Patents by Inventor Robert M. Hughes

Robert M. Hughes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210246117
    Abstract: The disclosure provides processes for preparing a compound of Formula (I).
    Type: Application
    Filed: December 7, 2018
    Publication date: August 12, 2021
    Inventors: Paul T. Angell, Cristian Harrison, Robert M. Hughes, Berenice Lewandowski, Benjamin J. Littler, Vito Melillo, William A. Nugent, David Andrew Siesel, David Smith, John Studley
  • Publication number: 20210047295
    Abstract: Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.
    Type: Application
    Filed: August 17, 2020
    Publication date: February 18, 2021
    Inventors: Alexander Russell Abela, Timothy Alcacio, Corey Anderson, Paul Timothy Angell, Minson Baek, Jeremy J. Clemens, Thomas Cleveland, Lori Ann Ferris, Peter Diederik Jan Grootenhuis, Raymond Stanley Gross, Anton V. Gulevich, Sara Sabina Hadida Ruah, Clara Kuang-Ju Hsia, Robert M. Hughes, Pramod Virupax Joshi, Ping Kang, Ali Keshavarz-Shokri, Haripada Khatuya, Paul John Krenitsky, Jason McCartney, Mark Thomas Miller, Prasuna Paraselli, Fabrice Jean Denis Pierre, Yi Shi, Muna Shrestha, David Andrew Siesel, Kathy Stavropoulos, Andreas P. Termin, Fredrick F. Van Goor, Johnny Uy, Timothy John Young, Jinglan Zhou
  • Publication number: 20200369608
    Abstract: Processes for preparing 5,5-dimethyl-3-methylenepyrrolidin-2-one, (S)-3,5,5-trimethylpyrrolidine-2-one, (R)-3,5,5-trimethylpyrrolidine-2-one, (S)-2,4,4-trimethylpyrrolidine, and (R)-2,4,4-trimethylpyrrolidine, and their salt forms are disclosed.
    Type: Application
    Filed: August 2, 2018
    Publication date: November 26, 2020
    Inventors: Paul T. Angell, Robert M. Hughes, Berenice Lewandowski, Benjamin J. Littler, William A. Nugent, David Smith, John Studley
  • Patent number: 10793547
    Abstract: Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.
    Type: Grant
    Filed: December 8, 2017
    Date of Patent: October 6, 2020
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Alexander Russell Abela, Timothy Alcacio, Corey Anderson, Paul Timothy Angell, Minson Baek, Jeremy J. Clemens, Thomas Cleveland, Lori Ann Ferris, Peter Diederik Jan Grootenhuis, Raymond Stanley Gross, Anton V. Gulevich, Sara Sabina Hadida Ruah, Clara Kuang-Ju Hsia, Robert M. Hughes, Pramod Virupax Joshi, Ping Kang, Ali Keshavarz-Shokri, Haripada Khatuya, Paul John Krenitsky, Jason McCartney, Mark Thomas Miller, Prasuna Paraselli, Fabrice Jean Denis Pierre, Yi Shi, Muna Shrestha, David Andrew Siesel, Kathy Stavropoulos, Andreas P. Termin, Fredrick F. Van Goor, Johnny Uy, Timothy John Young, Jinglan Zhou
  • Publication number: 20200283405
    Abstract: Compounds of Formula I: pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.
    Type: Application
    Filed: December 4, 2019
    Publication date: September 10, 2020
    Inventors: Timothy Alcacio, Minson Baek, Peter Grootenhuis, Sara Sabina Hadida Ruah, Robert M. Hughes, Ali Keshavarz-Shokri, Rachel McAuley-Aoki, Jason McCartney, Mark Thomas Miller, Fredrick Van Goor, Beili Zhang, Corey Anderson, Thomas Cleveland, Bryan A. Frieman, Haripada Khatuya, Pramod Virupax Joshi, Paul John Krenitsky, Vito Melillo, Fabrice Jean Denis Pierre, Andreas P. Termin, Johnny Uy, Jinglan Zhou, Alexander Russell Abela, Brett Bradley Busch, Prasuna Paraselli
  • Patent number: 10570115
    Abstract: Compounds of Formula I: pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: February 25, 2020
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Timothy Alcacio, Minson Baek, Peter Grootenhuis, Sara Sabina Hadida Ruah, Robert M. Hughes, Ali Keshavarz-Shokri, Rachel McAuley-Aoki, Jason McCartney, Mark Thomas Miller, Fredrick Van Goor, Beili Zhang, Corey Anderson, Thomas Cleveland, Bryan A. Frieman, Haripada Khatuya, Pramod Virupax Joshi, Paul John Krenitsky, Vito Melillo, Fabrice Jean Denis Pierre, Andreas P. Termin, Johnny Uy, Jinglan Zhou, Alexander Russell Abela, Brett Bradley Busch, Prasuna Paraselli, David Andrew Siesel
  • Publication number: 20180162839
    Abstract: Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.
    Type: Application
    Filed: December 8, 2017
    Publication date: June 14, 2018
    Inventors: Alexander Russell Abela, Timothy Alcacio, Corey Anderson, Paul Timothy Angell, Minson Baek, Jeremy J. Clemens, Thomas Cleveland, Lori Ann Ferris, Peter Diederik Jan Grootenhuis, Raymond Stanley Gross, Anton V. Gulevich, Sara Sabina Hadida Ruah, Clara Kuang-Ju Hsia, Robert M. Hughes, Pramod Virupax Joshi, Ping Kang, Ali Keshavarz-Shokri, Haripada Khatuya, Paul John Krenitsky, Jason McCartney, Mark Thomas Miller, Prasuna Paraselli, Fabrice Jean Denis Pierre, Yi Shi, Muna Shrestha, David Andrew Siesel, Kathy Stavropoulos, Andreas P. Termin, Fredrick F. Van Goor, Johnny Uy, Timothy John Young, Jinglan Zhou
  • Publication number: 20180093969
    Abstract: Compounds of Formula I: pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.
    Type: Application
    Filed: September 29, 2017
    Publication date: April 5, 2018
    Inventors: Timothy Alcacio, Minson Baek, Peter Grootenhuis, Sara Sabina Hadida Ruah, Robert M. Hughes, Ali Keshavarz-Shokri, Rachel McAuley-Aoki, Jason McCartney, Mark Thomas Miller, Fredrick Van Goor, Beili Zhang, Corey Anderson, Thomas Cleveland, Bryan A. Frieman, Haripada Khatuya, Pramod Virupax Joshi, Paul John Krenitsky, Vito Melillo, Fabrice Jean Denis Pierre, Andreas P. Termin, Johnny Uy, Jinglan Zhou, Alexander Russell Abela, Brett Bradley Busch, Prasuna Paraselli, David Andrew Siesel
  • Patent number: 7633749
    Abstract: An enclosure and method of construction for use with electronic devices such as computers, amplifiers, switching systems, receivers, video monitors, and televisions, allows a user to access virtually all connector ports on a given piece of equipment from the front of the equipment by displacing a moveable front accessible control panel which supports control mechanisms by which to regulate the equipment. The ideal enclosure may be elevated on adjustable feet such that connector cables from connected peripheral devices may be routed beneath the enclosure to corresponding connector ports at the front of the enclosure.
    Type: Grant
    Filed: December 21, 2007
    Date of Patent: December 15, 2009
    Inventor: Robert M. Hughes
  • Publication number: 20090161322
    Abstract: An enclosure and method of construction for use with electronic devices such as computers, amplifiers, switching systems, receivers, video monitors, and televisions, allows a user to access virtually all connector ports on a given piece of equipment from the front of the equipment by displacing a moveable front accessible control panel which supports control mechanisms by which to regulate the equipment. The ideal enclosure may be elevated on adjustable feet such that connector cables from connected peripheral devices may be routed beneath the enclosure to corresponding connector ports at the front of the enclosure. Alternatively, the enclosure may include one or more channels through which connector cables may be passed for greater concealment. Channels may be fixed, may include moveable panels for greater access, or may be completely removable for more easily accessing internal components of the enclosure.
    Type: Application
    Filed: December 21, 2007
    Publication date: June 25, 2009
    Inventor: Robert M. Hughes
  • Patent number: 5956983
    Abstract: A locking mechanism for bicycle or motorcycle wheels. The mechanism is a through-the-wheel lock that has a hook that attaches to a stationary fixed object, such as a pole. A first embodiment of the invention has a holding bracket attached to one side of the vehicle's front fork. A locking bracket is mounted on the other side of the front fork, directly opposite the holding bracket. A locking cane having a U-shaped end hook includes a number of rachet teeth on the end of the cane opposite the end hook. The holding bracket has a first opening for holding the locking bar in an inoperative position, and a second opening for holding the locking cane in a position wherein the rachet teeth end of the cane inserts between the front wheel spokes and into engagement with the locking mechanism. The end hook is looped around a pole, (or other suitable stationary object), and the cane is pushed into the locking mechanism until the bar and cycle are snug.
    Type: Grant
    Filed: June 12, 1997
    Date of Patent: September 28, 1999
    Inventor: Robert M. Hughes
  • Patent number: 4424194
    Abstract: The method for extraction of precious metals from leachable ores and forming a building materials which includes the steps of crushing a quantity of leachable ore into a powder of substantially uniform particle size, mixing with a quantity of a binding material and mixing with a leaching material. The materials are then formed into a masonry building construction article having at least one passage therein. A plurality of the masonry building construction articles are stacked with at least some of the passages disposed therein in generally parallel flow paths and a solvent is passed through the passages of the masonry building construction articles.
    Type: Grant
    Filed: January 4, 1982
    Date of Patent: January 3, 1984
    Inventor: Robert M. Hughes
  • Patent number: 4190436
    Abstract: Timed or regulated air bursts are employed to agitate and oxygenate leachable ores or other material containing valuable leachable elements in the presence of a leaching solution. The process provides a homogenous mixing of fines within the leaching solution thereby reducing channeling within the ore.
    Type: Grant
    Filed: December 20, 1977
    Date of Patent: February 26, 1980
    Inventor: Robert M. Hughes
  • Patent number: 4108365
    Abstract: Recording apparatus for "dubbing" (recording from one to the other) onto a customer's magnetic tape cartridge, selected audio and/or video recordings stored in the apparatus. The apparatus includes means for activating the apparatus, means for selecting the desired recordings, means for identifying and storing data representing the selected recordings for tabulating royalties accrued by playing the selected recordings, and magnetic tape cartridge receptacle, transport and recording means for the customer's cartridge. The record selection and recording means may be located directly on the record storage and playback machine or at a remote recording station.
    Type: Grant
    Filed: January 15, 1976
    Date of Patent: August 22, 1978
    Inventor: Robert M. Hughes
  • Patent number: 3990710
    Abstract: Recording apparatus for "dubbing" (recording from one to the other) onto a customer's magnetic tape cartridge, selected audio and/or video recordings stored in the apparatus. The apparatus includes means for activating the apparatus, means for selecting the desired recordings, means for identifying and storing data representing the selected recordings for tabulating royalties accrued by playing the selected recording, and magnetic tape cartridge receptacle, transport and recording means for the customer's cartridge. The record selection and recording means may be located directly on the record storage and playback machine or at a remote recording station.
    Type: Grant
    Filed: March 1, 1971
    Date of Patent: November 9, 1976
    Inventor: Robert M. Hughes
  • Patent number: D308451
    Type: Grant
    Filed: May 29, 1987
    Date of Patent: June 12, 1990
    Inventors: Robert M. Hughes, Robert M. Hughes, Jr.