Patents by Inventor Robert R. Whittle

Robert R. Whittle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polymorphic forms of 6-[4-(1-cyclohexyl-1h-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
    Publication number: 20030045549
    Abstract: Polymorphs Form B, Form C, and amorphous of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone, commonly known as cilostazol, have been identified. These polymorphs may be formed in pure form, in combination with each other, in combination with other polymorphs of cilostazol, or together with other pharmaceutical agents. Processes for preparing these polymorphs, and combinations of these polymorphs, as well as methods of use and unit dosages of these polymorphic forms, and their combinations, are described.
    Type: Application
    Filed: June 29, 2001
    Publication date: March 6, 2003
    Inventors: Grayson Walker Stowell, Robert R. Whittle
  • Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
    Publication number: 20030027838
    Abstract: Polymorphs Form B, Form C, and amorphous of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone, commonly known as cilostazol, have been identified. These polymorphs may be formed in pure form, in combination with each other, in combination with other polymorphs of cilostazol, or together with other pharmaceutical agents. Processes for preparing these polymorphs, and combinations of these polymorphs, as well as methods of use and unit dosages of these polymorphic forms, and their combinations, are described.
    Type: Application
    Filed: June 29, 2001
    Publication date: February 6, 2003
    Inventors: Grayson Walker Stowell, Robert R. Whittle
  • Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
    Publication number: 20030013736
    Abstract: Polymorphs Form B, Form C, and amorphous of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone, commonly known as cilostazol, have been identified. These polymorphs may be formed in pure form, in combination with each other, in combination with other polymorphs of cilostazol, or together with other pharmaceutical agents. Processes for preparing these polymorphs, and combinations of these polymorphs, as well as methods of use and unit dosages of these polymorphic forms, and their combinations, are described.
    Type: Application
    Filed: June 29, 2001
    Publication date: January 16, 2003
    Inventors: Grayson Walker Stowell, Robert R. Whittle
  • Polymorphic form of 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-alpha]pyrimidin-4-one and formulations thereof
    Publication number: 20020193386
    Abstract: A novel polymorphic form of risperidone (3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-&agr;]pyrimidin-4-one) is useful in pharmaceutical compositions, either in pure form or in combination with other forms of risperidone.
    Type: Application
    Filed: March 28, 2002
    Publication date: December 19, 2002
    Inventors: Inigo Pfeiffer, Robert R. Whittle, Grayson Walker Stowell, Linda B. Whittall
  • Form A of fluoxetine hydrochloride
    Patent number: 6492556
    Abstract: The present invention relates to novel polymorphic Form A of fluoxetine hydrochloride.
    Type: Grant
    Filed: November 5, 2001
    Date of Patent: December 10, 2002
    Inventors: Grayson Walker Stowell, Robert R. Whittle
  • Form A of fluoxetine hydrochloride
    Publication number: 20020169341
    Abstract: The present invention relates to novel polymorphic Form A of fluoxetine hydrochloride.
    Type: Application
    Filed: November 5, 2001
    Publication date: November 14, 2002
    Inventors: Grayson Walker Stowell, Robert R. Whittle
  • Process for purifying 6- methoxy omeprazole
    Publication number: 20020156103
    Abstract: The present invention provides processes for purifying 6-methoxy omeprazole, products using such processes, pharmaceutical formulations using such products, and methods of using such products for gastric acid inhibition.
    Type: Application
    Filed: April 20, 2001
    Publication date: October 24, 2002
    Inventors: Linda B. Whittall, Grayson Walker Stowell, Robert R. Whittle
  • Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
    Patent number: 6444689
    Abstract: Compounds represented by formula (Ia) are disclosed by the invention, along with compositions and complexes thereof, optionally in combination with compounds of formula (Ib). Pharmaceutical formulations and methods of making and using such compounds are also disclosed.
    Type: Grant
    Filed: January 25, 2002
    Date of Patent: September 3, 2002
    Inventors: Robert R. Whittle, Frederick D. Sancilio, Grayson Walker Stowell, Douglas John Jenkins, Linda B. Whittall
  • ALKOXY SUBSTITUTED BENZIMIDAZOLE COMPOUNDS, PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME, AND METHODS OF USING THE SAME
    Publication number: 20020103232
    Abstract: Compounds represented by formula (Ia) are disclosed by the invention, along with compositions and complexes thereof, optionally in combination with compounds of formula (Ib). Pharmaceutical formulations and methods of making and using such compounds are also disclosed.
    Type: Application
    Filed: January 25, 2002
    Publication date: August 1, 2002
    Inventors: Robert R. Whittle, Frederick D. Sancilio, Grayson Walker Stowell, Douglas John Jenkins, Linda B. Whittall
  • Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
    Patent number: 6388080
    Abstract: Polymorphs Form B, Form C, and amorphous of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone, commonly known as cilostazol, have been identified. These polymorphs may be formed in pure form, in combination with each other, in combination with other polymorphs of cilostazol, or together with other pharmaceutical agents. Processes for preparing these polymorphs, and combinations of these polymorphs, as well as methods of use and unit dosages of these polymorphic forms, and their combinations, are described.
    Type: Grant
    Filed: June 29, 2001
    Date of Patent: May 14, 2002
    Inventors: Grayson Walker Stowell, Robert R. Whittle
  • Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
    Patent number: 6369087
    Abstract: Compounds represented by formula (Ia) are disclosed by the invention, along with compositions and complexes thereof, optionally in combination with compounds of formula (Ib). Pharmaceutical formulations and methods of making and using such compounds are also disclosed.
    Type: Grant
    Filed: August 24, 2000
    Date of Patent: April 9, 2002
    Inventors: Robert R. Whittle, Frederick D. Sancilio, Grayson Walker Stowell, Douglas John Jenkins, Linda B. Whittall
  • Novel estrogenic compounds
    Publication number: 20020016316
    Abstract: Novel estrogenic compounds of Formula I are provided.
    Type: Application
    Filed: March 8, 2001
    Publication date: February 7, 2002
    Inventors: Edward N. Hill, Frederick D. Sancilio, Robert R. Whittle
  • Dry blend pharmaceutical unit dosage form
    Patent number: 6326384
    Abstract: The present invention provides dry blend pharmaceutical formulations in unit dosage forms comprising per dosage unit one or more active pharmaceutical ingredients or pharmaceutically acceptable salts, solvates, hydrates, or combinations thereof wherein the ratio of said one or more active pharmaceutical ingredients in said formulations is essentially the same as the ratio of said active pharmaceutical ingredients in the corresponding, non-formulated drug substance and, wherein said formulations in unit dosage form are adapted for oral administration.
    Type: Grant
    Filed: August 24, 2000
    Date of Patent: December 4, 2001
    Inventors: Robert R. Whittle, Frederick D. Sancilio, Grayson Walker Stowell, Douglas John Jenkins, Linda B. Whittall
  • Pharmaceutical formulations
    Patent number: 6316020
    Abstract: Pharmaceutical compositions and formulations comprised of one or more active ingredients or pharmaceutically acceptable salts, solvates, hydrates, or combinations thereof combined with at least one cyclodextrin.
    Type: Grant
    Filed: July 31, 2000
    Date of Patent: November 13, 2001
    Inventors: Robert R. Whittle, Frederick D. Sancilio, Grayson Walker Stowell, Douglas John Jenkins, Linda B. Whittall, Glenn Alan Meyer
  • Form a of fluoxetine hydrochloride
    Patent number: 6316672
    Abstract: The present invention relates to novel polymorphic Form A of fluoxetine hydrochloride.
    Type: Grant
    Filed: January 31, 2001
    Date of Patent: November 13, 2001
    Inventors: Grayson Walker Stowell, Robert R. Whittle
  • Method of improving bioavailability
    Patent number: 6312712
    Abstract: Improved bioavailability method of one or more of certain pharmaceutically active compounds or pharmaceutically acceptable salts, solvates, hydrates, or combinations thereof that include administering a non-toxic, therapeutically effective amount of the compounds combined with at least one cyclodextrin to a mammal in need of treatment of gastric acid related diseases.
    Type: Grant
    Filed: July 31, 2000
    Date of Patent: November 6, 2001
    Inventors: Robert R. Whittle, Frederick D. Sancilio, Grayson Walker Stowell, Douglas John Jenkins, Linda B. Whittall, Glenn Alan Meyer
  • Form a of fluoxetine hydrochloride
    Patent number: 6313350
    Abstract: The present invention provides novel processes for the preparation of Form A of fluoxetine hydrochloride.
    Type: Grant
    Filed: January 31, 2001
    Date of Patent: November 6, 2001
    Inventors: Grayson Walker Stowell, Robert R. Whittle
  • Pharmaceutical unit dosage form
    Patent number: 6312723
    Abstract: Pharmaceutical formulations, in oral unit dosage forms, have one or more active ingredients or pharmaceutically acceptable salts, solvates, hydrates, or combinations thereof combined with at least one cyclodextrin.
    Type: Grant
    Filed: July 31, 2000
    Date of Patent: November 6, 2001
    Inventors: Robert R. Whittle, Frederick D. Sancilio, Grayson Walker Stowell, Douglas John Jenkins, Linda B. Whittall, Glenn Alan Meyer, Steven A. Fontana
  • Form A of fluoxetine hydrochloride
    Patent number: 6310250
    Abstract: The present invention provides novel amorphous fluoxetine hydrochloride as a useful intermediate for the preparation of Form A of fluoxetine hydrochloride.
    Type: Grant
    Filed: January 31, 2001
    Date of Patent: October 30, 2001
    Inventors: Grayson Walker Stowell, Robert R. Whittle
  • Form a of fluoxetine hydrochloride
    Patent number: 6310251
    Abstract: The present invention provides novel processes for the preparation of Form A of fluoxetine hydrochloride.
    Type: Grant
    Filed: January 31, 2001
    Date of Patent: October 30, 2001
    Inventors: Grayson Walker Stowell, Robert R. Whittle