Abstract: The invention is in the field of TNF signalling. Compounds have been identified which are capable of modulating signalling of TNF trimers through receptors. Methods of identifying such compounds are therefore provided. The compounds themselves have utility in therapy.

Abstract: It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Antibodies which selectively bind to complexes of such compounds with TNF superfamily members are disclosed. These antibodies may be used to detect further compounds with the same activity, and as target engagement biomarker.

Abstract: A method of reducing the salt content of a neutralized aralkyl hydroperoxide cleavage mass stream comprising passing the neutralized stream into a vessel, the vessel having an inlet, two outlets, an aqueous layer and a hydrocarbon layer wherein the neutralized stream enters the vessel through a first inlet and a hydrocarbon stream exits the vessel through a first outlet that is in fluid communication with the hydrocarbon layer.

Abstract: Described herein is a system and method for coded streaming data to facilitate recovery from failed or slow processor(s). A batch of processing stream data can be partitioned into a plurality of data chunks. Parity chunk(s) for the plurality of data chunks. The plurality of data chunks and the parity chunk(s) can be provided to processors for processing. Processed data of at least some (e.g., one or more) of the plurality of data chunks, and, processed data of parity chunk(s) are received. When it is determined that processed data for a pre-defined quantity of data chunks has not been received by a pre-defined period of time, the processed data for particular data chunk(s) of particular processor(s) from which processed data has not been received are determined based, at least in part, upon the received processed parity chunk(s) and the received processed data chunk(s).

Abstract: Described herein is a system and method for coded streaming data to facilitate recovery from failed or slow processor(s). A batch of processing stream data can be partitioned into a plurality of data chunks. Parity chunk(s) for the plurality of data chunks. The plurality of data chunks and the parity chunk(s) can be provided to processors for processing. Processed data of at least some (e.g., one or more) of the plurality of data chunks, and, processed data of parity chunk(s) are received. When it is determined that processed data for a pre-defined quantity of data chunks has not been received by a pre-defined period of time, the processed data for particular data chunk(s) of particular processor(s) from which processed data has not been received are determined based, at least in part, upon the received processed parity chunk(s) and the received processed data chunk(s).

Abstract: It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Antibodies which selectively bind to complexes of such compounds with TNF superfamily members are disclosed. These antibodies may be used to detect further compounds with the same activity, and as target engagement biomarker.

Abstract: A new, stable trimeric TNF? structure is disclosed with distorted symmetry which can bind to the TNFR1 receptor to attenuate signalling therefrom, which can be used in the treatment and/or prevention of diseases associated with the soluble TNF?/TNFR1 interaction. Membrane-bound TNF? is not affected in its ability to signal through TNFR2, and thus the new structure of TNF? may be used in therapies which do not significantly raise the risk of infection or malignancy.

Abstract: It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Antibodies which selectively bind to complexes of such compounds with TNF superfamily members are disclosed. These antibodies may be used to detect further compounds with the same activity, and as target engagement biomarker.

Abstract: Apparatus and methods are disclosed which may keep retractable landscape lamps substantially free from water intrusion in operation for a variety of embodiments. Retractable lamps may have a lower fixed portion which could be buried in the ground and an upper portion which may rise and illuminate. When the upper portion rises it may create a low pressure or vacuum inside. Water may be pulled into the lamp which may lead to failure. The lamp may benefit from a seal between the lower and upper portions. A seal may consist of a flexible rubber material and a grease or other lubricant which may form a watertight seal with low friction. The upper portion may have a cap with provisions for aspiration. While traveling between the retracted and extended positions the lamp may aspirate through the bottom of this cap. The cap may be designed to trap an air reservoir when it retracts.

Abstract: Various examples are directed to a glucose sensor comprising a working electrode to support an oxidation reaction and a reference electrode to support a redox reaction. The reference electrode may comprise silver and silver chloride. The Glucose sensor may also comprise an anti-mineralization agent positioned at the reference electrode to reduce formation of calcium carbonate at the reference electrode.

Abstract: The invention is in the field of TNF signalling. Compounds have been identified which are capable of modulating signalling of TNF trimers through receptors. Methods of identifying such compounds are therefore provided. The compounds themselves have utility in therapy.

Abstract: It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Accordingly, these compounds can be used as modulators of TNF. A new assay for identifying compounds with this mechanism of action is also disclosed.

Abstract: Apparatus and methods are disclosed which may keep retractable landscape lamps substantially free from water intrusion in operation for a variety of embodiments. Retractable lamps may have a lower fixed portion which could be buried in the ground and an upper portion which may rise and illuminate. When the upper portion rises it may create a low pressure or vacuum inside. Water may be pulled into the lamp which may lead to failure. The lamp may benefit from a seal between the lower and upper portions. A seal may consist of a flexible rubber material and a grease or other lubricant which may form a watertight seal with low friction. The upper portion may have a cap with provisions for aspiration. While traveling between the retracted and extended positions the lamp may aspirate through the bottom of this cap. The cap may be designed to trap an air reservoir when it retracts.

Abstract: A new, stable trimeric TNF? structure is disclosed with distorted symmetry which can bind to the TNFR1 receptor to attenuate signalling therefrom, which can be used in the treatment and/or prevention of diseases associated with the soluble TNF?/TNFR1 interaction. Membrane-bound TNF? is not affected in its ability to signal through TNFR2, and thus the new structure of TNF? may be used in therapies which do not significantly raise the risk of infection or malignancy.

Abstract: Described herein is a system and method for a static streaming job startup sequence. During compilation of a streaming job, a graph of computing nodes of the streaming job is traversed to determine a minimum start time of computing node(s) downstream of each input computing node of the streaming job. Also, during compilation, a start time is assigned to each input computing node in accordance with the determined minimum start time. During execution of the streaming job, responsive to receipt of the trigger anchor by a particular input node, processing of the particular input computing node using the determined minimum start time is commenced. The input computing node further generates an anchor. Input data is received, and, a batch of data provided in accordance with the received input data and generated anchor.

Abstract: It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Accordingly, these compounds can be used as modulators of TNF. A new assay for identifying compounds with this mechanism of action is also disclosed.

Abstract: A system that provides for the accessing and playing of media files having differing associated rights such as non-DRM media files, purchased and downloaded media files, subscription download files such as tethered downloads, and subscription streamed DRM files. The system also provides a method and user interface for sharing a media collection among computing devices in communication via a network. The system allows access and playback, from each computing device on a network, of all media files in a media collection, regardless of their associated rights.

Abstract: In one aspect, the present disclosure provides for the accessing and playing of media files having differing associated rights such as non-DRM media files, purchased and downloaded media files, subscription download files such as tethered downloads, and subscription streamed DRM files. In one embodiment, the present disclosure provides a method and user interface for sharing a media collection among computing devices in communication via a network. In one embodiment, the disclosed method allows access and playback, from each computing device on a network, of all media files in a media collection, regardless of their associated rights.

Abstract: Described herein is a system and method for a static streaming job startup sequence. During compilation of a streaming job, a graph of computing nodes of the streaming job is traversed to determine a minimum start time of computing node(s) downstream of each input computing node of the streaming job. Also, during compilation, a start time is assigned to each input computing node in accordance with the determined minimum start time. During execution of the streaming job, responsive to receipt of the trigger anchor by a particular input node, processing of the particular input computing node using the determined minimum start time is commenced. The input computing node further generates an anchor. Input data is received, and, a batch of data provided in accordance with the received input data and generated anchor.

Abstract: It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Antibodies which selectively bind to complexes of such compounds with TNF superfamily members are disclosed. These antibodies may be used to detect further compounds with the same activity, and as target engagement biomarker.