Patents by Inventor Robert Osborne

Robert Osborne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9920355
    Abstract: Providing herein, among other things, is a method for preparing a nucleic acid for sequencing. In some embodiments, the method comprises a) amplifying a nucleic acid template using a dNTP mix that contains 5-methyl dCTP, thereby producing product nucleic acid molecules that contains methylcytosines; b) digesting the product nucleic acid molecules with a methylation-dependent restriction endonuclease, thereby cleaving the product nucleic acid molecules at sites that are adjacent to at least some of the methylcytosine and producing fragments of the product nucleic acid molecules; and c) ligating double-stranded adaptors onto the ends of the fragments to produce adaptor-ligated products.
    Type: Grant
    Filed: November 12, 2015
    Date of Patent: March 20, 2018
    Assignee: POPULATION GENETICS TECHNOLOGIES LTD.
    Inventors: Robert Osborne, Samuel Woodhouse, Esther Musgrave-Brown
  • Patent number: 9860368
    Abstract: The present disclosure includes descriptions of various aspects of unified communication (UC) systems, including UC management and analysis systems and related tools and techniques. Described systems, tools, and techniques are adapted for enhanced UC data capture, analysis, and reporting; enhanced UC monitoring services; and a user survey service that can be used for conducting user surveys related to UC services. Embodiments disclosed herein include a process for determining location-based quality metrics; a process for calculating weighted availability in a computer system (e.g., a UC system); a process for generating a set of test rules based on automatic inspection of a UC topology; a process for setting a response priority for a rule failure based on classification of the failure; and process for executing a survey instance for users of a UC system based on presence information.
    Type: Grant
    Filed: February 12, 2014
    Date of Patent: January 2, 2018
    Assignee: Unify Square, Inc.
    Inventors: Sudhanshu Aggarwal, Arun Raghavan, Robert Osborne
  • Publication number: 20170355968
    Abstract: The present invention provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.
    Type: Application
    Filed: April 19, 2017
    Publication date: December 14, 2017
    Inventors: Jovana Nazor, Robert Osborne, Jack Liang, Jonathan Vroom, Xiyun Zhang, David Entwistle, Rama Voladri, Ravi David Garcia, Jeffrey C. Moore, Shane Grosser, Birgit Kosjek, Matthew Truppo
  • Publication number: 20170334886
    Abstract: The present invention provides kinase inhibitor analogs with improved properties, such as improved efficacy, pharmacokinetics, safety, and specificity. In some embodiments, the present invention provides lapatinib analogs that provide therapeutic benefits.
    Type: Application
    Filed: August 27, 2015
    Publication date: November 23, 2017
    Applicant: Codexis, Inc.
    Inventors: Gjalt W. Huisman, Jed Lee Hubbs, Xiyun Zhang, Robert Osborne
  • Publication number: 20170335371
    Abstract: Providing herein, among other things, is a method for preparing a nucleic acid for sequencing. In some embodiments, the method comprises a) amplifying a nucleic acid template using a dNTP mix that contains 5-methyl dCTP, thereby producing product nucleic acid molecules that contains methylcytosines; b) digesting the product nucleic acid molecules with a methylation-dependent restriction endonuclease, thereby cleaving the product nucleic acid molecules at sites that are adjacent to at least some of the methylcytosine and producing fragments of the product nucleic acid molecules; and c) ligating double-stranded adaptors onto the ends of the fragments to produce adaptor-ligated products.
    Type: Application
    Filed: November 12, 2015
    Publication date: November 23, 2017
    Inventors: Robert Osborne, Samuel Woodhouse, Esther Musgrave-Brown
  • Publication number: 20170275598
    Abstract: The present invention provides improved P450-BM3 variants with improved activity. In some embodiments, the P450-BM3 variants exhibit improved activity over a wide range of substrates.
    Type: Application
    Filed: June 9, 2017
    Publication date: September 28, 2017
    Inventors: Robert Osborne, Vesna Mitchell, Khin Yu Naing Htwe, Xiyun Zhang, Erika M. Milczek, Jeffrey C. Moore
  • Publication number: 20170273978
    Abstract: The present invention provides kinase inhibitor analogs with improved properties, such as improved efficacy, pharmacokinetics, safety, and specificity. In some embodiments, the present invention provides nilotinib analogs that provide therapeutic benefits.
    Type: Application
    Filed: August 27, 2015
    Publication date: September 28, 2017
    Inventors: Gjalt W. Huisman, Jed Lee Hubbs, Xiyun Zhang, Robert Osborne
  • Publication number: 20170247667
    Abstract: The present invention provides improved P450-BM3 variants with improved activity. In some embodiments, the P450-BM3 variants exhibit improved activity over a wide range of substrates.
    Type: Application
    Filed: May 10, 2017
    Publication date: August 31, 2017
    Inventors: Robert Osborne, Vesna Mitchell, Khin Yu Naing Htwe, Xiyun Zhang, Erika M. Milczek, Jeffrey C. Moore
  • Publication number: 20170226562
    Abstract: Described herein is a method for adding a counter sequence to the individual polynucleotide molecules of an initial nucleic acid sample. After addition of the counter sequence, the sample may be amplified and the number of initial target molecules in the sample can be estimated by counting the number of counter sequences associated with the amplified target molecules.
    Type: Application
    Filed: April 27, 2017
    Publication date: August 10, 2017
    Inventors: Robert Osborne, James Casbon, Andreas Claas, Gi Mikawa, Esther Musgrave-Brown
  • Patent number: 9708587
    Abstract: The present invention provides improved P450-BM3 variants with improved activity. In some embodiments, the P450-BM3 variants exhibit improved activity over a wide range of substrates.
    Type: Grant
    Filed: July 8, 2015
    Date of Patent: July 18, 2017
    Assignee: Codexis, Inc.
    Inventors: Robert Osborne, Vesna Mitchell, Khin Yu Naing Htwe, Xiyun Zhang, Erika M. Milczek, Jeffrey C. Moore
  • Patent number: 9708540
    Abstract: A method and an apparatus for pyrolysing a solid organic feed material are disclosed. Solid organic material is moved through a reaction chamber and exposed to a temperature profile within the chamber that dries and pyrolyses the organic material and releases water vapour and a volatile products gas phase. The water vapour phase and the volatile products gas phase are moved counter-current to the solid organic material so that the water vapour phase and condensable components of the volatile products gas phase condense in cooler upstream sections of the chamber and form a liquid water product and a separate liquid oil product. The liquid water product is discharged via an outlet along the length of the chamber and a dried and pyrolysed solid product is discharged from a downstream outlet in the chamber.
    Type: Grant
    Filed: June 30, 2014
    Date of Patent: July 18, 2017
    Assignee: The Crucible Group Pty Ltd
    Inventors: Lazar Strezov, Steven Robert Osborn, Joseph George Herbertson, Gary Kenneth Ellem
  • Publication number: 20170201831
    Abstract: The present invention provides a portable and compact battery-powered stereo speaker assembly that incorporates a DC to DC converter, which enables power from the internal stereo speaker assembly battery to charge an interconnected hand-held device, such as a smartphone, through a USB connection, thereby extending the time that the device can be used untethered from the AC power grid. A DC to DC converter enables the charging function can be implemented even if the speaker assembly is not connected to the AC power grid, and even if the battery of the stereo speaker assembly is not fully charged. The stereo speaker assembly also incorporates Bluetooth connectivity, a proprietary open wireless technology standard, developed by Ericsson in 1994, employing frequency-hopping spread spectrum radio transmissions in the ISM band from 2400-2480 MHz.
    Type: Application
    Filed: March 27, 2017
    Publication date: July 13, 2017
    Applicant: BRAVEN LC
    Inventors: Warren Robert Osborn, Daniel Lester Hill
  • Publication number: 20170195480
    Abstract: A computing device receives an indication of a selected category of items relating to call quality for a plurality of voice calls, such as sites, wireless network identifiers, driver software versions, client software versions, protocols (e.g., virtual private network (VPN), Transmission Control Protocol (TCP), and User Datagram Protocol (UDP)), connectivity methods, and edge servers used in the calls. The computing device selects items in the selected category based on volume of calls. The computing device calculates percentages of poor calls associated with the items, and identifies high-volume poor call items. The computing device also may calculate impact ranks for categories of items, e.g., based on distribution of poor calls, with a lower rank being assigned if poor calls are evenly distributed, and a higher rank being assigned if a small number of items contribute disproportionately to the volume of poor calls.
    Type: Application
    Filed: December 9, 2016
    Publication date: July 6, 2017
    Applicant: Unify Square, Inc.
    Inventors: Edward Melomed, Ameya Sirpotdar, Christopher O'Brien, Robert Osborne, Arun Raghavan
  • Patent number: 9683220
    Abstract: The present invention provides improved P450-BM3 variants with improved activity. In some embodiments, the P450-BM3 variants exhibit improved activity over a wide range of substrates.
    Type: Grant
    Filed: June 2, 2016
    Date of Patent: June 20, 2017
    Assignee: Codexis, Inc.
    Inventors: Robert Osborne, Vesna Mitchell, Khin Yu Naing Htwe, Xiyun Zhang, Erika M. Milczek, Jeffrey C. Moore
  • Publication number: 20170171048
    Abstract: A computing device automatically detects technical conditions for calls, such as voice calls, in a communication system. The technical conditions include transport type (e.g., TCP, UDP), connection type (e.g., wired, wireless local area network, mobile/cellular), packet loss, latency, and jitter. The computing device performs automatic analysis of the detected technical conditions. The automatic analysis may include comparing the detected transport type with a preferred transport type (e.g., a non-TCP transport, such as UDP), comparing the detected connection type with a preferred connection type (e.g., wired), or comparing packet loss, latency, or jitter with corresponding threshold values (e.g., maximum values or average values). The computing device automatically generates output related to one or more of the detected technical conditions based at least in part on the automatic analysis.
    Type: Application
    Filed: December 9, 2016
    Publication date: June 15, 2017
    Applicant: Unify Square, Inc.
    Inventors: Thomas Christmann, Rokas Tamosevicius, Mark Herbert Achzenick, Robert Osborne, Arun Raghavan
  • Patent number: 9670493
    Abstract: The present invention provides compositions and methods comprising a low-phosphate repressible promoter. In particular, the present invention provides a low-phosphate repressible promoter from E. coli.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: June 6, 2017
    Assignee: Codexis, Inc.
    Inventors: Fernando Valle, Patricia Choudhary, Robert Osborne, Saul Nitsche Rocha, Monica Bhatia, U Loi Lao, Yihui Zhu
  • Patent number: 9670529
    Abstract: Described herein is a method for adding a counter sequence to the individual polynucleotide molecules of an initial nucleic acid sample. After addition of the counter sequence, the sample may be amplified and the number of initial target molecules in the sample can be estimated by counting the number of counter sequences associated with the amplified target molecules.
    Type: Grant
    Filed: February 26, 2013
    Date of Patent: June 6, 2017
    Assignee: POPULATION GENETICS TECHNOLOGIES LTD.
    Inventors: Robert Osborne, James Casbon, Andreas Claas, Gi Mikawa, Esther Musgrave-Brown
  • Patent number: 9670536
    Abstract: Aspects of the present invention include methods and compositions for determining the number of individual polynucleotide molecules originating from the same genomic region of the same original sample that have been sequenced in a particular sequence analysis configuration or process. In these aspects of the invention, a degenerate base region (DBR) is attached to the starting polynucleotide molecules that are subsequently sequenced (e.g., after certain process steps are performed, e.g., amplification and/or enrichment). The number of different DBR sequences present in a sequencing run can be used to determine/estimate the number of different starting polynucleotides that have been sequenced. DBRs can be used to enhance numerous different nucleic acid sequence analysis applications, including allowing higher confidence allele call determinations in genotyping applications.
    Type: Grant
    Filed: May 8, 2014
    Date of Patent: June 6, 2017
    Assignee: POPULATION GENETICS TECHNOLOGIES LTD.
    Inventors: James Casbon, Sydney Brenner, Robert Osborne, Conrad Lichtenstein, Andreas Claas
  • Publication number: 20170149628
    Abstract: The present disclosure includes descriptions of various aspects of unified communication (UC) systems, including UC management and analysis systems and related tools and techniques. Described systems, tools, and techniques are adapted for enhanced UC data capture, analysis, and reporting; enhanced UC monitoring services; and a user survey service that can be used for conducting user surveys related to UC services. Embodiments disclosed herein include computer systems and methods that can be used for analyzing service level objectives for call quality, classifying calls into distinct categories, and real-time user notification of call quality and reliability issues.
    Type: Application
    Filed: November 18, 2016
    Publication date: May 25, 2017
    Applicant: Unify Square, Inc.
    Inventors: Sudhanshu Aggarwal, Arun Raghavan, Robert Osborne
  • Patent number: 9609435
    Abstract: The present invention provides a portable and compact battery-powered stereo speaker assembly that incorporates a DC to DC converter, which enables power from the internal stereo speaker assembly battery to charge an interconnected hand-held device, such as a smartphone, through a USB connection, thereby extending the time that the device can be used untethered from the AC power grid. A DC to DC converter enables the charging function can be implemented even if the speaker assembly is not connected to the AC power grid, and even if the battery of the stereo speaker assembly is not fully charged. The stereo speaker assembly also incorporates Bluetooth connectivity, a proprietary open wireless technology standard, developed by Ericsson in 1994, employing frequency-hopping spread spectrum radio transmissions in the ISM band from 2400-2480 MHz.
    Type: Grant
    Filed: October 9, 2012
    Date of Patent: March 28, 2017
    Assignee: Braven LC
    Inventors: Warren Robert Osborn, Daniel Lester Hill