Patents by Inventor Robert S. Ward

Robert S. Ward has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200056221
    Abstract: The present invention provides an in vitro method for concentrating infectious pathogens found in a biological sample obtained from an individual who is suspected of being infected with the pathogens. Provided herein is also an in vitro method for reducing or eliminating blood cells from a sample obtained from an individual suspected to being infected with an infectious pathogen. The present invention also provides a method for diagnosing malaria and a method for determining if an individual is infected with a pathogen. Provided herein is also a concentrator and a kit for use with the methods.
    Type: Application
    Filed: October 25, 2019
    Publication date: February 20, 2020
    Inventors: Robert S. WARD, Keith R. McCREA
  • Patent number: 10537280
    Abstract: The present invention is directed to an integrated system and a method for utilizing the system to detect and remove blood-borne factors of interest, such as pathogens and/or toxins and/or cytokines, from blood or serum (blood) by contacting the blood with a solid, essentially nonporous substrate which has been surface treated with molecules or chemical groups (the adsorbent media or media) having a binding affinity for the pathogens and/or toxins to be removed (the adsorbents). The invention can be used to remove virulence factors, e.g. toxins, that are released from various pathogens. In one aspect, the invention is for the treatment of sepsis and infection, such as infections associated with battle field trauma.
    Type: Grant
    Filed: August 13, 2013
    Date of Patent: January 21, 2020
    Assignee: ExThera Medical Corporation
    Inventors: Keith McCrea, Robert S. Ward, George Pitarra, Jr.
  • Patent number: 10487350
    Abstract: The present invention provides an in vitro method for concentrating infectious pathogens found in a biological sample obtained from an individual who is suspected of being infected with the pathogens. Provided herein is also an in vitro method for reducing or eliminating blood cells from a sample obtained from an individual suspected to being infected with an infectious pathogen. The present invention also provides a method for diagnosing malaria and a method for determining if an individual is infected with a pathogen. Provided herein is also a concentrator and a kit for use with the methods.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: November 26, 2019
    Assignee: ExThera Medical Corporation
    Inventors: Robert S. Ward, Keith R. McCrea
  • Patent number: 10457974
    Abstract: The present invention provides an in vitro method for concentrating infectious pathogens found in a biological sample obtained from an individual who is suspected of being infected with the pathogens. Provided herein is also an in vitro method for reducing or eliminating blood cells from a sample obtained from an individual suspected to being infected with an infectious pathogen. The present invention also provides a method for diagnosing malaria and a method for determining if an individual is infected with a pathogen. Provided herein is also a concentrator and a kit for use with the methods.
    Type: Grant
    Filed: November 2, 2016
    Date of Patent: October 29, 2019
    Assignee: ExThera Medical Corporation
    Inventors: Robert S. Ward, Keith R. McCrea
  • Publication number: 20180361050
    Abstract: The present invention is directed to a method for removing cytokines and/or pathogens from blood or blood serum (blood) by contacting the blood with a solid, essentially non micro-porous substrate which has been surface treated with heparin, heparan sulfate and/or other molecules or chemical groups (the adsorbent media or media) having a binding affinity for the cytokine or pathogen(s) to be removed (the adsorbates), and wherein the size of the interstitial channels within said media is balanced with the amount of media surface area and the surface concentration of binding sites on the media in order to provide adequate adsorptive capacity while also allowing relatively high flow rates of blood through the adsorbent media.
    Type: Application
    Filed: August 27, 2018
    Publication date: December 20, 2018
    Applicant: EXTHERA MEDICAL CORPORATION
    Inventors: ROBERT S. WARD, Keith R. McCREA, Olle LARM, Lars ADOLFSSON
  • Patent number: 10086126
    Abstract: The present invention is directed to a method for removing cytokines and/or pathogens from blood or blood serum (blood) by contacting the blood with a solid, essentially non microporous substrate which has been surface treated with heparin, heparan sulfate and/or other molecules or chemical groups (the adsorbent media or media) having a binding affinity for the cytokine or pathogen(s) to be removed (the adsorbates), and wherein the size of the interstitial channels within said media is balanced with the amount of media surface area and the surface concentration of binding sites on the media in order to provide adequate adsorptive capacity while also allowing relatively high flow rates of blood through the adsorbent media.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: October 2, 2018
    Assignee: ExThera Medical Corporation
    Inventors: Robert S Ward, Keith R McCrea, Olle Larm, Lars Adolfsson
  • Publication number: 20180015120
    Abstract: Polymers having the formula R(LE)x wherein R is a polymeric core having a number average molecular weight of from 5000 to 7,000,000 daltons and having x endgroups, E is an endgroup covalently linked to polymeric core R by linkage L, L is a divalent oligomeric chain, having at least 5 identical repeat units, capable of self-assembly with L chains on adjacent molecules of the polymer, and the moieties (LE)x in the polymer may be the same as or different from one another. Design of monomers, oligomers, or other reactive structures otherwise analogous to known Self Assembled Monolayers but with at least one reactive chemical group capable of binding them to the terminus of a polymer, so that the thiol-free SAM analogue becomes the self-assembling surface modifying endgroup of that polymer. Use of the polymer to fabricate a configured article from the surface-modified polymer or a coating or topical treatment on an article made from another material.
    Type: Application
    Filed: August 10, 2017
    Publication date: January 18, 2018
    Inventors: Robert S. WARD, Keith R. McCREA, James Parakka, Shanger Wang, Yuan Tian
  • Publication number: 20170252502
    Abstract: Methods and devices are disclosed for the treatment of a subject suffering from drug intoxication by cleansing a contaminated sample from the subject with adsorption media. The adsorption media composition is selected for its antithrombogenic properties and for its ability to adhere to one or more drug targets to be reduced or eliminated. The media can further be held in a cartridge for use in extracorporeal treatments such as those of hemoperfusion. Contacting the contaminated sample from the subject with the absorption medium allows for the separation of a portion of the drug target from the sample, producing a cleansed sample that can be infused into the subject.
    Type: Application
    Filed: March 1, 2017
    Publication date: September 7, 2017
    Inventors: ROBERT S. WARD, KEITH R. McCREA
  • Patent number: 9669150
    Abstract: The present invention relates to a device for extracorporeal removal of harmful agents from blood or blood com-Components, comprising full length heparin immobilized on a solid substrate by covalent end point attachment. The present invention also relates to a method for extracorporeal removal of a harmful agent from mammalian blood or blood components. The present invention further relates to a process for covalent end point attachment of full length heparin to a solid substrate.
    Type: Grant
    Filed: January 15, 2014
    Date of Patent: June 6, 2017
    Assignee: EXTHERA MEDICAL CORPORATION
    Inventors: Olle Larm, Tomas Bergstrom, Jonas Axelsson, Lars Adolfsson, Robert S. Ward, Keith McCrae
  • Patent number: 9603932
    Abstract: Intravaginal drug delivery device comprising at least one pharmaceutically active substance, and a polyurethane copolymer, wherein the copolymer has the structure according to formula (I): Also, method comprising administering one or more pharmaceutically active substances to a patient in need thereof.
    Type: Grant
    Filed: January 12, 2016
    Date of Patent: March 28, 2017
    Assignee: DSM IP ASSETS, B.V.
    Inventors: Robert S. Ward, Shanger Wang, Li Li, Durgaprasad Chalasani, Patrick Kiser, Meredith Roberts Clark
  • Publication number: 20170073727
    Abstract: The present invention provides an in vitro method for concentrating infectious pathogens found in a biological sample obtained from an individual who is suspected of being infected with the pathogens. Provided herein is also an in vitro method for reducing or eliminating blood cells from a sample obtained from an individual suspected to being infected with an infectious pathogen. The present invention also provides a method for diagnosing malaria and a method for determining if an individual is infected with a pathogen. Provided herein is also a concentrator and a kit for use with the methods.
    Type: Application
    Filed: November 2, 2016
    Publication date: March 16, 2017
    Inventors: Robert S. WARD, Keith R. McCREA
  • Publication number: 20160331886
    Abstract: The present invention is directed to a method for removing cytokines and/or pathogens from blood or blood serum (blood) by contacting the blood with a solid, essentially non micro-porous substrate which has been surface treated with heparin, heparan sulfate and/or other molecules or chemical groups (the adsorbent media or media) having a binding affinity for the cytokine or pathogen(s) to be removed (the adsorbates), and wherein the size of the interstitial channels within said media is balanced with the amount of media surface area and the surface concentration of binding sites on the media in order to provide adequate adsorptive capacity while also allowing relatively high flow rates of blood through the adsorbent media.
    Type: Application
    Filed: June 30, 2016
    Publication date: November 17, 2016
    Applicant: EXTHERA MEDICAL CORPORATION
    Inventors: ROBERT S. WARD, Keith R. McCrea, Olle Larm, Lars Adolfsson
  • Patent number: 9408962
    Abstract: The present invention is directed to a method for removing cytokines and/or pathogens from blood or blood serum (blood) by contacting the blood with a solid, essentially non microporous substrate which has been surface treated with heparin, heparan sulfate and/or other molecules or chemical groups (the adsorbent media or media) having a binding affinity for the cytokine or pathogen(s) to be removed (the adsorbates), and wherein the size of the interstitial channels within said media is balanced with the amount of media surface area and the surface concentration of binding sites on the media in order to provide adequate adsorptive capacity while also allowing relatively high flow rates of blood through the adsorbent media.
    Type: Grant
    Filed: April 24, 2014
    Date of Patent: August 9, 2016
    Assignee: EXTHERA MEDICAL CORPORATION
    Inventors: Robert S. Ward, Keith R. McCrea, Olle Larm, Lars Adolfsson
  • Patent number: 9393311
    Abstract: The invention is directed to an intravaginal drug delivery device comprising at least one pharmaceutically active substance, and a polyurethane copolymer, wherein the copolymer has the structure according to formula (I): The invention is further directed to administering one or more pharmaceutically active substances to a patient in need thereof.
    Type: Grant
    Filed: November 15, 2011
    Date of Patent: July 19, 2016
    Assignees: DSM IP ASSETS B.V., DSM BIOMEDICAL INC.
    Inventors: Robert S. Ward, Shanger Wang, Li Li, Durgaprasad Chalasani, Patrick Kiser, Meredith Roberts Clark
  • Publication number: 20160120800
    Abstract: Intravaginal drug delivery device comprising at least one pharmaceutically active substance, and a polyurethane copolymer, wherein the copolymer has the structure according to formula (I): Also, method comprising administering one or more pharmaceutically active substances to a patient in need thereof.
    Type: Application
    Filed: January 12, 2016
    Publication date: May 5, 2016
    Applicant: DSM IP ASSETS B.V.
    Inventors: Robert S. WARD, Shanger WANG, Li Li, Durgaprasad CHALASANI, Patrick KISER, Meredith Roberts CLARK
  • Publication number: 20160082177
    Abstract: The present technology relates to methods and devices for the removal of toxins and pathogens from infected blood of patients. In particular, devices are designed to be portable, wearable, disposable and self-contained extracorporeal devices that can be easily assembled from a kit.
    Type: Application
    Filed: September 21, 2015
    Publication date: March 24, 2016
    Applicant: EXTHERA MEDICAL CORPORATION
    Inventors: ROBERT S. WARD, KEITH R. McCREA
  • Publication number: 20160084835
    Abstract: The present invention provides an in vitro method for concentrating infectious pathogens found in a biological sample obtained from an individual who is suspected of being infected with the pathogens. Provided herein is also an in vitro method for reducing or eliminating blood cells from a sample obtained from an individual suspected to being infected with an infectious pathogen. The present invention also provides a method for diagnosing malaria and a method for determining if an individual is infected with a pathogen. Provided herein is also a concentrator and a kit for use with the methods.
    Type: Application
    Filed: October 16, 2015
    Publication date: March 24, 2016
    Applicant: EXTHERA MEDICAL CORPORATION
    Inventors: ROBERT S. WARD, Keith R. McCrea
  • Patent number: 9255176
    Abstract: Polymer surface modification method comprising the steps of first forming a surface of primary reactive end groups tethered to the polymer chain ends during fabrication of an article, and then modifying the reactive surface with bio-active molecules, hydrophilic and hydrophobic monomers, oligomers, or polymers to attain specific surface properties. Alternatively, a multifunctional coupling agent can be used to couple the primary reactive group to a second reactive group capable of reacting with a functional group associated with bio-active molecules, hydrophilic and hydrophobic monomers, oligomers, and polymers to attain specific surface properties. The invention involves bringing reactive endgroups to the surface with surface active spacer attached to the polymer chain end. The surface active spacer allows the migration and enrichment of reactive end groups to the surface during fabrication.
    Type: Grant
    Filed: August 8, 2014
    Date of Patent: February 9, 2016
    Assignee: DSM IP ASSETS B.V.
    Inventors: Shanger Wang, Robert S. Ward, Yuan Tian, Xuwei Jiang, Keith McCrea, Scott Curtin
  • Publication number: 20140350184
    Abstract: Polymer surface modification method comprising the steps of first forming a surface of primary reactive end groups tethered to the polymer chain ends during fabrication of an article, and then modifying the reactive surface with bio-active molecules, hydrophilic and hydrophobic monomers, oligomers, or polymers to attain specific surface properties. Alternatively, a multifunctional coupling agent can be used to couple the primary reactive group to a second reactive group capable of reacting with a functional group associated with bio-active molecules, hydrophilic and hydrophobic monomers, oligomers, and polymers to attain specific surface properties. The invention involves bringing reactive endgroups to the surface with surface active spacer attached to the polymer chain end. The surface active spacer allows the migration and enrichment of reactive end groups to the surface during fabrication.
    Type: Application
    Filed: August 8, 2014
    Publication date: November 27, 2014
    Inventors: Shanger WANG, Robert S. WARD, Yuan TIAN, Xuwei JIANG, Keith MCCREA, Scott CURTIN
  • Publication number: 20140231357
    Abstract: The present invention is directed to a method for removing cytokines and/or pathogens from blood or blood serum (blood) by contacting the blood with a solid, essentially non microporous substrate which has been surface treated with heparin, heparan sulfate and/or other molecules or chemical groups (the adsorbent media or media) having a binding affinity for the cytokine or pathogen(s) to be removed (the adsorbates), and wherein the size of the interstitial channels within said media is balanced with the amount of media surface area and the surface concentration of binding sites on the media in order to provide adequate adsorptive capacity while also allowing relatively high flow rates of blood through the adsorbent media.
    Type: Application
    Filed: April 24, 2014
    Publication date: August 21, 2014
    Applicant: EXTHERA MEDICAL CORPORATION
    Inventors: Robert S Ward, Keith R. McCrea, Olle Larm, Lars Adolfsson