Abstract: The present invention relates to a pharmaceutical combination comprising a KRAS G12C inhibitor and one or more therapeutic agents which is selected from an agent targeting the MARK pathway or an agent targeting parallel pathways; and pharmaceutical compositions comprising the same. The invention also relates to KRAS G12C inhibitors alone or said combinations for use in methods of treating a cancer or a tumor, in particular wherein the cancer or tumor is KRAS G12C mutant.

Abstract: Purifying target biomolecules, such as nucleic acids or proteins, from a biological source is a time intensive process and is typically performed by a skilled technician or scientist owing to the highly technical nature of the work. Systems, devices, and methods disclosed herein enable the automated bioprocessing and purification of target biomolecules from a biological source. For example, an instrument and disposable cartridge are provided for automatedly isolating and purifying nucleic acids (such as plasmid DNA from a bacterial culture) or for isolating protein from any biological sample. Such an exemplary instrument and cartridge can work in concert to timely release, mix, and move the target biomolecule and various reagents and buffers through a target biomolecule purification process, resulting in a purified target biomolecule with less manual oversight than traditional approaches.

Abstract: A circuit arrangement includes a preprocessing circuit configured to obtain context information related to a user location, a learning circuit configured to determine a predicted user movement based on context information related to a user location to obtain a predicted route and to determine predicted radio conditions along the predicted route, and a decision circuit configured to, based on the predicted radio conditions, identify one or more first areas expected to have a first type of radio conditions and one or more second areas expected to have a second type of radio conditions different from the first type of radio conditions and to control radio activity while traveling on the predicted route according to the one or more first areas and the one or more second areas.

Abstract: A rotary impact tool including a motor housing, an electric motor supported in the motor housing, and a drive assembly for converting a continuous torque input from the motor to consecutive rotational impacts upon a workpiece. The drive assembly includes an anvil including an anvil lug, and a hammer that is both rotationally and axially movable relative to the anvil. The hammer includes a hammer lug for imparting the consecutive rotational impacts upon the anvil lug. The rotary impact tool further includes a first printed circuit board assembly including an anvil sensor, a first carrier supporting the first printed circuit board assembly, a second printed circuit board assembly including a hammer sensor, and a second carrier supporting the second printed circuit board assembly.

Abstract: An anvil for an impact tool including an impact receiving portion at an end of the anvil, the impact receiving portion including a lug having an impact receiving surface that receives impact from a hammer of the rotary power tool, a shank portion extending from the impact receiving portion, a drive portion located at an end of the shank portion opposite from the impact receiving portion, the drive portion including a plurality of drive surfaces configured to engage a tool bit, and a hardened layer formed on at least one of the drive portion or the impact receiving surface, the hardened layer having a higher hardness than a remaining portion of the anvil. The hardened layer is formed by a heating process.

Abstract: An apparatus and method for delivering fluid from a syringe to a subject using a pumping device of a flow control apparatus. The method includes locating the flow control apparatus on a horizontal support surface. Providing the syringe with a volume of fluid including a total amount of preferred nutrient and an amount of non-preferred nutrient liquid. Mounting the syringe relative to the flow control apparatus whereby the syringe is oriented in a generally vertical orientation such that an outlet of the syringe faces upward. Initiating operation of the pumping device to draw the fluid from the syringe for a duration of time to preferentially deliver at least a portion of the total amount of preferred nutrient in the fluid to the subject.

Abstract: Systems, devices, and methods for determining anosmia and/or ageusia in a subject. are provided. Devices may include a housing, a composition stored within the housing, and an applicator. The composition may include one or more active ingredients and one or more inactive ingredients, the one or more active ingredients including a flavoring agent that may include salt, sour, sweet, or bitter taste and odor properties. The composition may be configured to remain stable. The housing may include a back pressure mechanism. The applicator may be configured to remove a predetermined amount of the composition from the housing and deliver the predetermined amount of the composition to one or more of a nose and a mouth of the subject.

Abstract: A computer-implemented method includes receiving a first set of inductance data and a second set of inductance data, each representing one or more inductance measurements when a distorter is absent and when the distorter is present, respectively. The method includes training a machine learning system for compensating for distortion, in which the machine learning system is configured to generate an estimated value of distortion indicating an amount of distortion present in the electromagnetic field. The method includes receiving a set of inductance data and generating, by the trained machine learning system, the estimated value of distortion using the additional set of inductance data and measured pose data that represents position and orientation information for one or more sensors. The method includes providing the estimated value of the distortion for application to a computing device for calibrating the one or more sensors by compensating for the estimated value of the distortion.

Abstract: A system and method that enables the ongoing communication, tracking, and management review of feedback among a population of workers and their management.

Abstract: A composition of psilocin that is stable including at least one agent or chemical modification that provides enhanced stability. A method making stable psilocin, by providing a formulation of psilocin including at least one agent or chemical modification that provides enhanced stability. A method of treatment of a disease or condition, by administering a composition of psilocin that is stable to an individual and treating the disease or condition.

Abstract: A method of on-demand energy delivery to an active suspension system comprising an actuator body, hydraulic pump, electric motor, plurality of sensors, energy storage facility, and controller is provided. The method comprises disposing an active suspension system in a vehicle between a wheel mount and a vehicle body, detecting a wheel event requiring control of the active suspension; and sourcing energy from the energy storage facility and delivering it to the electric motor in response to the wheel event.

Abstract: An apparatus for monitoring a living target has a lock, a tamper-evidencing mechanism, and a mechanism for monitoring a GPS location of the apparatus. The apparatus has a mechanism for determining the apparatus is within at least one of a first threshold distance from a second apparatus or a first threshold distance from a pre-set GPS location, and a mechanism for warning the living target. The apparatus has a mechanism for determining the apparatus is in a banned location. The apparatus has a mechanism for emitting a debilitating sound and a mechanism for visually marking the living target. The apparatus has a communication mechanism for communicating a GPS location of the living target to at least the second apparatus and a third apparatus responsive to the determining the apparatus is in the banned location.

Abstract: A method for use in generating a computer-based visualization of 3D medical image data is described. The method includes receiving 3D medical image data and performing a selection process to select first image data forming a first portion of the 3D medical image data, the first image data representing a first anatomical object of a given type. An analysis process is performed on the first image data, a parameter of the analysis process being based on the given type of the first anatomical object. Based at least in part on a result of the analysis process, a visual parameter mapping for the first portion is determined, for use in a rendering process for generating a visualization of the 3D medical image data. Also described is a method of generating a computer-based visualization of 3D medical image data and an apparatus for performing the methods.

Abstract: Asynchronous fallback save operations herein (also referred to herein as a background save) provide a means for saving very large transactions from a client device within a stateless architecture. When dealing with large transactions, it may take a long time to process records—so long that the connection between the server and the client may time out, causing the user to lose all work or progress that was being saved. Thus, the present technology serves to prevent this “time out” problem while simultaneously allowing users to continue working on something else while a save is still completing. In some implementations, once a user has submitted a save request, the save operation may be carried out in a background thread pool, allowing the user to continue move on to a new task.

Abstract: An apparatus and method for delivering fluid from a syringe to a subject using a pumping device of a flow control apparatus. The method includes locating the flow control apparatus on a horizontal support surface. Providing the syringe with a volume of fluid including a total amount of preferred nutrient and an amount of non-preferred nutrient liquid. Mounting the syringe relative to the flow control apparatus whereby the syringe is oriented in a generally vertical orientation such that an outlet of the syringe faces upward. Initiating operation of the pumping device to draw the fluid from the syringe for a duration of time to preferentially deliver at least a portion of the total amount of preferred nutrient in the fluid to the subject.

Abstract: A magnetic tracking system is configured to determine an object pose of a tracked object in an environment of the magnetic tracking system. The tracking system includes a transmitter assembly that includes a transmitting coil configured to generate a magnetic signal indicative of an object pose of a tracked object with respect to the transmitter assembly and a marker that visually identifies a pose of the transmitter assembly with respect to a camera device. The camera device captures at least one image of the transmitter assembly. A computing device determines, based on the image, a pose for the transmitter assemblies in the image. Based on the magnetic signal and the pose associated with the transmitter assembly, the computing device determines the object pose of the tracked object in the environment.

Abstract: Purifying target biomolecules, such as nucleic acids or proteins, from a biological source is a time intensive process and is typically performed by a skilled technician or scientist owing to the highly technical nature of the work. Systems, devices, and methods disclosed herein enable the automated bioprocessing and purification of target biomolecules from a biological source. For example, an instrument and disposable cartridge are provided for automatedly isolating and purifying nucleic acids (such as plasmid DNA from a bacterial culture) or for isolating protein from any biological sample. Such an exemplary instrument and cartridge can work in concert to timely release, mix, and move the target biomolecule and various reagents and buffers through a target biomolecule purification process, resulting in a purified target biomolecule with less manual oversight than traditional approaches.

Abstract: A computer-implemented method and a corresponding apparatus are provided for the provision of a two-dimensional visualization image having a plurality of visualization pixels for the visualization of a three-dimensional object represented by volume data for a user. Context information for the visualization is obtained by the evaluation of natural language and is taken into account in the visualization. The natural language can be in the form of electronic documents, which are assigned or can be assigned to the visualization process. In addition, the natural language can be in the form of a speech input of a user, during or after the visualization.

Abstract: A method includes: obtaining an ultrasound image of an anatomical area from an ultrasound imaging device; inputting the ultrasound image into a first stage of a convolutional neural network, the first stage configured to determine key-point locations of the anatomical area; generating, for each of the key-point locations, a cropped region of the ultrasound image; inputting each of the cropped regions into a second stage of the convolutional neural network, the second stage configured to locate an anatomical landmark of the anatomical area; and outputting a location of the anatomical landmark.

Abstract: A computing device implemented method includes receiving data representing strains experienced at multiple positions along a fiber, the fiber being positioned within a surgical theater, determining a shape of the fiber from the received data representing the stains experienced at the multiple positions along the fiber by using a machine learning system, the machine learning system being trained using data representing shapes of fibers and data representing strains at multiple positions along each of the fibers, and representing the determined shape as functions of an orientation of a center of the fiber, a first radial axis of the fiber, and a second radial axis of the fiber.