may be configured to promote torque control and may have rectangular cross-sections. Interproximal archwire sections may be configured to be bent into force-promoting loops and may have round cross sections. Each archwire section may be straight or bent into any shape. Hybrid archwires may have sliding sections and non-sliding sections. Non-sliding sections may have male connectors configured to prevent the archwire from sliding relative to the orthodontic brackets and/or may have cross-sectional shapes, sizes, or coatings that resist sliding relative to sliding sections. Sliding sections may have linear archwire segments. Hybrid archwires may have distal or posterior non-sliding sections and an intermediate anterior or medial sliding section.

Abstract: A heat exchanger for use in an outdoor environment with a heat pump system is provided. The heat exchanger includes a first set of tubes arranged in a parallel flow manner between a first manifold and a second manifold, wherein central straight portions of adjacent tubes are disposed with a space therebetween along each tube of the first set of tube between the first and second manifolds. A second set of tubes are arranged in a parallel flow manner between a third manifold and a fourth manifold, wherein central straight portions of adjacent tubes within the second set of tubes are at least partially disposed within the space between adjacent tubes of the first set of tubes. A fluid that flows through the first set of tubes additionally flows through the second set of tubes before the fluid returns to again flow through the first set of tubes.

Abstract: A novel integrated wound closure device for laparoscopy having proximal activation means, a suture staging and management means, a distal anchoring means, an integrated tissue piercing means, a suture placement and suture grasping means, in an elongated body which can be reused multiple times per patient.

Abstract: An additive manufacturing system, and associated methods, comprise an image projection system comprising a plurality of image projectors that project a composite image onto a build area within a resin pool. The composite image comprises a plurality of sub-images arranged in an array. The properties of a sub-image and the alignment of the position of the sub image within the composite image can be adjusted using a set of filters comprising an irradiance mask that normalizes irradiance, and a gamma adjustment mask that adjusts sub-image energy based on a reactivity of the resin.

Abstract: A coated glass pharmaceutical package includes a glass body having a Type 1 chemical durability according to USP 660, at least a class A2 base resistance or better according to ISO 695, and at least a type HGB2 hydrolytic resistance or better according to ISO 719, the glass body having an interior surface and an exterior surface and a wall extending therebetween. A lubricous coating having a thickness of less than or equal to 90 nm may be positioned on at least a portion of the exterior surface of the glass body but not on any portion of the interior surface. The portion of the coated glass package with the lubricous coating comprises a coefficient of friction that is at least 20% less than an uncoated glass package and the coefficient of friction does not increase by more than 30% after undergoing a depyrogenation cycle including exposure to a temperature of 250° C. for a time period of 30 minutes.

Abstract: A method for processing blocks of flash memory to decrease raw bit errors from the flash memory is provided. The method includes identifying one or more blocks of the flash memory for a refresh operation and writing information regarding the identified blocks, to a data structure. The method includes issuing background reads to the identified blocks, according to the data structure, as the refresh operation. The method may be embodied on a computer readable medium. In some embodiments the background reads may be based on a time based refresh responsive to an increase in raw bit error count in the flash memory over time.

Abstract: Concepts presented herein relate to an interface module that can be electrically coupled to an electrical stimulation generator, a radio frequency generator and an instrument. A selection module is coupled to the interface module and operates in a first mode to deliver electrical stimulation signals from the electrical stimulation generator to the instrument and in a second mode to deliver radio frequency signals from the radio frequency generator to the instrument.

Abstract: A compound having the structures: or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of said compound or pharmaceutically acceptable salt, wherein; R selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy and —(CH2)m—W, where W is C3-C8 cycloalkyl, bicycloalkyl, bridged bicycloalkyl, phenyl, 5- or 6-membered heteroaryl or heterocyclic containing one, two or three heteroatoms selected from the group consisting of N, S and O atoms; wherein each of said alkyl, cycloalkyl, alkoxy, heterocyclic, phenyl, naphthyl or heteroaryl may be unsubstituted or substituted by phenyl, halo, cyano, deuterium, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, —SO2—R?, —CONR?R?, NR?COR?, —NR?CONR?R?, —NR?CO2R?, —(CH2)n—SO2—R?, —NHSO2—R?, —NR?SO2—R?, —SO2NR?R?, NR?R? or SR? where R? and R? are independently H, C1-C6 alkyl or C3-C8 cycloalkyl; R1 selected from the group consisting of phenyl, naphthyl, 5- or 6-membered heteroaryl or heterocyclic containing one, two, three or four heteroatoms se

Abstract: A novel smoke evacuation distal end having a distal port axially rotatable or fixedly attached to an energy assisted surgical device with at least one non-obstructing cutout to allow for improved surgical visibility while maintaining smoke suction performance.

Abstract: An optics-integrated confinement apparatus system comprises a confinement apparatus chip having a confinement apparatus formed thereon and having at least one apparatus optical element disposed and/or formed thereon.

Abstract: No known single-stage dry low emissions fuel injectors are capable of effectively operating over all ranges of hydrogen concentrations in hydrogen/natural gas fuel mixtures. Accordingly, a fuel injector is disclosed that is capable of operating in both a premix mode for fuel mixtures with lower hydrogen concentrations and a micromix mode for fuel mixtures with higher hydrogen concentrations. The fuel injector may comprise premix jets near an inlet of the fuel injector, optionally within one or more swirlers, and micromix jets near the outlet of the fuel injector. In the premix mode, fuel with lower hydrogen concentrations is provided to the premix jets, whereas in the micromix mode, fuel with higher hydrogen concentrations is provided to the micromix jets.

Abstract: Described herein are methods that define cellular populations that are sensitive to RARA agonists and identify patient populations that will benefit from treatment with RARA agonists. The methods may comprise administering RARA agonists to patient populations.

Abstract: A thermosetting composition comprising a crosslinkable component such as a vinyl ester and/or an unsaturated polyester, and an initiator component, such as cumene hydroperoxide or BPO or blends of cumene hydroperoxide and methyl ethyl ketone peroxide. The composition is suitable to be used in additive manufacturing to form objects such as molds or prototypes.

Abstract: A method of generating a blood pressure estimation for a subject includes receiving real-time PPG data from a PPG sensor attached to the subject, and generating a blood pressure estimation for the subject via an adaptive predictive model using the real time PPG data. The method includes receiving a real-time measurement of blood pressure via a blood pressure monitoring device attached to the subject and, in response to receiving the real-time measurement of blood pressure, updating one or more parameters of the model in real-time to improve blood pressure estimation accuracy of the model. The method may also include detecting whether the generated blood pressure estimation is above or below a threshold and, in response to determining that the generated biometric estimation is above or below the threshold, receiving a real-time measurement of blood pressure and then updating the parameters of the model to improve blood pressure estimation accuracy of the model.

Abstract: Provided here are methods of using a mutated patatin-like phospholipase II? (“pPLAII?,” renamed here MATRILINEAL) to induce haploid induction in plants, cloning a pPLAII? to induce haploid induction in plants, and genetically engineering a plant to contain a mutated pPLAII?. Also provided are methods of applying topical and spray chemicals, lipids, and RNAi molecules to plants during pollination in order to induce haploid production. Further provided are methods of chemically treating plants during pollination to induce haploids while also reducing embryo abortion and increasing seed set.