Patents by Inventor Robert S. Ward

Robert S. Ward has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8758286
    Abstract: The present invention is directed to a method for removing cytokines and/or pathogens from blood or blood serum (blood) by contacting the blood with a solid, essentially non micro-porous substrate which has been surface treated with heparin, heparan sulfate and/or other molecules or chemical groups (the adsorbent media or media) having a binding affinity for the cytokine or pathogen(s) to be removed (the adsorbates), and wherein the size of the interstitial channels within said media is balanced with the amount of media surface area and the surface concentration of binding sites on the media in order to provide adequate adsorptive capacity while also allowing relatively high flow rates of blood through the adsorbent media.
    Type: Grant
    Filed: December 1, 2010
    Date of Patent: June 24, 2014
    Assignee: Exthera Medical Corporation
    Inventors: Robert S Ward, Keith R. McCrea, Olle Larm, Lars Adolfsson
  • Publication number: 20140131276
    Abstract: The present invention relates to a device for extracorporeal removal of harmful agents from blood or blood com-Components, comprising full length heparin immobilized on a solid substrate by covalent end point attachment. The present invention also relates to a method for extracorporeal removal of a harmful agent from mammalian blood or blood components. The present invention further relates to a process for covalent end point attachment of full length heparin to a solid substrate.
    Type: Application
    Filed: January 15, 2014
    Publication date: May 15, 2014
    Inventors: Olle LARM, Tomas Bergström, Jonas AXELSSON, Lars ADOLFSSON, Robert S. WARD, Keith MCCREA
  • Patent number: 8663148
    Abstract: The present invention relates to a device for extracorporeal removal of harmful agents from blood or blood components, comprising full length heparin immobilized on a solid substrate by covalent end point attachment. The present invention also relates to a method for extracorporeal removal of a harmful agent from mammalian blood or blood components. The present invention further relates to a process for covalent end point attachment of full length heparin to a solid substrate.
    Type: Grant
    Filed: June 18, 2008
    Date of Patent: March 4, 2014
    Assignee: Exthera Medical Corporation
    Inventors: Olle Larm, Tomas Bergström, Jonas Axelsson, Lars Adolfsson, Robert S. Ward, Keith McCrea
  • Publication number: 20140045792
    Abstract: The invention is directed to an intravaginal drug delivery device comprising at least one pharmaceutically active substance, and a polyurethane copolymer, wherein the copolymer has the structure according to formula (I): The invention is further directed to administering one or more pharmaceutically active substances to a patient in need thereof.
    Type: Application
    Filed: November 15, 2011
    Publication date: February 13, 2014
    Applicant: DSM IP ASSETS B.V.
    Inventors: Robert S. Ward, Shanger Wang, Li Li, Durgaprasad Chalasani, Patrick Kiser, Meredith Roberts Clark
  • Publication number: 20140012097
    Abstract: The present invention is directed to an integrated system and a method for utilizing the system to detect and remove blood-borne factors of interest, such as pathogens and/or toxins and/or cytokines, from blood or serum (blood) by contacting the blood with a solid, essentially nonporous substrate which has been surface treated with molecules or chemical groups (the adsorbent media or media) having a binding affinity for the pathogens and/or toxins to be removed (the adsorbents). The invention can be used to remove virulence factors, e.g. toxins, that are released from various pathogens. In one aspect, the invention is for the treatment of sepsis and infection, such as infections associated with battle field trauma.
    Type: Application
    Filed: August 13, 2013
    Publication date: January 9, 2014
    Inventors: Keith McCrea, Robert S. Ward, George Pitarra, JR.
  • Patent number: 8344090
    Abstract: Methods for preparing functionalized polyvinylpyrrolidones with polymerizable functions. Also, amphipathic polydimethylsiloxane-PVP block copolymers, such as and (meth)acrylated and (meth)acrylamide-functionalized polyvinylpyrrolidone compounds, such as The block copolymers are useful as biomaterial components in biomedical devices. They provide improved wettability, lubricity, and material compatibility to the biomedical device, e.g., ophthalmic lenses.
    Type: Grant
    Filed: December 14, 2011
    Date of Patent: January 1, 2013
    Assignee: DSM IP Assets B.V.
    Inventors: James Parakka, Keith R. McCrea, Robert S. Ward
  • Publication number: 20120305482
    Abstract: A method to remove virulence factors from infected blood by passing the blood through a surface cartridge with immobilized carbohydrates, such as heparin, wherein the virulence factors are toxins released from pathogens such as B. anthracis, S. aureus, and P. aeruginosa.
    Type: Application
    Filed: February 9, 2011
    Publication date: December 6, 2012
    Applicant: EXTHERA MEDICAL, LLC
    Inventors: Keith McCrea, Robert S. Ward
  • Publication number: 20120095166
    Abstract: Polymers having the formula R(LE)X wherein R is a polymeric core having a number average molecular weight of from 5000 to 7,000,000 daltons and x endgroups, E is an endgroup that is covalently linked to polymeric core R by linkage L, L is a divalent oligomeric chain having at least 5 identical repeat units that is capable of self-assembly with L chains on adjacent molecules of the polymer, and the moieties (LE)X in the polymer may be the same as or different from one another. Monomers, oligomers, or other reactive structures otherwise analogous to known Self Assembled Monolayers but with at least one reactive chemical group capable of binding them to the terminus of a polymer, so that the thiol-free SAM analogue becomes the self-assembling surface modifying endgroup of that polymer, may be designed. Use of the polymer to fabricate a configured article from the surface-modified polymer or to fabricate a coating or topical treatment on an article made from another material.
    Type: Application
    Filed: October 14, 2011
    Publication date: April 19, 2012
    Inventors: Robert S. WARD, Keith R. McCREA, Yuan TIAN, James P. PARAKKA, Shanger WANG
  • Patent number: 8153728
    Abstract: Methods for preparing functionalized polyvinylpyrrolidones with polymerizable functions. Also, amphipathic polydimethylsiloxane-PVP block copolymers, such as and (meth)acrylated and (meth)acrylamide-functionalized polyvinylpyrrolidone compounds, such as The block copolymers are useful as biomaterial components in biomedical devices. They provide improved wettability, lubricity, and material compatibility to the biomedical device, e.g., ophthalmic lenses.
    Type: Grant
    Filed: March 13, 2008
    Date of Patent: April 10, 2012
    Assignee: DSM IP Assets B.V.
    Inventors: James Parakka, Keith R. McCrea, Robert S. Ward
  • Publication number: 20120083573
    Abstract: Methods for preparing functionalized polyvinylpyrrolidones with polymerizable functions. Also, amphipathic polydimethylsiloxane-PVP block copolymers, such as and (meth)acrylated and (meth)acrylamide-functionalized polyvinylpyrrolidone compounds, such as The block copolymers are useful as biomaterial components in biomedical devices. They provide improved wettability, lubricity, and material compatibility to the biomedical device, e.g., ophthalmic lenses.
    Type: Application
    Filed: December 14, 2011
    Publication date: April 5, 2012
    Inventors: James PARAKKA, Keith R. McCrea, Robert S. Ward
  • Publication number: 20110293522
    Abstract: Polymer surface modification method comprising the steps of first forming a surface of primary reactive end groups tethered to the polymer chain ends during fabrication of an article, and then modifying the reactive surface with bio-active molecules, hydrophilic and hydrophobic monomers, oligomers, or polymers to attain specific surface properties. Alternatively, a multifunctional coupling agent can be used to couple the primary reactive group to a second reactive group capable of reacting with a functional group associated with bio-active molecules, hydrophilic and hydrophobic monomers, oligomers, and polymers to attain specific surface properties. The invention involves bringing reactive endgroups to the surface with surface active spacer attached to the polymer chain end. The surface active spacer allows the migration and enrichment of reactive end groups to the surface during fabrication.
    Type: Application
    Filed: November 16, 2009
    Publication date: December 1, 2011
    Applicant: DSM IP ASSETS B.V.
    Inventors: Shanger Wang, Robert S. Ward, Yuan Tian, Xuwei Jiang, Keith Mccrea, Scott Curtin
  • Publication number: 20110207897
    Abstract: Block copolymer having improved compression set comprising 40-98 wt-% soft segment, 1.9-20 wt-% hard segment, and 0.05-3 wt-% monofunctional ionic endgroups. The incorporation of ionomers into diisocyanate-based thermoplastic polyurethane materials greatly improves compression set with little impact on the overall TPU formulation. A typical formulation for making the block copolymer contains 84.2% polydimethylsiloxane, 12.9% diisocyanate, 2.9% diamine chain extender, 0.15% sodium 2-[bis(2-hydroxyethyl)amino]ethylsulfonate, and 0.05% isethionic acid. The polymeric material may be configured, for instance, as a contact lens, prosthetic spinal nucleus, orthopedic bearing surface, gasket, or sealant.
    Type: Application
    Filed: December 17, 2008
    Publication date: August 25, 2011
    Applicant: DSM IP ASSETS B.V.
    Inventors: Keith R. Mccrba, Robert S. Ward, Yuan Tian, Jim Yang, Keith Kurczewski
  • Publication number: 20110184377
    Abstract: The present invention is directed to a method for removing cytokines and/or pathogens from blood or blood serum (blood) by contacting the blood with a solid, essentially non micro-porous substrate which has been surface treated with heparin, heparan sulfate and/or other molecules or chemical groups (the adsorbent media or media) having a binding affinity for the cytokine or pathogen(s) to be removed (the adsorbates), and wherein the size of the interstitial channels within said media is balanced with the amount of media surface area and the surface concentration of binding sites on the media in order to provide adequate adsorptive capacity while also allowing relatively high flow rates of blood through the adsorbent media.
    Type: Application
    Filed: December 1, 2010
    Publication date: July 28, 2011
    Applicant: EXTHERA MEDICAL, LLC
    Inventors: Robert S. WARD, Keith R. MCCREA, Olle Larm, Lars Adolfsson
  • Publication number: 20110124772
    Abstract: Polymers with non-leaching antimicrobial activity and their use as surface coatings or bulk resins for medical devices. The antimicrobial polymers are prepared with antimicrobial moieties covalently bonded to a polymer chain end or to a polymer backbone at a side chain end. The antimicrobial moiety-containing endgroups include surface active (or surface assembling) moieties which promote enrichment of antimicrobial endgroups at the polymer surface and thus formation of an antimicrobially active surface. Polymers with built-in antimicrobial endgroups can be used as bulk resins, as antimicrobial additives, or as infection preventative coatings in the manufacture of medical devices (e.g., catheters, vascular access devices, peripheral lines, IV sites, drains, gastric feeding and tubes, and other implantable devices).
    Type: Application
    Filed: May 26, 2009
    Publication date: May 26, 2011
    Applicant: DSM IP Assets B.V.
    Inventors: Shanger Wang, Robert S. Ward, Yuan Tian, Li Li, Keith Mccrea, James Parakka, Robert L. Jones, JR.
  • Publication number: 20110086077
    Abstract: A silicone hydrogel formulation may contains random and/or block copolymers or oligomers or macromers. The silicone copolymer is copolymerized or blended with other polymers or monomers or macromers to obtain final formulation. The silicone hydrogel may contain crosslinking groups to provide a complete or partially crosslinked final structure. The silicone hydrogel formulation may be pre-formed as a film or other structure, or it may be polymerized during application as in the case of an adhesive formulation. A wound dressing comprising a silicone hydrogel formed as a film, either prior to application to a wound or in situ on a wound, which film has gas permeability, moisture permeability, and high water content, wherein said silicone hydrogel is formed from a polymerizable silicone such as a difunctional polydimethylsiloxane methacrylate and crosslinking agents such as N,N-dimethyllacrylamide (DMA), 2-hydroxyethyl methacrylate (HEMA), and trimethylsiloxy silane (TRIS).
    Type: Application
    Filed: November 21, 2008
    Publication date: April 14, 2011
    Applicant: The Polymer Technology Group, Inc.
    Inventors: Keith R. McCrea, Robert S. Ward, Yuan Tian
  • Patent number: 7884171
    Abstract: Polymers whose surfaces are modified by endgroups that include amphipathic surface-modifying moieties. An amphipathic endgroup of a polymer molecule is an endgroup that contains at least two moieties of significantly differing composition, such that the amphipathic endgroup spontaneously rearranges its positioning in a polymer body to position the moiety on the surface of the body, depending upon the composition of the medium with which the body is in contact, when that re-positioning causes a reduction in interfacial energy. An example of an amphipathic surface-modifying endgroup is one that has both a hydrophobic moiety and a hydrophilic moiety in a single endgroup. For instance, a hydrophilic poly(ethylene oxide) terminated with a hydrophilic hydroxyl group is not surface active in air when the surface-modifying endgroup is bonded to a more hydrophobic base polymer.
    Type: Grant
    Filed: December 15, 2009
    Date of Patent: February 8, 2011
    Assignee: DSM IP Assets B.V.
    Inventors: Robert S. Ward, Keith R. McCrea, Yuan Tian, James P. Parakka
  • Publication number: 20110028661
    Abstract: Block copolymers are formulated with multifunctional chain extenders. The block copolymers include a soft segment and a hard segment made from a diisocyanate, an alkylene diamine chain extender, and a multifunctional chain extender which provides delayed crosslinking. The multifunctional chain extenders have a functionality and typically have at least one OH group. The multifunctional chain extenders may be aliphatic or aromatic triols or polyols, or may have other configurations, as described. The resulting block copolymers have improved mechanical properties such as compression set. They may be used in medical applications, or in industrial applications such as seal and gasket applications, including O-rings, window seals, and automotive gaskets. The initially-formed polyurethane resin behaves as a thermoplastic processable material, while the configured end-use product is thermoset.
    Type: Application
    Filed: December 18, 2008
    Publication date: February 3, 2011
    Inventors: Robert S. Ward, Keith R. McCrea, Yuan Tian, Jim Yang
  • Publication number: 20100249689
    Abstract: The present invention relates to a device for extracorporeal removal of harmful agents from blood or blood components, comprising full length heparin immobilized on a solid substrate by covalent end point attachment. The present invention also relates to a method for extracorporeal removal of a harmful agent from mammalian blood or blood components. The present invention further relates to a process for covalent end point attachment of full length heparin to a solid substrate.
    Type: Application
    Filed: June 18, 2008
    Publication date: September 30, 2010
    Applicant: EXTHERA MEDICAL LLC
    Inventors: Olle Larm, Tomas Bergström, Jones Axelsson, Lars Adolfsson, Robert S. Ward, Keith Mccrea
  • Publication number: 20100179284
    Abstract: Medical device, prosthesis, or packaging assembly made up of polymer body comprising at least one polymer having the formula R(LE)x wherein R is a polymeric core having a number average molecular weight of from 5000 to 7,000,000 daltons, and having x endgroups, x is an integer?1, E is an endgroup which is covalently linked to polymeric core R by linkage L, L is a divalent oligomeric chain which has at least 5 repeat units and which can self-assembly with L chains on adjacent molecules of the polymer, and moieties L and/or E in the polymer(s) may be the same as or different from one another in composition and/or molecular weight. The polymer body includes plural polymer molecules located internally within the body, at least some of which internal polymer molecules have endgroups that form a surface of the body. The surface endgroups include at least one self-assembling moiety.
    Type: Application
    Filed: May 28, 2008
    Publication date: July 15, 2010
    Applicant: DSM IP ASSETS B.V.
    Inventors: Robert S. Ward, Keith McCrea, Yuan Tian, Shanger Wang, Larry Jones, Anfeng Wang, James P. Parakka
  • Publication number: 20100113711
    Abstract: Polymers whose surfaces are modified by endgroups that include amphipathic surface-modifying moieties. An amphipathic endgroup of a polymer molecule is an endgroup that contains at least two moieties of significantly differing composition, such that the amphipathic endgroup spontaneously rearranges its positioning in a polymer body to position the moiety on the surface of the body, depending upon the composition of the medium with which the body is in contact, when that re-positioning causes a reduction in interfacial energy. An example of an amphipathic surface-modifying endgroup is one that has both a hydrophobic moiety and a hydrophilic moiety in a single endgroup. For instance, a hydrophilic poly(ethylene oxide) terminated with a hydrophilic hydroxyl group is not surface active in air when the surface-modifying endgroup is bonded to a more hydrophobic base polymer.
    Type: Application
    Filed: December 15, 2009
    Publication date: May 6, 2010
    Inventors: Robert S. Ward, Keith R. McCrea, Yuan Tian, James P. Parakka