Patents by Inventor Robert M. Burk

Robert M. Burk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cyclopentane heptan(ENE)OIC acid, 2-heteroarylalkenyl derivatives as therapeutic agents
    Patent number: 8557860
    Abstract: A compound comprising or a pharmaceutically acceptable salt or a prodrug thereof, having the groups described in detail herein is disclosed. Also disclosed herein are compounds comprising or derivatives thereof, or pharmaceutically acceptable salts, tetrazoles, or prodrugs of compounds of the structure or derivatives thereof, said derivatives being described in detail herein. Also disclosed herein are methods of treating diseases or conditions, including glaucoma and elevated intraocular pressure. Compositions and methods of manufacturing medicaments related thereto are also disclosed.
    Type: Grant
    Filed: December 14, 2010
    Date of Patent: October 15, 2013
    Assignee: Allergan, Inc.
    Inventors: Yariv Donde, Robert M. Burk, Michael Garst
  • Substituted cyclopentanes having prostaglandin activity
    Patent number: 8546603
    Abstract: Disclosed herein are compounds having a formula: Therapeutic methods, medicaments, and compositions related thereto are also disclosed.
    Type: Grant
    Filed: March 19, 2012
    Date of Patent: October 1, 2013
    Assignee: Allergan, Inc.
    Inventor: Robert M. Burk
  • THERAPEUTIC AND DELIVERY METHODS OF PROSTAGLANDIN EP4 AGONISTS
    Publication number: 20130245283
    Abstract: A compound comprising a prodrug of a prostaglandin EP4 agonist, wherein said prodrug is an ester, ether, or amide of an amino acid is disclosed herein. Maintenance of the colonic mucosal barrier by method comprising administering a therapeutically effective amount of a prostaglandin EP4 agonist to a colon of a mammal is also disclosed herein. Dosage forms, medicaments, and compositions, related thereto are also disclosed.
    Type: Application
    Filed: April 23, 2013
    Publication date: September 19, 2013
    Applicant: Allergan, Inc.
    Inventors: Wha-Bin Im, Robert M. Burk, Mark Holoboski
  • Substituted cyclopentanes having prostaglandin activity
    Patent number: 8487091
    Abstract: Disclosed herein are compounds represented by the formula: Therapeutic methods, compositions, and medicaments related thereto are also disclosed.
    Type: Grant
    Filed: February 25, 2009
    Date of Patent: July 16, 2013
    Assignee: Allergan, Inc.
    Inventors: Mark Holoboski, Robert M. Burk, Mari Posner, Yariv Donde, David W. Old
  • Substituted cyclopentanes having prostaglandin activity
    Patent number: 8455547
    Abstract: Therapeutic compounds, compositions, methods, and medicaments related thereto are disclosed herein.
    Type: Grant
    Filed: February 2, 2009
    Date of Patent: June 4, 2013
    Assignee: Allergan, Inc.
    Inventor: Robert M. Burk
  • Prostaglandins and analogues as agents for lowering intraocular pressure
    Patent number: 8389566
    Abstract: The present invention relates to cyclopentane heptenoic acid-5-cis-2-(3?-hydroxy or lower alkyloxy-5-thienylpentyl)-3, 5-dihydroxy, [1?, 2?, 3?, 5?] compounds, lower alkyl, hydroxyl lower alkyl and indole lower alkyl amides and esters thereof as potent ocular hypotensives that are particularly suited for the management of glaucoma.
    Type: Grant
    Filed: December 17, 2010
    Date of Patent: March 5, 2013
    Assignee: Allergan, Inc.
    Inventor: Robert M. Burk
  • N,N-DIALKYLALKYLENYL ESTERS, COMPOSITIONS THEREOF, AND METHODS FOR USE THEREOF
    Publication number: 20130029992
    Abstract: The invention provides well defined N,N-dialkylalkenyl ester compounds for treating glaucoma or ocular hypertension. The esters of the invention are particularly advantageous due to their stability in aqueous solutions.
    Type: Application
    Filed: July 25, 2012
    Publication date: January 31, 2013
    Applicant: Allergan, Inc.
    Inventors: Robert M. Burk, David W. Old
  • Ester Derivatives of Bimatoprost Compositions and Methods
    Publication number: 20120295972
    Abstract: Provided herein, inter alia, are prodrugs of bimatoprost, methods of using the same and compositions including the same.
    Type: Application
    Filed: February 13, 2012
    Publication date: November 22, 2012
    Inventors: David F. Woodward, Jenny W. Wang, Neil J. Poloso, Todd Gac, Robert M. Burk, Michael E. Garst
  • SUBSTITUTED CYCLOPENTANES HAVING PROSTAGLANDIN ACTIVITY
    Publication number: 20120178798
    Abstract: Disclosed herein are compounds having a formula: Therapeutic methods, medicaments, and compositions related thereto are also disclosed.
    Type: Application
    Filed: March 19, 2012
    Publication date: July 12, 2012
    Applicant: ALLERGAN, INC.
    Inventor: Robert M. BURK
  • Therapeutic amides
    Patent number: 8198318
    Abstract: Compounds comprising or a pharmaceutically acceptable salt or a prodrug thereof, are disclosed, wherein G, E, B, Y, and A are as described. Methods, compositions, and medicaments related thereto are also disclosed.
    Type: Grant
    Filed: March 16, 2009
    Date of Patent: June 12, 2012
    Assignee: Allergen, Inc.
    Inventors: David W. Old, Robert M. Burk, Todd Gac
  • COMPOUNDS AND METHODS FOR SKIN REPAIR
    Publication number: 20120142684
    Abstract: The disclosure provides compositions and methods for treating a skin blemish. The compositions comprise a therapeutically effective amount of a compound useful for treating skin blemishes such as wounds, scars and wrinkles.
    Type: Application
    Filed: November 29, 2011
    Publication date: June 7, 2012
    Applicant: ALLERGAN, INC.
    Inventors: Robert M. Burk, Wha Bin Im, Scott M. Whitcup
  • Therapeutic compounds
    Patent number: 8193373
    Abstract: Compound having the formula below are disclosed herein: formula (I). Therapeutic methods, compositions, and medicaments related thereto are also disclosed.
    Type: Grant
    Filed: December 4, 2007
    Date of Patent: June 5, 2012
    Assignee: Allergan, Inc.
    Inventors: Mark Holoboski, Robert M. Burk, Mari Posner
  • COMPOUNDS AND METHODS FOR SKIN REPAIR
    Publication number: 20120136011
    Abstract: The disclosure provides compositions and methods for treating a skin blemish. The compositions comprise a therapeutically effective amount of a compound useful for treating skin blemishes such as wounds, scars and wrinkles.
    Type: Application
    Filed: July 29, 2011
    Publication date: May 31, 2012
    Applicant: ALLERGAN, INC.
    Inventors: Guang L. Jiang, Wha-Bin Im, Frederick C. Beddingfield, Larry A. Wheeler, Scott M. Whitcup, Robert M. Burk
  • Cyclopentane heptan(ENE)OIC acid, 2-heteroarylalkenyl derivatives as therapeutic agents
    Patent number: 8168680
    Abstract: A compound comprising or a pharmaceutically acceptable salt or a prodrug thereof, having the groups described in detail herein is disclosed. Also disclosed herein are compounds comprising or derivatives thereof, or pharmaceutically acceptable salts, tetrazoles, or prodrugs of compounds of the structure or derivatives thereof, said derivatives being described in detail herein. Also disclosed herein are methods of treating diseases or conditions, including glaucoma and elevated intraocular pressure. Compositions and methods of manufacturing medicaments related thereto are also disclosed.
    Type: Grant
    Filed: February 8, 2011
    Date of Patent: May 1, 2012
    Assignee: Allergan, Inc.
    Inventors: Yariv Donde, Robert M. Burk, Michael E. Garst
  • Substituted cyclopentanes having prostaglandin activity
    Patent number: 8158676
    Abstract: Disclosed herein are compounds having a formula: Therapeutic methods, medicaments, and compositions related thereto are also disclosed.
    Type: Grant
    Filed: November 24, 2008
    Date of Patent: April 17, 2012
    Assignee: Allergan, Inc.
    Inventor: Robert M. Burk
  • Therapeutic lactams
    Patent number: 8124648
    Abstract: Compounds comprising or a pharmaceutically acceptable salt or a prodrug thereof, are disclosed, wherein J1, J2, B, Y, and A are as described. Methods, compositions, and medicaments related thereto are also disclosed.
    Type: Grant
    Filed: May 13, 2009
    Date of Patent: February 28, 2012
    Assignee: Allergan, Inc.
    Inventors: David W. Old, Robert M. Burk
  • NON-ACIDIC CYCLOPENTANE HEPTANOIC ACID, 2-CYCLOALKYL OR ARYLALKYL DERIVATIVES AS THERAPEUTIC AGENTS
    Publication number: 20110294893
    Abstract: The present invention provides cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl compounds, which may be substituted in the 1-position with amino, amido, ether or ester groups, e.g., a 1-OH cyclopentane heptanoic acid, 2-(cycloalkyl or arylalkyl) compound. The cyclopentane heptanoic acid, 2-(cycloalkyl or arylalkyl) compounds of the present invention are potent ocular hypotensives, and are particularly suitable for the management of glaucoma. Moreover, the cyclopentane heptanoic, 2-(cycloalkyl or arylalkyl) compounds of this invention are smooth muscle relaxants with broad application in systemic hypertensive and pulmonary diseases; smooth muscle relaxants with application in gastrointestinal disease, reproduction, fertility, incontinence, shock, etc.
    Type: Application
    Filed: August 8, 2011
    Publication date: December 1, 2011
    Applicant: ALLERGAN, INC.
    Inventors: David F. Woodward, Steven W. Andrews, Robert M. Burk, Michael E. Garst
  • Therapeutic beta-lactams
    Patent number: 8063033
    Abstract: Compounds comprising or a pharmaceutically acceptable salt or a prodrug thereof, are disclosed, wherein Y is A is —(CH2)6—, cis —CH2CH?CH—(CH2)3—, or —CH2C?C—(CH2)3—, wherein 1 or 2 carbon atoms may be substituted with S or O; or A is —(CH2)m—Ar—(CH2)o— wherein Ar is substituted or unsubstituted phenyl or monocyclic heteroaryl, the sum of m and o is from 1 to 4, and wherein one CH2 may be replaced with S or O; X is S or O; R is a hydrocarbyl or a hydroxyhydrocarbyl moiety having from 1 to 12 carbon atoms; D is independently a moiety comprising from 1 to 6 non-hydrogen atoms; and n is an integer from 0 to 4. Methods, compositions, and medicaments related thereto are also disclosed.
    Type: Grant
    Filed: January 13, 2009
    Date of Patent: November 22, 2011
    Assignee: Allergan, Inc.
    Inventors: David W. Old, Danny T. Dinh, Robert M. Burk
  • Therapeutic compounds
    Patent number: 8044092
    Abstract: A compound having a substituted five or six-membered carbocycle or heterocycle directly bonded to a substituted aryl or heteroaryl ring, wherein said compound has an EC50 value of 20 nM or less at the prostaglandin EP2 receptor according to the cAMP assay. Methods, compositions, and medicaments related thereto are also disclosed.
    Type: Grant
    Filed: August 20, 2010
    Date of Patent: October 25, 2011
    Assignee: Allergan, Inc.
    Inventors: Yariv Donde, Robert M. Burk, David W. Old
  • Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
    Patent number: 8017655
    Abstract: The present invention provides cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl compounds, which may be substituted in the 1-position with amino, amido, ether or ester groups, e.g., a 1-OH cyclopentane heptanoic acid, 2-(cycloalkyl or arylalkyl) compound. The cyclopentane heptanoic acid, 2-(cycloalkyl or arylalkyl) compounds of the present invention are potent ocular hypotensives, and are particularly suitable for the management of glaucoma. Moreover, the cyclopentane heptanoic, 2-(cycloalkyl or arylalkyl) compounds of this invention are smooth muscle relaxants with broad application in systemic hypertensive and pulmonary diseases; smooth muscle relaxants with application in gastrointestinal disease, reproduction, fertility, incontinence, shock, etc.
    Type: Grant
    Filed: December 19, 2008
    Date of Patent: September 13, 2011
    Assignee: Allergan, Inc.
    Inventors: David F. Woodward, Steven W. Andrews, Robert M. Burk, Michael E. Garst