Abstract: Methods and devices for the diagnosis and treatment of microvascular dysfunction, such as microvascular obstruction (MVO) and other dysfunctional diseases of the microvasculature of many organs, including the heart. The present subject matter provides novel devices and methods to successfully diagnose, restore patency, open and preserve flow, and limit reperfusion injury in organs and cases with microvascular dysfunction. The present subject matter provides apparatus and method to detect, measure and treat microvascular dysfunction in real time during scenarios such as invasive angiographic/therapeutic procedures. Such procedures include therapy for organ systems including the heart (acute myocardial infarction—primary percutaneous coronary intervention (PPCI)), brain stroke (CVA), bowel ischemia/infarction, pulmonary emboli/infarction, critical limb ischemia/infarction, renal ischemia/infarction, and others.

Abstract: Devices and methods of treating conditions cause or exacerbated by excessive fluid pressures or retentions, such as pulmonary hypertension, that involves shunting excessive fluid pressure from one bodily chamber or vessel to another bodily chamber or vessel.

Abstract: An apparatus comprises at least one processing device configured to generate a model of an outbreak of a disease based on physiological monitoring and location data received from wearable devices of a plurality of users, to determine a first subset of the plurality of users that have potentially contracted the disease based on a comparison of the physiological monitoring data and known symptoms of the disease, to identify a second subset of the plurality of users that are at risk for contracting the disease from the first subset of the plurality of users utilizing the model of the outbreak of the disease and the location data, and to generate notifications for delivery to the plurality of users comprising information related to outbreak of the disease and measures for at least one of treating and mitigating spread of the disease.

Abstract: An apparatus comprises a processing device configured to receive health data characterizing outbreak of a disease and physiological monitoring data from wearable devices associated with users and to calculate user-specific risks of at least one of contracting and spreading the disease based on analysis of the physiological monitoring data and the health data characterizing the outbreak of the disease. The processing device is also configured to generate notifications for delivery to the users based on the user-specific risks, the notifications comprising information related to outbreak of the disease and measures for treating and mitigating spread of the disease. The processing device is further configured to modify at least a given one of the notifications to be delivered to the given user based at least in part on identifying that the given user is associated with at least one of the first responder network and the local caregiver network.

Abstract: Systems and methods for controlling blood pressure by controlling atrial pressure and atrial stretch are disclosed. In some embodiments, a stimulation circuit may be configured to deliver a stimulation pulse to at least one cardiac chamber of a heart of a patient, and at least one controller may be configured to execute delivery of one or more stimulation patterns of stimulation pulses to the at least one cardiac chamber, wherein at least one of the stimulation pulses stimulates the heart such that an atrial pressure resulting from atrial contraction of an atrium overlaps in time a passive pressure build-up of the atrium, such that an atrial pressure of the atrium resulting from the stimulation is a combination of the atrial pressure resulting from atrial contraction and the passive pressure build-up and is higher than an atrial pressure of the atrium would be without the stimulation, and such that the blood pressure of the patient is reduced.

Abstract: An apparatus comprises a processing device configured to receive physiological monitoring data from wearable devices, to generate telemedicine data based on telemedicine interactions between a given user and telemedical support staff of a telemedicine network, and to calculate, for the given user, a predicted outcome and associated user-specific risk of contracting and spreading a disease for two or more telemedical treatment scenarios based on the physiological monitoring data and the telemedicine data. The processing device is also configured to recommend a given telemedical treatment scenario for the given user based on the predicted outcomes and associated user-specific risks for the telemedical treatment scenarios, and to generate notifications for delivery to at least one of the given user and one or more other users based on the recommended telemedical treatment scenario, the notifications comprising information related to outbreak of and measures for treating and mitigating spread of the disease.

Abstract: A gateway device comprises a processing device, network interface, and sensor device interconnect. The processing device is configured to pair sensor devices associated with a subject with the gateway device utilizing the sensor device interconnect, wherein pairing the sensor devices comprises identifying sensing capabilities of the sensor devices. The processing device is also configured to provide, to a study coordinating system over a first network connection established utilizing the network interface, a gateway identifier and information characterizing the identified sensing capabilities of the sensor devices paired with the gateway device.

Abstract: An apparatus comprises at least one processing device comprising a processor coupled to a memory. The at least one processing device is configured to obtain physiologic data from sensors associated with a wearable device of a subject, the sensors being attached to skin of the subject over vascular structures of the subject. The at least one processing device is also configured to determine differences between measured physiologic metrics in the obtained physiologic data and baseline physiologic metrics, and to detect anomalous physiologic events indicative of hypovolemic shock of the subject based at least in part on the determined differences between the measured physiologic metrics and the baseline physiologic metrics. The at least one processing device is further configured to generate notifications responsive to detecting the anomalous physiologic event indicative of hypovolemic shock of the subject, and to deliver the notifications in accordance with notification settings associated with the subject.

Abstract: An apparatus comprises at least one processing device comprising a processor coupled to a memory. The at least one processing device is configured to select physiologic data to be visualized, the selected physiologic data comprising a given set of one or more physiologic parameters collected from a given set of one or more subjects over a given period of time. The at least one processing device is also configured to determine a plot type for visualization of the selected physiologic data, the plot type being determined based at least in part on a repetitiveness of the selected physiologic data over a plurality of time segments in the given period of time. The at least one processing device is further configured to generate a visualization of the selected physiologic data utilizing the determined plot type, and to output the generated visualization of the selected physiologic data via an interactive graphical user interface.

Abstract: Methods and devices that prevent stasis in the LAA by either increasing the flow through the LAA or by closing off or sealing the LAA. Increasing the flow is accomplished through shunts, flow diverters, agitators, or by increasing the size of the ostium. Closing off the LAA is accomplished using seals or by cinching the LAA.

Abstract: A system for controlled neuromodulation procedures is disclosed. A system for controlled micro ablation procedures is disclosed. Systems and methods for imaging, monitoring, stimulating, and/or ablating neurological structures coupled to one or more organs of the lower urinary tract (LUT) are disclosed. Such processes may be used to alter the hormonal secretions from one or more organs, to modulate the growth of an organ, alter the growth rate or rate of perineural invasion of a tumor, or the like. In particular such processes may be used to slow, halt and/or reverse the growth of a prostate gland or a prostate tumor.

Abstract: A method that electrically stimulates a heart muscle to alter the ejection profile of the heart, to control the mechanical function of the heart and reduce the observed blood pressure of the patient. The therapy may be invoked by an implantable blood pressure sensor associated with a pacemaker like device. In some cases, where a measured pretreatment blood pressure exceeds a treatment threshold, a patient's heart may be stimulated with an electrical stimulus timed relative to the patient's cardiac ejection cycle. This is done to cause dyssynchrony between at least two cardiac chambers or within a cardiac chamber, which alters the patient's cardiac ejection profile from a pretreatment cardiac ejection profile. This has the effect of reducing the patient's blood pressure from the measured pretreatment blood pressure.

Abstract: Several embodiments and methods are described for draining a lymphatic system for therapeutic purposes. The lymphatic draining can be performed by removal of fluid from the lymphatic system via a needle, a catheter, an access port, a reservoir, a shunt, or a combination of these devices. The drainage devices can be configured for use during only a single procedure or for reoccurring procedures.

Abstract: Systems and methods for controlling blood pressure via electrical stimulation of the heart are disclosed. Embodiments may include at least two different stimulation patterns, each configured to reduce blood pressure to a different degree, and may alternate between stimulation patterns based on the need of a patient, for example, alternating between day and night or between periods of strenuous and light activity. Some embodiments may take advantage of a slow baroreflex response that occurs after treatment is stopped, suspending treatment for extended periods, and then resuming treatment before blood pressure levels reach pretreatment values. Embodiments may control blood pressure by controlling atrial pressure and atrial stretch.

Abstract: Methods and devices for reducing ventricle filling volume are disclosed. In some embodiments, an electrical stimulator may be used to stimulate a patient's heart to reduce ventricle filling volume or even blood pressure. When the heart is stimulated in a consistent way to reduce blood pressure, the cardiovascular system may over time adapt to the stimulation and revert back to the higher blood pressure. In some embodiments, the stimulation pattern may be configured to be inconsistent such that the adaptation response of the heart is reduced or even prevented. In some embodiments, an electrical stimulator may be used to stimulate a patient's heart to cause at least a portion of an atrial contraction to occur while the atrioventricular valve is closed. Such an atrial contraction may deposit less blood into the corresponding ventricle than when the atrioventricular valve is opened throughout an atrial contraction.

Abstract: Methods and devices that prevent stasis in the LAA by either increasing the flow through the LAA or by closing off or sealing the LAA. Increasing the flow is accomplished through shunts, flow diverters, agitators, or by increasing the size of the ostium. Closing off the LAA is accomplished using seals or by cinching the LAA.

Abstract: Systems and apparatus are included that are configured to determine the effectiveness of apparatus and methods used to diagnose and unblock microvascular obstruction (MVO). An infusion system blocks antegrade flow for a short time and measures vascular pressure response as an infusate is infused in stepwise fashion at increasingly higher flowrates. During the antegrade flow occlusion, calculations of the real-time vascular resistance can be obtained using the formula R(t)=P(t)/Qmean(t) where: Qmean(t) is the flow mean values generated by the infusion system; P(t) is the distal pressure response in the vessel generated from the flow infusion; and R(t) is the calculated vascular resistance using the two other known parameters.

Abstract: A system for controlled neuromodulation procedures is disclosed. A system for controlled micro ablation procedures is disclosed. Systems and methods for imaging, monitoring, stimulating, and/or ablating neurological structures coupled to one or more organs of the lower urinary tract (LUT) are disclosed. Such processes may be used to alter the hormonal secretions from one or more organs, to modulate the growth of an organ, alter the growth rate or rate of perineural invasion of a tumor, or the like. In particular such processes may be used to slow, halt and/or reverse the growth of a prostate gland or a prostate tumor.

Abstract: Methods and devices that prevent stasis in the LAA by either increasing the flow through the LAA or by closing off or sealing the LAA. Increasing the flow is accomplished through shunts, flow diverters, agitators, or by increasing the size of the ostium. Closing off the LAA is accomplished using seals or by cinching the LAA.

Abstract: A method includes receiving monitoring data from at least one sensing device coupled to a subject and analyzing the monitoring data to identify one or more physiologic parameters of the subject. The method also includes providing signaling to at least one stimulating device in response to the identified physiologic parameters, the signaling comprising instructions to apply a stimulus to the subject. The method further includes receiving additional monitoring data from the at least one sensing device, analyzing the additional monitoring data to identify one or more changes in the one or more physiologic parameters of the subject after application of the stimulus to the subject, and providing additional signaling to the at least one stimulating device, the additional signaling comprising instructions to modify the stimulus applied to the subject based on the identified changes in the one or more physiologic parameters.