Patents by Inventor Robert McKay

Robert McKay has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20040228820
    Abstract: The present invention relates to cosmetic compositions containing an amidine, an alkane polyol having a ClogP of from +0.2 to +1.55 and water. The present invention also relates to methods of using such cosmetic compositions to regulate hair growth and the condition of mammalian skin. Said methods generally comprise the step of topically applying the composition to the skin of a mammal needing such treatment, a safe and effective amount of such compositions.
    Type: Application
    Filed: May 7, 2004
    Publication date: November 18, 2004
    Applicant: The Procter & Gamble Company
    Inventors: Russell Philip Elliott, Barnaby George Robert McKay, Kristina Emma Inge Vanoosthuyze
  • Patent number: 6809193
    Abstract: Compositions and methods for the treatment and diagnosis of diseases or disorders amenable to treatment through modulation of expression of a gene encoding a Jun N-terminal kinase (JNK protein) are provided. Oligonucleotide are herein provided which are specifically hybridizable with nucleic acids encoding JNK1, JNK2 and JNK3, as well as other JNK proteins and specific isoforms thereof. Methods of treating animals suffering from diseases or disorders amenable to therapeutic intervention by modulating the expression of one or more JNK proteins with such oligonucleotide are also provided. Methods for the treatment and diagnosis of diseases or disorders associated with aberrant expression of one or more JNK proteins are also provided. Methods for inducing apoptosis and for treating diseases or conditions associated with a reduction in apoptosis are also provided.
    Type: Grant
    Filed: January 31, 2001
    Date of Patent: October 26, 2004
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Robert McKay, Nicholas M. Dean, Brett P. Monia, Pamela Nero, William A. Gaarde
  • Publication number: 20040171566
    Abstract: Compositions and methods for the treatment and diagnosis of diseases or conditions amenable to treatment through modulation of expression of a gene encoding a p38 mitogen-activated protein kinase (p38 MAPK) are provided. Methods for the treatment and diagnosis of diseases or conditions associated with aberrant expression of one or more p38 MAPKs are also provided.
    Type: Application
    Filed: August 15, 2003
    Publication date: September 2, 2004
    Inventors: Brett P. Monia, William A. Gaarde, Pamela Nero, Robert McKay, Wai Shiu Fred Wong
  • Publication number: 20040161402
    Abstract: Film-forming compositions for topical application are provided that deliver decreased dry-down times, increased moisturization and improved application and removal characteristics. The film-forming compositions herein comprise a film-forming polymer and a zwitterionic bulking agent. Kits comprising the film-forming compositions of the present invention are also provided herein.
    Type: Application
    Filed: February 18, 2004
    Publication date: August 19, 2004
    Applicant: The Procter & Gamble Company
    Inventors: Alan Brooks, Russell Philip Elliott, Barnaby George Robert McKay
  • Publication number: 20040121376
    Abstract: Compositions and methods are provided for antisense modulation of interleukin-5 signal transduction. Antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding interleukin-5 and interleukin-5 receptor a are preferred. Methods of using these compounds for modulation of interleukin-5 signal transduction and for treatment of diseases associated with interleukin-5 signal transduction are also provided.
    Type: Application
    Filed: October 6, 2003
    Publication date: June 24, 2004
    Inventors: Nicholas M. Dean, James G. Karras, Robert McKay, Muthiah Manoharan
  • Publication number: 20040115637
    Abstract: Compounds, compositions and methods are provided for modulating the expression of PPAR-alpha. The compositions comprise oligonucleotides, targeted to nucleic acid encoding PPAR-alpha. Methods of using these compounds for modulation of PPAR-alpha expression and for diagnosis and treatment of disease associated with expression of PPAR-alpha are provided.
    Type: Application
    Filed: December 11, 2002
    Publication date: June 17, 2004
    Applicant: Isis Pharmaceuticals Inc.
    Inventors: Robert McKay, Kenneth W. Dobie
  • Publication number: 20040029823
    Abstract: Compositions and methods for the treatment and diagnosis of diseases or disorders amenable to treatment through modulation of expression of a gene encoding a Jun N-terminal kinase (JNK protein) are provided. Oligonucleotide are herein provided which are specifically hybridizable with nucleic acids encoding JNK1, JNK2 and JNK3, as well as other JNK proteins and specific isoforms thereof. Methods of treating animals suffering from diseases or disorders amenable to therapeutic intervention by modulating the expression of one or more JNK proteins with such oligonucleotide are also provided. Methods for the treatment and diagnosis of diseases or disorders associated with aberrant expression of one or more JNK proteins are also provided. Methods for inducing apoptosis and for treating diseases or conditions associated with a reduction in apoptosis are also provided.
    Type: Application
    Filed: January 15, 2003
    Publication date: February 12, 2004
    Inventors: Robert McKay, Nicholas M. Dean, Brett P. Monia, Pamela S. Nero, William A. Gaarde
  • Publication number: 20030220282
    Abstract: Compounds, compositions and methods are provided for modulating the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTP1B. Methods of using these compounds for modulation of PTP1B expression and for treatment of diseases associated with expression of PTP1B are provided.
    Type: Application
    Filed: February 7, 2003
    Publication date: November 27, 2003
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: Sanjay Bhanot, Lex M. Cowsert, Jacqueline R. Wyatt, Brett P. Monia, Madeline M. Butler, Robert McKay, Susan M. Freier
  • Publication number: 20030216333
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of glycogen synthase kinase 3 alpha. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding glycogen synthase kinase 3 alpha. Methods of using these compounds for modulation of glycogen synthase kinase 3 alpha expression and for treatment of diseases associated with expression of glycogen synthase kinase 3 alpha are provided.
    Type: Application
    Filed: November 4, 2002
    Publication date: November 20, 2003
    Inventors: Brett P Monia, Robert McKay, Madeline M Butler, Jacqueline Wyatt
  • Publication number: 20030211608
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of glycogen synthase kinase 3 beta. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding glycogen synthase kinase 3 beta. Methods of using these compounds for modulation of glycogen synthase kinase 3 beta expression and for treatment of diseases associated with expression of glycogen synthase kinase 3 beta are provided.
    Type: Application
    Filed: November 4, 2002
    Publication date: November 13, 2003
    Inventors: Madeline M. Butler, Robert McKay, Brett P. Monia, Jacqueline Wyatt
  • Publication number: 20030194738
    Abstract: Compositions and methods for the treatment and diagnosis of diseases or disorders amenable to treatment through modulation of Activating Protein 1 (AP-1) expression are provided. In accordance with various embodiments of the present invention, oligonucleotides are provided which are specifically hybridizable with c-fos or c-jun, the genes encoding c-Fos or c-Jun, respectively. In a preferred embodiment, a method of modulating the metastasis of malignant tumors via modulation of one or more of the AP-1 subunits is provided; this method can be effected using the oligonucleotides of the invention or any other agent which modulates AP-1 or AP-1-mediated transcription.
    Type: Application
    Filed: May 5, 2003
    Publication date: October 16, 2003
    Inventors: Nicholas M. Dean, Robert McKay, Loren Miraglia, Brenda Baker
  • Publication number: 20030176383
    Abstract: Compositions and methods for the treatment and diagnosis of diseases or conditions amenable to treatment through modulation of expression of a gene encoding a p38 mitogen-activated protein kinase (p38 MAPK) are provided. Methods for the treatment and diagnosis of diseases or conditions associated with aberrant expression of one or more p38 MAPKs are also provided.
    Type: Application
    Filed: September 9, 2002
    Publication date: September 18, 2003
    Inventors: Brett P. Monia, William A. Gaarde, Pamela Nero, Robert McKay
  • Publication number: 20030175232
    Abstract: Compositions comprising a stabilized enzyme, at least 30% water, a polyhydric alcohol, present in an amount such that the ratio of polyhydric alcohol to water is from 1:2 to 1:100; less than 5% of an earth alkali metal salt, and an osmo-protectant selected from a certain group of osmo-protectants defined herein. Also, a method of providing a skin care benefits, e.g. skin feel and/or skin appearance, preferably skin moisturization, skin softness, and/or skin smoothness, comprising topically applying a safe and effective amount of the inventive compositions described herein to skin in need of such a skin care benefit. Further, a method comprising providing a consumer with an enzyme-containing personal care product, wherein the enzyme is stable on shelf, and is active on both shelf and skin, preferably wherein the enzyme-containing personal care product comprises one of the inventive compositions described herein.
    Type: Application
    Filed: November 12, 2002
    Publication date: September 18, 2003
    Applicant: The Procter & Gamble Company
    Inventors: Russell Phillip Elliott, Barnaby George Robert McKay
  • Patent number: 6602857
    Abstract: Compounds, compositions and methods are provided for modulating the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTP1B. Methods of using these compounds for modulation of PTP1B expression and for treatment of diseases associated with expression of PTP1B are provided.
    Type: Grant
    Filed: July 31, 2000
    Date of Patent: August 5, 2003
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Lex M. Cowsert, Jacqueline Wyatt, Brett P. Monia, Madeline M. Butler, Robert McKay
  • Publication number: 20030060433
    Abstract: The present invention provides compositions that can be administered to an individual and inhibit a stress activated protein kinase pathway. The invention also provides methods of increasing the sensitivity of cancer cells to a cancer therapy by contacting the cancer cells with a stress activated protein kinase pathway inhibitor. The invention further provides methods of reducing the severity of cancer in a patient by administering to the patients a stress activated protein kinase pathway inhibitor and treating the patient with a conventional cancer therapy.
    Type: Application
    Filed: March 9, 1999
    Publication date: March 27, 2003
    Inventors: DANIEL A. MERCOLA, NICHOLAS M. DEAN, ROBERT MCKAY
  • Publication number: 20030004120
    Abstract: Compositions and methods for the treatment and diagnosis of diseases or disorders amenable to treatment through modulation of expression of a gene encoding a Jun N-terminal kinase (JNK protein) are provided. Oligonucleotide are herein provided which are specifically hybridizable with nucleic acids encoding JNK1, JNK2 and JNK3, as well as other JNK proteins and specific isoforms thereof. Methods of treating animals suffering from diseases or disorders amenable to therapeutic intervention by modulating the expression of one or more JNK proteins with such oligonucleotide are also provided. Methods for the treatment and diagnosis of diseases or disorders associated with aberrant expression of one or more JNK proteins are also provided. Methods for inducing apoptosis and for treating diseases or conditions associated with a reduction in apoptosis are also provided.
    Type: Application
    Filed: January 31, 2001
    Publication date: January 2, 2003
    Inventors: Robert McKay, Nicholas M. Dean, Brett P. Monia, Pamela Nero, William A. Gaarde
  • Publication number: 20020147163
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of Casein kinase 2-alpha. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Casein kinase 2-alpha. Methods of using these compounds for modulation of Casein kinase 2-alpha expression and for treatment of diseases associated with expression of Casein kinase 2-alpha are provided.
    Type: Application
    Filed: February 8, 2001
    Publication date: October 10, 2002
    Applicant: Isis Pharmaceuticals Inc.
    Inventors: Robert McKay, Susan M. Freier, Jacqueline Wyatt
  • Patent number: 6455307
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of Casein kinase 2-alpha prime. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Casein kinase 2-alpha prime. Methods of using these compounds for modulation of Casein kinase 2-alpha prime expression and for treatment of diseases associated with expression of Casein kinase 2-alpha prime are provided.
    Type: Grant
    Filed: February 8, 2001
    Date of Patent: September 24, 2002
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Robert McKay, Susan M. Freier, Jacqueline Wyatt
  • Publication number: 20020128216
    Abstract: Compositions and methods are provided for antisense modulation of interleukin-5 signal transduction. Antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding interleukin-5 and interleukin-5 receptor a are preferred. Methods of using these compounds for modulation of interleukin-5 signal transduction and for treatment of diseases associated with interleukin-5 signal transduction are also provided.
    Type: Application
    Filed: March 7, 2001
    Publication date: September 12, 2002
    Inventors: Nicholas M. Dean, James G. Karras, Robert McKay, Muthiah Manoharan
  • Patent number: D498584
    Type: Grant
    Filed: December 18, 2003
    Date of Patent: November 23, 2004
    Assignee: Warner-Lambert Company LLC
    Inventors: Silvio J. DiMarchi, Robert McKay, Lawrence P. Scanzillo