Patents by Inventor Robert R. Whittle

Robert R. Whittle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6660726
    Abstract: Novel estrogenic compounds of Formula I are provided. wherein the bond represented by the wavy line may be a single or double bond such that when the wavy line is a single bond, R1 is selected from the group consisting of hydrogen, sulfate and glucoronate or other esters, and when the wavy line is a double bond, R1 does not exist; R2 is lower alkyl; R3 may be selected from the group consisting of hydrogen, sulfate, or glucuronide or other esters; and R4 through R13 may independently be selected from the group consisting of hydrogen, hydroxy, ketone, lower alkyl, lower alkoxy, halogen, and carbonyl groups and R14 is selected from the group consisting of hydrogen, sulfate and glucoronide and other esters. When R1 is hydroxy, the hydroxy or ester substituent may have either an &agr; or a &bgr; orientation. Compositions of matter including compounds of the present invention are also provided as are methods of treating mammals in need of treatment using compounds of the present invention.
    Type: Grant
    Filed: March 8, 2001
    Date of Patent: December 9, 2003
    Assignee: Endeavor Pharmaceuticals
    Inventors: Edward N. Hill, Frederick D. Sancilio, Robert R. Whittle
  • Patent number: 6660864
    Abstract: Polymorphs Form B, Form C, and amorphous of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone, commonly known as cilostazol, have been identified. These polymorphs may be formed in pure form, in combination with each other, in combination with other polymorphs of cilostazol, or together with other pharmaceutical agents. Processes for preparing these polymorphs, and combinations of these polymorphs, as well as methods of use and unit dosages of these polymorphic forms, and their combinations, are described.
    Type: Grant
    Filed: June 29, 2001
    Date of Patent: December 9, 2003
    Inventors: Grayson Walker Stowell, Robert R. Whittle
  • Publication number: 20030225136
    Abstract: Compounds represented by formula (Ia) are disclosed by the invention, along with compositions and complexes thereof, optionally in combination with compounds of formula (Ib). Pharmaceutical formulations and methods of making and using such compounds are also disclosed.
    Type: Application
    Filed: May 8, 2003
    Publication date: December 4, 2003
    Inventors: Robert R. Whittle, Frederick D. Sancilio, Grayson Walker Stowell, Douglas John Jenkins, Linda B. Whittall
  • Publication number: 20030225137
    Abstract: Compounds represented by formula (Ia) are disclosed by the invention, along with compositions and complexes thereof, optionally in combination with compounds of formula (Ib). Pharmaceutical formulations and methods of making and using such compounds are also disclosed.
    Type: Application
    Filed: May 16, 2003
    Publication date: December 4, 2003
    Inventors: Robert R. Whittle, Frederick D. Sancilio, Grayson Walker Stowell, Douglas John Jenkins, Linda B. Whittall
  • Publication number: 20030225135
    Abstract: Compounds represented by formula (Ia) are disclosed by the invention, along with compositions and complexes thereof, optionally in combination with compounds of formula (Ib). Pharmaceutical formulations and methods of making and using such compounds are also disclosed.
    Type: Application
    Filed: May 7, 2003
    Publication date: December 4, 2003
    Inventors: Robert R. Whittle, Frederick D. Sancilio, Grayson Walker Stowell, Douglas John Jenkins, Linda D. Whittall
  • Patent number: 6657061
    Abstract: Polymorphs Form B, Form C, and amorphous of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone, commonly known as cilostazol, have been identified. These polymorphs may be formed in pure form, in combination with each other, in combination with other polymorphs of cilostazol, or together with other pharmaceutical agents. Processes for preparing these polymorphs, and combinations of these polymorphs, as well as methods of use and unit dosages of these polymorphic forms, and their combinations, are described.
    Type: Grant
    Filed: June 29, 2001
    Date of Patent: December 2, 2003
    Inventors: Grayson Walker Stowell, Robert R. Whittle
  • Patent number: 6653329
    Abstract: Compounds represented by formula (Ia) are disclosed by the invention, along with compositions and complexes thereof, optionally in combination with compounds of formula (Ib). Pharmaceutical formulations and methods of making and using such compounds are also disclosed.
    Type: Grant
    Filed: May 16, 2003
    Date of Patent: November 25, 2003
    Inventors: Robert R. Whittle, Frederick D. Sancilio, Grayson Walker Stowell, Douglas John Jenkins, Linda B. Whittall
  • Publication number: 20030207855
    Abstract: Novel estrogenic compounds of Formula I are provided.
    Type: Application
    Filed: May 15, 2003
    Publication date: November 6, 2003
    Inventors: Edward N. Hill, Frederick D. Sancilio, Robert R. Whittle
  • Publication number: 20030191141
    Abstract: A novel polymorphic form of risperidone (3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-&agr;]pyrimidin-4-one) is useful in pharmaceutical compositions, either in pure form or in combination with other forms of risperidone.
    Type: Application
    Filed: March 28, 2002
    Publication date: October 9, 2003
    Inventors: Inigo Pfeiffer, Robert R. Whittle, Grayson Walker Stowell, Linda B. Whittall
  • Publication number: 20030191140
    Abstract: A novel polymorphic form of risperidone (3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-&agr;]pyrimidin-4-one) is useful in pharmaceutical compositions, either in pure form or in combination with other forms of risperidone.
    Type: Application
    Filed: March 28, 2002
    Publication date: October 9, 2003
    Inventors: Inigo Pfeiffer, Robert R. Whittle, Grayson Walker Stowell, Linda B. Whittall
  • Patent number: 6608091
    Abstract: The present invention provides processes for purifying 6-methoxy omeprazole, products using such processes, pharmaceutical formulations using such products, and methods of using such products for gastric acid inhibition.
    Type: Grant
    Filed: April 20, 2001
    Date of Patent: August 19, 2003
    Inventors: Linda B. Whittall, Grayson Walker Stowell, Robert R. Whittle
  • Patent number: 6596871
    Abstract: Polymorphs Form B, Form C, and amorphous of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone, commonly known as cilostazol, have been identified. These polymorphs may be formed in pure form, in combination with each other, in combination with other polymorphs of cilostazol, or together with other pharmaceutical agents. Processes for preparing these polymorphs, and combinations of these polymorphs, as well as methods of use and unit dosages of these polymorphic forms, and their combinations, are described.
    Type: Grant
    Filed: June 29, 2001
    Date of Patent: July 22, 2003
    Inventors: Grayson Walker Stowell, Robert R. Whittle
  • Publication number: 20030105360
    Abstract: The present invention relates to novel polymorphic Form A of fluoxetine hydrochloride.
    Type: Application
    Filed: August 20, 2002
    Publication date: June 5, 2003
    Inventors: Grayson Walker Stowell, Robert R. Whittle
  • Patent number: 6573382
    Abstract: Polymorphs Form B, Form C, and amorphous of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone, commonly known as cilostazol, have been identified. These polymorphs may be formed in pure form, in combination with each other, in combination with other polymorphs of cilostazol, or together with other pharmaceutical agents. Processes for preparing these polymorphs, and combinations of these polymorphs, as well as methods of use and unit dosages of these polymorphic forms, and their combinations, are described.
    Type: Grant
    Filed: June 29, 2001
    Date of Patent: June 3, 2003
    Inventors: Grayson Walker Stowell, Robert R. Whittle
  • Publication number: 20030096845
    Abstract: Compounds represented by formula (Ia) are disclosed by the invention, along with compositions and complexes thereof, optionally in combination with compounds of formula (Ib). Pharmaceutical formulations and methods of making and using such compounds are also disclosed.
    Type: Application
    Filed: July 3, 2002
    Publication date: May 22, 2003
    Inventors: Robert R. Whittle, Frederick D. Sancillio, Grayson Walker Stowell, Douglas John Jenkins, Linda B. Whittall
  • Publication number: 20030088106
    Abstract: The present invention provides processes for purifying 6-methoxy omeprazole, products using such processes, pharmaceutical formulations using such products, and methods of using such products for gastric acid inhibition.
    Type: Application
    Filed: April 20, 2001
    Publication date: May 8, 2003
    Inventors: Linda B. Whittall, Grayson Walker Stowell, Robert R. Whittle
  • Publication number: 20030065009
    Abstract: Polymorphs Form B, Form C, and amorphous of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone, commonly known as cilostazol, have been identified. These polymorphs may be formed in pure form, in combination with each other, in combination with other polymorphs of cilostazol, or together with other pharmaceutical agents. Processes for preparing these polymorphs, and combinations of these polymorphs, as well as methods of use and unit dosages of these polymorphic forms, and their combinations, are described.
    Type: Application
    Filed: June 29, 2001
    Publication date: April 3, 2003
    Inventors: Grayson Walker Stowell, Robert R. Whittle
  • Publication number: 20030055082
    Abstract: Polymorphs Form B, Form C, and amorphous of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone, commonly known as cilostazol, have been identified. These polymorphs may be formed in pure form, in combination with each other, in combination with other polymorphs of cilostazol, or together with other pharmaceutical agents. Processes for preparing these polymorphs, and combinations of these polymorphs, as well as methods of use and unit dosages of these polymorphic forms, and their combinations, are described.
    Type: Application
    Filed: June 29, 2001
    Publication date: March 20, 2003
    Inventors: Grayson Walker Stowell, Robert R. Whittle
  • Patent number: 6531603
    Abstract: Polymorphs Form B, Form C, and amorphous of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone, commonly known as cilostazol, have been identified. These polymorphs may be formed in pure form, in combination with each other, in combination with other polymorphs of cilostazol, or together with other pharmaceutical agents. Processes for preparing these polymorphs, and combinations of these polymorphs, as well as methods of use and unit dosages of these polymorphic forms, and their combinations, are described.
    Type: Grant
    Filed: June 29, 2001
    Date of Patent: March 11, 2003
    Inventors: Grayson Walker Stowell, Robert R. Whittle
  • Publication number: 20030045548
    Abstract: Polymorphs Form B, Form C, and amorphous of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone, commonly known as cilostazol, have been identified. These polymorphs may be formed in pure form, in combination with each other, in combination with other polymorphs of cilostazol, or together with other pharmaceutical agents. Processes for preparing these polymorphs, and combinations of these polymorphs, as well as methods of use and unit dosages of these polymorphic forms, and their combinations, are described.
    Type: Application
    Filed: June 29, 2001
    Publication date: March 6, 2003
    Inventors: Grayson Walker Stowell, Robert R. Whittle