Patents by Inventor Robert M. Burk

Robert M. Burk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Therapeutic substituted piperidone compounds
    Patent number: 7994195
    Abstract: Compounds comprising or a pharmaceutically acceptable salt or a prodrug thereof are disclosed herein. Details are provided herein. Compositions, methods, and medicaments related thereto are also disclosed.
    Type: Grant
    Filed: November 2, 2005
    Date of Patent: August 9, 2011
    Assignee: Allergan, Inc.
    Inventors: David W. Old, Robert M. Burk
  • Therapeutic amides
    Patent number: 7985767
    Abstract: Compounds of the formula are disclosed herein. Therapeutic methods, compositions, and medicaments related thereto are also disclosed.
    Type: Grant
    Filed: September 6, 2007
    Date of Patent: July 26, 2011
    Assignee: Allergan, Inc.
    Inventors: David W. Old, Robert M. Burk, Todd S. Gac
  • Combination Therapy For Glaucoma
    Publication number: 20110152328
    Abstract: Disclosed herein is method of treating glaucoma or ocular hypertension comprising administering a prostaglandin agonist and a second therapeutically active agent to a mammal in need thereof, wherein said second therapeutically active agent is selected from: ?-Blockers, Adrenergic Agonists, non-selective adrenergic agonists, ?2-selective adrenergic agonists, Carbonic Anhydrase Inhibitors, Cholinergic Agonists, direct acting cholinergic agonists, chlolinesterase inhibitors, Glutamate Antagonists, Ca2+ channel blockers, Prostamides, Prostaglandins, Cannabinoids, and combinations thereof. Compositions and medicaments containing a combination of these two active agents are also disclosed.
    Type: Application
    Filed: April 13, 2009
    Publication date: June 23, 2011
    Inventors: Scott M. Whitcup, Robert M. Burk, David W. Old, Yariv Donde, Wha-Bin Im, Mark A. Holoboski
  • PROSTAGLANDINS AND ANALOGUES AS AGENTS FOR LOWERING INTRAOCULAR PRESSURE
    Publication number: 20110152797
    Abstract: The present invention relates to cyclopentane heptenoic acid-5-cis-2-(3?-hydroxy or lower alkyloxy-5-thienylpentyl)-3,5-dihydroxy, [1?, 2?, 3?, 5?] compounds, lower alkyl, hydroxyl lower alkyl and indole lower alkyl amides and esters thereof as potent ocular hypotensives that are particularly suited for the management of glaucoma.
    Type: Application
    Filed: December 17, 2010
    Publication date: June 23, 2011
    Applicant: ALLERGAN, INC.
    Inventor: Robert M. Burk
  • Thiophenyl prostaglandin derivatives for treating glaucoma and ocular hypertension
    Patent number: 7964595
    Abstract: Disclosed herein is a compound according to one of the formulas wherein R is Additionally, pharmaceutically acceptable salt thereof, and methods of treating disease, medicaments, and compositions related thereto, are further elaborated herein.
    Type: Grant
    Filed: January 13, 2009
    Date of Patent: June 21, 2011
    Assignee: Allergan, Inc.
    Inventors: Brent A. Johnson, David W.. Old, Yariv Donde, Robert M. Burk
  • Therapeutic compounds
    Patent number: 7964634
    Abstract: Compounds having a structure are disclosed herein. Compositions, methods, and medicaments related to the therapeutic use of these compounds are also disclosed.
    Type: Grant
    Filed: April 21, 2009
    Date of Patent: June 21, 2011
    Assignee: Allergan, Inc.
    Inventors: Yariv Donde, Jeremiah H. Nguyen, Mark Holoboski, Mari Posner, Robert M. Burk
  • Therapeutic compounds
    Patent number: 7960379
    Abstract: Compounds comprising or a pharmaceutically acceptable salt or a prodrug thereof, are disclosed, wherein J1, J2, B, Y, A and D are as described. Methods, compositions, and medicaments related thereto are also disclosed.
    Type: Grant
    Filed: March 12, 2009
    Date of Patent: June 14, 2011
    Assignee: Allergan, Inc.
    Inventors: David W. Old, Robert M. Burk
  • Therapeutic compounds
    Patent number: 7960378
    Abstract: Compounds comprising or a pharmaceutically acceptable salt or a prodrug thereof, are disclosed, wherein Y, A, R1, R2, Z, and G are as described. Methods, compositions, and medicaments related thereto are also disclosed.
    Type: Grant
    Filed: March 17, 2009
    Date of Patent: June 14, 2011
    Assignee: Allergan, Inc.
    Inventors: Mark Holoboski, Robert M. Burk, Mari Posner
  • Thiophenyl prostaglandin derivatives for treating glaucoma and ocular hypertension
    Patent number: 7960431
    Abstract: Disclosed herein is a compound according to one of the formulas or a pharmaceutically acceptable salt thereof, medicaments for the treatment of glaucoma or ocular hypertension and compositions related thereto, as further elaborated herein.
    Type: Grant
    Filed: January 30, 2008
    Date of Patent: June 14, 2011
    Assignee: Allergan, Inc.
    Inventors: Brent A. Johnson, David W. Old, Yariv Donde, Robert M. Burk
  • STABLE AQUEOUS COMPOSITIONS OF PROSTGLANDIN AGONIST PRODRUGS AND METHODS FOR USE THEREOF
    Publication number: 20110136872
    Abstract: The present invention is based on the discovery that a marked increase in aqueous stability (and thereby shelf life) of prostanoid agonist prodrug compositions is achieved by incorporating into the compositions certain well-defined carboxylic acids, and thereafter adjusting the pH of the compositions from about 4.0 to about 8.0. As a result, the compositions and methods of the invention provide the aqueous stability required for marketable topical drug treatments of a wide variety of ocular disorders.
    Type: Application
    Filed: November 4, 2010
    Publication date: June 9, 2011
    Inventor: Robert M. Burk
  • CYCLOPENTANE HEPTAN(ENE)OIC ACID, 2-HETEROARYLALKENYL DERIVATIVES AS THERAPEUTIC AGENTS
    Publication number: 20110130439
    Abstract: A compound comprising or a pharmaceutically acceptable salt or a prodrug thereof, having the groups described in detail herein is disclosed. Also disclosed herein are compounds comprising or derivatives thereof, or pharmaceutically acceptable salts, tetrazoles, or prodrugs of compounds of the structure or derivatives thereof, said derivatives being described in detail herein. Also disclosed herein are methods of treating diseases or conditions, including glaucoma and elevated intraocular pressure. Compositions and methods of manufacturing medicaments related thereto are also disclosed.
    Type: Application
    Filed: February 8, 2011
    Publication date: June 2, 2011
    Applicant: ALLERGAN, INC.
    Inventors: Yariv Donde, Robert M. Burk, Michael E. Garst
  • Arylsulfanyl and heteroarylsulfanyl derivatives for treating pain
    Patent number: 7935825
    Abstract: According to the invention there is provided a compound the formula I; wherein A, X, B, R1, R2, R3 and R4 are as defined in the specification.
    Type: Grant
    Filed: May 4, 2007
    Date of Patent: May 3, 2011
    Assignee: Allergan, Inc.
    Inventors: Robert M. Burk, Sophie Beauchemin
  • Sulfonamides
    Patent number: 7932420
    Abstract: The present invention provides wherein R1 is selected from the group consisting of C1-C10 alkoxy, OH and NR4R5; R2 is selected from the group consisting of C1-C10 alkyl and (CH2)nOH; R3 is selected from the group consisting of C1-C10 alkyl, heteroaryl, e.g. thienyl, furanyl and pyridyl, phenyl, mono, -di-, tri-substituted phenyl and heteroaryl; R4 and R5 are independently selected from the group consisting of H, C1-C10 alkyl, C1-C10 alkyl hydroxyl; m is 0 or an integer from 1 to 3 and n is an integer of from 1 to 4. These compounds are useful in lowering intraocular pressure and/or treating glaucoma or providing neuroprotection to the eye of a human patient.
    Type: Grant
    Filed: March 14, 2008
    Date of Patent: April 26, 2011
    Assignee: Allergan, Inc.
    Inventor: Robert M. Burk
  • CYCLOPENTANE HEPTAN(ENE)OIC ACID, 2-HETEROARYLALKENYL DERIVATIVES AS THERAPEUTIC AGENTS
    Publication number: 20110082184
    Abstract: A compound comprising or a pharmaceutically acceptable salt or a prodrug thereof, having the groups described in detail herein is disclosed. Also disclosed herein are compounds comprising or derivatives thereof, or pharmaceutically acceptable salts, tetrazoles, or prodrugs of compounds of the structure or derivatives thereof, said derivatives being described in detail herein. Also disclosed herein are methods of treating diseases or conditions, including glaucoma and elevated intraocular pressure. Compositions and methods of manufacturing medicaments related thereto are also disclosed.
    Type: Application
    Filed: December 14, 2010
    Publication date: April 7, 2011
    Applicant: ALLERGAN, INC.
    Inventors: Yariv Donde, Robert M. Burk, Michael Garst
  • Sulfonamides
    Patent number: 7915316
    Abstract: The present invention provides R, R1, R2, R3, X, c, d, e, f, g, x, y, a, b, z and n are defined in the specification. These compounds are useful in lowering IOP and/or treating glaucoma or providing neuroprotection to the eye of a human patient.
    Type: Grant
    Filed: August 21, 2006
    Date of Patent: March 29, 2011
    Assignee: Allergan, Inc
    Inventor: Robert M. Burk
  • Cyclopentane heptan(ENE)OIC acid, 2-heteroarylalkenyl derivatives as therapeutic agents
    Patent number: 7906552
    Abstract: A compound comprising or a pharmaceutically acceptable salt or a prodrug thereof, having the groups described in detail herein is disclosed. Also disclosed herein are compounds comprising or derivatives thereof, or pharmaceutically acceptable salts, tetrazoles, or prodrugs of compounds of the structure or derivatives thereof, said derivatives being described in detail herein. Also disclosed herein are methods of treating diseases or conditions, including glaucoma and elevated intraocular pressure. Compositions and methods of manufacturing medicaments related thereto are also disclosed.
    Type: Grant
    Filed: August 10, 2004
    Date of Patent: March 15, 2011
    Assignee: Allergan, Inc.
    Inventors: Yariv Donde, Robert M. Burk, Michael E. Garst
  • Therapeutic compounds
    Patent number: 7897629
    Abstract: Disclosed herein is a compound having a structure or a pharmaceutically acceptable salt thereof, or a prodrug thereof. Therapeutic methods, compositions, and medicaments related thereto are also disclosed.
    Type: Grant
    Filed: June 2, 2009
    Date of Patent: March 1, 2011
    Assignee: Allergan, Inc.
    Inventors: Robert M. Burk, David W. Old, Todd S. Gac
  • Combination therapy for glaucoma treatment
    Patent number: 7872045
    Abstract: A method is disclosed herein comprising administering a compound and a second drug to an eye of a mammal for the treatment of glaucoma or the reduction of intraocular pressure, said compound represented by the general formula I; wherein A, B, D, X, Y, Z, R1, R3 and R4 are as defined in the specification.
    Type: Grant
    Filed: May 16, 2005
    Date of Patent: January 18, 2011
    Assignee: Allergan, Inc.
    Inventors: Robert M. Burk, Mark Holoboski, Scott M. Whitcup, Wha-Bin Im
  • Therapeutic esters
    Patent number: 7868035
    Abstract: A compound comprising or a pharmaceutically acceptable salt or a prodrug thereof; wherein X and Y are described herein.
    Type: Grant
    Filed: January 31, 2006
    Date of Patent: January 11, 2011
    Assignee: Allergan, Inc.
    Inventors: David F. Woodward, Robert M. Burk
  • Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents
    Patent number: 7863319
    Abstract: A compound comprising or a pharmaceutically acceptable salt or a prodrug thereof, having the groups described in detail herein is disclosed. Also disclosed herein are compounds comprising or derivatives thereof, or pharmaceutically acceptable salts, tetrazoles, or prodrugs of compounds of the structure or derivatives thereof, said derivatives being described in detail herein. Also disclosed herein are methods of treating diseases or conditions, including glaucoma and elevated intraocular pressure. Compositions and methods of manufacturing medicaments related thereto are also disclosed.
    Type: Grant
    Filed: January 16, 2007
    Date of Patent: January 4, 2011
    Assignee: Allergan, Inc.
    Inventors: Yariv Donde, Robert M. Burk, Michael E. Garst