Patents by Inventor Robert S. Salter
Robert S. Salter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230330657Abstract: Sample preparation and detection devices, methods, and assemblies are shown and described. In one embodiment, an assembly for preparing a sample for predicting a bacterial presence includes a compartmentalized container having a sample collector reservoir, a first storage compartment, and a second storage compartment. The result is improved efficient and effective predicting of a bacterial presence.Type: ApplicationFiled: September 27, 2021Publication date: October 19, 2023Applicant: Charm Sciences, Inc.Inventors: Robert S Salter, Richard Skiffington, Shishan Wang
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Patent number: 11427849Abstract: Culture medium devices and systems are shown and described. In one embodiment, the device comprises a culture medium adapted for test fluid inoculation without the concerns associated with a spreading step. In particular examples, a printed grid on the outer surface of a culture device is visible on the inner surface for colony counting after a test has been developed. The result is a device that allows for detection, identification, and transportation of various microorganisms without preparation or spreading steps, and more particularly to a culture medium in which a test fluid inoculated thereto diffuses rapidly.Type: GrantFiled: September 16, 2013Date of Patent: August 30, 2022Assignee: Charm Sciences, Inc.Inventors: Robert S. Salter, Gregory W. Durbin, Stanley E. Charm, Richard T. Skiffington
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Publication number: 20210308667Abstract: Sample collection and analysis devices, methods, and assemblies are shown and described. In one embodiment, an assembly includes a sample collection device and a removable vial having a penetrable barrier seal to prevent access to the vial until at least one penetrable activation. The result is improved efficient and effective sample collection and analysis.Type: ApplicationFiled: April 6, 2021Publication date: October 7, 2021Applicant: Charm Sciences, Inc.Inventors: Robert S. Salter, Robert J. Markovsky, Meikel Brewster
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Patent number: 11009446Abstract: Reader observation and monitoring of the imaging of biological development is shown and described. In one embodiment, a method for monitoring biological growth includes identifying an alert from comparing a background value identified on a plate to a non-background value identified on a plate. In particular examples, a pre-filter, threshold, and histogram analysis identifies an alert count.Type: GrantFiled: October 29, 2019Date of Patent: May 18, 2021Assignee: Charm Sciences, Inc.Inventors: Richard T. Skiffington, Robert S. Salter, Robert J. Markovsky, Stanley E. Charm, Paul E. Graham, Jovo Djuragic
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Patent number: 10988720Abstract: Peel plates and plate assemblies are shown and described. In one embodiment, a peel plate assembly includes a semi-rigid plate, a removable cover seal, and an adhesive to provide a moisture vapor barrier. In particular embodiments, the moisture vapor barrier provides less than about one pound peel adhesion and a stiffness for reapplication without wrinkling. The result is a peel plate, assembly, and method for the enumerating a microorganism, when present, in a sample.Type: GrantFiled: November 9, 2015Date of Patent: April 27, 2021Assignee: Charm Sciences, Inc.Inventors: Richard Skiffington, Robert Markovsky, Byron D. Roberts, Stanley E. Charm, Benjamin Mathieu, Robert S. Salter
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Patent number: 10563164Abstract: Reader and plate methods, operations, and systems for observing a biological sample are shown and described. In one embodiment, a reader device includes selecting a plate type between at least two plate type selections on a user interface. One embodiment includes aligning a peel plate within a tray holder nest to define a semi-fixed processing position. One embodiment includes transporting a peel plate from a loading position into a focal alignment with an imaging device for monitoring biological growth, when present.Type: GrantFiled: October 11, 2016Date of Patent: February 18, 2020Assignee: Charm Sciences, Inc.Inventors: Richard T Skiffington, Robert S Salter, Robert J Markovsky, Stanley E Charm, Paul E Graham, Byron A. Roberts
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Patent number: 10495563Abstract: Reader observation and monitoring of the imaging of biological development is shown and described. In one embodiment, a method for monitoring biological growth includes identifying an alert from comparing a background value identified on a plate to a non-background value identified on a plate. In particular examples, a pre-filter, threshold, and histogram analysis identifies an alert count.Type: GrantFiled: April 28, 2017Date of Patent: December 3, 2019Assignee: Charm Sciences, Inc.Inventors: Richard T. Skiffington, Robert S. Salter, Robert J. Markovsky, Stanley E. Charm
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Patent number: 9376704Abstract: Phages can be detected as rapid indicators of the hygienic quality of a sample. Both continuous flow methods and devices, single sample methods and devices, of various volumes, can be used. Single samples may be tested by single or multi-step testing methods. Test kits can be provided in easy-to-use formats. Certain phages, such as coliphage, are useful as indicators of fecal contamination.Type: GrantFiled: August 7, 2009Date of Patent: June 28, 2016Assignee: Charm Sciences, Inc.Inventors: Robert S. Salter, Gregory W. Durbin
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Publication number: 20160040211Abstract: Culture medium devices and systems are shown and described. In one embodiment, the device comprises a culture medium adapted for test fluid inoculation without the concerns associated with a spreading step. In particular examples, a printed grid on the outer surface of a culture device is visible on the inner surface for colony counting after a test has been developed. The result is a device that allows for detection, identification, and transportation of various microorganisms without preparation or spreading steps, and more particularly to a culture medium in which a test fluid inoculated thereto diffuses rapidly.Type: ApplicationFiled: September 16, 2013Publication date: February 11, 2016Applicant: Charm Sciences, Inc.Inventors: Robert S. Salter, Gregory W. Durbin, Stanley E. Charm, Richard T. Skiffington
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Patent number: 8476064Abstract: An aspect of the disclosure is a method and device for the detection of antibiotics in a sample. Embodiments include a microbial culture with growth indicators and sensitivity adjustment reagents. Adjustment reagents include a variety of antibiotic binders that can be added to microbial culture to reduce sensitivity to certain antibiotics. Some embodiments include multiple buffers with a variety of pKa ranges. Some embodiments also include a complete self-contained apparatus for sampling and testing.Type: GrantFiled: July 26, 2010Date of Patent: July 2, 2013Assignee: Charm Sciences, Inc.Inventors: Robert S. Salter, Steven J. Saul, Martin T. Rossi
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Patent number: 8236515Abstract: Methods are provided for detection of concentrations of less than 3.4 picomolar of adenosine triphosphate (ATP) using recombinant luciferase in the luciferin-luciferase reaction. Aspects include a low pH composition for use in detecting the presence of ATP. The low pH composition can include low concentrations of detergents and can be used in combination with methods for reading, calculating and interpreting luminescence generated by the ATP-luciferin-luciferase reaction.Type: GrantFiled: September 27, 2010Date of Patent: August 7, 2012Assignee: Charm Sciences, Inc.Inventors: Stanley E. Charm, Cheryl B. Francisco, Robert J. Markovsky, Robert S. Salter, Steven J. Saul
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Patent number: 7993871Abstract: Disclosed herein is test device and method for detection of sample analytes in which after sampling has occurred a closure is provided. Such a test device and method can be usefully employed to detect a variety of analytes including microorganisms.Type: GrantFiled: December 19, 2005Date of Patent: August 9, 2011Assignee: Charm Sciences, Inc.Inventors: Richard T. Skiffington, Robert S. Salter, John F. Fitchen
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Publication number: 20110065116Abstract: Methods are provided for detection of concentrations of less than 3.4 picomolar of adenosine triphosphate (ATP) using recombinant luciferase in the luciferin-luciferase reaction. Aspects include a low pH composition for use in detecting the presence of ATP. The low pH composition can include low concentrations of detergents and can be used in combination with methods for reading, calculating and interpreting luminescence generated by the ATP-luciferin-luciferase reaction.Type: ApplicationFiled: September 27, 2010Publication date: March 17, 2011Inventors: Stanley E. Charm, Cheryl B. Francisco, Robert J. Markovsky, Robert S. Salter, Steven J. Saul
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Patent number: 7897365Abstract: The present invention relates to a method for adjusting the sensitivity of a microbial culture to an antibiotic. The method employs a substance derived from a bacterial species with sensitivity to the antibiotic. Such bacterial species include the same species used in the culture or a different species.Type: GrantFiled: November 5, 2004Date of Patent: March 1, 2011Assignee: Charm Sciences, Inc.Inventors: Robert S. Salter, Steven J. Saul, Martin T. Rossi, Robert J. Markovsky
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Publication number: 20100285572Abstract: An aspect of the disclosure is a method and device for the detection of antibiotics in a sample. Embodiments include a microbial culture with growth indicators and sensitivity adjustment reagents. Adjustment reagents include a variety of antibiotic binders that can be added to microbial culture to reduce sensitivity to certain antibiotics. Some embodiments include multiple buffers with a variety of pKa ranges. Some embodiments also include a complete self-contained apparatus for sampling and testing.Type: ApplicationFiled: July 26, 2010Publication date: November 11, 2010Inventors: Robert S. Salter, Steven J. Saul, Martin T. Rossi
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Patent number: 7824878Abstract: Methods are provided for sensitive detection of adenosine triphosphate (ATP) in samples using the luciferin-luciferase reaction. Aspects include using a pH composition that maximizes a signal to noise ratio. The maximum signal to noise ratio can be particularly useful with recombinant luciferase including recombinant Coleoptera luciferase.Type: GrantFiled: January 9, 2009Date of Patent: November 2, 2010Assignee: Charm Sciences, Inc.Inventors: Stanley E. Charm, Cheryl B. Francisco, Robert J. Markovsky, Robert S. Salter, Steven J. Saul
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Publication number: 20090298051Abstract: Phages can be detected as rapid indicators of the hygienic quality of a sample. Both continuous flow methods and devices, single sample methods and devices, of various volumes, can be used. Single samples may be tested by single or multi-step testing methods. Test kits can be provided in easy-to-use formats. Certain phages, such as coliphage, are useful as indicators of fecal contamination.Type: ApplicationFiled: August 7, 2009Publication date: December 3, 2009Inventors: Robert S. Salter, Gregory W. Durbin
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Publication number: 20090148852Abstract: Methods are provided for sensitive detection of adenosine triphosphate (ATP) in samples using the luciferin-luciferase reaction. Aspects include using a pH composition that maximizes a signal to noise ratio. The maximum signal to noise ratio can be particularly useful with recombinant luciferase including recombinant Coleoptera luciferase.Type: ApplicationFiled: January 9, 2009Publication date: June 11, 2009Inventors: Stanley E. Charm, Cheryl B. Francisco, Robert J. Markovsky, Robert S. Salter, Steven J. Saul
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Patent number: 7494781Abstract: Methods, devices and systems are provided for detection of adenosine triphosphate (ATP) in samples using the luciferin-luciferase reaction. Aspects include a low pH composition for use in detecting the presence of ATP. The low pH composition can include low molarity buffers and detergents and can be used in combination with methods for reading, calculating and interpreting luminescence generated by the ATP-luciferin-luciferase reaction. Both the low molarity and low pH composition, and the methods for reading, calculating and interpreting luminescence, can be used with a single service hygiene monitoring format.Type: GrantFiled: May 31, 2005Date of Patent: February 24, 2009Assignee: Charm Sciences, Inc.Inventors: Stanley E. Charm, Cheryl B. Francisco, Robert J. Markovsky, Robert S. Salter, Steven J. Saul
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Publication number: 20080206740Abstract: Disclosed herein is test device and method for detection of sample analytes in which after sampling has occurred a closure is provided. Such a test device and method can be usefully employed to detect a variety of analytes including microorganisms.Type: ApplicationFiled: December 19, 2005Publication date: August 28, 2008Inventors: Richard T. Skiffington, Robert S. Salter, John F. Fitchen