Abstract: A system and method for examining a route and/or vehicle system obtain a route parameter and/or a vehicle parameter from discrete examinations of the route and/or the vehicle system. The route parameter is indicative of a health of the route over which the vehicle system travels. The vehicle parameter is indicative of a health of the vehicle system. The discrete examinations of the route and/or the vehicle system are separated from each other by location and/or time. The route parameter and/or the vehicle parameter are examined to determine whether the route and/or the vehicle system is damaged and, responsive to determining that the route and/or the vehicle is damaged, the route and/or the vehicle system are continually monitored, such as by examination equipment onboard the vehicle system.

Abstract: A downhole control method for use in a wellbore that includes deploying a stand-alone power source and a stand-alone hydraulic reservoir downhole; powering a downhole controller using the stand-alone power source; measuring a downhole fluid parameter; and actuating an inflow control device, using the stand-alone hydraulic reservoir and the downhole controller, based on the measured downhole fluid parameter. In one aspect, the stand-alone power source is selected from the group consisting of a battery and a downhole power generator. In another aspect, the stand-alone hydraulic reservoir, the downhole controller, the stand-alone power source, and the inflow control device comprise a remotely-powered, open-hole completion system.

Abstract: A method of positioning a monitor frame using a counter-balanced hinging mechanism coupled to the monitor frame and seating a display monitor within the monitor frame includes rotating the monitor frame into an approximately horizontal orientation using the counter-balanced hinging mechanism, where the counter-balanced hinging mechanism may include at least one arm linkage assembly, and at least one bias member coupled to the at least one arm linkage assembly. The method also includes aligning an outer edge of the display monitor with an inner surface of the monitor frame, translating the display monitor to a seated position within the monitor frame, and rotating the monitor frame into an approximately vertical orientation using the counter-balanced hinging mechanism.

Abstract: A system for supporting a plurality of display monitors includes a support stanchion having a first anchor end, a second coupling end, and a stanchion body extending therebetween. The system also includes at least one counter-balanced hinging mechanism coupled to the second coupling end of the support stanchion and at least one monitor frame. The counter-balanced hinging mechanism includes at least one arm linkage assembly configured to permit the at least one monitor frame to pivot with respect to the support stanchion, and at least one bias member coupled to the at least one arm linkage assembly. The at least one bias member is configured to apply a variable amount of force to maintain the at least one monitor frame stationary in any of a plurality of intermediate positions between an approximately vertical operational position and an approximately horizontal maintenance position.

Abstract: A method and system for an overhead display assembly for an electronic machine are provided. The overhead display assembly includes a display monitor supported in a monitor frame translatable between an operational position and a maintenance and installation position angularly displaced from the operational position by a predetermined angle. The overhead display assembly also includes a support stanchion including a first anchor end, a second coupling end, and a stanchion body extending therebetween, the first anchor end configured to couple to a supporting structure. The overhead display assembly further includes a counter-balanced hinging mechanism coupled to and between the second coupling end and the monitor frame.

Abstract: The present invention provides a topical formulation including (i) comfrey or a comfrey-derived compound, or an analogue or derivative thereof and (ii) a penetration enhancer, and optionally including tannic acid, or an analogue or derivative thereof. The present invention also provides a topical formulation including (i) comfrey or a comfrey-derived compound, or an analogue or derivative thereof, and (ii) tannic acid, or an analogue or derivative thereof, optionally including a penetration enhancer. Also provided are kits and methods of prophylactic or therapeutic treatment of inflammatory and/or degenerative conditions using the combination of active ingredients as herein described.

Abstract: The present invention provides a topical formulation including (i) comfrey or a comfrey-derived compound, or an analog or derivative thereof and (ii) a penetration enhancer, and optionally including tannic acid, or an analog or derivative thereof. The present invention also provides a topical formulation including (i) comfrey or a comfrey-derived compound, or an analog or derivative thereof, and (ii) tannic acid, or an analog or derivative thereof, optionally including a penetration enhancer. Also provided are kits and methods of prophylactic or therapeutic treatment of inflammatory and/or degenerative conditions using the combination of active ingredients as herein described.

Abstract: System includes a controller configured to obtain one or more of a route parameter or a vehicle parameter from discrete examinations of one or more of a route or a vehicle system. The route parameter is indicative of a health of the route over which the vehicle system travels. The vehicle parameter is indicative of a health of the vehicle system. The discrete examinations of the one or more of the route or the vehicle system separated from each other by one or more of location or time. The controller is configured to examine the one or more of the route parameter or the vehicle parameter to determine whether the one or more of the route or the vehicle system is damaged. The system also includes examination equipment configured to continually monitor the one or more of the route or the vehicle system responsive to determining that the one or more of the route or the vehicle is damaged.

Abstract: A system may transmit a time-based token to the merchant device. The system may receive a second merchant session key, a customer session key, a customer ID, a customer device certificate, and a second transaction amount from a customer device. The system may further match the first merchant session key to the second merchant session key, and transmit the time-based token to the customer device in response to the first merchant session key matching the second merchant session key.

Abstract: The present disclosure describes short antisense compounds, including such compounds comprising chemically-modified high-affinity monomers 8-16 monomers in length. Certain such short antisense compound are useful for the reduction of target nucleic acids and/or proteins in cells, tissues, and animals with increased potency and improved therapeutic index. Thus, provided herein are short antisense compounds comprising high-affinity nucleotide modifications useful for reducing a target RNA in vivo. Such short antisense compounds are effective at lower doses than previously described antisense compounds, allowing for a reduction in toxicity and cost of treatment. In addition, the described short antisense compounds have greater potential for oral dosing.

Abstract: A tool for finishing an outside corner comprises a handle and a V-shaped blade coupled to the handle. The V-shaped blade has a pair of planar blade surfaces which each extend from a vertex thereof. A retaining mechanism releasably retains a sponge against the surfaces of the V-shaped blade.

Abstract: The present disclosure describes short antisense compounds, including such compounds comprising chemically-modified high-affinity monomers 8-16 monomers in length. Certain such short antisense compound are useful for the reduction of target nucleic acids and/or proteins in cells, tissues, and animals with increased potency and improved therapeutic index. Thus, provided herein are short antisense compounds comprising high-affinity nucleotide modifications useful for reducing a target RNA in vivo. Such short antisense compounds are effective at lower doses than previously described antisense compounds, allowing for a reduction in toxicity and cost of treatment. In addition, the described short antisense compounds have greater potential for oral dosing.

Abstract: Methods, systems, and software for mediating SMS messages, and especially type 0 SMS messages, in a wireless mobile communications device configured to send and receive data using a GSM protocol and including a subscriber identity module (“SIM”) including electronic hardware and computer software executed by the hardware such that the SIM is configured to send, receive, and process messages using a Short Message System (“SMS”) between the wireless mobile communications device and a communications network. One aspect includes a method for mediating SMS messages comprising: configuring electronic hardware on the wireless mobile communications device to implement a firewall on the wireless mobile communications device, the firewall configured to identify and optionally mediate infrastructure SMS messages.

Abstract: A tool for finishing an outside corner comprises a handle and a V-shaped blade coupled to the handle. The V-shaped blade has a pair of planar blade surfaces which each extend from a vertex thereof. A retaining mechanism releasably retains a sponge against the planar blade surfaces V-shaped blade.

Abstract: The present disclosure describes short antisense compounds, including such compounds comprising chemically-modified high-affinity monomers 8-16 monomers in length. Certain such short antisense compound are useful for the reduction of target nucleic acids and/or proteins in cells, tissues, and animals with increased potency and improved therapeutic index. Thus, provided herein are short antisense compounds comprising high-affinity nucleotide modifications useful for reducing a target RNA in vivo. Such short antisense compounds are effective at lower doses than previously described antisense compounds, allowing for a reduction in toxicity and cost of treatment. In addition, the described short antisense compounds have greater potential for oral dosing.

Abstract: The present disclosure describes short antisense compounds, including such compounds comprising chemically-modified high-affinity monomers 8-16 monomers in length. Certain such short antisense compound are useful for the reduction of target nucleic acids and/or proteins in cells, tissues, and animals with increased potency and improved therapeutic index. Thus, provided herein are short antisense compounds comprising high-affinity nucleotide modifications useful for reducing a target RNA in vivo. Such short antisense compounds are effective at lower doses than previously described antisense compounds, allowing for a reduction in toxicity and cost of treatment. In addition, the described short antisense compounds have greater potential for oral dosing.

Abstract: The present disclosure describes short antisense compounds, including such compounds comprising chemically-modified high-affinity monomers 8-16 monomers in length. Certain such short antisense compound are useful for the reduction of target nucleic acids and/or proteins in cells, tissues, and animals with increased potency and improved therapeutic index. Thus, provided herein are short antisense compounds comprising high-affinity nucleotide modifications useful for reducing a target RNA in vivo. Such short antisense compounds are effective at lower doses than previously described antisense compounds, allowing for a reduction in toxicity and cost of treatment. In addition, the described short antisense compounds have greater potential for oral dosing.

Abstract: The present invention relates to novel chimeric oligomeric compounds having a plurality of alternating regions having either RNA like having northern or 3?-endo conformational geometry (3?-endo regions) or DNA like having southern or C2?-endo/O4?-endo conformational geometry. The oligomeric compounds of the present invention have shown reduction in mRNA levels in multiple in vitro and in vivo assay systems and are useful, for example, for investigative and therapeutic purposes.

Abstract: Compounds, compositions and methods are provided for modulating the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTP1B. Methods of using these compounds for modulation of PTP1B expression and for treatment of diseases associated with expression of PTP1B are provided.