Abstract: This specification generally relates to trinucleotide RNA cap analogs, methods of use thereof, and kits comprising same. In particular, the trinucleotide cap analogs provided herein permit ready detection and/or isolation of capped RNA transcripts in vitro and translation of capped mRNAs in vivo.

Abstract: A drinking vessel includes a fluid reservoir for containing a first fluid, a first tube extending from the fluid reservoir to an outlet at a distal end of the first tube and configured to carry the first fluid to the outlet responsive to the user drinking from the drinking vessel, a mixing chamber positioned along the first tube between the fluid reservoir and the outlet, one or more pumps fluidly coupled with the mixing chamber and configured to dispense one or more additives into the mixing chamber to be mixed with the first fluid, an airflow sensor configured to detect that the user is drinking from the drinking vessel, and a controller configured to activate at least one of the one or more pumps according to a selected dosing profile responsive to detecting that the user is drinking from the vessel.

Abstract: The present disclosure generally relates to compositions and methods for the synthesis of nucleic acid molecules with low error rates. Provided, as examples, are compositions and methods for high throughput synthesis and assembly of nucleic acid molecules, in many instances, with high sequence fidelity. In many instances, thermostable mismatch recognition proteins (e.g., thermostable mismatch binding protein, thermostable mismatch endonucleases) will be present in compositions and use methods provided.

Abstract: Embodiments described herein relate to systems and methods for carbonating a liquid at ambient temperature. The system may include a liquid source; a carbon dioxide source; and a contactor for carbonating the liquid. The contactor may include channels and a sparge for carbonating liquid flowing through the channels. The system may produce a liquid having high levels of carbonation at ambient temperature. The sparge may generate microbubbles or nanobubbles to allow for cost-effective carbonation at ambient temperatures. The bubbles may have an average diameter of 100 ?m or less. The system may carbonate liquid at a rate of 1 gram to 10 grams carbon dioxide per liter.

Abstract: Systems and methods for mixing and/or reconstituting drugs are presented. A system may include an injection device, a vial, a needle, and a base station. The device has a chamber containing a first material. The vial has a chamber containing a second material. A drive unit of the base station moves the vial and/or the housing of the device relative to each other into an activated position. In the activated position, the needle is fluidly connected with the vial's chamber, and the drive unit is connected to a driver that moves the plunger in the axial direction of the device such that during fluid connection of the needle with the vial's chamber the first material is expelled from the device's chamber into the vial's chamber or the second material is expelled from the vial's chamber into the device's chamber.

Abstract: Software-based orchestration of communication payloads in satellites. In an embodiment, a payload model of a satellite payload, defined in a data modeling language (e.g., YANG) and representing a configuration for the satellite payload, is received. The configuration specifies a setting for at least one component of the satellite payload. The payload model is translated into one or more satellite commands for configuring the satellite payload according to the configuration represented in the payload model, and the satellite payload is reconfigured using the satellite command(s).

Abstract: The present disclosure relates to recombinant nucleases, recombinant nucleases operatively linked to nucleic acid binding domains, and methods of making and using them.

Abstract: The present disclosure generally relates to compositions and methods for improving the efficiency of homologous recombination. In particular, the disclosure relates to reagents and the use of such reagents.

Abstract: The present disclosure relates, in part, to improved methods of making single-stranded DNA (ssDNA) from double-stranded DNA (dsDNA), as well as use of the resulting ssDNA for genome engineering. The disclosure also relates, in part, to improved methods of genetic modification using single stranded DNA binding proteins.

Abstract: The present disclosure generally relates to compositions and methods for the genetic modification of cells. In particular, the disclosure relates to CRISPR reagents and the use of such reagents.

Abstract: This specification generally relates to trinucleotide RNA cap analogs, methods of use thereof, and kits comprising same. In particular, the trinucleotide cap analogs provided herein permit ready detection and/or isolation of capped RNA transcripts in vitro and translation of capped mRNAs in vivo.

Abstract: Software-based orchestration of communication payloads in satellites. In an embodiment, a payload model of a satellite payload, defined in a data modeling language (e.g., YANG) and representing a configuration for the satellite payload, is received. The configuration specifies a setting for at least one component of the satellite payload. The payload model is translated into one or more satellite commands for configuring the satellite payload according to the configuration represented in the payload model, and the satellite payload is reconfigured using the satellite command(s).

Abstract: A method visualizes data sources. A user selects a data source, and the computer system displays a first data visualization according to placement of data fields in shelves of the user interface. The data visualization comprises visual data marks representing the data source. A user selects some of the data marks. In response, the system displays a metric window including a data metric object preview, a summary of the selected data marks, and setting controls. The user provides input to create the data metric object. In response, the system creates the data metric object, including: configuration parameters derived from the first data visualization; an initial extract from the data source according to the configuration parameters; and a schedule for recurring retrieval of data from the data source to update the extract. The system then displays a second data visualization according to the configuration parameters and the extract.

Abstract: Systems and methods for mixing and/or reconstituting drugs are presented. A system may include an injection device, a vial, a needle, and a base station. The device has a chamber containing a first material. The vial has a chamber containing a second material. A drive unit of the base station moves the vial and/or the housing of the device relative to each other into an activated position. In the activated position, the needle is fluidly connected with the vial's chamber, and the drive unit is connected to a driver that moves the plunger in the axial direction of the device such that during fluid connection of the needle with the vial's chamber the first material is expelled from the device's chamber into the vial's chamber or the second material is expelled from the vial's chamber into the device's chamber.

Abstract: The present disclosure generally relates to compositions and methods for improving the efficiency of homologous recombination. In particular, the disclosure relates to reagents and the use of such reagents.

Abstract: The present disclosure generally relates to compositions and methods for improving the efficiency of homologous recombination. In particular, the disclosure relates to reagents and the use of such reagents.

Abstract: The present disclosure generally relates to compositions and methods for improving the efficiency of homologous recombination. In particular, the disclosure relates to reagents and the use of such reagents.

Abstract: Systems, devices, and methods for satellite communications are disclosed. The devices and methods can be used for communications diversity in a system having multiple radio frequency terminals (RFTs). In a transmit chain, each RFT can be associated with an antenna for the transmission of signals to a satellite. The system can select one or more uplinks for transmission of one or more versions of a transmit signal via associated antennas. The one or more versions can have a piggyback signal associated with and phase locked to a symbol rate of the transmit signal. In a receive chain, phase differences between the piggyback signals can allow adjustment of one or more time delays in the transmit chain to provide improved signal to noise ratio of the received versions of the transmit signal in the receive chain.

Abstract: Systems, devices, and methods for satellite communications are disclosed. The devices and methods can be used for communications diversity in a system having multiple radio frequency terminals (RFTs). In a transmit chain, each RFT can be associated with an antenna for the transmission of signals to a satellite. The system can select one or more uplinks for transmission of one or more versions of a transmit signal via associated antennas. The one or more versions can have a piggyback signal associated with and phase locked to a symbol rate of the transmit signal. In a receive chain, phase differences between the piggyback signals can allow adjustment of one or more time delays in the transmit chain to provide improved signal to noise ratio of the received versions of the transmit signal in the receive chain.

Abstract: This disclosure provides a system and method for separating a first signal from a second signal of a plurality of constituent signals within a composite signal. The method can include receiving a first portion of the composite signal at a first clock rate and exponentiating it to detect the first signal and the second signal within the composite signal and determine modulation estimates of the first and second signals and at least one symbol rate. The method can also include resampling the first portion based on the modulation estimates at x-times the at least one symbol rate to determine symbol trajectory, modulation type, and offset information between the first signal and the second signal. The method can include determining a synthesized first signal and a synthesized second signal representing the first signal and the second signal within the first period of time at a second clock rate that is a multiple of the first clock rate.