Patents by Inventor Robert McDaniel

Robert McDaniel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modular polyketide synthases with altered activity
    Publication number: 20050032176
    Abstract: The substrate specificity of modular polyketide synthases is altered by mutating or replacing acyltransferase regions thereof.
    Type: Application
    Filed: May 19, 2004
    Publication date: February 10, 2005
    Inventors: Chaitan Khosla, Gary Ashley, Hong Fu, Camilla Kao, Robert McDaniel
  • 2-Desmethyl ansamycin compounds
    Publication number: 20050026894
    Abstract: 2-Desmethyl ansamycins having a structure according to formula I, where R1, R2, R3, R4, R5 and R6 are as defined herein, and other 2-desmethyl ansamycins are useful as antiproliferative agents.
    Type: Application
    Filed: June 14, 2004
    Publication date: February 3, 2005
    Inventors: Zong-Qiang Tian, Robert McDaniel, David Myles, Kedar Patel, Misty Piagentini, Zhan Wang
  • Recombinant narbonolide polyketide synthase
    Publication number: 20050026244
    Abstract: Recombinant DNA compounds that encode all or a portion of the narbonolide polyketide synthase are used to express recombinant polyketide synthase genes in host cells for the production of narbonolide, narbonolide derivatives, and polyketides that are useful as antibiotics and as intermediates in the synthesis of compounds with pharmaceutical value.
    Type: Application
    Filed: February 22, 2002
    Publication date: February 3, 2005
    Inventors: Gary Ashley, Melanie Betlach, Mary Betlach, Robert McDaniel, Li Tang
  • Overproduction hosts for biosynthesis of polyketides
    Patent number: 6838265
    Abstract: Generic overproduction host cells can be used to produce any polyketide and obviate the need for performing conventional strain improvement.
    Type: Grant
    Filed: May 1, 2001
    Date of Patent: January 4, 2005
    Assignee: Kosan Biosciences, Inc.
    Inventors: Daniel Santi, Robert McDaniel, Li Tang, Chaitan Khosla
  • Methods for introducing hydroxyl or epoxide groups into polyketides using OleP
    Patent number: 6828126
    Abstract: The heterologous expression of the oleandomycin polyketide synthase (OlePKS) in Streptomyces lividans, produces 8,8 a-deoxyoleandolide, an aglycone precursor of oleandomycin. The co-expression with deoxyerythronolide B synthase (DEBS) in S. lividans of the P450 monooxygenase OleP produces 8,8 a-dihydroxy-6-deoxyerythonolide B and other derivatives that are precursors to important macrolide antibiotics.
    Type: Grant
    Filed: November 16, 2001
    Date of Patent: December 7, 2004
    Assignee: Kosan Biosciences, Inc.
    Inventor: Robert McDaniel
  • Motilide compounds
    Publication number: 20040138150
    Abstract: Motilide compounds having the formula (I), 1
    Type: Application
    Filed: August 26, 2003
    Publication date: July 15, 2004
    Inventors: Daniel V. Santi, Brian Metcalf, Christopher Carreras, Yaoquan Liu, Robert McDaniel, Eduardo J. Rodriguez
  • Recombinant polynucleotides encoding pro-geldanamycin producing polyketide synthase and accessory proteins, and uses thereof
    Publication number: 20040077058
    Abstract: The invention relates to recombinant polyketide synthase enzymes, polyketide modifying proteins, and other proteins involved in polyketide biosynthesis or function. The invention provides domains of geldanamycin and herbimycin polyketide synthases, polynucleotides that encode such enzymes, and to host cells in which such encoding polynucleotides can be advantageously expressed.
    Type: Application
    Filed: June 13, 2003
    Publication date: April 22, 2004
    Inventors: Richard C. Hutchinson, Ralph C. Reid, Zhihao Hu, Andreas Rascher, Andreas Schirmer, Robert McDaniel
  • Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
    Publication number: 20030194785
    Abstract: Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for erythromycin. The combinatorial library is useful as a source of pharmaceutically active compounds. In addition, novel polyketides and antibiotics are prepared using this method.
    Type: Application
    Filed: January 10, 2003
    Publication date: October 16, 2003
    Inventors: Chaitan Khosla, Gary Ashley, Hong Fu, Camilla M. Kao, Robert McDaniel
  • Recombinant narbonolide polyketide synthase
    Publication number: 20030162262
    Abstract: Recombinant DNA compounds that encode all or a portion of the narbonolide polyketide synthase are used to express recombinant polyketide synthase genes in host cells for the production of narbonolide, narbonolide derivatives, and polyketides that are useful as antibiotics and as intermediates in the synthesis of compounds with pharmaceutical value.
    Type: Application
    Filed: May 29, 2002
    Publication date: August 28, 2003
    Inventors: Gary Ashley, Melanie C. Betlach, Mary Betlach, Robert McDaniel, Li Tang
  • Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
    Publication number: 20030148469
    Abstract: Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for picromycin. The combinatorial library is useful as a source of pharmaceutically active compounds. In addition, novel polyketides and antibiotics are prepared using this method.
    Type: Application
    Filed: July 22, 2002
    Publication date: August 7, 2003
    Inventors: Gary Ashley, Melanie C. Betlach, Mary Betlach, Robert McDaniel, Li Tang
  • Library of novel ''unnatural'' natural products
    Publication number: 20030138841
    Abstract: Genetic engineering of the erythromycin polyketide synthase genes to effect combinatorial alterations of catalytic activities in the biosynthetic pathway can be used to generate a library of macrolides impractical to produce by chemical methods. The library includes examples of analogs with one, two and three altered carbon centers of the polyketide products.
    Type: Application
    Filed: April 22, 2002
    Publication date: July 24, 2003
    Inventor: Robert McDaniel
  • Alteration of acyltransferase domain substrate specificity
    Publication number: 20030124680
    Abstract: Three distinct primary regions of acyltransferase (AT) domains of modular polyketide synthases (PKS) can be changed by site-specific mutagenesis of the corresponding coding sequences to change the specificity of the domain and the structure of the polyketide produced by the PKS.
    Type: Application
    Filed: August 7, 2002
    Publication date: July 3, 2003
    Inventors: Christopher Reeves, Robert McDaniel, Ralph Reid
  • Recombinant narbonolide polyketide synthase
    Publication number: 20030104597
    Abstract: Recombinant DNA compounds that encode all or a portion of the narbonolide polyketide synthase are used to express recombinant polyketide synthase genes in host cells for the production of narbonolide, narbonolide derivatives, and polyketides that are useful as antibiotics and as intermediates in the synthesis of compounds with pharmaceutical value.
    Type: Application
    Filed: February 22, 2001
    Publication date: June 5, 2003
    Inventors: Gary Ashley, Melanie C. Betlach, Mary Betlach, Robert McDaniel, Li Tang
  • Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
    Publication number: 20030077760
    Abstract: Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for erythromycin. The combinatorial library is useful as a source of pharmaceutically active compounds.
    Type: Application
    Filed: March 12, 2002
    Publication date: April 24, 2003
    Inventors: Chaitan Khosla, Gary Ashley, Hong Fu, Camilla M. Kao, Robert McDaniel
  • Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold
    Publication number: 20030077707
    Abstract: Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for erythromycin. The combinatorial library is useful as a source of pharmaceutically active compounds.
    Type: Application
    Filed: March 12, 2002
    Publication date: April 24, 2003
    Inventors: Chaitan Khosla, Gary Ashley, Hong Fu, Camilla M. Kao, Robert McDaniel
  • Macrolide analogs
    Publication number: 20030040084
    Abstract: Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for erythromycin. The combinatorial library is useful as a source of pharmaceutically active compounds. In addition, novel polyketides and antibiotics are prepared using this method.
    Type: Application
    Filed: May 9, 2001
    Publication date: February 27, 2003
    Inventors: Chaitan Khosla, Gary Ashley, Hong Fu, Camilla M. Kao, Robert McDaniel
  • Recombinant megalomicin biosynthetic genes and uses thereof
    Patent number: 6524841
    Abstract: Recombinant nucleic acids that encode all or a portion of the megAI gene of the megalomicin polyketide synthase (PKS) of Micromonospora megalomicea are used to produce recombinant PKS enzymes in host cells to make megalomicin, megalomicin derivatives, and other polyketides that are useful as antibiotics, motilides, and antiparasitics.
    Type: Grant
    Filed: October 4, 2000
    Date of Patent: February 25, 2003
    Assignee: Kosan Biosciences, Inc.
    Inventors: Robert McDaniel, Yanina Volchegursky
  • Recombinant oleandolide polyketide synthase
    Publication number: 20030027287
    Abstract: Recombinant DNA compounds that encode all or a portion of the oleandolide polyketide synthase are used to express recombinant polyketide synthase genes in host cells for the production of oleandolide, oleandolide derivatives, and polyketides that are useful as antibiotics and motilides.
    Type: Application
    Filed: March 14, 2001
    Publication date: February 6, 2003
    Inventors: Mary C. Betlach, Sanjay Krishnakant Shah, Robert McDaniel, Li Tang
  • Recombinant narbonolide polyketide synthase
    Patent number: 6509455
    Abstract: Recombinant DNA compounds that encode all or a portion of the narbonolide polyketide synthase are used to express recombinant polyketide synthase genes in host cells for the production of narbonolide, narbonolide derivatives, and polyketides that are useful as antibiotics and as intermediates in the synthesis of compounds with pharmaceutical value.
    Type: Grant
    Filed: September 7, 2000
    Date of Patent: January 21, 2003
    Assignee: Kosan Biosciences, Inc.
    Inventors: Gary Ashley, Melanie C. Betlach, Mary Betlach, Robert McDaniel, Li Tang
  • Polyketide synthase genes from Streptomyces venezuelae
    Patent number: 6503741
    Abstract: Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for picromycin. The combinatorial library is useful as a source of pharmaceutically active compounds. In addition, novel polyketides and antibiotics are prepared using this method.
    Type: Grant
    Filed: August 28, 1998
    Date of Patent: January 7, 2003
    Assignee: Kosan Biosciences, Inc.
    Inventors: Gary Ashley, Melanie C. Betlach, Mary Betlach, Robert McDaniel, Li Tang