Abstract: The present disclosure relates to recombinant nucleases, recombinant nucleases operatively linked to nucleic acid binding domains, and methods of making and using them.

Abstract: This specification generally relates to trinucleotide RNA cap analogs, methods of use thereof, and kits comprising same. In particular, the trinucleotide cap analogs provided herein permit ready detection and/or isolation of capped RNA transcripts in vitro and translation of capped mRNAs in vivo.

Abstract: This specification generally relates to trinucleotide RNA cap analogs, methods of use thereof, and kits comprising same. In particular, the trinucleotide cap analogs provided herein permit ready detection and/or isolation of capped RNA transcripts in vitro and translation of capped mRNAs in vivo.

Abstract: The present disclosure generally relates to compositions and methods for the synthesis of nucleic acid molecules with low error rates. Provided, as examples, are compositions and methods for high throughput synthesis and assembly of nucleic acid molecules, in many instances, with high sequence fidelity. In many instances, thermostable mismatch recognition proteins (e.g., thermostable mismatch binding protein, thermostable mismatch endonucleases) will be present in compositions and use methods provided.

Abstract: Software-based orchestration of communication payloads in satellites. In an embodiment, a payload model of a satellite payload, defined in a data modeling language (e.g., YANG) and representing a configuration for the satellite payload, is received. The configuration specifies a setting for at least one component of the satellite payload. The payload model is translated into one or more satellite commands for configuring the satellite payload according to the configuration represented in the payload model, and the satellite payload is reconfigured using the satellite command(s).

Abstract: The present disclosure relates to recombinant nucleases, recombinant nucleases operatively linked to nucleic acid binding domains, and methods of making and using them.

Abstract: The present disclosure generally relates to compositions and methods for improving the efficiency of homologous recombination. In particular, the disclosure relates to reagents and the use of such reagents.

Abstract: The present disclosure relates, in part, to improved methods of making single-stranded DNA (ssDNA) from double-stranded DNA (dsDNA), as well as use of the resulting ssDNA for genome engineering. The disclosure also relates, in part, to improved methods of genetic modification using single stranded DNA binding proteins.

Abstract: The present disclosure generally relates to compositions and methods for the genetic modification of cells. In particular, the disclosure relates to CRISPR reagents and the use of such reagents.

Abstract: This specification generally relates to trinucleotide RNA cap analogs, methods of use thereof, and kits comprising same. In particular, the trinucleotide cap analogs provided herein permit ready detection and/or isolation of capped RNA transcripts in vitro and translation of capped mRNAs in vivo.

Abstract: Software-based orchestration of communication payloads in satellites. In an embodiment, a payload model of a satellite payload, defined in a data modeling language (e.g., YANG) and representing a configuration for the satellite payload, is received. The configuration specifies a setting for at least one component of the satellite payload. The payload model is translated into one or more satellite commands for configuring the satellite payload according to the configuration represented in the payload model, and the satellite payload is reconfigured using the satellite command(s).

Abstract: The present disclosure generally relates to compositions and methods for improving the efficiency of homologous recombination. In particular, the disclosure relates to reagents and the use of such reagents.

Abstract: The present disclosure generally relates to compositions and methods for improving the efficiency of homologous recombination. In particular, the disclosure relates to reagents and the use of such reagents.

Abstract: The present disclosure generally relates to compositions and methods for improving the efficiency of homologous recombination. In particular, the disclosure relates to reagents and the use of such reagents.

Abstract: Systems, devices, and methods for satellite communications are disclosed. The devices and methods can be used for communications diversity in a system having multiple radio frequency terminals (RFTs). In a transmit chain, each RFT can be associated with an antenna for the transmission of signals to a satellite. The system can select one or more uplinks for transmission of one or more versions of a transmit signal via associated antennas. The one or more versions can have a piggyback signal associated with and phase locked to a symbol rate of the transmit signal. In a receive chain, phase differences between the piggyback signals can allow adjustment of one or more time delays in the transmit chain to provide improved signal to noise ratio of the received versions of the transmit signal in the receive chain.

Abstract: Systems, devices, and methods for satellite communications are disclosed. The devices and methods can be used for communications diversity in a system having multiple radio frequency terminals (RFTs). In a transmit chain, each RFT can be associated with an antenna for the transmission of signals to a satellite. The system can select one or more uplinks for transmission of one or more versions of a transmit signal via associated antennas. The one or more versions can have a piggyback signal associated with and phase locked to a symbol rate of the transmit signal. In a receive chain, phase differences between the piggyback signals can allow adjustment of one or more time delays in the transmit chain to provide improved signal to noise ratio of the received versions of the transmit signal in the receive chain.

Abstract: This disclosure provides a system and method for separating a first signal from a second signal of a plurality of constituent signals within a composite signal. The method can include receiving a first portion of the composite signal at a first clock rate and exponentiating it to detect the first signal and the second signal within the composite signal and determine modulation estimates of the first and second signals and at least one symbol rate. The method can also include resampling the first portion based on the modulation estimates at x-times the at least one symbol rate to determine symbol trajectory, modulation type, and offset information between the first signal and the second signal. The method can include determining a synthesized first signal and a synthesized second signal representing the first signal and the second signal within the first period of time at a second clock rate that is a multiple of the first clock rate.

Abstract: This disclosure provides a system and method for separating a first signal from a second signal of a plurality of constituent signals within a composite signal. The method can include receiving a first portion of the composite signal at a first clock rate and exponentiating it to detect the first signal and the second signal within the composite signal and determine modulation estimates of the first and second signals and at least one symbol rate. The method can also include resampling the first portion based on the modulation estimates at x-times the at least one symbol rate to determine symbol trajectory, modulation type, and offset information between the first signal and the second signal. The method can include determining a synthesized first signal and a synthesized second signal representing the first signal and the second signal within the first period of time at a second clock rate that is a multiple of the first clock rate.

Abstract: The present disclosure generally relates to compositions and methods for the genetic modification of cells. In particular, the disclosure relates to CRISPR reagents and the use of such reagents.

Abstract: The disclosure provides systems and methods for interference reduction in wireless communications. The method can include receiving a composite signal having multiple overlapping constituent signals and a noise floor. The noise floor can have at least one interfering coherent signal. The system can characterize and synthesize the multiple overlapping constituent signals without a priori know. The method can include receiving a secondary input comprising the at least one interfering coherent signal. The method can include canceling the interfering coherent signal from the noise floor. The method can include outputting the first signal and the second signal having a reduced noise floor.