Abstract: A compressor for a heat transfer circuit includes a variable frequency drive (VFD), an electric motor that rotates a driveshaft, bearing(s) for supporting the driveshaft, a backup gas supply, and a power supply. During a utility power interruption, the backup gas supply operates utilizing DC electrical power generated by a back electromotive force of the electric motor. A method of operating an electric power supply system for a compressor includes operating in a utility power mode and operating in a backup power mode during a utility power interruption. In the utility power mode, AC electrical power is supplied from the VFD to the motor. In the backup power mode, DC electrical power generated in the VFD by a back electromotive force of the motor it used to operate a backup gas supply to supply compressed working fluid to gas bearing(s) of the compressor.

Abstract: The disclosure provides processes for preparing a compound of Formula (I):

Abstract: Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.

Abstract: The disclosure provides processes for preparing a compound of Formula (I).

Abstract: Compounds of Formula I: pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

Abstract: Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.

Abstract: Processes for preparing 5,5-dimethyl-3-methylenepyrrolidin-2-one, (S)-3,5,5-trimethylpyrrolidine-2-one, (R)-3,5,5-trimethylpyrrolidine-2-one, (S)-2,4,4-trimethylpyrrolidine, and (R)-2,4,4-trimethylpyrrolidine, and their salt forms are disclosed.

Abstract: Compounds of Formula I: pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

Abstract: The disclosure provides processes for preparing a compound of Formula (I).

Abstract: Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.

Abstract: Processes for preparing 5,5-dimethyl-3-methylenepyrrolidin-2-one, (S)-3,5,5-trimethylpyrrolidine-2-one, (R)-3,5,5-trimethylpyrrolidine-2-one, (S)-2,4,4-trimethylpyrrolidine, and (R)-2,4,4-trimethylpyrrolidine, and their salt forms are disclosed.

Abstract: Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.

Abstract: Compounds of Formula I: pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

Abstract: Compounds of Formula I: pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

Abstract: Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.

Abstract: Compounds of Formula I: pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

Abstract: An enclosure and method of construction for use with electronic devices such as computers, amplifiers, switching systems, receivers, video monitors, and televisions, allows a user to access virtually all connector ports on a given piece of equipment from the front of the equipment by displacing a moveable front accessible control panel which supports control mechanisms by which to regulate the equipment. The ideal enclosure may be elevated on adjustable feet such that connector cables from connected peripheral devices may be routed beneath the enclosure to corresponding connector ports at the front of the enclosure.

Abstract: An enclosure and method of construction for use with electronic devices such as computers, amplifiers, switching systems, receivers, video monitors, and televisions, allows a user to access virtually all connector ports on a given piece of equipment from the front of the equipment by displacing a moveable front accessible control panel which supports control mechanisms by which to regulate the equipment. The ideal enclosure may be elevated on adjustable feet such that connector cables from connected peripheral devices may be routed beneath the enclosure to corresponding connector ports at the front of the enclosure. Alternatively, the enclosure may include one or more channels through which connector cables may be passed for greater concealment. Channels may be fixed, may include moveable panels for greater access, or may be completely removable for more easily accessing internal components of the enclosure.

Abstract: A locking mechanism for bicycle or motorcycle wheels. The mechanism is a through-the-wheel lock that has a hook that attaches to a stationary fixed object, such as a pole. A first embodiment of the invention has a holding bracket attached to one side of the vehicle's front fork. A locking bracket is mounted on the other side of the front fork, directly opposite the holding bracket. A locking cane having a U-shaped end hook includes a number of rachet teeth on the end of the cane opposite the end hook. The holding bracket has a first opening for holding the locking bar in an inoperative position, and a second opening for holding the locking cane in a position wherein the rachet teeth end of the cane inserts between the front wheel spokes and into engagement with the locking mechanism. The end hook is looped around a pole, (or other suitable stationary object), and the cane is pushed into the locking mechanism until the bar and cycle are snug.