Abstract: The invention relates to pyrazole derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to HbS modulators of formula (I) or tautomers thereof, or pharmaceutically acceptable salts of said modulators or tautomers thereof, wherein X, Y, R2 and R3 are as defined in the description. HbS modulators are potentially useful in the treatment of a wide range of disorders, including sickle cell disease (SCD).

Abstract: A novel invention squeegee cleans in a first direction, manually or by robot, the inner surface of a bore referred to as a hollow-shape, comprising a longitudinal shaft with a distal end squeegee element, and a cooperatively aligned sheath. Said squeegee element is comprised of shape conforming flexible disks in combination with shape conforming flexible tabbed fins having incrementally sized surface openings to form an ascending or descending path to incrementally collect contaminants. From said first direction the invention exits said hollow-shape distal end, cleaning said inner surface. Said sheath is selectively moved from a first proximal position to a second distal position covering said squeegee element and isolating collected contaminants. A second opposite direction retracts said invention from said hollow-shape, with manual or robotic means, by removing said isolated contaminants preventing recontamination of said inner surface.

Abstract: A client device is configured to receive bookmarking data from a data processing and aggregating server, the bookmarking data referencing a specific point in a media content item playable from the client device. The client the bookmarking data and outputs a first signal which instructs a display device to display at least one bookmark that includes at least a user-selectable portion and a descriptive portion. Upon receiving an input signal at the client device from a user input device, the input signal indicating a user selection of a bookmark displayed by the display device, the client device outputs a second signal to the display device which instructs the display device to display a media content item from a specific point specified by the bookmarking data.

Abstract: A method for proactively rebuilding user data in a plurality of storage nodes of a storage cluster in a single chassis is provided. The method includes distributing user data and metadata throughout the plurality of storage nodes such that the plurality of storage nodes can read the user data, using erasure coding, despite loss of two of the plurality of storage nodes. The method includes determining to rebuild the user data for one of the plurality of storage nodes in the absences of an error condition. The method includes rebuilding the user data for the one of the plurality of storage nodes. A plurality of storage nodes within a single chassis that can proactively rebuild the user data stored within the storage nodes is also provided.

Abstract: In some embodiments, a photoreactive 3D printing system includes: a moveable print platform; a resin tub comprising a membrane; a tension apparatus; a volume of resin contained within the resin tub; an illumination system; a print platform force sensor; and a print recipe comprising information for layers in a 3D printed part to be built on the print platform. In some embodiments, the photoreactive 3D printing system is configured to: project an image through the membrane at a polymer interface using the illumination system; moving the print platform in a z-direction; apply a tensioning force using the tension apparatus to induce a membrane tension on the membrane; measure an amount of print platform force using the print platform force sensor; and update the print platform movement in the print recipe during a printing run based on the amount of print platform force measured by the print platform force sensor.

Abstract: A delivery system may include a pallet wrapper system having a turntable, a camera directed toward an area above the turntable, and a stretch wrap dispenser adjacent the turntable. A computer receives images from the camera of multiple sides of a pallet loaded with packages on the turntable. The computer stitches images from different sides of the stack of packages that correspond to the same package. At least one machine learning model may be used to infer SKUs of each package. Optical character recognition may be performed in parallel on the images. The determination of the SKU of each package may be based upon the inferred SKUs and on the OCR.

Abstract: A system including a processor may filter a population to identify a group having members, and deliver, over an electronic network, a survey to members of the group to determine value preferences and value gaps. The survey may be made according to a set of paired comparisons or other related techniques. The system may generate vectors according to the determined value preferences and value gaps for members of the group, which may have lengths equal to numbers of determined values for the members. The system may cluster members of the group into segments by calculating patterns of differences between generated vectors. Results of this process enable the creation of a predictive model to estimate segment membership, which can be used in the generation of a promotion for display corresponding to a clustered segment, and deliver the promotion to a client device associated for display.

Abstract: In various example embodiments, a system and method for data mesh visualization are presented. An avatar representation of a user is generated. A user-specified change to the avatar representation is received and the avatar representation is changed based on the user-specified change. A current status of the user is determined, and an updated avatar representation is generated based on the current status of the user. The updated avatar is displayed in association with a communication of the user.

Abstract: Systems and methods for fabricating indirect bonding trays are disclosed. Physical models of a patient’s teeth can be created with non-functional placeholder brackets, impressions of which can be transferred to indirect bonding trays. This can create wells in which functional brackets can be placed into, reducing errors created from transferring functional brackets from the physical model onto the indirect bonding trays.

Abstract: A method for storage cluster expansion is provided. The method includes distributing user data throughout a storage cluster as directed by each of a plurality of authorities in the storage cluster. Each of the plurality of authorities has a plurality of wards, and each of the plurality of wards has ownership of a range of the user data. The method includes splitting one of the plurality of authorities, as a parent authority, into at least two child authorities and assigning a first subset of the plurality of wards of the parent authority to one of the at least two child authorities, and a second subset of the plurality of wards of the parent authority to another one of the at least two child authorities.

Abstract: A redundant array of independent drives (RAID) stripe is formed across a set of storage controllers of a plurality of storage controllers, wherein the RAID stripe comprises two or more of a plurality of modular storage devices of at least one of the set of storage controllers. The RAID stripe is written across the set of storage controllers.

Abstract: Systems and methods of repairing damage to the body structure of a vehicle based on a comparison of vehicle damage to vehicle specification data to indicate the magnitude and direction of vehicle damage to formulate a repair plan for review.

Abstract: A pallet wrapper and imaging system a pallet loaded with containers to calculate a sustainability based upon a type of the pallet and the containers on the pallet. The system also determines the stability of the pallet and containers, a speed at which the pallet and containers can be wrapped, and an amount of stretch film needed to secure the load for transport. After validation by the imaging system (with or without a wrapper), a QC bot assists a QC worker in remedying or checking any detected errors or potential errors.

Abstract: One or more performance parameters associated with data stored at a storage device of a plurality of storage devices are received by a storage controller. A first number of blocks of the storage device to a high resiliency portion and a second number of blocks of the storage device to a low resiliency portion of the storage device are allocated based on the one or more performance parameters.

Abstract: This document describes techniques and apparatuses directed to the mitigation of physical impact-induced mechanical stress damage to printed circuit boards through the utilization of a conductive shield track having a varied width (dynamic width). In an aspect, disclosed is a device that includes a printed circuit board, an electrical component on the printed circuit board in a shielded area, a conductive shield track on the printed circuit board, a component shield having a sidewall and a sidewall base, and solder disposed between the sidewall base and the conductive shield track to couple the component shield to the ground plane of the PCB to form a shielded compartment over the shielded area.

Abstract: The invention provides a compound of Formula (I) or a pharmaceutically acceptable salt of the compound, wherein R1, R2, R3, Z, A1, L and A2 are as described herein; pharmaceutical compositions thereof; and the use thereof in treating diseases, conditions or disorders modulated by the inhibition of an acetyl-CoA carboxylase enzyme(s) in an animal.

Abstract: Various illustrative aspects are directed to a data storage device, comprising one or more disks; a head, configured to be positioned proximate to a disk surface among the one or more disks; a temperature sensor; and one or more processing devices. The one or more processing devices are configured to: detect, via the temperature sensor, a non-nominal heat dissipation of a portion of the head; and, in response to detecting the non-nominal heat dissipation of the portion of the head, mitigate the non-nominal heat dissipation of the portion of the head.

Abstract: Chip cards that are protected from unauthorized access to information and instructions stored in the chip card's chip by unauthorized persons using illicit devices that emulate chip readers to interrogate the chips in chip cards and obtain or download confidential data stored in the chips. The chip cards are disabled when not ready to be used, such that the chips cannot be accessed by illicit devices, thus protecting the chip card owner and/or issuer from potential losses.

Abstract: A delivery system may include a pallet wrapper system having a turntable, a camera directed toward an area above the turntable, and a stretch wrap dispenser adjacent the turntable. A computer receives images from the camera of multiple sides of a pallet loaded with packages on the turntable. The computer stitches images from different sides of the stack of packages that correspond to the same package. At least one machine learning model may be used to infer SKUs of each package. Optical character recognition may be performed in parallel on the images. The determination of the SKU of each package may be based upon the inferred SKUs and on the OCR.

Abstract: A method of operating a storage system, and related storage system, are provided. The storage system establishes resiliency groups, each having a defined level of redundancy of resources of the storage system. The resiliency groups include at least one compute resources resiliency group and at least one storage resources resiliency group. The storage system supports capability of configurations that have multiples of each of the resiliency groups. Blades of the storage system perform distributed data and metadata storage across modular storage devices, in accordance with the resiliency groups.