Abstract: A multi-functional gardening implement that, in some embodiments, functions as a pair of shears, a spade, a garden cultivator, a saw, a machete, a weeder and a rake. The implement comprises two shears that cooperate to cut vegetation placed between them when a user presses the handles of the shears together. The implement also has at least one appendage, which may be a shovel, a hoe, a garden cultivator, or another garden tool that is attached to the central portions of the shears and can be rotated to an operating position where the appendage is supported by the blades of the shears. The implement may have a second appendage that rotates in the opposite direction to a similar operating position against the other sides of the blades. In some embodiments, the cutting portions of the shears may be configured to define a spade blade in the closed position.

Abstract: Certain embodiments are directed to compounds and compositions targeted to human androgen receptor (AR) for inhibiting androgen receptor levels in a cell, which can be useful for methods of treating cancer and inhibiting cancer cell growth or proliferation.

Abstract: Disclosed herein are methods for decreasing Factor 12 and treating or preventing thromboembolic conditions in an individual in need thereof. Examples of disease conditions that can be ameliorated with the administration of antisense compounds targeted to Factor 12 include thrombosis, embolism, and thromboembolism, such as, deep vein thrombosis, pulmonary embolism, myocardial infarction, stroke, and mesenteric thrombosis. Methods for inhibiting Factor 12 can also be used as a prophylactic treatment to prevent individuals at risk for thrombosis and embolism.

Abstract: Provided herein are methods, compounds, and compositions for reducing expression of a DMPK mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for preferentially reducing CUGexp DMPK RNA, reducing myotonia or reducing spliceopathy in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate type 1 myotonic dystrophy, or a symptom thereof.

Abstract: An electrochemical-based analytical test strip (“EBAT”) for the determination of an analyte in a bodily fluid sample includes an electrically insulating substrate layer with a distal end and a patterned conductor layer that is disposed over the electrically-insulating substrate layer and has a working electrode (“WE”) and a counter/reference electrode (“C/RE”). The EBAT also includes a patterned insulation layer with an electrode exposure window configured to expose a WE exposed portion and a C/RE exposed portion, an enzymatic reagent layer; and a patterned spacer layer. The patterned insulation layer and the patterned spacer layer define a sample receiving chamber with a sample-receiving opening (“SRO”) at the distal end of the electrically insulating substrate layer and that extends across the WE exposed portion and the C/RE exposed portion. Furthermore, the enzymatic reagent layer is disposed over the WE and C/RE exposed portions and extends no more than 400 ?m toward the SRO.

Abstract: Disclosed herein are antisense compounds and methods for decreasing STAT3 mRNA and protein expression. Such methods, compounds, and compositions are useful to treat, prevent, or ameliorate hyperproliferative diseases.

Abstract: Disclosed herein are antisense compounds and methods for modulating Factor XI and modulating an inflammatory disease, disorder or condition in an individual in need thereof. Inflammatory diseases in an individual such as arthritis and colitis can be ameliorated or prevented with the administration of antisense compounds targeted to Factor XI.

Abstract: One embodiment is a system for processing a complex ambiguity function (CAF) comprising creating a CAF surface from incoming data and a model vector, wherein the CAF surface has at least one feature, processing for a peak value, establishing a sub-window about the peak, wherein the peak is within the sub-window, and flattening the peak.

Abstract: Performing approximate diagonalization of a correlation metric by user permutation to improve Multiuser Detector (MUD) processing. The system reorders the entries in the S-Matrix in order to move the bit decisions closer together in the decision tree. In one embodiment the reordering is a sequential pairwise correlation.

Abstract: The invention relates to the modulation of gene expression. In particular, the invention relates to compositions comprising antisense oligonucleotides which inhibit expression of a gene in operable association with protein effectors of a product of that gene, and methods of using the same. In addition, the invention relates to the modulation of mammalian gene expression regulated by methylation.

Abstract: A multiple access processing system for a plurality of users employing a multiuser detector processing partial blocks of data within a window. The multiuser detector processes the data for all users within a processing window and is interrupted at successive frame boundaries. Once an entire block is processed by the MUD, the blocks for that user are decoded and the processing continues.

Abstract: Techniques for reading data from a storage medium (150) having a high track density prone to adjacent track interference are disclosed. One or more sensing elements (120) are used to extract data stored on adjacent tracks. Multiuser detection (130) is then used to detect/decode a single track that is closely spaced to its neighboring tracks, resolve interference from adjacent tracks, or to simultaneously detect/decode multiple adjacent closely packed tracks.

Abstract: The invention relates to the modulation of gene expression. In particular, the invention relates to compositions comprising antisense oligonucleotides which inhibit expression of a gene in operable association with protein effectors of a product of that gene, and methods of using the same.

Abstract: This invention relates to the inhibition of DNA MeTase expression and enzymatic activity. The invention provides methods and agents for inhibiting specific DNA MeTase isoforms by inhibiting expression at the nucleic acid level or enzymatic activity at the protein level.

Abstract: The invention relates to the inhibition of histone deacetylase expression and enzymatic activity and, in particular, to the inhibition of a specific histone deacetylase. The invention also relates to compositions comprising antisense oligonucleotides and methods of using the same to inhibit a histone deacetylase. Also disclosed are methods for identifying a histone deacetylase involved in induction of cell proliferation, and methods for identifying compounds that interact with and reduce the enzymatic activity of such a histone deacetylase.

Abstract: The invention provides optimized antisense oligonucleotides complementary to the DNA methyltransferase gene or its RNA transcript. The invention further provides methods for using such antisense oligonucleotides as analytical and diagnostic tools, as potentiators of transgenic plant and animal studies and gene therapy approaches, and as potential therapeutic agents.

Abstract: The invention provides optimized antisense oligonucleotides complementary to the DNA methyltransferase gene or its RNA transcript. The invention further provides methods for using such antisense oligonucleotides as analytical and diagnostic tools, as potentiators of transgenic plant and animal studies and gene therapy approaches, and as potential therapeutic agents.

Abstract: A container for holding a cassette that includes a rectangular casing into which a cassette can be directly inserted and stored and a frame-like bottomless slide which is positioned in the casing and selectively operated for moving the cassette into and out of the casing. An hourglass-type spring is positioned between the slide and casing to urge the slide to an upwardly extended cassette-exposing position. A selectively releasable locking mechanism for retaining the slide in a cassette-storing position includes a finger pressure contact indentation formed in the front wall of the slide and double-latch locking projections formed on the front of the slide and casing at opposite sides of the finger pressure contact indentation. Hublock projections formed on the slide engage the hub-openings of a stored cassette only when the slide is in its cassette-storing position.