Patents by Inventor Robert MacLeod

Robert MacLeod has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250136986
    Abstract: The present embodiments provide methods, compounds, and compositions useful for inhibiting MALAT1 expression, which may be useful for treating, preventing, or ameliorating a cancer associated with MALAT1.
    Type: Application
    Filed: October 18, 2024
    Publication date: May 1, 2025
    Applicant: Ionis Pharmaceuticals, Inc.
    Inventors: Susan M. FREIER, Youngsoo KIM, Robert MACLEOD
  • Patent number: 12157890
    Abstract: The present embodiments provide methods, compounds, and compositions useful for inhibiting MALAT1 expression, which may be useful for treating, preventing, or ameliorating a cancer associated with MALAT1.
    Type: Grant
    Filed: February 8, 2022
    Date of Patent: December 3, 2024
    Assignee: Ionis Pharmaceuticals, Inc.
    Inventors: Susan M. Freier, Youngsoo Kim, Robert Macleod
  • Patent number: 12042510
    Abstract: The present embodiments provide methods, compounds, and compositions useful for inhibiting IRF4 expression, which may be useful for treating, preventing, or ameliorating a cancer associated with IRF4.
    Type: Grant
    Filed: December 17, 2021
    Date of Patent: July 23, 2024
    Assignee: Ionis Pharmaceuticals, Inc.
    Inventors: Tianyuan Zhou, Youngsoo Kim, Robert MacLeod, Huynh-Hoa Bui, Susan M. Freier
  • Publication number: 20220315927
    Abstract: The present embodiments provide methods, compounds, and compositions useful for inhibiting YAP1 expression, which may be useful for treating, preventing, or ameliorating a cancer associated with YAP1.
    Type: Application
    Filed: November 16, 2021
    Publication date: October 6, 2022
    Applicant: Ionis Pharmaceuticals, Inc.
    Inventors: Youngsoo Kim, Xiaolin Luo, Robert MacLeod, Susan M. Freier, Huynh-Hoa Bui
  • Publication number: 20220243205
    Abstract: The present embodiments provide methods, compounds, and compositions useful for inhibiting MALAT1 expression, which may be useful for treating, preventing, or ameliorating a cancer associated with MALAT1.
    Type: Application
    Filed: February 8, 2022
    Publication date: August 4, 2022
    Applicant: Ionis Pharmaceuticals, Inc.
    Inventors: Susan M. FREIER, Youngsoo KIM, Robert MACLEOD
  • Publication number: 20220241320
    Abstract: The present embodiments provide methods, compounds, and compositions useful for inhibiting IRF4 expression, which may be useful for treating, preventing, or ameliorating a cancer associated with IRF4.
    Type: Application
    Filed: December 17, 2021
    Publication date: August 4, 2022
    Inventors: Tianyuan ZHOU, Youngsoo KIM, Robert MACLEOD, Huynh-Hoa BUI, Susan M. FREIER
  • Patent number: 11365416
    Abstract: The present embodiments provide methods, compounds, and compositions useful for inhibiting EZH2 expression, which may be useful for treating, preventing, or ameliorating a cancer associated with EZH2.
    Type: Grant
    Filed: April 11, 2019
    Date of Patent: June 21, 2022
    Assignee: Ionis Pharmaceuticals, Inc.
    Inventors: Minji Jo, Youngsoo Kim, Robert MacLeod, Susan M. Freier
  • Patent number: 11279932
    Abstract: The present embodiments provide methods, compounds, and compositions useful for inhibiting MALAT1 expression, which may be useful for treating, preventing, or ameliorating a cancer associated with MALAT1.
    Type: Grant
    Filed: February 27, 2020
    Date of Patent: March 22, 2022
    Assignee: IONIS PHARMACEUTICALS, INC.
    Inventors: Susan M. Freier, Youngsoo Kim, Robert MacLeod
  • Patent number: 11241451
    Abstract: The present embodiments provide methods, compounds, and compositions useful for inhibiting IRF4 expression, which may be useful for treating, preventing, or ameliorating a cancer associated with IRF4.
    Type: Grant
    Filed: March 1, 2019
    Date of Patent: February 8, 2022
    Assignee: Ionis Pharmaceuticals, Inc.
    Inventors: Tianyuan Zhou, Youngsoo Kim, Robert MacLeod, Huynh-Hoa Bui, Susan M. Freier
  • Patent number: 11214803
    Abstract: The present embodiments provide methods, compounds, and compositions useful for inhibiting YAP1 expression, which may be useful for treating, preventing, or ameliorating a cancer associated with YAP1.
    Type: Grant
    Filed: January 31, 2020
    Date of Patent: January 4, 2022
    Assignee: Ionis Pharmaceuticals, Inc.
    Inventors: Youngsoo Kim, Xiaolin Luo, Robert MacLeod, Susan M. Freier, Huynh-Hoa Bui
  • Publication number: 20210155935
    Abstract: The present embodiments provide methods, compounds, and compositions useful for inhibiting EZH2 expression, which may be useful for treating, preventing, or ameliorating a cancer associated with EZH2.
    Type: Application
    Filed: April 11, 2019
    Publication date: May 27, 2021
    Applicant: Ionis Pharmaceuticals, Inc.
    Inventors: Minji Jo, Youngsoo Kim, Robert MacLeod, Susan M. Freier
  • Publication number: 20210123059
    Abstract: The present embodiments provide methods, compounds, and compositions useful for inhibiting YAP1 expression, which may be useful for treating, preventing, or ameliorating a cancer associated with YAP1.
    Type: Application
    Filed: January 31, 2020
    Publication date: April 29, 2021
    Applicant: Ionis Pharmaceuticals, Inc.
    Inventors: Youngsoo Kim, Xiaolin Luo, Robert MacLeod, Susan M. Freier, Huynh-Hoa Bui
  • Publication number: 20210038631
    Abstract: The present embodiments provide methods, compounds, and compositions useful for inhibiting IRF4 expression, which may be useful for treating, preventing, or ameliorating a cancer associated with IRF4.
    Type: Application
    Filed: March 1, 2019
    Publication date: February 11, 2021
    Applicant: Ionis Pharmaceuticals, Inc.
    Inventors: Tianyuan Zhou, Youngsoo Kim, Robert MacLeod, Huynh-Hoa Bui, Susan M. Freier
  • Publication number: 20200277604
    Abstract: The present embodiments provide methods, compounds, and compositions useful for inhibiting MALAT1 expression, which may be useful for treating, preventing, or ameliorating a cancer associated with MALAT1.
    Type: Application
    Filed: February 27, 2020
    Publication date: September 3, 2020
    Applicant: Ionis Pharmaceuticals, Inc.
    Inventors: Susan M. Freier, Youngsoo Kim, Robert MacLeod
  • Patent number: 8707491
    Abstract: A multi-functional gardening implement that, in some embodiments, functions as a pair of shears, a spade, a garden cultivator, a saw, a machete, a weeder and a rake. The implement comprises two shears that cooperate to cut vegetation placed between them when a user presses the handles of the shears together. The implement also has at least one appendage, which may be a shovel, a hoe, a garden cultivator, or another garden tool that is attached to the central portions of the shears and can be rotated to an operating position where the appendage is supported by the blades of the shears. The implement may have a second appendage that rotates in the opposite direction to a similar operating position against the other sides of the blades. In some embodiments, the cutting portions of the shears may be configured to define a spade blade in the closed position.
    Type: Grant
    Filed: October 23, 2013
    Date of Patent: April 29, 2014
    Assignee: 2378807 Ontario Inc.
    Inventors: John Dykyj, John Askwith, Robert MacLeod
  • Publication number: 20130199942
    Abstract: An electrochemical-based analytical test strip (“EBAT”) for the determination of an analyte in a bodily fluid sample includes an electrically insulating substrate layer with a distal end and a patterned conductor layer that is disposed over the electrically-insulating substrate layer and has a working electrode (“WE”) and a counter/reference electrode (“C/RE”). The EBAT also includes a patterned insulation layer with an electrode exposure window configured to expose a WE exposed portion and a C/RE exposed portion, an enzymatic reagent layer; and a patterned spacer layer. The patterned insulation layer and the patterned spacer layer define a sample receiving chamber with a sample-receiving opening (“SRO”) at the distal end of the electrically insulating substrate layer and that extends across the WE exposed portion and the C/RE exposed portion. Furthermore, the enzymatic reagent layer is disposed over the WE and C/RE exposed portions and extends no more than 400 ?m toward the SRO.
    Type: Application
    Filed: February 7, 2012
    Publication date: August 8, 2013
    Inventors: Neil WHITEHEAD, Stuart Phillips, David Morris, Joanne McIlrath, Robert MacLeod, Lynsey Whyte, Karn Campbell, Ramsay Darling, James McLaren, Russell Bain
  • Publication number: 20070047676
    Abstract: One embodiment is a system for processing a complex ambiguity function (CAF) comprising creating a CAF surface from incoming data and a model vector, wherein the CAF surface has at least one feature, processing for a peak value, establishing a sub-window about the peak, wherein the peak is within the sub-window, and flattening the peak.
    Type: Application
    Filed: April 10, 2006
    Publication date: March 1, 2007
    Applicant: BAE Systems and Electronic Systems Integration Inc
    Inventor: Robert MacLeod
  • Publication number: 20060115026
    Abstract: Performing approximate diagonalization of a correlation metric by user permutation to improve Multiuser Detector (MUD) processing. The system reorders the entries in the S-Matrix in order to move the bit decisions closer together in the decision tree. In one embodiment the reordering is a sequential pairwise correlation.
    Type: Application
    Filed: December 1, 2005
    Publication date: June 1, 2006
    Applicant: BAE Systems Information and Electronic Systems Integration Inc.
    Inventor: Robert MacLeod
  • Publication number: 20050053173
    Abstract: A multiple access processing system for a plurality of users employing a multiuser detector processing partial blocks of data within a window. The multiuser detector processes the data for all users within a processing window and is interrupted at successive frame boundaries. Once an entire block is processed by the MUD, the blocks for that user are decoded and the processing continues.
    Type: Application
    Filed: September 10, 2003
    Publication date: March 10, 2005
    Inventors: Dianne Egnor, Robert MacLeod
  • Publication number: 20050036437
    Abstract: Techniques for reading data from a storage medium (150) having a high track density prone to adjacent track interference are disclosed. One or more sensing elements (120) are used to extract data stored on adjacent tracks. Multiuser detection (130) is then used to detect/decode a single track that is closely spaced to its neighboring tracks, resolve interference from adjacent tracks, or to simultaneously detect/decode multiple adjacent closely packed tracks.
    Type: Application
    Filed: September 19, 2003
    Publication date: February 17, 2005
    Inventors: Rachel Learned, Robert MacLeod